CN108138230B - 用于捕获融合基因的锁核酸 - Google Patents

用于捕获融合基因的锁核酸 Download PDF

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CN108138230B
CN108138230B CN201680054945.9A CN201680054945A CN108138230B CN 108138230 B CN108138230 B CN 108138230B CN 201680054945 A CN201680054945 A CN 201680054945A CN 108138230 B CN108138230 B CN 108138230B
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nucleotides
polynucleotide
probe
nucleic acid
sequence
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CN108138230A (zh
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斯特凡尼·安·沃德·莫蒂默
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Guardant Health Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN201680054945.9A 2015-07-21 2016-07-21 用于捕获融合基因的锁核酸 Active CN108138230B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562195280P 2015-07-21 2015-07-21
US62/195,280 2015-07-21
PCT/US2016/043430 WO2017015513A1 (en) 2015-07-21 2016-07-21 Locked nucleic acids for capturing fusion genes

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CN108138230A CN108138230A (zh) 2018-06-08
CN108138230B true CN108138230B (zh) 2023-03-10

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US (3) US20190071730A9 (enExample)
EP (2) EP3325667B1 (enExample)
JP (1) JP7074661B2 (enExample)
CN (1) CN108138230B (enExample)
AU (1) AU2016297096B2 (enExample)
ES (1) ES2844852T3 (enExample)
WO (1) WO2017015513A1 (enExample)

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CN109457030B (zh) 2012-10-29 2022-02-18 约翰·霍普金斯大学 卵巢和子宫内膜癌的帕帕尼科拉乌测试
US11286531B2 (en) 2015-08-11 2022-03-29 The Johns Hopkins University Assaying ovarian cyst fluid
US9850523B1 (en) 2016-09-30 2017-12-26 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
KR20240155386A (ko) 2016-09-30 2024-10-28 가던트 헬쓰, 인크. 무세포 핵산의 다중-해상도 분석 방법
US20200165687A1 (en) * 2017-06-27 2020-05-28 The University Of Tokyo Probe and method for detecting transcript resulting from fusion gene and/or exon skipping
EP3665308A1 (en) 2017-08-07 2020-06-17 The Johns Hopkins University Methods and materials for assessing and treating cancer
CN108642159B (zh) * 2018-06-27 2022-07-01 上海宏滩生物科技有限公司 生物芯片检测系统
EP3918089B1 (en) 2019-01-31 2025-01-15 Guardant Health, Inc. Method for isolating and sequencing cell-free dna
EP3938505A4 (en) * 2019-02-25 2022-11-30 Twist Bioscience Corporation COMPOSITIONS AND METHODS FOR SEQUENCING THE NEXT GENERATION
CN110195098A (zh) * 2019-05-10 2019-09-03 广州安必平医药科技股份有限公司 用于检测braf相关融合基因的探针组、试剂盒及其应用
WO2021061842A1 (en) 2019-09-23 2021-04-01 Twist Bioscience Corporation Variant nucleic acid libraries for single domain antibodies
BR112022015909A2 (pt) 2020-02-14 2022-10-04 Univ Johns Hopkins Métodos e materiais para avaliação de ácidos nucleicos
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
CN111979307B (zh) * 2020-08-31 2022-07-08 伯科生物科技有限公司 用于检测基因融合的靶向测序方法
CN116240268B (zh) * 2023-02-27 2024-04-26 北京大学口腔医学院 用于检测多个基因重排探针系统

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JP2018524014A (ja) 2018-08-30
EP3325667A1 (en) 2018-05-30
US20220411877A1 (en) 2022-12-29
CA2993019A1 (en) 2017-01-26
US20180195131A1 (en) 2018-07-12
EP3325667B1 (en) 2020-11-11
ES2844852T3 (es) 2021-07-22
CN108138230A (zh) 2018-06-08
AU2016297096A1 (en) 2018-02-15
EP3325667A4 (en) 2018-12-19
WO2017015513A1 (en) 2017-01-26
US20170226590A1 (en) 2017-08-10
EP3828292A1 (en) 2021-06-02
JP7074661B2 (ja) 2022-05-25
WO2017015513A9 (en) 2018-04-12
US20190071730A9 (en) 2019-03-07
AU2016297096B2 (en) 2021-03-18
AU2016297096A9 (en) 2019-07-25

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