KR102736981B1 - 악성 고형 종양 치료를 위한 병독성 약독화된 박테리아 - Google Patents

악성 고형 종양 치료를 위한 병독성 약독화된 박테리아 Download PDF

Info

Publication number
KR102736981B1
KR102736981B1 KR1020187016568A KR20187016568A KR102736981B1 KR 102736981 B1 KR102736981 B1 KR 102736981B1 KR 1020187016568 A KR1020187016568 A KR 1020187016568A KR 20187016568 A KR20187016568 A KR 20187016568A KR 102736981 B1 KR102736981 B1 KR 102736981B1
Authority
KR
South Korea
Prior art keywords
ser
protein
leu
ala
lys
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020187016568A
Other languages
English (en)
Korean (ko)
Other versions
KR20180081583A (ko
Inventor
시몬 이티그
말리스 암스튜츠
크리스토프 카스퍼
가이 알. 코넬리스
Original Assignee
우니페르시테트 바젤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 우니페르시테트 바젤 filed Critical 우니페르시테트 바젤
Publication of KR20180081583A publication Critical patent/KR20180081583A/ko
Application granted granted Critical
Publication of KR102736981B1 publication Critical patent/KR102736981B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/025Enterobacteriales, e.g. Enterobacter
    • A61K39/0258Escherichia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/025Enterobacteriales, e.g. Enterobacter
    • A61K39/0275Salmonella
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/025Enterobacteriales, e.g. Enterobacter
    • A61K39/0291Yersinia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/104Pseudomonadales, e.g. Pseudomonas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020187016568A 2015-11-19 2016-11-17 악성 고형 종양 치료를 위한 병독성 약독화된 박테리아 Active KR102736981B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15195490.6 2015-11-19
EP15195490 2015-11-19
PCT/EP2016/078084 WO2017085233A1 (en) 2015-11-19 2016-11-17 Virulence attenuated bacteria for treatment of malignant solid tumors

Publications (2)

Publication Number Publication Date
KR20180081583A KR20180081583A (ko) 2018-07-16
KR102736981B1 true KR102736981B1 (ko) 2024-12-02

Family

ID=54697464

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020187016568A Active KR102736981B1 (ko) 2015-11-19 2016-11-17 악성 고형 종양 치료를 위한 병독성 약독화된 박테리아

Country Status (24)

Country Link
US (1) US11166987B2 (enExample)
EP (2) EP3903813A1 (enExample)
JP (1) JP7060503B2 (enExample)
KR (1) KR102736981B1 (enExample)
CN (1) CN108472348B (enExample)
AU (1) AU2016358257B2 (enExample)
BR (2) BR122023024697A2 (enExample)
CA (1) CA3003563A1 (enExample)
CY (1) CY1124564T1 (enExample)
DK (1) DK3377094T3 (enExample)
EA (1) EA201890868A1 (enExample)
ES (1) ES2880431T3 (enExample)
HR (1) HRP20211191T1 (enExample)
HU (1) HUE055132T2 (enExample)
IL (1) IL259052B2 (enExample)
LT (1) LT3377094T (enExample)
PL (1) PL3377094T3 (enExample)
PT (1) PT3377094T (enExample)
RS (1) RS62152B1 (enExample)
SG (1) SG11201803643TA (enExample)
SI (1) SI3377094T1 (enExample)
SM (1) SMT202100423T1 (enExample)
WO (1) WO2017085233A1 (enExample)
ZA (1) ZA201803902B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6797025B2 (ja) 2014-05-21 2020-12-09 ウニヴェルズィテート バーゼル 細菌に基づくタンパク質送達
KR102689434B1 (ko) 2015-11-19 2024-07-29 우니페르시테트 바젤 박테리아-기반의 단백질 전달
JP6976351B2 (ja) 2016-12-20 2021-12-08 ウニヴェルズィテート・バーゼルUniversitat Basel 弱毒化細菌に基づくタンパク質送達
KR102110993B1 (ko) * 2018-12-20 2020-05-14 한국생명공학연구원 클레브시엘라 아에로제네스(Klebsiella aerogenes) 균주를 유효성분으로 포함하는 암 진단, 예방 또는 치료용 조성물
AU2021370840A1 (en) * 2020-10-27 2023-06-22 T3 Pharmaceuticals Ag Bacteria based protein delivery
CN114712496B (zh) * 2022-04-29 2023-10-13 中山大学·深圳 一种展示新抗原的细菌衍生外膜囊泡疫苗及制备方法和在制备癌症免疫治疗试剂盒中的应用
CN116064877B (zh) * 2023-02-09 2024-09-20 宁夏大学 利用lamp技术快速检测阴沟肠杆菌的试剂盒及方法
CN116855496B (zh) * 2023-07-05 2024-08-16 郑州大学 含有干扰序列siRNA-HIF-1α的表达质粒在制备抗肝细胞癌药物中的应用
WO2025037284A2 (en) * 2023-08-17 2025-02-20 Baccine Ltd. Genetically modified bacteria for multi-modal secretion of a neoantigen

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002077249A2 (en) * 2001-03-26 2002-10-03 Universite Catholique De Louvain Type iii bacterial strains for use in medicine

