JP7098325B2 - Cs1標的化キメラ抗原レセプター改変t細胞 - Google Patents
Cs1標的化キメラ抗原レセプター改変t細胞 Download PDFInfo
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- JP7098325B2 JP7098325B2 JP2017529682A JP2017529682A JP7098325B2 JP 7098325 B2 JP7098325 B2 JP 7098325B2 JP 2017529682 A JP2017529682 A JP 2017529682A JP 2017529682 A JP2017529682 A JP 2017529682A JP 7098325 B2 JP7098325 B2 JP 7098325B2
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
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- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C12N5/0634—Cells from the blood or the immune system
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- A61K2039/515—Animal cells
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/033—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the internal surface of the plasma membrane, e.g. containing a myristoylation motif
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C12N2510/00—Genetically modified cells
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022001433A JP7252379B2 (ja) | 2014-12-05 | 2022-01-07 | Cs1標的化キメラ抗原受容体修飾t細胞 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462088423P | 2014-12-05 | 2014-12-05 | |
| US62/088,423 | 2014-12-05 | ||
| PCT/US2015/064303 WO2016090369A1 (en) | 2014-12-05 | 2015-12-07 | Cs1 targeted chimeric antigen receptor-modified t cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022001433A Division JP7252379B2 (ja) | 2014-12-05 | 2022-01-07 | Cs1標的化キメラ抗原受容体修飾t細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017537627A JP2017537627A (ja) | 2017-12-21 |
| JP2017537627A5 JP2017537627A5 (enExample) | 2019-01-17 |
| JP7098325B2 true JP7098325B2 (ja) | 2022-07-11 |
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ID=55069093
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017529682A Active JP7098325B2 (ja) | 2014-12-05 | 2015-12-07 | Cs1標的化キメラ抗原レセプター改変t細胞 |
| JP2022001433A Active JP7252379B2 (ja) | 2014-12-05 | 2022-01-07 | Cs1標的化キメラ抗原受容体修飾t細胞 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022001433A Active JP7252379B2 (ja) | 2014-12-05 | 2022-01-07 | Cs1標的化キメラ抗原受容体修飾t細胞 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10821161B2 (enExample) |
| EP (2) | EP4219530A1 (enExample) |
| JP (2) | JP7098325B2 (enExample) |
| KR (1) | KR102558502B1 (enExample) |
| CN (2) | CN107429253B (enExample) |
| AU (2) | AU2015357485B2 (enExample) |
| BR (1) | BR112017011893A2 (enExample) |
| CA (1) | CA2969704C (enExample) |
| IL (3) | IL290459B2 (enExample) |
| MX (2) | MX384964B (enExample) |
| RU (1) | RU2727451C2 (enExample) |
| WO (1) | WO2016090369A1 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2934532B1 (en) | 2012-12-20 | 2019-10-23 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| MX382541B (es) | 2014-04-23 | 2025-03-13 | Juno Therapeutics Inc | Métodos para aislar, cultivar y diseñar genéticamente poblaciones de células inmunes para terapia adoptiva. |
| AU2015357485B2 (en) * | 2014-12-05 | 2020-10-15 | City Of Hope | CS1 targeted chimeric antigen receptor-modified T cells |
| CN107406516B (zh) | 2015-01-26 | 2021-11-23 | 塞勒克提斯公司 | 用于癌症免疫治疗的抗CLL1特异性单链嵌合抗原受体(scCAR) |
| CN108350462B (zh) | 2015-09-11 | 2022-05-27 | 生物权威(英国)有限公司 | 嵌合抗原受体及其用途 |
| WO2017130223A2 (en) | 2016-01-29 | 2017-08-03 | Virocan Therapeutics Pvt. Ltd. | A chimeric antigen receptor specific to b-cell maturation antigen, a recombinant expression vector and a method thereof |
| SG10201912489QA (en) | 2016-04-01 | 2020-02-27 | Kite Pharma Inc | Chimeric antigen and t cell receptors and methods of use |
| NZ746700A (en) | 2016-04-01 | 2023-04-28 | Kite Pharma Inc | Bcma binding molecules and methods of use thereof |
| PE20200400A1 (es) | 2016-04-01 | 2020-02-26 | Kite Pharma Inc | Receptores quimericos y metodos de uso de los mismos |
| JP7282521B2 (ja) | 2016-04-08 | 2023-05-29 | パーデュー・リサーチ・ファウンデイション | Car t細胞療法のための方法および組成物 |
| CN105949324B (zh) * | 2016-06-30 | 2019-08-27 | 上海恒润达生生物科技有限公司 | 靶向gpc3的嵌合抗原受体及其用途 |
| WO2018002358A1 (en) | 2016-06-30 | 2018-01-04 | F. Hoffmann-La Roche Ag | Improved adoptive t-cell therapy |
| WO2018064626A1 (en) * | 2016-09-30 | 2018-04-05 | Baylor College Of Medicine | Adaptive chimeric antigen receptor t-cell design |
