CA2969704C - Cs1 targeted chimeric antigen receptor-modified t cells - Google Patents
Cs1 targeted chimeric antigen receptor-modified t cells Download PDFInfo
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| PCT/US2015/064303 WO2016090369A1 (en) | 2014-12-05 | 2015-12-07 | Cs1 targeted chimeric antigen receptor-modified t cells |
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| ES2949648T3 (es) | 2012-12-20 | 2023-10-02 | Purdue Research Foundation | Células T que expresan un receptor antigénico quimérico como terapia contra el cáncer |
| ES2759260T3 (es) | 2014-04-23 | 2020-05-08 | Juno Therapeutics Inc | Métodos para aislar, cultivar y modificar genéticametne poblaciones de células inmunes para la terapia adoptiva |
| JP7098325B2 (ja) | 2014-12-05 | 2022-07-11 | シティ・オブ・ホープ | Ｃｓ１標的化キメラ抗原レセプター改変ｔ細胞 |
| JP2018504145A (ja) | 2015-01-26 | 2018-02-15 | セレクティスＣｅｌｌｅｃｔｉｓ | 再発性／難治性急性骨髄性リンパ腫または芽球性形質細胞様樹状細胞新生物を処置するための、ｃｄ１２３に結合するキメラ抗原受容体を賦与された、操作されたｔ細胞受容体ノックアウト免疫細胞 |
| WO2017041143A1 (en) | 2015-09-11 | 2017-03-16 | Ctm@Crc Ltd. | Chimeric antigen receptors and uses thereof |
| US11090334B2 (en) | 2016-01-29 | 2021-08-17 | Med Manor Organics (P) Ltd. | Chimeric antigen receptor specific to b-cell maturation antigen, a recombinant expression vector and a method thereof |
| SG10201912515XA (en) | 2016-04-01 | 2020-02-27 | Kite Pharma Inc | Bcma binding molecules and methods of use thereof |
| ES2930058T3 (es) | 2016-04-01 | 2022-12-05 | Kite Pharma Inc | Receptores quiméricos y métodos de uso de los mismos |
| TWI787599B (zh) | 2016-04-01 | 2022-12-21 | 美商凱特製藥公司 | 嵌合抗原和ｔ細胞受體及使用方法 |
| WO2017177149A2 (en) | 2016-04-08 | 2017-10-12 | Purdue Research Foundation | Methods and compositions for car t cell therapy |
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| EP3518944A4 (en) * | 2016-09-30 | 2020-06-17 | Baylor College of Medicine | ADAPTIVE CHIMERIC ANTIGENT RECEPTOR T-CELL DESIGN |
| US12083148B2 (en) | 2017-02-22 | 2024-09-10 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | IL13Ra2-binding chimeric antigen receptors |
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| WO2018169922A2 (en) | 2017-03-13 | 2018-09-20 | Kite Pharma, Inc. | Chimeric antigen receptors for melanoma and uses thereof |
| AU2018240111A1 (en) * | 2017-03-20 | 2019-10-10 | City Of Hope | CS1 targeted chimeric antigen receptor-modified T cells for treatment of AL amyloidosis |
| BR112019020168A2 (pt) | 2017-03-27 | 2020-06-02 | F. Hoffmann-La Roche Ag | Receptores de ligação ao antígeno, células t transduzidas, polinucleotídeo isolado, vetor, kits, métodos para tratar uma doença e para induzir a lise de uma célula alvo e uso do receptor de ligação ao antígeno |
| JOP20180042A1 (ar) | 2017-04-24 | 2019-01-30 | Kite Pharma Inc | نطاقات ربط مولد ضد متوافقة مع البشر وطرق الاستخدام |
| US11149073B2 (en) | 2017-04-28 | 2021-10-19 | Julius-Maximilians-Universität Würzburg | ROR1-specific chimeric antigen receptors (CAR) with humanized targeting domains |
| JP7560356B2 (ja) * | 2017-08-01 | 2024-10-02 | ユリウス－マクシミリアン－ウニヴェルシテート・ヴュルツブルク | 急性骨髄性白血病を治療するためのｆｌｔ３ ｃａｒ－ｔ細胞及びｆｌｔ３阻害剤の使用 |
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| PL3704230T3 (pl) * | 2017-11-01 | 2025-02-24 | Juno Therapeutics, Inc. | Proces wytwarzania kompozycji terapeutycznych z komórek zmodyfikowanych genetycznie |
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| MX2020004933A (es) * | 2017-11-14 | 2021-01-08 | Arcellx Inc | Polipéptidos que contienen dominios d y sus usos. |
| WO2019099707A1 (en) | 2017-11-16 | 2019-05-23 | Kite Pharma, Inc | Modified chimeric antigen receptors and methods of use |
