KR102736981B1 - 악성 고형 종양 치료를 위한 병독성 약독화된 박테리아 - Google Patents

악성 고형 종양 치료를 위한 병독성 약독화된 박테리아 Download PDF

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KR102736981B1
KR102736981B1 KR1020187016568A KR20187016568A KR102736981B1 KR 102736981 B1 KR102736981 B1 KR 102736981B1 KR 1020187016568 A KR1020187016568 A KR 1020187016568A KR 20187016568 A KR20187016568 A KR 20187016568A KR 102736981 B1 KR102736981 B1 KR 102736981B1
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KR20180081583A (ko
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시몬 이티그
말리스 암스튜츠
크리스토프 카스퍼
가이 알. 코넬리스
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우니페르시테트 바젤
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0275—Salmonella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0291—Yersinia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/104—Pseudomonadales, e.g. Pseudomonas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020187016568A 2015-11-19 2016-11-17 악성 고형 종양 치료를 위한 병독성 약독화된 박테리아 Active KR102736981B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15195490.6 2015-11-19
EP15195490 2015-11-19
PCT/EP2016/078084 WO2017085233A1 (en) 2015-11-19 2016-11-17 Virulence attenuated bacteria for treatment of malignant solid tumors

Publications (2)

Publication Number Publication Date
KR20180081583A KR20180081583A (ko) 2018-07-16
KR102736981B1 true KR102736981B1 (ko) 2024-12-02

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KR1020187016568A Active KR102736981B1 (ko) 2015-11-19 2016-11-17 악성 고형 종양 치료를 위한 병독성 약독화된 박테리아

Country Status (24)

Country Link
US (1) US11166987B2 (enExample)
EP (2) EP3377094B1 (enExample)
JP (1) JP7060503B2 (enExample)
KR (1) KR102736981B1 (enExample)
CN (1) CN108472348B (enExample)
AU (1) AU2016358257B2 (enExample)
BR (2) BR112018009753B1 (enExample)
CA (1) CA3003563A1 (enExample)
CY (1) CY1124564T1 (enExample)
DK (1) DK3377094T3 (enExample)
EA (1) EA201890868A1 (enExample)
ES (1) ES2880431T3 (enExample)
HR (1) HRP20211191T1 (enExample)
HU (1) HUE055132T2 (enExample)
IL (1) IL259052B2 (enExample)
LT (1) LT3377094T (enExample)
PL (1) PL3377094T3 (enExample)
PT (1) PT3377094T (enExample)
RS (1) RS62152B1 (enExample)
SG (1) SG11201803643TA (enExample)
SI (1) SI3377094T1 (enExample)
SM (1) SMT202100423T1 (enExample)
WO (1) WO2017085233A1 (enExample)
ZA (1) ZA201803902B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107001431B (zh) 2014-05-21 2022-11-01 巴塞尔大学 基于细菌的蛋白质递送
SMT202000620T1 (it) 2015-11-19 2021-01-05 Univ Basel Distribuzione di proteine basata su batteri
JP6976351B2 (ja) 2016-12-20 2021-12-08 ウニヴェルズィテート・バーゼルUniversitat Basel 弱毒化細菌に基づくタンパク質送達
KR102110993B1 (ko) * 2018-12-20 2020-05-14 한국생명공학연구원 클레브시엘라 아에로제네스(Klebsiella aerogenes) 균주를 유효성분으로 포함하는 암 진단, 예방 또는 치료용 조성물
IL302334A (en) * 2020-10-27 2023-06-01 T3 Pharmaceuticals Ag Providing bacteria-based protein
CN114712496B (zh) * 2022-04-29 2023-10-13 中山大学·深圳 一种展示新抗原的细菌衍生外膜囊泡疫苗及制备方法和在制备癌症免疫治疗试剂盒中的应用
CN116064877B (zh) * 2023-02-09 2024-09-20 宁夏大学 利用lamp技术快速检测阴沟肠杆菌的试剂盒及方法
CN116855496B (zh) * 2023-07-05 2024-08-16 郑州大学 含有干扰序列siRNA-HIF-1α的表达质粒在制备抗肝细胞癌药物中的应用
EP4761753A2 (en) * 2023-08-17 2026-06-24 Baccine Ltd. Genetically modified bacteria for multi-modal secretion of a neoantigen

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002077249A2 (en) * 2001-03-26 2002-10-03 Universite Catholique De Louvain Type iii bacterial strains for use in medicine

