JP7110199B2 - 抗第ＸＩ／ＸＩａ因子抗体による処置法 - Google Patents

抗第ＸＩ／ＸＩａ因子抗体による処置法 Download PDF

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JP7110199B2
JP7110199B2 JP2019533396A JP2019533396A JP7110199B2 JP 7110199 B2 JP7110199 B2 JP 7110199B2 JP 2019533396 A JP2019533396 A JP 2019533396A JP 2019533396 A JP2019533396 A JP 2019533396A JP 7110199 B2 JP7110199 B2 JP 7110199B2
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antibody
fxi
seq
amino acid
fxia
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JP2020504110A (ja
JP2020504110A5 (https=
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フリードマン，カローラ
キーダー，ヤセル
レフコウィッツ，マーティン
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ノバルティス アーゲー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
JP2019533396A 2016-12-23 2017-12-22 抗第ＸＩ／ＸＩａ因子抗体による処置法 Active JP7110199B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022115212A JP7500662B2 (ja) 2016-12-23 2022-07-20 抗第ＸＩ／ＸＩａ因子抗体による処置法
JP2024091065A JP2024116221A (ja) 2016-12-23 2024-06-05 抗第ＸＩ／ＸＩａ因子抗体による処置法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662438654P 2016-12-23 2016-12-23
US62/438,654 2016-12-23
US201762589851P 2017-11-22 2017-11-22
US62/589,851 2017-11-22
PCT/IB2017/058345 WO2018116267A2 (en) 2016-12-23 2017-12-22 Methods of treatment with anti-factor xi/xia antibodies

Related Child Applications (1)

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JP2022115212A Division JP7500662B2 (ja) 2016-12-23 2022-07-20 抗第ＸＩ／ＸＩａ因子抗体による処置法

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JP2020504110A JP2020504110A (ja) 2020-02-06
JP2020504110A5 JP2020504110A5 (https=) 2021-04-30
JP7110199B2 true JP7110199B2 (ja) 2022-08-01

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JP2019533396A Active JP7110199B2 (ja) 2016-12-23 2017-12-22 抗第ＸＩ／ＸＩａ因子抗体による処置法
JP2022115212A Active JP7500662B2 (ja) 2016-12-23 2022-07-20 抗第ＸＩ／ＸＩａ因子抗体による処置法
JP2024091065A Pending JP2024116221A (ja) 2016-12-23 2024-06-05 抗第ＸＩ／ＸＩａ因子抗体による処置法

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JP2022115212A Active JP7500662B2 (ja) 2016-12-23 2022-07-20 抗第ＸＩ／ＸＩａ因子抗体による処置法
JP2024091065A Pending JP2024116221A (ja) 2016-12-23 2024-06-05 抗第ＸＩ／ＸＩａ因子抗体による処置法

Country Status (9)

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US (3) US20200231701A1 (https=)
EP (1) EP3558370A2 (https=)
JP (3) JP7110199B2 (https=)
KR (3) KR102702288B1 (https=)
CN (2) CN110325211A (https=)
AU (2) AU2017383537B2 (https=)
CA (1) CA3048157A1 (https=)
IL (2) IL267519B2 (https=)
WO (1) WO2018116267A2 (https=)

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JP6799530B2 (ja) 2014-10-01 2020-12-16 メディミューン リミテッド チカグレロルに対する抗体および使用方法
UY36751A (es) 2015-06-26 2017-01-31 Novartis Ag Anticuerpos de factor xi y métodos de uso
TW201802121A (zh) 2016-05-25 2018-01-16 諾華公司 抗因子XI/XIa抗體之逆轉結合劑及其用途
IL267519B2 (en) * 2016-12-23 2025-04-01 Novartis Ag Factor XI/XIA for use in the prevention, treatment, management, or reduction of the risk of stroke or thromboembolism in a patient with end-stage renal disease
AU2017383232B2 (en) 2016-12-23 2024-09-12 Novartis Ag Factor XI antibodies and methods of use
KR102880762B1 (ko) 2018-09-20 2025-11-03 에스에프제이 파마 엑스, 인코포레이티드 티카그렐러 활성을 반전시키는 방법
KR20210151774A (ko) 2019-04-16 2021-12-14 쓰촨 케룬-바이오테크 바이오파마수티컬 컴퍼니 리미티드 항-FXI/FXIa 항체 및 그 용도
CN110423278B (zh) * 2019-08-08 2020-07-17 上海博槿生物科技有限公司 一种抗凝血因子XI活化形式因子XIa的抗体及其制备方法和应用
US20230071973A1 (en) * 2019-12-20 2023-03-09 Anthos Therapeutics, Inc. Pharmaceutical formulations and dosage regimens for factor xi/xia antibodies
EP4177274A4 (en) * 2020-07-02 2024-04-03 Beijing Tuo Jie Biopharmaceutical Co. Ltd. Anti-fxi/fxia antibody, antigen-binding fragment thereof, and pharmaceutical use thereof
TW202405022A (zh) * 2022-06-24 2024-02-01 美商安瑟斯治療公司 與抗因子ｘｉ／因子ｘｉａ抗體之組合療法
WO2025201156A1 (zh) * 2024-03-28 2025-10-02 施能康生物医药（苏州）有限公司 靶向凝血因子xi的核酸及其用途

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JP2018526976A (ja) 2015-06-26 2018-09-20 ノバルティス アーゲー 第ｘｉ因子抗体および使用方法

Also Published As

Publication number Publication date
IL267519B2 (en) 2025-04-01
US20200231701A1 (en) 2020-07-23
JP2020504110A (ja) 2020-02-06
EP3558370A2 (en) 2019-10-30
AU2017383537B2 (en) 2024-10-03
IL316673A (en) 2024-12-01
IL267519B1 (en) 2024-12-01
JP2024116221A (ja) 2024-08-27
US20250197522A1 (en) 2025-06-19
JP7500662B2 (ja) 2024-06-17
CN118320078A (zh) 2024-07-12
KR102702288B1 (ko) 2024-09-05
US20230002507A1 (en) 2023-01-05
WO2018116267A2 (en) 2018-06-28
WO2018116267A3 (en) 2018-08-02
AU2024287181A1 (en) 2025-03-06
JP2022141831A (ja) 2022-09-29
KR20260023597A (ko) 2026-02-20
CN110325211A (zh) 2019-10-11
IL267519A (en) 2019-08-29
KR20190099256A (ko) 2019-08-26
KR102918597B1 (ko) 2026-01-28
KR20240134248A (ko) 2024-09-06
CA3048157A1 (en) 2018-06-28
AU2017383537A1 (en) 2019-06-27

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