JP7074661B2 - 融合遺伝子を捕捉するためのロックド核酸 - Google Patents

融合遺伝子を捕捉するためのロックド核酸 Download PDF

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JP7074661B2
JP7074661B2 JP2018502674A JP2018502674A JP7074661B2 JP 7074661 B2 JP7074661 B2 JP 7074661B2 JP 2018502674 A JP2018502674 A JP 2018502674A JP 2018502674 A JP2018502674 A JP 2018502674A JP 7074661 B2 JP7074661 B2 JP 7074661B2
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nucleotides
polynucleotide
length
probe
fusion gene
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ステファニー アン ウォード モーティマー，
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ガーダント ヘルス， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
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JP2018502674A 2015-07-21 2016-07-21 融合遺伝子を捕捉するためのロックド核酸 Active JP7074661B2 (ja)

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US201562195280P 2015-07-21 2015-07-21
US62/195,280 2015-07-21
PCT/US2016/043430 WO2017015513A1 (en) 2015-07-21 2016-07-21 Locked nucleic acids for capturing fusion genes

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JP2018524014A JP2018524014A (ja) 2018-08-30
JP2018524014A5 JP2018524014A5 (enExample) 2019-09-05
JP7074661B2 true JP7074661B2 (ja) 2022-05-25

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US (3) US20190071730A9 (enExample)
EP (2) EP3828292A1 (enExample)
JP (1) JP7074661B2 (enExample)
CN (1) CN108138230B (enExample)
AU (1) AU2016297096B2 (enExample)
CA (1) CA2993019A1 (enExample)
ES (1) ES2844852T3 (enExample)
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US11525163B2 (en) 2012-10-29 2022-12-13 The Johns Hopkins University Papanicolaou test for ovarian and endometrial cancers
US11286531B2 (en) 2015-08-11 2022-03-29 The Johns Hopkins University Assaying ovarian cyst fluid
US9850523B1 (en) 2016-09-30 2017-12-26 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
ES2840003T3 (es) 2016-09-30 2021-07-06 Guardant Health Inc Métodos para análisis multi-resolución de ácidos nucleicos libres de células
US20200165687A1 (en) * 2017-06-27 2020-05-28 The University Of Tokyo Probe and method for detecting transcript resulting from fusion gene and/or exon skipping
SG11202001010UA (en) 2017-08-07 2020-03-30 Univ Johns Hopkins Methods and materials for assessing and treating cancer
CN108642159B (zh) * 2018-06-27 2022-07-01 上海宏滩生物科技有限公司 生物芯片检测系统
CN113661249B (zh) 2019-01-31 2025-07-01 夸登特健康公司 用于分离无细胞dna的组合物和方法
JP2022521766A (ja) * 2019-02-25 2022-04-12 ツイスト バイオサイエンス コーポレーション 次世代シーケンシングのための組成物および方法
CN110195098A (zh) * 2019-05-10 2019-09-03 广州安必平医药科技股份有限公司 用于检测braf相关融合基因的探针组、试剂盒及其应用
US12173282B2 (en) 2019-09-23 2024-12-24 Twist Bioscience, Inc. Antibodies that bind CD3 epsilon
CA3170345A1 (en) 2020-02-14 2021-08-19 The Johns Hopkins University Methods and materials for assessing nucleic acids
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
CN111979307B (zh) * 2020-08-31 2022-07-08 伯科生物科技有限公司 用于检测基因融合的靶向测序方法
CN116240268B (zh) * 2023-02-27 2024-04-26 北京大学口腔医学院 用于检测多个基因重排探针系统

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US20140296081A1 (en) 2013-03-15 2014-10-02 The Board Of Trustees Of The Leland Stanford Junior University Identification and use of circulating tumor markers
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US5200313A (en) * 1983-08-05 1993-04-06 Miles Inc. Nucleic acid hybridization assay employing detectable anti-hybrid antibodies
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US20130059294A1 (en) * 2010-05-16 2013-03-07 Xiangdong Ren Identification of polymorphic hepatitis b viruses and kras oncogene mutations and clinical use
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CN108138230A (zh) 2018-06-08
US20180195131A1 (en) 2018-07-12
JP2018524014A (ja) 2018-08-30
EP3828292A1 (en) 2021-06-02
AU2016297096A1 (en) 2018-02-15
EP3325667B1 (en) 2020-11-11
US20170226590A1 (en) 2017-08-10
WO2017015513A1 (en) 2017-01-26
AU2016297096A9 (en) 2019-07-25
ES2844852T3 (es) 2021-07-22
WO2017015513A9 (en) 2018-04-12
CA2993019A1 (en) 2017-01-26
EP3325667A1 (en) 2018-05-30
EP3325667A4 (en) 2018-12-19
AU2016297096B2 (en) 2021-03-18
US20220411877A1 (en) 2022-12-29
US20190071730A9 (en) 2019-03-07
CN108138230B (zh) 2023-03-10

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