JP7124248B1 - エピナスチン又はその塩を含有する塗布投与用医薬組成物 - Google Patents

エピナスチン又はその塩を含有する塗布投与用医薬組成物 Download PDF

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JP7124248B1
JP7124248B1 JP2022531600A JP2022531600A JP7124248B1 JP 7124248 B1 JP7124248 B1 JP 7124248B1 JP 2022531600 A JP2022531600 A JP 2022531600A JP 2022531600 A JP2022531600 A JP 2022531600A JP 7124248 B1 JP7124248 B1 JP 7124248B1
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pharmaceutical composition
epinastine
salt
acid
present
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JPWO2022138826A5 (https=
JPWO2022138826A1 (https=
Inventor
直樹 小倉
悠 梶原
幸史 藤澤
善彦 江崎
浩二 阪中
豊実 藤澤
祐子 刀祢
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Santen Pharmaceutical Co Ltd
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Santen Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dispersion Chemistry (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2022531600A 2020-12-24 2021-12-23 エピナスチン又はその塩を含有する塗布投与用医薬組成物 Active JP7124248B1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022128183A JP2022160664A (ja) 2020-12-24 2022-08-10 エピナスチン又はその塩を含有する塗布投与用医薬組成物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2020215231 2020-12-24
JP2020215231 2020-12-24
JP2021146903 2021-09-09
JP2021146903 2021-09-09
PCT/JP2021/047886 WO2022138826A1 (ja) 2020-12-24 2021-12-23 エピナスチン又はその塩を含有する塗布投与用医薬組成物

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JP2022128183A Division JP2022160664A (ja) 2020-12-24 2022-08-10 エピナスチン又はその塩を含有する塗布投与用医薬組成物

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JPWO2022138826A1 JPWO2022138826A1 (https=) 2022-06-30
JP7124248B1 true JP7124248B1 (ja) 2022-08-23
JPWO2022138826A5 JPWO2022138826A5 (https=) 2022-12-05

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JP2022128183A Pending JP2022160664A (ja) 2020-12-24 2022-08-10 エピナスチン又はその塩を含有する塗布投与用医薬組成物

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Country Status (7)

Country Link
US (1) US20240074973A1 (https=)
EP (1) EP4268827A4 (https=)
JP (2) JP7124248B1 (https=)
KR (1) KR20230124624A (https=)
AU (1) AU2021410145A1 (https=)
TW (1) TW202241449A (https=)
WO (1) WO2022138826A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025205960A1 (ja) * 2024-03-27 2025-10-02 参天製薬株式会社 エピナスチン又はその塩を含有する経皮投与用医薬組成物と抗アレルギー薬との組み合わせ

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005053907A (ja) * 2003-08-01 2005-03-03 Boehringer Ingelheim Internatl Gmbh エピナスチンと１種以上のさらなる抗−ｈ１−ヒスタミン類との組合せを含む皮膚疾患治療用製薬組成物
JP2006522053A (ja) * 2003-04-04 2006-09-28 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 皮膚疾患治療用エピナスチン含有医薬組成物
JP2007530481A (ja) * 2004-03-24 2007-11-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング エピナスチン及び１又は２以上の追加のミネラル又は１又は２以上の生薬のコンビネーションを含む皮膚疾患の治療用医薬組成物
JP2009500397A (ja) * 2005-07-08 2009-01-08 千寿製薬株式会社 エピナスチンを含む眼科用経皮吸収型製剤
JP2010502564A (ja) * 2006-08-28 2010-01-28 千寿製薬株式会社 眼科用経皮吸収型製剤

Family Cites Families (9)

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US3536816A (en) * 1964-09-30 1970-10-27 Atlas Chem Ind Water-in-oil emulsion
US6387383B1 (en) * 2000-08-03 2002-05-14 Dow Pharmaceutical Sciences Topical low-viscosity gel composition
KR20050092429A (ko) 2003-01-22 2005-09-21 니찌방 가부시기가이샤 안질환 치료용 경피 흡수형 제제, 그 사용, 및 안질환치료약의 눈의 국소 조직으로의 이행 방법
CN101036659A (zh) * 2006-03-13 2007-09-19 张文静 一组盐酸依匹斯汀制剂及其制备方法
US20080194544A1 (en) * 2007-02-08 2008-08-14 Ramesh Krishnamoorthy Aqueous formulations of epinastine for treating allergic rhinitis
KR20240023714A (ko) * 2015-02-02 2024-02-22 산텐 세이야꾸 가부시키가이샤 폴리아프론 및 이의 안검 투여
JP6134853B1 (ja) * 2016-10-28 2017-05-24 参天製薬株式会社 エピナスチン含有点眼液
JP7355539B2 (ja) * 2018-07-20 2023-10-03 ロート製薬株式会社 眼科組成物
JP7458159B2 (ja) * 2018-09-28 2024-03-29 ロート製薬株式会社 眼科組成物

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006522053A (ja) * 2003-04-04 2006-09-28 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 皮膚疾患治療用エピナスチン含有医薬組成物
JP2005053907A (ja) * 2003-08-01 2005-03-03 Boehringer Ingelheim Internatl Gmbh エピナスチンと１種以上のさらなる抗−ｈ１−ヒスタミン類との組合せを含む皮膚疾患治療用製薬組成物
JP2007530481A (ja) * 2004-03-24 2007-11-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング エピナスチン及び１又は２以上の追加のミネラル又は１又は２以上の生薬のコンビネーションを含む皮膚疾患の治療用医薬組成物
JP2009500397A (ja) * 2005-07-08 2009-01-08 千寿製薬株式会社 エピナスチンを含む眼科用経皮吸収型製剤
JP2010502564A (ja) * 2006-08-28 2010-01-28 千寿製薬株式会社 眼科用経皮吸収型製剤

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025205960A1 (ja) * 2024-03-27 2025-10-02 参天製薬株式会社 エピナスチン又はその塩を含有する経皮投与用医薬組成物と抗アレルギー薬との組み合わせ

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Publication number Publication date
WO2022138826A1 (ja) 2022-06-30
TW202241449A (zh) 2022-11-01
EP4268827A4 (en) 2024-12-11
JP2022160664A (ja) 2022-10-19
US20240074973A1 (en) 2024-03-07
KR20230124624A (ko) 2023-08-25
AU2021410145A1 (en) 2023-07-27
JPWO2022138826A1 (https=) 2022-06-30
AU2021410145A9 (en) 2024-07-25
EP4268827A1 (en) 2023-11-01

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