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US5965381A (en) 1998-03-06 1999-10-12 Ludwig Institute For Cancer Research Delivery of proteins into eukaryotic cells with recombinant yersinia
US6596509B1 (en) 1998-07-10 2003-07-22 Cornell Research Foundation, Inc. Recombinant constructs and systems for secretion of proteins via type III secretion systems
US20020160502A1 (en) 2000-09-26 2002-10-31 Roger Williams Hospital Recombinant BCG vaccines for the prevention and treatment of cancer
US8058442B2 (en) 2002-11-07 2011-11-15 Technion Research And Development Foundation Ltd. Neuroprotective iron chelators and pharmaceutical compositions comprising them
FR2862312B1 (fr) 2003-11-13 2006-02-17 Univ Grenoble 1 Outil de transfert et de production de proteines mettant en oeuvre le systeme de secretion de type iii de pseudomonas
US8357373B2 (en) 2005-10-04 2013-01-22 Ludwig Institute For Cancer Research Methods for stimulating an immune response using bacterial antigen delivery system
WO2008019183A2 (en) 2006-05-18 2008-02-14 The Regents Of The University Of California Biopolymer and protein production using type iii secretion systems of gram negative bacteria
TW200819540A (en) * 2006-07-11 2008-05-01 Genelux Corp Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders
EP2268313A2 (en) 2008-03-17 2011-01-05 Universitätsklinikum Münster Yopm as delivery vehicle for cargo molecules and as biological therapeutic for immunomodulation of inflammatory reactions
EP2717886B1 (en) 2011-06-08 2021-09-01 Chelation Partners Incorporated Metal chelating compositions and methods for controlling the growth or activities of a living cell or organism
US9127284B2 (en) * 2012-05-04 2015-09-08 The University Of Hong Kong Modified bacteria and their uses thereof for the treatment of cancer or tumor
JP6936934B2 (ja) 2013-09-24 2021-09-22 メディシナ セラピューティクス インコーポレイテッド インターロイキン−４受容体結合融合タンパク質及びその使用
US10143743B2 (en) 2013-11-18 2018-12-04 Yale University Non-replicating bacterial nanoparticle delivery system and methods of use
CN107001431B (zh) 2014-05-21 2022-11-01 巴塞尔大学 基于细菌的蛋白质递送
SMT202000620T1 (it) 2015-11-19 2021-01-05 Univ Basel Distribuzione di proteine basata su batteri
JP6976351B2 (ja) 2016-12-20 2021-12-08 ウニヴェルズィテート・バーゼルUniversitat Basel 弱毒化細菌に基づくタンパク質送達

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002077249A2 (en) * 2001-03-26 2002-10-03 Universite Catholique De Louvain Type iii bacterial strains for use in medicine

Non-Patent Citations (1)

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I. Gentschev et al., BMC Cancer. 2005, 5, Article number 15.

Also Published As

Publication number Publication date
IL259052A (en) 2018-07-31
JP7060503B2 (ja) 2022-04-26
CA3003563A1 (en) 2017-05-26
US20190015497A1 (en) 2019-01-17
EP3377094A1 (en) 2018-09-26
HRP20211191T1 (hr) 2021-10-29
ZA201803902B (en) 2019-03-27
CN108472348A (zh) 2018-08-31
JP2019500026A (ja) 2019-01-10
IL259052B2 (en) 2024-03-01
BR122023024697A2 (pt) 2023-12-26
BR112018009753A2 (pt) 2018-11-13
IL259052B1 (en) 2023-11-01
SMT202100423T1 (it) 2021-09-14
US11166987B2 (en) 2021-11-09
CN108472348B (zh) 2022-12-27
HUE055132T2 (hu) 2021-11-29
AU2016358257A1 (en) 2018-05-10
ES2880431T3 (es) 2021-11-24
BR112018009753A8 (pt) 2019-02-26
AU2016358257B2 (en) 2023-08-17
LT3377094T (lt) 2021-08-10
BR112018009753B1 (pt) 2024-02-20
PT3377094T (pt) 2021-07-08
EP3377094B1 (en) 2021-04-28
RS62152B1 (sr) 2021-08-31
HK1256137A1 (en) 2019-09-13
DK3377094T3 (da) 2021-08-02
EA201890868A1 (ru) 2018-12-28
PL3377094T3 (pl) 2021-12-13
SI3377094T1 (sl) 2021-09-30
WO2017085233A1 (en) 2017-05-26
EP3903813A1 (en) 2021-11-03
SG11201803643TA (en) 2018-06-28
KR20180081583A (ko) 2018-07-16
CY1124564T1 (el) 2022-07-22

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