JP7062673B2 - 前立腺がんの治療 - Google Patents

前立腺がんの治療 Download PDF

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Publication number
JP7062673B2
JP7062673B2 JP2019538720A JP2019538720A JP7062673B2 JP 7062673 B2 JP7062673 B2 JP 7062673B2 JP 2019538720 A JP2019538720 A JP 2019538720A JP 2019538720 A JP2019538720 A JP 2019538720A JP 7062673 B2 JP7062673 B2 JP 7062673B2
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administration
oral
weeks
present disclosure
once
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JP2019538720A
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Japanese (ja)
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JP2019529574A (ja
JP2019529574A5 (enExample
Inventor
ラジャセクアール、ヴィジェイクマール、レディ
マーク ジョンソン、ブレンダン
ビー. マクリーン、デイヴィッド
シーリ、リン
エヌ. マッド、ジュニア、ポール
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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Application filed by Takeda Pharmaceutical Co Ltd filed Critical Takeda Pharmaceutical Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/501Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41661,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2019538720A 2016-09-30 2017-09-29 前立腺がんの治療 Active JP7062673B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662402004P 2016-09-30 2016-09-30
US201662402150P 2016-09-30 2016-09-30
US62/402,150 2016-09-30
US62/402,004 2016-09-30
PCT/EP2017/074849 WO2018060463A2 (en) 2016-09-30 2017-09-29 Treatment of prostate cancer

Publications (3)

Publication Number Publication Date
JP2019529574A JP2019529574A (ja) 2019-10-17
JP2019529574A5 JP2019529574A5 (enExample) 2020-11-12
JP7062673B2 true JP7062673B2 (ja) 2022-05-06

Family

ID=60915459

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019538720A Active JP7062673B2 (ja) 2016-09-30 2017-09-29 前立腺がんの治療

Country Status (21)

Country Link
US (8) US10449191B2 (enExample)
EP (2) EP3518932B1 (enExample)
JP (1) JP7062673B2 (enExample)
CN (1) CN110248661A (enExample)
AU (2) AU2017334035B2 (enExample)
BR (1) BR112019006228A2 (enExample)
CA (1) CA3038875A1 (enExample)
DK (1) DK3518932T3 (enExample)
ES (1) ES3002857T3 (enExample)
FI (1) FI3518932T3 (enExample)
HR (1) HRP20241740T1 (enExample)
HU (1) HUE070578T2 (enExample)
IL (3) IL300071A (enExample)
LT (1) LT3518932T (enExample)
MA (1) MA46361A (enExample)
MX (2) MX2019003733A (enExample)
NZ (1) NZ752918A (enExample)
PL (1) PL3518932T3 (enExample)
PT (1) PT3518932T (enExample)
SI (1) SI3518932T1 (enExample)
WO (1) WO2018060463A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE044048T2 (hu) 2012-09-28 2019-09-30 Takeda Pharmaceuticals Co Eljárás tienopirimidin származék elõállítására
HUE070578T2 (hu) 2016-09-30 2025-06-28 Sumitomo Pharma Switzerland Gmbh Prosztatarák kezelése
WO2018060501A2 (en) 2016-09-30 2018-04-05 Myovant Sciences Gmbh Methods of treating uterine fibroids and endometriosis
CN110194776B (zh) * 2019-06-27 2021-05-28 四川伊诺达博医药科技有限公司 一种瑞卢戈利的合成方法
JP7713934B2 (ja) * 2019-10-10 2025-07-28 スミトモ ファーマ スウィッツァーランド ゲーエムベーハー N-(4-(1-(2,6-ジフルオロベンジル)-5-((ジメチルアミノ)メチル)-3-(6-メトキシ-3-ピリダジニル)-2,4-ジオキソ-1,2,3,4-テトラヒドロチエノ[2,3-d]ピリミジン-6-イル)フェニル)-N’-メトキシ尿素の結晶溶媒和形
JP2022551316A (ja) * 2019-10-10 2022-12-08 ミオバント サイエンシズ ゲーエムベーハー N-(4-(1-(2,6-ジフルオロベンジル)-5-((ジメチルアミノ)メチル)-3-(6-メトキシ-3-ピリダジニル)-2,4-ジオキソ-1,2,3,4-テトラヒドロチエノ[2,3-d]ピリミジン-6-イル)フェニル)-N’-メトキシ尿素の結晶形
WO2021239917A1 (en) 2020-05-29 2021-12-02 Myovant Sciences Gmbh Combination solid oral dosage forms of gonadotropin-releasing hormone antagonists
US20230384316A1 (en) * 2020-10-20 2023-11-30 Baylor College Of Medicine Multiplex metabolic markers in plasma for early detection of african american prostate cancer
EP4243829A1 (en) 2020-11-11 2023-09-20 Myovant Sciences GmbH Methods of administering relugolix
JP2024540922A (ja) 2021-10-18 2024-11-06 スミトモ ファーマ スウィッツァーランド ゲーエムベーハー N-(4-(1-(2,6-ジフルオロベンジル)-5-((ジメチルアミノ)メチル)-3-(6-メトキシ-3-ピリダジニル)-2,4-ジオキソ-1,2,3,4-テトラヒドロチエノ[2,3-d]ピリミジン-6-イル)フェニル)-N’-メトキシ尿素のエタノール溶媒和物の結晶形
WO2023152611A1 (en) * 2022-02-11 2023-08-17 Aragon Pharmaceuticals, Inc. Apalutamide and relugolix for the treatment of prostate cancer

