JP7060503B2 - 悪性固形腫瘍の治療のための弱毒化細菌 - Google Patents

悪性固形腫瘍の治療のための弱毒化細菌 Download PDF

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JP7060503B2
JP7060503B2 JP2018526167A JP2018526167A JP7060503B2 JP 7060503 B2 JP7060503 B2 JP 7060503B2 JP 2018526167 A JP2018526167 A JP 2018526167A JP 2018526167 A JP2018526167 A JP 2018526167A JP 7060503 B2 JP7060503 B2 JP 7060503B2
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protein
proteins
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recombinant attenuated
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JP2019500026A (ja
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シモン イッティグ，
マリッセ アムスタッツ，
クリストフ カスペル，
ギー エール． コルネリス，
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Universitaet Basel
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0275—Salmonella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0291—Yersinia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/104—Pseudomonadales, e.g. Pseudomonas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2018526167A 2015-11-19 2016-11-17 悪性固形腫瘍の治療のための弱毒化細菌 Active JP7060503B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15195490.6 2015-11-19
EP15195490 2015-11-19
PCT/EP2016/078084 WO2017085233A1 (en) 2015-11-19 2016-11-17 Virulence attenuated bacteria for treatment of malignant solid tumors

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JP2019500026A JP2019500026A (ja) 2019-01-10
JP2019500026A5 JP2019500026A5 (enExample) 2021-12-16
JP7060503B2 true JP7060503B2 (ja) 2022-04-26

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US (1) US11166987B2 (enExample)
EP (2) EP3903813A1 (enExample)
JP (1) JP7060503B2 (enExample)
KR (1) KR102736981B1 (enExample)
CN (1) CN108472348B (enExample)
AU (1) AU2016358257B2 (enExample)
BR (2) BR122023024697A2 (enExample)
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DK (1) DK3377094T3 (enExample)
EA (1) EA201890868A1 (enExample)
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HU (1) HUE055132T2 (enExample)
IL (1) IL259052B2 (enExample)
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PL (1) PL3377094T3 (enExample)
PT (1) PT3377094T (enExample)
RS (1) RS62152B1 (enExample)
SG (1) SG11201803643TA (enExample)
SI (1) SI3377094T1 (enExample)
SM (1) SMT202100423T1 (enExample)
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JP6797025B2 (ja) 2014-05-21 2020-12-09 ウニヴェルズィテート バーゼル 細菌に基づくタンパク質送達
KR102689434B1 (ko) 2015-11-19 2024-07-29 우니페르시테트 바젤 박테리아-기반의 단백질 전달
JP6976351B2 (ja) 2016-12-20 2021-12-08 ウニヴェルズィテート・バーゼルUniversitat Basel 弱毒化細菌に基づくタンパク質送達
KR102110993B1 (ko) * 2018-12-20 2020-05-14 한국생명공학연구원 클레브시엘라 아에로제네스(Klebsiella aerogenes) 균주를 유효성분으로 포함하는 암 진단, 예방 또는 치료용 조성물
AU2021370840A1 (en) * 2020-10-27 2023-06-22 T3 Pharmaceuticals Ag Bacteria based protein delivery
CN114712496B (zh) * 2022-04-29 2023-10-13 中山大学·深圳 一种展示新抗原的细菌衍生外膜囊泡疫苗及制备方法和在制备癌症免疫治疗试剂盒中的应用
CN116064877B (zh) * 2023-02-09 2024-09-20 宁夏大学 利用lamp技术快速检测阴沟肠杆菌的试剂盒及方法
CN116855496B (zh) * 2023-07-05 2024-08-16 郑州大学 含有干扰序列siRNA-HIF-1α的表达质粒在制备抗肝细胞癌药物中的应用
WO2025037284A2 (en) * 2023-08-17 2025-02-20 Baccine Ltd. Genetically modified bacteria for multi-modal secretion of a neoantigen

Citations (3)

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JP2002508939A (ja) 1998-03-06 2002-03-26 ピエール・ベー・ヴァン・デア・ブルッジェン 組換えエルジニアによる真核生物へのタンパク質のデリバリー
JP2006515599A (ja) 2002-11-07 2006-06-01 テクニオン リサーチ アンド ディベラップメント ファウンデイション リミテッド 神経保護鉄キレート剤及びそれを含む医薬組成物
JP2014522405A (ja) 2011-06-08 2014-09-04 キレーション パートナーズ インコーポレイテッド 生きている細胞または生物体の増殖または活性を制御するための金属キレート組成物および方法

