JP7112384B2 - 可溶性グアニル酸シクラーゼ刺激剤の新規な調製方法 - Google Patents
可溶性グアニル酸シクラーゼ刺激剤の新規な調製方法 Download PDFInfo
- Publication number
- JP7112384B2 JP7112384B2 JP2019500355A JP2019500355A JP7112384B2 JP 7112384 B2 JP7112384 B2 JP 7112384B2 JP 2019500355 A JP2019500355 A JP 2019500355A JP 2019500355 A JP2019500355 A JP 2019500355A JP 7112384 B2 JP7112384 B2 JP 7112384B2
- Authority
- JP
- Japan
- Prior art keywords
- formula
- amount
- suitable amount
- temperature
- organic solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662359453P | 2016-07-07 | 2016-07-07 | |
| US62/359,453 | 2016-07-07 | ||
| PCT/US2017/040810 WO2018009597A1 (en) | 2016-07-07 | 2017-07-06 | Novel processes for preparation of soluble guanylate cyclase stimulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019525913A JP2019525913A (ja) | 2019-09-12 |
| JP2019525913A5 JP2019525913A5 (cg-RX-API-DMAC7.html) | 2020-08-20 |
| JP7112384B2 true JP7112384B2 (ja) | 2022-08-03 |
Family
ID=59416789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019500355A Active JP7112384B2 (ja) | 2016-07-07 | 2017-07-06 | 可溶性グアニル酸シクラーゼ刺激剤の新規な調製方法 |
Country Status (16)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7112384B2 (ja) | 2016-07-07 | 2022-08-03 | サイクレリオン・セラピューティクス，インコーポレーテッド | 可溶性グアニル酸シクラーゼ刺激剤の新規な調製方法 |
| SG10202100168XA (en) * | 2016-07-07 | 2021-02-25 | Cyclerion Therapeutics Inc | Novel processes for preparation of soluble guanylate cyclase stimulators |
| WO2019161534A1 (en) * | 2018-02-22 | 2019-08-29 | Ironwood Pharmaceuticals, Inc. | Novel processes and intermediates for preparation of soluble guanylate cyclase stimulators |
| AU2019206560B2 (en) | 2018-01-10 | 2023-08-24 | Cyclerion Therapeutics, Inc. | Novel processes and intermediates for the preparation of soluble guanylate cyclase stimulators |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013101830A1 (en) | 2011-12-27 | 2013-07-04 | Ironwood Pharmaceuticals, Inc. | 2 - benzyl, 3 - (pyrimidin- 2 -yl) substituted pyrazoles useful as sgc stimulators |
| WO2014144100A2 (en) | 2013-03-15 | 2014-09-18 | Takashi Nakai | Sgc stimulators |
| WO2015089182A1 (en) | 2013-12-11 | 2015-06-18 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| WO2016044447A1 (en) | 2014-09-17 | 2016-03-24 | Ironwood Pharmaceuticals, Inc. | Pyrazole derivatives as sgc stimulators |
| WO2017095697A1 (en) | 2015-11-30 | 2017-06-08 | Ironwood Pharmaceuticals, Inc. | Solid dispersions comprising a sgc stimulator |
| JP2019524712A (ja) | 2016-07-07 | 2019-09-05 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | 可溶性グアニル酸シクラーゼ刺激剤の新規な調製方法 |
| JP2019524710A (ja) | 2016-07-07 | 2019-09-05 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | Ｓｇｃ刺激剤の固体形態 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2800618C (en) | 2010-05-26 | 2018-08-28 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
| DK2588465T3 (en) | 2010-06-30 | 2017-05-01 | Ironwood Pharmaceuticals Inc | SGC stimulators |
| US9487508B2 (en) * | 2012-09-19 | 2016-11-08 | Ironwood Pharmaceuticals, Inc. | SGC stimulators |
| BR112017005248A2 (pt) * | 2014-09-17 | 2017-12-12 | Ironwood Pharmaceuticals Inc | estimuladores de sgc |
| WO2016044445A2 (en) * | 2014-09-17 | 2016-03-24 | Ironwood Pharmaceuticals, Inc. | sGC STIMULATORS |
| AU2015317823A1 (en) * | 2014-09-17 | 2017-03-23 | Ironwood Pharmaceuticals, Inc. | sGC stimulators |
| JP7112384B2 (ja) | 2016-07-07 | 2022-08-03 | サイクレリオン・セラピューティクス，インコーポレーテッド | 可溶性グアニル酸シクラーゼ刺激剤の新規な調製方法 |
| EA202091502A1 (ru) * | 2017-12-19 | 2020-11-12 | Сайклерион Терапьютикс, Инк. | СТИМУЛЯТОРЫ sGC |
| AU2019206560B2 (en) * | 2018-01-10 | 2023-08-24 | Cyclerion Therapeutics, Inc. | Novel processes and intermediates for the preparation of soluble guanylate cyclase stimulators |
-
2017
- 2017-07-06 JP JP2019500355A patent/JP7112384B2/ja active Active
- 2017-07-06 CA CA3029375A patent/CA3029375A1/en active Pending
- 2017-07-06 EP EP17745553.2A patent/EP3481818B1/en active Active
- 2017-07-06 KR KR1020197003459A patent/KR102487872B1/ko active Active
- 2017-07-06 AU AU2017291827A patent/AU2017291827B2/en active Active
- 2017-07-06 MX MX2019000105A patent/MX389920B/es unknown
- 2017-07-06 US US16/315,218 patent/US11319308B2/en active Active
- 2017-07-06 EA EA201990237A patent/EA201990237A1/ru unknown
- 2017-07-06 BR BR112019000291A patent/BR112019000291A2/pt not_active Application Discontinuation
- 2017-07-06 SG SG11201900096QA patent/SG11201900096QA/en unknown
- 2017-07-06 WO PCT/US2017/040810 patent/WO2018009597A1/en not_active Ceased
- 2017-07-06 CN CN201780047020.6A patent/CN109563077A/zh active Pending
- 2017-07-06 ES ES17745553T patent/ES2963563T3/es active Active
- 2017-07-06 EP EP23185002.5A patent/EP4249488A3/en active Pending