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965381A (en) * 1998-03-06 1999-10-12 Ludwig Institute For Cancer Research Delivery of proteins into eukaryotic cells with recombinant yersinia
AU5209399A (en) 1998-07-10 2000-02-01 Cornell Research Foundation Inc. Recombinant constructs and systems for secretion of proteins via type iii secretion systems
US20020160502A1 (en) 2000-09-26 2002-10-31 Roger Williams Hospital Recombinant BCG vaccines for the prevention and treatment of cancer
EP1565185A4 (en) 2002-11-07 2011-01-05 Technion Res & Dev Foundation NEUROPROTECTIVE IRON CHELATORS AND PHARMACEUTICAL COMPOSITIONS THEREWITH
FR2862312B1 (fr) 2003-11-13 2006-02-17 Univ Grenoble 1 Outil de transfert et de production de proteines mettant en oeuvre le systeme de secretion de type iii de pseudomonas
WO2007044406A2 (en) 2005-10-04 2007-04-19 Ludwig Institute For Cancer Research Methods for stimulating an immune response using bacterial antigen delivery system
WO2008019183A2 (en) 2006-05-18 2008-02-14 The Regents Of The University Of California Biopolymer and protein production using type iii secretion systems of gram negative bacteria
TW200819540A (en) * 2006-07-11 2008-05-01 Genelux Corp Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders
AU2009226972B2 (en) 2008-03-17 2014-05-29 Gerhard Heusipp YopM as delivery vehicle for cargo molecules and as biological therapeutic for immunomodulation of inflammatory reactions
DK2717886T3 (da) 2011-06-08 2021-12-06 Chelation Partners Incorporated Metalchelateringssammensætninger og fremgangsmåder til styring af en levende celles eller organismes vækst eller aktiviteter
US9127284B2 (en) * 2012-05-04 2015-09-08 The University Of Hong Kong Modified bacteria and their uses thereof for the treatment of cancer or tumor
EP3049526B1 (en) 2013-09-24 2021-02-24 Medicenna Therapeutics, Inc. Interleukin-4 receptor-binding fusion proteins and uses thereof
US10143743B2 (en) 2013-11-18 2018-12-04 Yale University Non-replicating bacterial nanoparticle delivery system and methods of use
JP6797025B2 (ja) 2014-05-21 2020-12-09 ウニヴェルズィテート バーゼル 細菌に基づくタンパク質送達
KR102689434B1 (ko) 2015-11-19 2024-07-29 우니페르시테트 바젤 박테리아-기반의 단백질 전달
JP6976351B2 (ja) 2016-12-20 2021-12-08 ウニヴェルズィテート・バーゼルUniversitat Basel 弱毒化細菌に基づくタンパク質送達

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002077249A2 (en) * 2001-03-26 2002-10-03 Universite Catholique De Louvain Type iii bacterial strains for use in medicine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
I. Gentschev et al., BMC Cancer. 2005, 5, Article number 15.

Also Published As

Publication number Publication date
EA201890868A1 (ru) 2018-12-28
CN108472348B (zh) 2022-12-27
HRP20211191T1 (hr) 2021-10-29
KR20180081583A (ko) 2018-07-16
US20190015497A1 (en) 2019-01-17
BR122023024697A2 (pt) 2023-12-26
DK3377094T3 (da) 2021-08-02
EP3903813A1 (en) 2021-11-03
AU2016358257A1 (en) 2018-05-10
BR112018009753A8 (pt) 2019-02-26
US11166987B2 (en) 2021-11-09
ES2880431T3 (es) 2021-11-24
EP3377094B1 (en) 2021-04-28
LT3377094T (lt) 2021-08-10
BR112018009753A2 (pt) 2018-11-13
JP7060503B2 (ja) 2022-04-26
PT3377094T (pt) 2021-07-08
JP2019500026A (ja) 2019-01-10
HK1256137A1 (en) 2019-09-13
SMT202100423T1 (it) 2021-09-14
AU2016358257B2 (en) 2023-08-17
IL259052A (en) 2018-07-31
IL259052B1 (en) 2023-11-01
BR112018009753B1 (pt) 2024-02-20
WO2017085233A1 (en) 2017-05-26
IL259052B2 (en) 2024-03-01
EP3377094A1 (en) 2018-09-26
CY1124564T1 (el) 2022-07-22
PL3377094T3 (pl) 2021-12-13
CA3003563A1 (en) 2017-05-26
HUE055132T2 (hu) 2021-11-29
SI3377094T1 (sl) 2021-09-30
ZA201803902B (en) 2019-03-27
CN108472348A (zh) 2018-08-31
RS62152B1 (sr) 2021-08-31
SG11201803643TA (en) 2018-06-28

Similar Documents

Publication Publication Date Title
KR102736981B1 (ko) 악성 고형 종양 치료를 위한 병독성 약독화된 박테리아
US20230250138A1 (en) Virulence Attenuated Bacteria Based Protein Delivery
US20240401065A1 (en) Bacteria-Based Protein Delivery
KR102689434B1 (ko) 박테리아-기반의 단백질 전달
HK1256137B (en) Virulence attenuated bacteria for treatment of malignant solid tumors
EA040558B1 (ru) Бактерии с ослабленной вирулентностью для лечения злокачественных солидных опухолей
HK1256138B (en) Bacteria-based protein delivery
HK40015324B (en) Virulence attenuated bacteria based protein delivery
HK40015324A (en) Virulence attenuated bacteria based protein delivery
HK1236208A1 (en) Bacteria-based protein delivery
HK1236208B (en) Bacteria-based protein delivery

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20180611

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20211005

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20231120

Patent event code: PE09021S01D

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20240729

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20241024

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20241127

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20241128

End annual number: 3

Start annual number: 1

PG1601 Publication of registration