JP7104141B2 - 脂質化ペプチドの水溶性塩、その製造方法および用途 - Google Patents

脂質化ペプチドの水溶性塩、その製造方法および用途 Download PDF

Info

Publication number
JP7104141B2
JP7104141B2 JP2020505847A JP2020505847A JP7104141B2 JP 7104141 B2 JP7104141 B2 JP 7104141B2 JP 2020505847 A JP2020505847 A JP 2020505847A JP 2020505847 A JP2020505847 A JP 2020505847A JP 7104141 B2 JP7104141 B2 JP 7104141B2
Authority
JP
Japan
Prior art keywords
compound
acid
pharmaceutical composition
type
amorphous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2020505847A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020529435A5 (enExample
JP2020529435A (ja
Inventor
サン ウク カン
Original Assignee
ブリッジ バイオセラピューティクス インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ブリッジ バイオセラピューティクス インコーポレイテッド filed Critical ブリッジ バイオセラピューティクス インコーポレイテッド
Publication of JP2020529435A publication Critical patent/JP2020529435A/ja
Publication of JP2020529435A5 publication Critical patent/JP2020529435A5/ja
Priority to JP2022067393A priority Critical patent/JP2022106788A/ja
Application granted granted Critical
Publication of JP7104141B2 publication Critical patent/JP7104141B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Analytical Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Immunology (AREA)
JP2020505847A 2018-02-28 2019-02-27 脂質化ペプチドの水溶性塩、その製造方法および用途 Active JP7104141B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022067393A JP2022106788A (ja) 2018-02-28 2022-04-15 脂質化ペプチドの水溶性塩、その製造方法および用途

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862636552P 2018-02-28 2018-02-28
US62/636,552 2018-02-28
PCT/KR2019/002397 WO2019168357A1 (en) 2018-02-28 2019-02-27 Water soluble salts of lipidated peptides and methods for preparing and using the same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022067393A Division JP2022106788A (ja) 2018-02-28 2022-04-15 脂質化ペプチドの水溶性塩、その製造方法および用途

Publications (3)

Publication Number Publication Date
JP2020529435A JP2020529435A (ja) 2020-10-08
JP2020529435A5 JP2020529435A5 (enExample) 2021-09-24
JP7104141B2 true JP7104141B2 (ja) 2022-07-20

Family

ID=67684306

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020505847A Active JP7104141B2 (ja) 2018-02-28 2019-02-27 脂質化ペプチドの水溶性塩、その製造方法および用途
JP2022067393A Pending JP2022106788A (ja) 2018-02-28 2022-04-15 脂質化ペプチドの水溶性塩、その製造方法および用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2022067393A Pending JP2022106788A (ja) 2018-02-28 2022-04-15 脂質化ペプチドの水溶性塩、その製造方法および用途

Country Status (10)

Country Link
US (1) US11739120B2 (enExample)
EP (1) EP3759070A4 (enExample)
JP (2) JP7104141B2 (enExample)
KR (1) KR102058853B1 (enExample)
CN (1) CN110959002A (enExample)
MY (1) MY200470A (enExample)
PH (1) PH12020551233A1 (enExample)
SG (1) SG11202007544RA (enExample)
TW (2) TWI811767B (enExample)
WO (1) WO2019168357A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102104507B1 (ko) * 2019-08-23 2020-04-24 브릿지바이오테라퓨틱스(주) 팔미토일-l-프롤릴-l-프롤릴-글리실-l-타이로신 나트륨을 포함하는 약제학적 제제 및 이의 제조방법
CN111297905B (zh) * 2020-03-18 2022-11-04 四川大学华西医院 一种基于皮肤前体细胞的提取物及其制备方法和用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103724204A (zh) 2013-11-27 2014-04-16 北京化工大学 一种水溶性引发剂及制备
US20170008924A1 (en) 2015-07-08 2017-01-12 Research & Business Foundation Sungkyunkwan University Pyrrolidine carboxamido derivatives and methods for preparing and using the same

