JP7123935B2 - 微粒子 - Google Patents

微粒子 Download PDF

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Publication number
JP7123935B2
JP7123935B2 JP2019533688A JP2019533688A JP7123935B2 JP 7123935 B2 JP7123935 B2 JP 7123935B2 JP 2019533688 A JP2019533688 A JP 2019533688A JP 2019533688 A JP2019533688 A JP 2019533688A JP 7123935 B2 JP7123935 B2 JP 7123935B2
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JP
Japan
Prior art keywords
acid
hemoglobin
microparticles
blood substitute
self
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JP2019533688A
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English (en)
Japanese (ja)
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JP2019526640A5 (enExample
JP2019526640A (ja
Inventor
ドナルド エイ ウェリングス
Original Assignee
スフェリテック リミテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1273—Polymersomes; Liposomes with polymerisable or polymerised bilayer-forming substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2019533688A 2016-09-05 2017-09-05 微粒子 Active JP7123935B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1615050.0 2016-09-05
GBGB1615050.0A GB201615050D0 (en) 2016-09-05 2016-09-05 Microparticles
PCT/EP2017/072270 WO2018042059A1 (en) 2016-09-05 2017-09-05 Microparticles

Publications (3)

Publication Number Publication Date
JP2019526640A JP2019526640A (ja) 2019-09-19
JP2019526640A5 JP2019526640A5 (enExample) 2020-10-15
JP7123935B2 true JP7123935B2 (ja) 2022-08-23

Family

ID=57140038

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019533688A Active JP7123935B2 (ja) 2016-09-05 2017-09-05 微粒子

Country Status (6)

Country Link
US (2) US10471130B2 (enExample)
EP (1) EP3506887A1 (enExample)
JP (1) JP7123935B2 (enExample)
GB (2) GB201615050D0 (enExample)
WO (1) WO2018042059A1 (enExample)
ZA (1) ZA201902128B (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119500071A (zh) * 2024-11-25 2025-02-25 广东龙康方承医疗器械有限公司 毒素吸附蛋白复合物、毒素去除方法及其制成的毒素吸附器

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014513737A (ja) 2011-04-20 2014-06-05 スフィリテック・リミテッド 架橋ポリ−ε−リシン粒子

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2689418B1 (fr) 1992-04-03 1994-07-01 Centre Nat Rech Scient Procede de preparation de micro-capsules ou de liposomes de tailles controlees par application d'un cisaillement constant sur une phase lamellaire.
DE102006016307B4 (de) 2006-04-06 2011-07-28 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., 80686 Thermisch stabile Matrixmikropartikel und Mikrokapseln für die Kunststoffadditivierung und Verfahren zu ihrer Herstellung und ihre Verwendung
JP4918880B2 (ja) 2007-05-23 2012-04-18 日産化学工業株式会社 ジルコニアゾルの製造方法
PL2014280T3 (pl) 2007-07-13 2015-04-30 Cc Ery Gmbh Mikrocząsteczki, substytut krwi i sposób ich formowania
US8729108B2 (en) 2008-06-17 2014-05-20 Christopher J Dannaker Waterborne topical compositions for the delivery of active ingredients such as azelaic acid
US20150119427A1 (en) 2008-06-17 2015-04-30 Epikinetics Pharma, LLC Waterborne topical compositions for the delivery of azelaic acid for treatment of skin conditions such as acne vulgaris, rosacea, seborrheic dermatitis
JP5233482B2 (ja) 2008-07-31 2013-07-10 東レ株式会社 共重合ポリアミド、それよりなる微粒子および炭素繊維強化複合材料
EP2991627B1 (en) 2013-05-03 2018-09-05 Washington University Blood substitute composition and method of use
GB201503566D0 (en) 2015-03-03 2015-04-15 Spheritech Ltd Microparticles

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014513737A (ja) 2011-04-20 2014-06-05 スフィリテック・リミテッド 架橋ポリ−ε−リシン粒子

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Biomacromolecules, 2012, Vol.13, pp.2748-2759
SHAHID RAMEEZ，BIOCOMPATIBLE AND BIODEGRADABLE POLYMERSOME ENCAPSULATED HEMOGLOBIN: A POTENTIAL OXYGEN CARRIER，BIOCONJUGATE CHEMISTRY，2008年05月，VOL:19, NR:5,，PAGE(S):1025 - 1032，http://dx.doi.org/10.1021/bc700465v
YU XIONG，HEMOGLOBIN-BASED OXYGEN CARRIER MICROPARTICLES: SYNTHESIS, PROPERTIES, AND IN VITRO AND 以下備考，BIOMACROMOLECULES，2012年10月08日，VOL:13, NR:10,，PAGE(S):3292 - 3300，http://dx.doi.org/10.1021/bm301085x，IN VIVO INVESTIGATIONS

Also Published As

Publication number Publication date
GB201714257D0 (en) 2017-10-18
US11273207B2 (en) 2022-03-15
US20200038490A1 (en) 2020-02-06
US20190201497A1 (en) 2019-07-04
ZA201902128B (en) 2021-01-27
GB2558976A (en) 2018-07-25
WO2018042059A1 (en) 2018-03-08
GB2558976B (en) 2021-10-20
EP3506887A1 (en) 2019-07-10
GB201615050D0 (en) 2016-10-19
US10471130B2 (en) 2019-11-12
JP2019526640A (ja) 2019-09-19

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