JP7067827B1 - インターフェロン産生促進剤 - Google Patents
インターフェロン産生促進剤 Download PDFInfo
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- JP7067827B1 JP7067827B1 JP2021542354A JP2021542354A JP7067827B1 JP 7067827 B1 JP7067827 B1 JP 7067827B1 JP 2021542354 A JP2021542354 A JP 2021542354A JP 2021542354 A JP2021542354 A JP 2021542354A JP 7067827 B1 JP7067827 B1 JP 7067827B1
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- Prior art keywords
- clostridium butyricum
- interferon
- ifn
- culture
- production promoter
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Abstract
Description
本発明の一形態は、クロストリジウム・ブチリカム(Clostridium butyricum)またはその培養物を有効成分として含む、I型および/またはIII型のインターフェロン産生促進剤である。
本発明の一形態は、有効量のクロストリジウム・ブチリカム(Clostridium butyricum)またはその培養物を対象に投与することを有する、インターフェロンの産生を促進する方法である。
本発明の一形態は、上述のインターフェロン産生促進剤を有効成分として含む、ウイルス感染症の予防および/または治療剤である。
クロストリジウム・ブチリカムまたはその培養物を有効成分として含む、ウイルス感染症の予防および/または治療剤;
ウイルス感染症の予防および/または治療剤として使用するためのクロストリジウム・ブチリカムまたはその培養物の使用;
ウイルス感染症の予防および/または治療剤の製造のためのクロストリジウム・ブチリカムまたはその培養物の使用。
本発明の一形態は、上述のインターフェロン産生促進剤の有効量を、それを必要とする対象に投与することを含む、ウイルス感染症の予防および/または治療方法である。
本発明の一形態は、上述のインターフェロン産生促進剤を含む、飲食品である。
Balb/cマウス(9~10週齢、雌、日本チャールス・リバー株式会社より購入)に対し、7日間の検疫・馴化期間を設け、全個体健康状態に異常がなく体重減少を認めないことを確認して、試験に供した。マウスには、12時間照明、温度20~26℃、湿度30~70%の飼育環境で、餌および水を自由摂取させた。
CBM588投与群では、インフルエンザウイルス感染モデルマウス1に生理食塩水へ懸濁したクロストリジウム・ブチリカム・ミヤイリ 588(Clostridium butyricum MIYAIRI 588、FERM BP-2789)の培養物(以下、単に「CBM588」とも称する)を500mg/kg/dayとなるように経口投与した(n=5)。CBM588中の菌量は、3.3×1010cfu/gであった。なお、CBM588は、クロストリジウム・ブチリカム・ミヤイリ 588をコーンスターチ2.0(w/v)%、アミノ酸液2.0(w/v)%および炭酸カルシウム0.75(w/v)%を含むCS液体培地を用いて37℃で48時間静置培養した後、培養液を遠心分離して得られた残渣の乾燥物である。
CBM588投与群では、インフルエンザウイルス感染モデルマウス2に生理食塩水へ懸濁したCBM588を500mg/kg/dayとなるように経口投与した(n=5)。コントロール群では、インフルエンザウイルス感染モデルマウス2に生理食塩水を0.4mL/day経口投与した(n=5)。
CBM588投与群では、インフルエンザウイルス感染モデルマウス2に生理食塩水へ懸濁したCBM588を500mg/kg/dayとなるように経口投与した(n=5)。コントロール群では、インフルエンザウイルス感染モデルマウス2に生理食塩水を0.4mL/day経口投与した(n=5)。
IFN-α:VeriKineTM IFN-α 測定ELISAキット(マウス)、PBL製、#42120-1
IFN-β:Mouse IFN-beta Quantikine ELISA Kit、RSD製、#MIFNB0
INF-λ:Mouse IL-28 ELISA Kit、abcam製、#ab100708。
CBM588投与群では、インフルエンザウイルス感染モデルマウス2に生理食塩水へ懸濁したCBM588を500mg/kg/dayとなるように経口投与した(n=5)。コントロール群では、インフルエンザウイルス感染モデルマウス2に生理食塩水を0.4mL/day経口投与した(n=5)。
IgA:IgA Mouse ELISA kit、Thermofisher製、#EMIGA。
Claims (4)
- クロストリジウム・ブチリカム・ミヤイリ 588(Clostridium butyricum MIYAIRI 588、FERM BP-2789)またはその培養物を有効成分として含む、インターフェロン産生促進剤であって、
前記クロストリジウム・ブチリカム・ミヤイリ 588は、生菌であり、
前記インターフェロンがIFN-α、IFN-βおよびIFN-λからなる群から選択される少なくとも1つであり、
ウイルス感染症に罹患しているまたはその可能性がある対象に投与される、インターフェロン産生促進剤。 - 前記ウイルス感染症がインフルエンザウイルス感染症である、請求項1に記載のインターフェロン産生促進剤。
- 請求項1または2に記載のインターフェロン産生促進剤を有効成分として含み、前記インターフェロンがIFN-α、IFN-βおよびIFN-λからなる群から選択される少なくとも1つである、インフルエンザウイルス感染症の予防および/または治療剤。
- 請求項1または2に記載のインターフェロン産生促進剤を含み、ウイルス感染症に罹患しているまたはその可能性がある対象に投与される、IFN-α、IFN-βおよびIFN-λからなる群から選択される少なくとも1つのインターフェロンの産生を促進するための飲食品。
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WO2007114378A1 (ja) * | 2006-03-31 | 2007-10-11 | Nippon Paper Chemicals Co., Ltd. | 飲食用組成物 |
KR20160115202A (ko) * | 2015-03-26 | 2016-10-06 | 한국생명공학연구원 | 면역 증진 및 항바이러스 활성을 가지는 클로스트리디움 부티리쿰 균주 및 이의 용도 |
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JPH08252088A (ja) | 1995-03-17 | 1996-10-01 | Nippo Kagaku Kk | クロストリジウム属細菌の培養方法 |
JP5950827B2 (ja) | 2010-12-28 | 2016-07-13 | キリンホールディングス株式会社 | 乳酸菌を含むインターフェロン産生誘導剤 |
JP2013227250A (ja) * | 2012-04-25 | 2013-11-07 | Miyarisan Pharmaceutical Co Ltd | Nrf2活性化剤およびその用途 |
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WO2007114378A1 (ja) * | 2006-03-31 | 2007-10-11 | Nippon Paper Chemicals Co., Ltd. | 飲食用組成物 |
KR20160115202A (ko) * | 2015-03-26 | 2016-10-06 | 한국생명공학연구원 | 면역 증진 및 항바이러스 활성을 가지는 클로스트리디움 부티리쿰 균주 및 이의 용도 |
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Title |
---|
HAGIHARA, Mao et al.,Clostridium butyricum modulates the microbiome to protect intestinal barrier function in mice with a,iScience,2020年,Vol. 23,pp. 1-18 |
HAGIHARA, MAO ET AL.: "Clostridium butyricum modulates the microbiome to protect intestinal barrier function in mice with a", ISCIENCE, vol. 23, JPN6021017457, 2020, pages 1 - 18, ISSN: 0004588289 * |
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