JP7061802B2 - 抗老化用組成物 - Google Patents
抗老化用組成物 Download PDFInfo
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- JP7061802B2 JP7061802B2 JP2018554589A JP2018554589A JP7061802B2 JP 7061802 B2 JP7061802 B2 JP 7061802B2 JP 2018554589 A JP2018554589 A JP 2018554589A JP 2018554589 A JP2018554589 A JP 2018554589A JP 7061802 B2 JP7061802 B2 JP 7061802B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
(化学式1中、
R1は、水素、(C1~C30)アルキル、(C2~C30)アルケニル、(C2~C30)アルキニル、(C1~C30)アルコキシ、またはヒドロキシ(C1~C30)アルキルであり;
R2は、(C1~C30)アルキル、(C2~C30)アルケニル、(C2~C30)アルキニル、(C1~C30)アルコキシ、またはヒドロキシ(C1~C30)アルキルであり;
R3は、
または置換されているか若しくは置換されていないアミノ酸基であり、式中、R11はヒドロキシ(C1~C30)アルキルである。)
(化学式1中、
R1は、水素、(C1~C30)アルキル、(C2~C30)アルケニル、(C2~C30)アルキニル、(C1~C30)アルコキシ、またはヒドロキシ(C1~C30)アルキルであり;
R2は、(C1~C30)アルキル、(C2~C30)アルケニル、(C2~C30)アルキニル、(C1~C30)アルコキシ、またはヒドロキシ(C1~C30)アルキルであり;
R3は、
または置換されているか若しくは置換されていないアミノ酸基であり、式中、R11はヒドロキシ(C1~C30)アルキルである。)
N‐(1,3‐ジヒドロキシプロパン‐2‐イル)‐2‐エチルヘキサンアミドをヒト繊維芽細胞の培養液(DMEM培養液、10% fetal bovine serum(ウシ胎児血清)、1% antibiotics(抗生物質))に添加し、細胞レベルで1型コラーゲン(type‐I collagen)の合成促進効果を確認した。合成されたコラーゲンの測定は、PICP EIA kit(プロコラーゲン1型C-ペプチドエンザイムイムノアッセイキット:Procollagen Type I C‐Peptide Enzyme Immuno Assay KIT)を用いて定量した。
人工皮膚(EpiDermFTTM from MatTek、Ashland、USA)を購入し、専用培地(EFT‐400)で18時間安定化させた。前記人工皮膚の表面に、有効成分としてN‐(1,3‐ジヒドロキシプロパン‐2‐イル)‐2‐エチルヘキサンアミド(抗老化用組成物)を1%の濃度で100μl塗布した。24時間後、人工皮膚組織を10%のホルムアルデヒドで固定およびパラフィンで包埋し、5μmに薄切した組織を、コラーゲン合成促進効果を確認するために使用した(図2参照)。
有効成分を使用しなかったこと(陰性対照群)を除き、前期実施例1と同様の方法により、1型コラーゲンの合成促進効果を確認した。また、前記陰性対照群に対する相対的な1型コラーゲン合成能を比率で計算し、増加率で示した(表1および図1参照)。
前記実施例2と同様の方法により人工皮膚を安定化させた後、有効成分のないPBSのみを100μl塗布した。24時間後、人工皮膚組織を10%のホルムアルデヒドで固定およびパラフィンで包埋し、5μmに薄切した組織を、コラーゲン合成促進効果を確認するために使用した。
Claims (6)
- 前記化合物は、組成物の総重量に対して0.001~50重量%で含まれる、請求項1に記載の抗老化用組成物。
- 医薬組成物または化粧料組成物である、請求項1に記載の抗老化用組成物。
- 前記医薬組成物は、ローション、軟膏、ゲル、クリーム、パッチ、または噴霧剤に剤型化したものである、請求項3に記載の抗老化用組成物。
- 前記化粧料組成物は、柔軟化粧水、収れん化粧水、栄養化粧水、アイクリーム、栄養クリーム、マッサージクリーム、クレンジングクリーム、クレンジングフォーム、クレンジングウォーター、パウダー、エッセンス、またはパックに剤型化したものである、請求項3に記載の抗老化用組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2016-0051598 | 2016-04-27 | ||
KR1020160051598A KR101750238B1 (ko) | 2016-04-27 | 2016-04-27 | 항노화용 조성물 |
PCT/KR2017/003824 WO2017188623A1 (ko) | 2016-04-27 | 2017-04-07 | 항노화용 조성물 |
Publications (2)
Publication Number | Publication Date |
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JP2019514867A JP2019514867A (ja) | 2019-06-06 |
JP7061802B2 true JP7061802B2 (ja) | 2022-05-16 |
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Application Number | Title | Priority Date | Filing Date |
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JP2018554589A Active JP7061802B2 (ja) | 2016-04-27 | 2017-04-07 | 抗老化用組成物 |
Country Status (6)
Country | Link |
---|---|