| TW201940182A (zh) | 2018-01-22 | 2019-10-16 | 美商安德賽特公司 | Car t 細胞之使用方法 |
| US20210040449A1 (en) | 2018-02-16 | 2021-02-11 | Kite Pharma, Inc. | Modified pluripotent stem cells and methods of making and use |
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| JP2021524248A (ja) * | 2018-05-21 | 2021-09-13 | バイオセプター・（ユーケー）・リミテッド | 修飾されたリンカードメインを有するキメラ抗原受容体およびその使用 |
| WO2020009868A1 (en) * | 2018-07-03 | 2020-01-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-slamf7 chimeric antigen receptors |
| EP3830133A1 (en) | 2018-08-01 | 2021-06-09 | City of Hope | Tag72 targeted chimeric antigen receptor modified t cells for treatment of tag72-positive tumors |
| CN112469734A (zh) * | 2018-08-03 | 2021-03-09 | 南京驯鹿医疗技术有限公司 | 表达嵌合抗原受体的t细胞、该嵌合抗原相关表达载体以及它们的应用 |
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| JP2022538397A (ja) * | 2019-06-19 | 2022-09-02 | ユリウス－マクシミリアン－ウニヴェルシテート・ヴュルツブルク | キメラ抗原受容体設計で実施するためのウルトラモジュラー（ｕｌｔｒａｍｏｄｕｌａｒ） ＩｇＧ３ベーススペーサードメイン及び多機能部位 |
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| KR20230010228A (ko) * | 2020-05-08 | 2023-01-18 | 시애틀 칠드런즈 호스피탈 디/비/에이 시애틀 칠드런즈 리서치 인스티튜트 | 자연 살해 세포를 표적으로 하는 키메라 항원 수용체 (cars) |
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| JP7776493B2 (ja) * | 2020-08-10 | 2025-11-26 | ユリウス－マクシミリアン－ウニヴェルシテート・ヴュルツブルク | シグレック６結合ポリペプチド |
| JP2024500847A (ja) | 2020-12-18 | 2024-01-10 | センチュリー セラピューティクス，インコーポレイテッド | 適合可能な受容体特異性を有するキメラ抗原受容体システム |
| CN117083292A (zh) * | 2021-04-02 | 2023-11-17 | 科济生物医药（上海）有限公司 | Cs1工程化细胞及其组合物 |
| WO2023107898A1 (en) * | 2021-12-06 | 2023-06-15 | The Children's Hospital Of Philadelphia | Dual targeting of pediatric malignancies through car t-cells secreting bispecific innate immune cell engagers (bices) |
| CN116410331B (zh) * | 2021-12-31 | 2024-01-30 | 合源生物科技(天津)有限公司 | 靶向cs1的嵌合抗原受体、靶向bcma/cs1的双特异性嵌合抗原受体及其应用 |
| WO2023180511A1 (en) * | 2022-03-25 | 2023-09-28 | F. Hoffmann-La Roche Ag | Improved chimeric receptors |
| CN120344563A (zh) * | 2022-12-02 | 2025-07-18 | 广州荔泰生物科技有限公司 | 人cs1 car-t细胞 |
| CN119019554B (zh) * | 2023-05-25 | 2025-08-12 | 东莞市朋志生物科技有限公司 | 抗白介素6抗体、检测白介素6的试剂和试剂盒 |
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| WO2007047829A2 (en) | 2005-10-19 | 2007-04-26 | Laboratoires Serono S.A. | Novel heterodimeric proteins and uses thereof |
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| EP3805269A1 (en) * | 2006-06-12 | 2021-04-14 | Aptevo Research and Development LLC | Single-chain multivalent binding proteins with effector function |
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| EP3421489B1 (en) | 2012-03-23 | 2021-05-05 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Anti-mesothelin chimeric antigen receptors |
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| PT2992020T (pt) * | 2013-05-03 | 2020-02-28 | Ohio State Innovation Foundation | Células efetoras imunes projetadas específicas do recetor de antígeno quimérico cs1 |
| WO2015105522A1 (en) * | 2014-01-13 | 2015-07-16 | Forman Stephen J | Chimeric antigen receptors (cars) having mutations in the fc spacer region and methods for their use |
| TR201819571T4 (tr) | 2014-02-14 | 2019-01-21 | Cellectis | Hem immün hücrelerde hem de patolojik hücrelerde bulunan antijenleri hedef almak amacıyla değiştirilmiş immünoterapiye yönelik hücreler. |
| EP3524616A1 (en) * | 2014-05-02 | 2019-08-14 | Cellectis | Cs1 specific multi-chain chimeric antigen receptor |
| JP7098325B2 (ja) | 2014-12-05 | 2022-07-11 | シティ・オブ・ホープ | Ｃｓ１標的化キメラ抗原レセプター改変ｔ細胞 |
| AU2018240111A1 (en) * | 2017-03-20 | 2019-10-10 | City Of Hope | CS1 targeted chimeric antigen receptor-modified T cells for treatment of AL amyloidosis |
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