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1195762B (it) * 1980-10-13 1988-10-27 Reiner Alberto Real Sas Derivati idrosolubili della cefalexina e procedimento per la loro produzione
DE3839127A1 (de) 1988-11-19 1990-05-23 Hoechst Ag Pyrrolidon-2-carbonsaeure-derivate mit psychotroper wirkung
AUPM906594A0 (en) 1994-10-26 1994-11-17 Peptide Technology Limited Synthetic polyunsaturated fatty acid analogues
NZ332585A (en) 1996-05-01 2000-04-28 Ortho Mcneil Pharm Inc Carboxamide derivatives of pyrrolidine, piperidine and hexahydroazepine for the treatment of thrombosis disorders
ES2213985T3 (es) 1998-11-05 2004-09-01 Pfizer Products Inc. Derivados de hidroxiamida de acido 5-oxo-pirrolidin-2-carboxilico.
WO2003007876A2 (en) 2001-06-25 2003-01-30 University Of Massachusetts N-fatty acid-amino acid conjugates and therapeutic uses
WO2006113942A2 (en) 2005-04-20 2006-10-26 Schering Corporation Method of inhibiting cathepsin activity
US7842662B2 (en) 2006-11-10 2010-11-30 Cara Therapeutics, Inc. Synthetic peptide amide dimers
MX2010002300A (es) * 2007-08-29 2010-03-18 Pfizer Prod Inc Polimorfos de sal sodica del acido (3-(((4-terc-butil-bencil)-(pir idin-3-sulfonil)-amino)-metil)-fenoxi)-acetico o un hidrato de los mismos y procedimientos para fabricar los mismos.
WO2010059922A1 (en) * 2008-11-21 2010-05-27 Ligand Pharmaceuticals Incorporated Pyrrolidine carboxamide compounds
KR101151878B1 (ko) 2010-06-08 2012-05-31 미원상사주식회사 지방산 트리펩타이드염 및 이를 함유하는 항균 조성물
KR101348284B1 (ko) 2010-09-09 2014-01-03 주식회사 나이벡 인간 유래 세포 투과성 펩타이드와 생리활성 펩타이드 결합체 및 그 용도
KR20120048864A (ko) 2010-11-08 2012-05-16 주식회사 네오디엠 트리 펩타이드 유도체를 함유한 아토피 피부염 예방 및 치료용 조성물과 그 제조방법
KR20130038426A (ko) 2011-10-07 2013-04-18 성균관대학교산학협력단 지방산이 결합된 항당뇨 펩티드가 소수성 결합된 글리콜 키토산 히드로겔 및 이를 포함하는 당뇨병 예방 또는 치료용 약학적 조성물
KR101359886B1 (ko) 2011-12-28 2014-02-12 성균관대학교산학협력단 스매드 6번(Ｓｍａｄ６)으로부터 유래된 펩타이드를 유효성분으로 포함하는 패혈증 또는 패혈성 쇼크의 치료용 조성물
US20150368197A1 (en) * 2012-06-21 2015-12-24 Radikal Therapeutics Ins. Compositions and methods for treatment of inflammatory diseases of the lung

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103724204A (zh) 2013-11-27 2014-04-16 北京化工大学 一种水溶性引发剂及制备
US20170008924A1 (en) 2015-07-08 2017-01-12 Research & Business Foundation Sungkyunkwan University Pyrrolidine carboxamido derivatives and methods for preparing and using the same

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Advanced Drug Delivery Reviews，2007年，Vol. 59，pp. 603-616
European Journal of Pharmaceutical Sciences，2013年，Vol. 49，pp. 614-623
Organic Process Research & Development，2000年，Vol. 4，pp. 427-435