US (1) | US11446223B2 (ja) |
EP (1) | EP3431082B1 (ja) |
JP (1) | JP7061802B2 (ja) |
KR (1) | KR101750238B1 (ja) |
CN (1) | CN109069454B (ja) |
WO (1) | WO2017188623A1 (ja) |
Families Citing this family (9)
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KR101828241B1 (ko) * | 2016-10-17 | 2018-02-13 | (주)네오팜 | 항염용 조성물 |
KR102012012B1 (ko) | 2017-10-11 | 2019-08-19 | 대봉엘에스 주식회사 | 신규 유사 세라마이드 화합물, 및 그의 용도 |
KR101875842B1 (ko) * | 2017-11-14 | 2018-07-09 | (주)네오팜 | 피부 미백용 조성물 |
KR101871153B1 (ko) * | 2017-11-14 | 2018-06-26 | (주)네오팜 | 항노화용 조성물 |
KR101983566B1 (ko) | 2018-03-09 | 2019-05-29 | 닥터 레이몬드 래보라토리 | 피부 외용제 조성물 |
KR102208220B1 (ko) * | 2018-09-12 | 2021-01-28 | 닥터 레이몬드 래보라토리 | 신규한 세리놀계 화합물, 이를 포함하는 화장료 조성물 및 약학 조성물 |
WO2020055153A1 (ko) * | 2018-09-12 | 2020-03-19 | 닥터 레이몬드 래보라토리 | 신규한 세리놀계 화합물, 이를 포함하는 화장료 조성물 및 약학 조성물 |
KR102312654B1 (ko) * | 2020-12-28 | 2021-10-15 | (주)네오팜 | 안티인플라메이징 조성물 |
KR102323657B1 (ko) * | 2021-10-06 | 2021-11-09 | (주)네오팜 | 항염용 조성물 |
Family Cites Families (6)
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KR100341793B1 (ko) * | 1999-07-02 | 2002-06-24 | 권 영 근 | 스핑고신 1-포스페이트를 유효성분으로 포함하는 혈관신생 촉진제 |
EP1534213B1 (en) | 2002-03-13 | 2013-04-24 | Sköld, Thomas | Water-based delivery systems |
WO2006049404A1 (en) | 2004-11-03 | 2006-05-11 | Neopharm Co., Ltd. | Sphingosine kinase activator and skin disease treating agent comprising the same |
KR100607438B1 (ko) | 2004-11-03 | 2006-08-02 | (주)네오팜 | 스핑고신키나제 활성화제를 포함하는 피부질환치료제 |
EP2233128A1 (en) * | 2009-03-25 | 2010-09-29 | Cognis IP Management GmbH | Cosmetic composition |
KR101828241B1 (ko) | 2016-10-17 | 2018-02-13 | (주)네오팜 | 항염용 조성물 |
-
2016
- 2016-04-27 KR KR1020160051598A patent/KR101750238B1/ko active IP Right Grant
-
2017
- 2017-04-07 US US16/095,765 patent/US11446223B2/en active Active
- 2017-04-07 JP JP2018554589A patent/JP7061802B2/ja active Active
- 2017-04-07 EP EP17789808.7A patent/EP3431082B1/en active Active
- 2017-04-07 WO PCT/KR2017/003824 patent/WO2017188623A1/ko active Application Filing
- 2017-04-07 CN CN201780026310.2A patent/CN109069454B/zh active Active
Non-Patent Citations (1)
Title |
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Arch Pharm Chem,2009年,342,34-40 |
Also Published As
Publication number | Publication date |
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EP3431082B1 (en) | 2021-06-09 |
KR101750238B1 (ko) | 2017-06-27 |
US20200330352A1 (en) | 2020-10-22 |
CN109069454B (zh) | 2021-09-07 |
EP3431082A1 (en) | 2019-01-23 |
US11446223B2 (en) | 2022-09-20 |
EP3431082A4 (en) | 2019-12-04 |
CN109069454A (zh) | 2018-12-21 |
WO2017188623A1 (ko) | 2017-11-02 |
JP2019514867A (ja) | 2019-06-06 |
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