JP7084881B2 - Ｉｌ－１０の免疫刺激特性および抗炎症特性を調節するための組成物および方法 - Google Patents

Ｉｌ－１０の免疫刺激特性および抗炎症特性を調節するための組成物および方法 Download PDF

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JP7084881B2
JP7084881B2 JP2018566552A JP2018566552A JP7084881B2 JP 7084881 B2 JP7084881 B2 JP 7084881B2 JP 2018566552 A JP2018566552 A JP 2018566552A JP 2018566552 A JP2018566552 A JP 2018566552A JP 7084881 B2 JP7084881 B2 JP 7084881B2
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amino acid
polypeptide
linker
protein
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ムスターカス、ディミトリ、ティー．
ナムチュク、マーク、エヌ．
ロージー、ヘザー、シー．
アルバレス、ファン、シー．
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アルカームス インコーポレーテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2066—IL-10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5428—IL-10
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2018566552A 2016-06-22 2017-06-22 Ｉｌ－１０の免疫刺激特性および抗炎症特性を調節するための組成物および方法 Expired - Fee Related JP7084881B2 (ja)

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US201662353478P 2016-06-22 2016-06-22
US62/353,478 2016-06-22
PCT/US2017/038747 WO2018005226A2 (en) 2016-06-22 2017-06-22 Compositions and methods for modulating il-10 immunostimulatory and anti-inflammatory properties

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JP2019527200A JP2019527200A (ja) 2019-09-26
JP2019527200A5 JP2019527200A5 (enExample) 2020-07-30
JP7084881B2 true JP7084881B2 (ja) 2022-06-15

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US (2) US10335459B2 (enExample)
EP (1) EP3474884A4 (enExample)
JP (1) JP7084881B2 (enExample)
AU (2) AU2017291321B2 (enExample)
CA (1) CA3026393C (enExample)
WO (1) WO2018005226A2 (enExample)

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JP2023520508A (ja) * 2020-04-03 2023-05-17 ベイラー カレッジ オブ メディスン ＴＮＦαシグナル伝達は治療の標的とされ得る腫瘍促進性炎症の引き金を引く
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JP2023527359A (ja) * 2020-05-28 2023-06-28 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 改変インターロイキン－１０ポリペプチド及びその使用
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WO2024094755A1 (en) * 2022-11-02 2024-05-10 Synerkine Pharma B.V. Engineered immunocytokines, fusion polypeptides, and il10 polypeptides
WO2024131864A1 (zh) * 2022-12-21 2024-06-27 广东菲鹏制药股份有限公司 一种il-10单体融合蛋白
WO2024144336A1 (ko) * 2022-12-30 2024-07-04 주식회사 프로젠 신규 이중 특이성 융합단백질 및 그의 용도
KR20260034078A (ko) * 2023-06-02 2026-03-10 신테카인, 인크. 융합된 il10 폴리펩티드
TW202613172A (zh) * 2024-05-31 2026-04-01 大陸商江蘇先聲生物製藥有限公司 抗cdh17抗體、綴合物及其應用

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Publication number Publication date
EP3474884A2 (en) 2019-05-01
US20190336582A1 (en) 2019-11-07
AU2020204457A1 (en) 2020-07-23
US11534480B2 (en) 2022-12-27
JP2019527200A (ja) 2019-09-26
AU2017291321A1 (en) 2018-12-13
US10335459B2 (en) 2019-07-02
WO2018005226A3 (en) 2018-04-05
WO2018005226A2 (en) 2018-01-04
AU2017291321B2 (en) 2020-06-18
CA3026393C (en) 2023-03-14
EP3474884A4 (en) 2020-08-19
NZ748787A (en) 2021-06-25
CA3026393A1 (en) 2018-01-04
US20170368144A1 (en) 2017-12-28

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