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2016136849A1 (ja) 2015-02-26 2016-09-01 武田薬品工業株式会社 固形製剤

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FR2710637B1 (fr) 1993-09-28 1995-12-08 Roquette Freres Mannitol pulvérulent de friabilité modérée et son procédé de préparation.
TWI225863B (en) 1999-03-24 2005-01-01 Takeda Chemical Industries Ltd Thienopyrimidine compounds, their production and use
RU2233284C2 (ru) 1999-03-24 2004-07-27 Такеда Кемикал Индастриз, Лтд. Тиенопиримидиновые производные, способ их получения, фармацевтическая композиция и способ антагонизации гонадотропин-рилизинг гормона
CN1173977C (zh) 2000-02-29 2004-11-03 武田药品工业株式会社 制备噻吩并嘧啶衍生物的方法
US20050043315A1 (en) 2002-01-02 2005-02-24 Hideo Tsutsumi Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them
WO2003064429A1 (en) 2002-01-30 2003-08-07 Takeda Chemical Industries, Ltd. Thienopyrimidines, process for preparing the same and use thereof
KR101002374B1 (ko) 2002-02-26 2010-12-17 아스트라제네카 아베 수용성 셀룰로스 유도체를 포함하는 이레사의 약학 조제물
CA2514407C (en) 2003-01-29 2012-01-03 Takeda Pharmaceutical Company Limited Thienopyrimidine compounds and use thereof
WO2005007165A1 (en) 2003-07-07 2005-01-27 Neurocrine Biosciences, Inc. Pyrimidine-2, 4-dione derivatives as gonadotropin-releasing hormone receptor antagonists
US20090048273A1 (en) 2005-07-22 2009-02-19 Takeda Pharmaceutical Company Limited Premature ovulation preventive agent
AR065948A1 (es) 2007-04-06 2009-07-15 Neurocrine Biosciences Inc Antagonistas del receptor de la hormona liberadora de gonadotropina y procedimientos relacionados con los mismos
WO2009062087A1 (en) 2007-11-07 2009-05-14 Neurocrine Biosciences, Inc. Processes for the preparation of uracil derivatives
TWI539959B (zh) 2008-02-11 2016-07-01 菲瑞茵國際中心股份有限公司 治療轉移階段攝護腺癌的方法
WO2010026993A1 (ja) 2008-09-03 2010-03-11 武田薬品工業株式会社 製剤における吸収性改善方法および吸収性が改善された製剤
HUE044048T2 (hu) 2012-09-28 2019-09-30 Takeda Pharmaceuticals Co Eljárás tienopirimidin származék elõállítására
EP3185881B1 (en) 2014-08-26 2022-03-09 Betanien Hospital Methods, agents and compositions for treatment of inflammatory conditions
AU2016317955B2 (en) 2015-09-01 2021-05-20 Abbvie Inc. Methods of administering Elagolix
US20180044977A1 (en) 2016-08-12 2018-02-15 Raynor Mfg. Co. Rolling door construction for controlling air leakage
WO2018060501A2 (en) 2016-09-30 2018-04-05 Myovant Sciences Gmbh Methods of treating uterine fibroids and endometriosis
HUE070578T2 (hu) 2016-09-30 2025-06-28 Sumitomo Pharma Switzerland Gmbh Prosztatarák kezelése

