JP2019526640A5 - - Google Patents
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- Publication number
- JP2019526640A5 JP2019526640A5 JP2019533688A JP2019533688A JP2019526640A5 JP 2019526640 A5 JP2019526640 A5 JP 2019526640A5 JP 2019533688 A JP2019533688 A JP 2019533688A JP 2019533688 A JP2019533688 A JP 2019533688A JP 2019526640 A5 JP2019526640 A5 JP 2019526640A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- blood substitute
- preparation according
- hemoglobin
- organic base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002253 acid Substances 0.000 claims description 38
- 239000003633 blood substitute Substances 0.000 claims description 37
- 238000002360 preparation method Methods 0.000 claims description 31
- 102000001554 Hemoglobins Human genes 0.000 claims description 21
- 108010054147 Hemoglobins Proteins 0.000 claims description 21
- 150000007530 organic bases Chemical class 0.000 claims description 18
- 239000010419 fine particle Substances 0.000 claims description 14
- 230000002378 acidificating effect Effects 0.000 claims description 11
- 239000000243 solution Substances 0.000 claims description 11
- 239000002904 solvent Substances 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 6
- 238000009472 formulation Methods 0.000 claims description 5
- 239000011859 microparticle Substances 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 150000001412 amines Chemical class 0.000 claims description 2
- 239000008346 aqueous phase Substances 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 150000004982 aromatic amines Chemical class 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 claims description 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 2
- 229920000768 polyamine Polymers 0.000 claims description 2
- 239000007762 w/o emulsion Substances 0.000 claims description 2
- 150000007513 acids Chemical class 0.000 claims 1
- SJRJJKPEHAURKC-UHFFFAOYSA-N N-Methylmorpholine Chemical group CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 description 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 2
- RUPBZQFQVRMKDG-UHFFFAOYSA-M Didecyldimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC RUPBZQFQVRMKDG-UHFFFAOYSA-M 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- BDJRBEYXGGNYIS-UHFFFAOYSA-N nonanedioic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 description 2
- 229920000371 poly(diallyldimethylammonium chloride) polymer Polymers 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- CXMXRPHRNRROMY-UHFFFAOYSA-N sebacic acid Chemical compound OC(=O)CCCCCCCCC(O)=O CXMXRPHRNRROMY-UHFFFAOYSA-N 0.000 description 2
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Substances CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 1
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 1
- UEEJHVSXFDXPFK-UHFFFAOYSA-N N-dimethylaminoethanol Chemical compound CN(C)CCO UEEJHVSXFDXPFK-UHFFFAOYSA-N 0.000 description 1
- 150000001735 carboxylic acids Chemical group 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 229960004670 didecyldimethylammonium chloride Drugs 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 229940073455 tetraethylammonium hydroxide Drugs 0.000 description 1
- LRGJRHZIDJQFCL-UHFFFAOYSA-M tetraethylazanium;hydroxide Chemical compound [OH-].CC[N+](CC)(CC)CC LRGJRHZIDJQFCL-UHFFFAOYSA-M 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1615050.0 | 2016-09-05 | ||
| GBGB1615050.0A GB201615050D0 (en) | 2016-09-05 | 2016-09-05 | Microparticles |
| PCT/EP2017/072270 WO2018042059A1 (en) | 2016-09-05 | 2017-09-05 | Microparticles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019526640A JP2019526640A (ja) | 2019-09-19 |
| JP2019526640A5 true JP2019526640A5 (enExample) | 2020-10-15 |
| JP7123935B2 JP7123935B2 (ja) | 2022-08-23 |
Family
ID=57140038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019533688A Active JP7123935B2 (ja) | 2016-09-05 | 2017-09-05 | 微粒子 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10471130B2 (enExample) |
| EP (1) | EP3506887A1 (enExample) |
| JP (1) | JP7123935B2 (enExample) |
| GB (2) | GB201615050D0 (enExample) |
| WO (1) | WO2018042059A1 (enExample) |
| ZA (1) | ZA201902128B (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119500071A (zh) * | 2024-11-25 | 2025-02-25 | 广东龙康方承医疗器械有限公司 | 毒素吸附蛋白复合物、毒素去除方法及其制成的毒素吸附器 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2689418B1 (fr) | 1992-04-03 | 1994-07-01 | Centre Nat Rech Scient | Procede de preparation de micro-capsules ou de liposomes de tailles controlees par application d'un cisaillement constant sur une phase lamellaire. |
| DE102006016307B4 (de) | 2006-04-06 | 2011-07-28 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., 80686 | Thermisch stabile Matrixmikropartikel und Mikrokapseln für die Kunststoffadditivierung und Verfahren zu ihrer Herstellung und ihre Verwendung |
| JP4918880B2 (ja) | 2007-05-23 | 2012-04-18 | 日産化学工業株式会社 | ジルコニアゾルの製造方法 |
| PL2014280T3 (pl) | 2007-07-13 | 2015-04-30 | Cc Ery Gmbh | Mikrocząsteczki, substytut krwi i sposób ich formowania |
| US8729108B2 (en) | 2008-06-17 | 2014-05-20 | Christopher J Dannaker | Waterborne topical compositions for the delivery of active ingredients such as azelaic acid |
| US20150119427A1 (en) | 2008-06-17 | 2015-04-30 | Epikinetics Pharma, LLC | Waterborne topical compositions for the delivery of azelaic acid for treatment of skin conditions such as acne vulgaris, rosacea, seborrheic dermatitis |
| JP5233482B2 (ja) | 2008-07-31 | 2013-07-10 | 東レ株式会社 | 共重合ポリアミド、それよりなる微粒子および炭素繊維強化複合材料 |
| GB201106742D0 (en) * | 2011-04-20 | 2011-06-01 | Spheritech Ltd | Cross-linked poly-e-lysine |
| EP2991627B1 (en) | 2013-05-03 | 2018-09-05 | Washington University | Blood substitute composition and method of use |
| GB201503566D0 (en) | 2015-03-03 | 2015-04-15 | Spheritech Ltd | Microparticles |
-
2016
- 2016-09-05 GB GBGB1615050.0A patent/GB201615050D0/en not_active Ceased
-
2017
- 2017-09-05 JP JP2019533688A patent/JP7123935B2/ja active Active
- 2017-09-05 WO PCT/EP2017/072270 patent/WO2018042059A1/en not_active Ceased
- 2017-09-05 US US16/330,184 patent/US10471130B2/en active Active
- 2017-09-05 EP EP17768043.6A patent/EP3506887A1/en active Pending
- 2017-09-05 GB GB1714257.1A patent/GB2558976B/en active Active
-
2019
- 2019-04-04 ZA ZA2019/02128A patent/ZA201902128B/en unknown
- 2019-10-02 US US16/590,854 patent/US11273207B2/en active Active
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