| WO2018156711A1 (en) * | 2017-02-22 | 2018-08-30 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Il13ra2-binding chimeric antigen receptors |
| JP7178355B2 (ja) | 2017-02-28 | 2022-11-25 | エンドサイト・インコーポレイテッド | Car t細胞療法のための組成物および方法 |
| WO2018169922A2 (en) | 2017-03-13 | 2018-09-20 | Kite Pharma, Inc. | Chimeric antigen receptors for melanoma and uses thereof |
| US11744862B2 (en) | 2017-03-20 | 2023-09-05 | City Of Hope | CS1 targeted chimeric antigen receptor-modified T cells for treatment of AL amyloidosis |
| KR102712254B1 (ko) | 2017-03-27 | 2024-10-04 | 에프. 호프만-라 로슈 아게 | 개선된 항원 결합 수용체 |
| JOP20180042A1 (ar) | 2017-04-24 | 2019-01-30 | Kite Pharma Inc | نطاقات ربط مولد ضد متوافقة مع البشر وطرق الاستخدام |
| EP3615059B1 (en) | 2017-04-28 | 2025-11-19 | Julius-Maximilians-Universität Würzburg | Ror1-specific chimeric antigen receptors (car) with humanized targeting domains |
| US20200206266A1 (en) * | 2017-08-01 | 2020-07-02 | Julius-Maximilians-Universität Würzburg | Use of flt3 car-t cells and flt3 inhibitors to treat acute myeloid leukemia |
| US11950198B2 (en) | 2017-08-11 | 2024-04-02 | Interdigital Patent Holdings, Inc. | Traffic steering and switching between multiple access networks |
| EP4512823A3 (en) * | 2017-11-01 | 2025-05-14 | Juno Therapeutics, Inc. | Process for generating therapeutic compositions of engineered cells |
| US11464803B2 (en) | 2017-11-14 | 2022-10-11 | Arcellx, Inc. | D-domain containing polypeptides and uses thereof |
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| EP3710471A1 (en) | 2017-11-16 | 2020-09-23 | Kite Pharma, Inc. | Modified chimeric antigen receptors and methods of use |
| CA3089319A1 (en) | 2018-01-22 | 2019-07-25 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Methods of use for car t cells |
| CN112534044A (zh) | 2018-02-16 | 2021-03-19 | 凯德药业股份有限公司 | 经修饰的多能干细胞及制备和使用方法 |
| US12240870B2 (en) | 2018-02-23 | 2025-03-04 | Purdue Research Foundation | Sequencing method for CAR T cell therapy |
| AU2019275479B2 (en) * | 2018-05-21 | 2022-12-08 | Biosceptre (Aust) Pty Ltd | Chimeric antigen receptors with modified linker domains and uses thereof |
| WO2020009868A1 (en) * | 2018-07-03 | 2020-01-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-slamf7 chimeric antigen receptors |
| AU2019312673A1 (en) | 2018-08-01 | 2021-02-25 | City Of Hope | TAG72 targeted chimeric antigen receptor modified T cells for treatment of TAG72-positive tumors |
| WO2020025039A1 (zh) * | 2018-08-03 | 2020-02-06 | 南京驯鹿医疗技术有限公司 | 表达嵌合抗原受体的t细胞、该嵌合抗原相关表达载体以及它们的应用 |
| BR112021012172A2 (pt) | 2018-12-12 | 2021-08-31 | Kite Pharma, Inc. | Receptores de antígenos quiméricos e de célula t e métodos de uso |
| AU2020253538A1 (en) | 2019-04-03 | 2021-11-18 | Precision Biosciences, Inc. | Genetically-modified immune cells comprising a microRNA-adapted shRNA (shRNAmiR) |
| WO2020243007A1 (en) * | 2019-05-24 | 2020-12-03 | City Of Hope | Ccr4 targeted chimeric antigen receptor modified t cells for treatment of ccr4 positive malignancies |
| AU2020295715A1 (en) * | 2019-06-19 | 2022-02-17 | Julius-Maximilians-Universität Würzburg | Ultramodular IgG3-based spacer domain and multi-function site for implementation in chimeric antigen receptor design |
| CN112442126B (zh) * | 2019-09-04 | 2022-07-29 | 杭州济元基因科技有限公司 | 一种抗人cs1抗原的单克隆抗体及其car-t细胞 |
| KR20230010228A (ko) * | 2020-05-08 | 2023-01-18 | 시애틀 칠드런즈 호스피탈 디/비/에이 시애틀 칠드런즈 리서치 인스티튜트 | 자연 살해 세포를 표적으로 하는 키메라 항원 수용체 (cars) |
| CA3184784A1 (en) * | 2020-05-27 | 2021-12-02 | The Medical College Of Wisconsin, Inc. | Improved lentiviral vector transfer plasmid and methods of use |
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| CA3190797A1 (en) * | 2020-08-10 | 2022-02-17 | Julius-Maximilians-Universitat Wurzburg | Siglec-6-binding polypeptides |
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| WO2022206941A1 (zh) * | 2021-04-02 | 2022-10-06 | 克莱格医学有限公司 | Cs1工程化细胞及其组合物 |
| US20250032543A1 (en) * | 2021-12-06 | 2025-01-30 | The Children's Hospital Of Philadelphia | Dual targeting of pediatric malignancies through car t-cells secreting bispecific innate immune cell engagers (bices) |
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