Patent Citations (1)

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WO2016136849A1 (ja) 2015-02-26 2016-09-01 武田薬品工業株式会社 固形製剤

Non-Patent Citations (5)

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ClinicalTrials.gov archive, NCT02083185, A Phase 2 Study to Evaluate the Safety and Efficacy of TAK-385, Together With a Leuprorelin Observational Cohort, in Patients With Prostate Cancer, May 6 2016, https://clinicaltrials.gov/cv2/history/NCT02083185?V 9=View#StudyPageTop[検索日:07/10/2021]
CliticalTrials.gov archive, NCT02135445, Safety and Efficacy of TAK-385 for Patients with Localized Prostate Cancer, May 6 2016, https://clinicaltrials.gov/cv2/history/NCT02135445?V 7=View#StudyPageTop [検索日:07/10/2021]
European Journal of Pharmacology,2014年,723,pp.167-174
J Clin Endocrinol Metab,2015年,100(12),pp.4579-4587
Journal of Medicinal Chemistry,2011年,54,pp.4998-5012

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Publication number Publication date
IL300071A (en) 2023-03-01
BR112019006228A2 (pt) 2019-06-18
FI3518932T3 (fi) 2025-02-03
EP3518932A2 (en) 2019-08-07
DK3518932T3 (da) 2025-01-27
JP2019529574A (ja) 2019-10-17
WO2018060463A2 (en) 2018-04-05
AU2017334035A1 (en) 2019-05-16
WO2018060463A3 (en) 2018-05-11
US20210205303A1 (en) 2021-07-08
NZ752918A (en) 2022-09-30
US20190224196A1 (en) 2019-07-25
MX2023001468A (es) 2023-03-03
HUE070578T2 (hu) 2025-06-28
US20250332166A1 (en) 2025-10-30
PL3518932T3 (pl) 2025-04-07
US12336990B2 (en) 2025-06-24
AU2023201047B2 (en) 2025-04-03
EP4520398A3 (en) 2025-04-02
SI3518932T1 (sl) 2025-03-31
US12097198B2 (en) 2024-09-24
IL308528A (en) 2024-01-01
EP4520398A2 (en) 2025-03-12
US20200129507A1 (en) 2020-04-30
IL265697B2 (en) 2023-07-01
US10786501B2 (en) 2020-09-29
US20240358700A1 (en) 2024-10-31
AU2023201047A1 (en) 2023-03-23
IL265697A (en) 2019-05-30
PT3518932T (pt) 2025-01-16
AU2017334035B2 (en) 2022-11-24
EP3518932B1 (en) 2024-11-13
IL265697B1 (en) 2023-03-01
CA3038875A1 (en) 2018-04-05
ES3002857T3 (en) 2025-03-07
US20250082632A1 (en) 2025-03-13
US10449191B2 (en) 2019-10-22
US20250057839A1 (en) 2025-02-20
MX2019003733A (es) 2019-09-26
US20220401443A1 (en) 2022-12-22
HRP20241740T1 (hr) 2025-02-28
LT3518932T (lt) 2025-02-10
MA46361A (fr) 2021-03-31
US12144809B1 (en) 2024-11-19
US11583526B2 (en) 2023-02-21
CN110248661A (zh) 2019-09-17

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