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AU5209399A (en) 1998-07-10 2000-02-01 Cornell Research Foundation Inc. Recombinant constructs and systems for secretion of proteins via type iii secretion systems
US20020160502A1 (en) 2000-09-26 2002-10-31 Roger Williams Hospital Recombinant BCG vaccines for the prevention and treatment of cancer
US20040147719A1 (en) 2001-03-26 2004-07-29 Guy Cornelis Type III bacterial strains for use in medicine
FR2862312B1 (fr) 2003-11-13 2006-02-17 Univ Grenoble 1 Outil de transfert et de production de proteines mettant en oeuvre le systeme de secretion de type iii de pseudomonas
WO2007044406A2 (en) 2005-10-04 2007-04-19 Ludwig Institute For Cancer Research Methods for stimulating an immune response using bacterial antigen delivery system
WO2008019183A2 (en) 2006-05-18 2008-02-14 The Regents Of The University Of California Biopolymer and protein production using type iii secretion systems of gram negative bacteria
TW200819540A (en) * 2006-07-11 2008-05-01 Genelux Corp Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders
AU2009226972B2 (en) 2008-03-17 2014-05-29 Gerhard Heusipp YopM as delivery vehicle for cargo molecules and as biological therapeutic for immunomodulation of inflammatory reactions
US9127284B2 (en) * 2012-05-04 2015-09-08 The University Of Hong Kong Modified bacteria and their uses thereof for the treatment of cancer or tumor
EP3049526B1 (en) 2013-09-24 2021-02-24 Medicenna Therapeutics, Inc. Interleukin-4 receptor-binding fusion proteins and uses thereof
US10143743B2 (en) 2013-11-18 2018-12-04 Yale University Non-replicating bacterial nanoparticle delivery system and methods of use
JP6797025B2 (ja) 2014-05-21 2020-12-09 ウニヴェルズィテート バーゼル 細菌に基づくタンパク質送達
KR102689434B1 (ko) 2015-11-19 2024-07-29 우니페르시테트 바젤 박테리아-기반의 단백질 전달
JP6976351B2 (ja) 2016-12-20 2021-12-08 ウニヴェルズィテート・バーゼルUniversitat Basel 弱毒化細菌に基づくタンパク質送達

Patent Citations (3)

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JP2002508939A (ja) 1998-03-06 2002-03-26 ピエール・ベー・ヴァン・デア・ブルッジェン 組換えエルジニアによる真核生物へのタンパク質のデリバリー
JP2006515599A (ja) 2002-11-07 2006-06-01 テクニオン リサーチ アンド ディベラップメント ファウンデイション リミテッド 神経保護鉄キレート剤及びそれを含む医薬組成物
JP2014522405A (ja) 2011-06-08 2014-09-04 キレーション パートナーズ インコーポレイテッド 生きている細胞または生物体の増殖または活性を制御するための金属キレート組成物および方法

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EA201890868A1 (ru) 2018-12-28
CN108472348B (zh) 2022-12-27
HRP20211191T1 (hr) 2021-10-29
KR20180081583A (ko) 2018-07-16
US20190015497A1 (en) 2019-01-17
BR122023024697A2 (pt) 2023-12-26
DK3377094T3 (da) 2021-08-02
EP3903813A1 (en) 2021-11-03
AU2016358257A1 (en) 2018-05-10
BR112018009753A8 (pt) 2019-02-26
US11166987B2 (en) 2021-11-09
KR102736981B1 (ko) 2024-12-02
ES2880431T3 (es) 2021-11-24
EP3377094B1 (en) 2021-04-28
LT3377094T (lt) 2021-08-10
BR112018009753A2 (pt) 2018-11-13
PT3377094T (pt) 2021-07-08
JP2019500026A (ja) 2019-01-10
HK1256137A1 (en) 2019-09-13
SMT202100423T1 (it) 2021-09-14
AU2016358257B2 (en) 2023-08-17
IL259052A (en) 2018-07-31
IL259052B1 (en) 2023-11-01
BR112018009753B1 (pt) 2024-02-20
WO2017085233A1 (en) 2017-05-26
IL259052B2 (en) 2024-03-01
EP3377094A1 (en) 2018-09-26
CY1124564T1 (el) 2022-07-22
PL3377094T3 (pl) 2021-12-13
CA3003563A1 (en) 2017-05-26
HUE055132T2 (hu) 2021-11-29
SI3377094T1 (sl) 2021-09-30
ZA201803902B (en) 2019-03-27
CN108472348A (zh) 2018-08-31
RS62152B1 (sr) 2021-08-31
SG11201803643TA (en) 2018-06-28

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