Also Published As

Publication number Publication date
US20190263859A1 (en) 2019-08-29
TWI811767B (zh) 2023-08-11
MY200470A (en) 2023-12-27
KR20190103986A (ko) 2019-09-05
SG11202007544RA (en) 2020-09-29
KR102058853B1 (ko) 2019-12-24
EP3759070A1 (en) 2021-01-06
CN110959002A (zh) 2020-04-03
US11739120B2 (en) 2023-08-29
EP3759070A4 (en) 2021-12-08
TWI762770B (zh) 2022-05-01
JP2022106788A (ja) 2022-07-20
JP2020529435A (ja) 2020-10-08
PH12020551233A1 (en) 2021-05-17
TW202222818A (zh) 2022-06-16
WO2019168357A1 (en) 2019-09-06
TW201936577A (zh) 2019-09-16

Similar Documents

Publication Publication Date Title
KR102890565B1 (ko) 2-(3,5-디클로로-4-((5-이소프로필-6-옥소-1,6-디히드로피리다진-3-일)옥시)페닐)-3,5-디옥소-2,3,4,5-테트라히드로-1,2,4-트리아진-6-카르보니트릴의 고체 형태
ES2652187T3 (es) Fenilacetato de l-ornitina y métodos para elaborar el mismo
CN105658643A (zh) Ido抑制剂
US11524939B2 (en) Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid
TW201043226A (en) Salts of 3-pentylphenylacetic acid and pharmaceutical uses thereof
JP2022106788A (ja) 脂質化ペプチドの水溶性塩、その製造方法および用途
JP2014144916A (ja) ２−アシルアミノチアゾール化合物の結晶
JP2025503139A (ja) 固形腫瘍の治療のためのユビキチン特異的プロセシングプロテアーゼ１（ｕｓｐ１）阻害剤
CN102740856B (zh) 神经营养蛋白模拟化合物及其盐的晶型
WO2021013085A1 (zh) 一种肽酰胺盐及其制备方法和在医药上的用途
JP2015535842A (ja) ニューロトロフィン模倣化合物の結晶形及びその塩
CN118178369A (zh) 氨基硫醇类化合物作为脑神经或心脏保护剂的用途
JP5888612B2 (ja) 縮合ピリジン化合物塩の結晶
WO2023193563A1 (zh) 一种噻吩并吡啶化合物的晶型a、制备方法及其药物组合物
CN112759546B (zh) 3-(二甲氨基甲基)哌啶-4-醇衍生物及其制备方法和药物用途
HK40025156A (en) Water soluble salts of lipidated peptides and methods for preparing and using the same
US11440908B2 (en) Crystalline forms of dasatinib
CN115960080B (zh) 一种多环化合物及其作为胃饥饿素受体激动剂的用途
JP7517705B2 (ja) フロピリミジン化合物の塩および結晶形ならびにその医薬用途
CN105073109A (zh) 眼部疾病用治疗剂
RU2819399C2 (ru) Пептиды и фармацевтические композиции для лечения глазных болезней
RU2802964C2 (ru) Твердые формы 2-(5-(4-(2-морфолиноэтокси)фенил)пиридин-2-ил)-n-бензилацетамида
TW202328073A (zh) Ｅｐ４拮抗劑化合物及其鹽、多晶型及其製備方法和用途
KR20250139359A (ko) 인터류킨-23 수용체의 결정질 펩티드 억제제의 제조 방법
TW202440535A (zh) 吡喃葡萄糖基衍生物的晶型及其用途

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20200129

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20210204

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20210506

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20210702

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20210804

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20210804

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20211215

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220415

C60 Trial request (containing other claim documents, opposition documents)

Free format text: JAPANESE INTERMEDIATE CODE: C60

Effective date: 20220415

C11 Written invitation by the commissioner to file amendments

Free format text: JAPANESE INTERMEDIATE CODE: C11

Effective date: 20220427

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20220519

C21 Notice of transfer of a case for reconsideration by examiners before appeal proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C21

Effective date: 20220523

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20220608

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20220707

R150 Certificate of patent or registration of utility model

Ref document number: 7104141

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250