- 2017-07-06 MA MA045603A patent/MA45603A/fr unknown
-
2018
- 2018-12-27 IL IL263995A patent/IL263995B/en active IP Right Grant
-
2019
- 2019-01-04 CL CL2019000016A patent/CL2019000016A1/es unknown
- 2019-01-07 MX MX2022001495A patent/MX2022001495A/es unknown
-
2022
- 2022-03-30 US US17/708,296 patent/US11773089B2/en active Active
-
2023
- 2023-01-24 CL CL2023000228A patent/CL2023000228A1/es unknown
- 2023-08-24 US US18/237,435 patent/US20240059684A1/en not_active Abandoned
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013101830A1 (en) | 2011-12-27 | 2013-07-04 | Ironwood Pharmaceuticals, Inc. | 2 - benzyl, 3 - (pyrimidin- 2 -yl) substituted pyrazoles useful as sgc stimulators |
| WO2014144100A2 (en) | 2013-03-15 | 2014-09-18 | Takashi Nakai | Sgc stimulators |
| WO2015089182A1 (en) | 2013-12-11 | 2015-06-18 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| WO2016044447A1 (en) | 2014-09-17 | 2016-03-24 | Ironwood Pharmaceuticals, Inc. | Pyrazole derivatives as sgc stimulators |
| WO2017095697A1 (en) | 2015-11-30 | 2017-06-08 | Ironwood Pharmaceuticals, Inc. | Solid dispersions comprising a sgc stimulator |
| JP2019524712A (ja) | 2016-07-07 | 2019-09-05 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | 可溶性グアニル酸シクラーゼ刺激剤の新規な調製方法 |
| JP2019524710A (ja) | 2016-07-07 | 2019-09-05 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | Ｓｇｃ刺激剤の固体形態 |
Non-Patent Citations (1)
| Title |
|---|
| NAKAI, T et al.，Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans，ACS Medicinal Chemistry Letters，2016年，Vol. 7，pp. 465-469 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20240059684A1 (en) | 2024-02-22 |
| EP4249488A3 (en) | 2023-12-20 |
| ES2963563T3 (es) | 2024-03-27 |
| CL2019000016A1 (es) | 2019-05-03 |
| AU2017291827A1 (en) | 2019-02-07 |
| SG11201900096QA (en) | 2019-02-27 |
| MX389920B (es) | 2025-03-20 |
| WO2018009597A1 (en) | 2018-01-11 |
| MA45603A (fr) | 2019-05-15 |
| NZ750123A (en) | 2025-02-28 |
| AU2017291827B2 (en) | 2021-10-21 |
| KR20190025986A (ko) | 2019-03-12 |
| CL2023000228A1 (es) | 2023-09-29 |
| US11319308B2 (en) | 2022-05-03 |
| EA201990237A1 (ru) | 2019-08-30 |
| US20210323951A1 (en) | 2021-10-21 |
| IL263995B (en) | 2021-02-28 |
| JP2019525913A (ja) | 2019-09-12 |
| EP3481818C0 (en) | 2023-09-06 |
| EP4249488A2 (en) | 2023-09-27 |
| US20220227748A1 (en) | 2022-07-21 |
| EP3481818B1 (en) | 2023-09-06 |
| CA3029375A1 (en) | 2018-01-11 |
| MX2019000105A (es) | 2019-04-22 |
| IL263995A (en) | 2019-02-28 |
| CN109563077A (zh) | 2019-04-02 |
| US11773089B2 (en) | 2023-10-03 |
| KR102487872B1 (ko) | 2023-01-12 |
| EP3481818A1 (en) | 2019-05-15 |
| MX2022001495A (es) | 2022-03-11 |
| BR112019000291A2 (pt) | 2019-04-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK2970303T3 (en) | SUBSTITUTED XANTHINES AND PROCEDURES FOR USING IT | |
| US11773089B2 (en) | Process for preparation of soluble guanylate cyclase stimulators | |
| US12247025B2 (en) | Processes for preparation of soluble guanylate cyclase stimulators | |
| TW201713629A (zh) | 新穎苯并咪唑化合物及其醫藥用途 | |
| HK40103206A (en) | Novel processes for preparation of soluble guanylate cyclase stimulators | |
| HK40007031A (en) | Novel processes for preparation of soluble guanylate cyclase stimulators | |
| HK40007031B (en) | Novel processes for preparation of soluble guanylate cyclase stimulators | |
| EA041479B1 (ru) | Новые способы получения промежуточных соединений для синтеза стимуляторов растворимой гуанилатциклазы | |
| EA047613B1 (ru) | Новые способы получения стимуляторов растворимой гуанилатциклазы | |
| HK40007032A (en) | Novel processes for preparation of soluble guanylate cyclase stimulators | |
| HK40007032B (en) | Novel processes for preparation of soluble guanylate cyclase stimulators | |
| OA19467A (en) | Novel processes for preparation of soluble Guanylate Cyclase stimulators. | |
| EA040047B1 (ru) | Новые способы получения стимуляторов растворимой гуанилатциклазы | |
| BR112015021164B1 (pt) | Composto de xantina substituída e seu sal |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20190710 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200706 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20200706 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20210527 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A132 Effective date: 20210607 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210906 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20220111 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20220411 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20220624 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20220722 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 7112384 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |