JP7056858B2 - 新規な組換え型二機能性融合タンパク質、その調製方法および用途 - Google Patents
新規な組換え型二機能性融合タンパク質、その調製方法および用途 Download PDFInfo
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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| CN201710151979.6 | 2017-03-15 | ||
| CN201710151979.6A CN108623689B (zh) | 2017-03-15 | 2017-03-15 | 新型重组双功能融合蛋白及其制备方法和用途 |
| PCT/CN2018/079187 WO2018166507A1 (zh) | 2017-03-15 | 2018-03-15 | 新型重组双功能融合蛋白及其制备方法和用途 |
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| CN112533954B (zh) * | 2018-08-08 | 2024-06-18 | 宜明昂科生物医药技术（上海）股份有限公司 | 靶向cd47和her2的重组双功能蛋白 |
| WO2020088164A1 (zh) * | 2018-11-01 | 2020-05-07 | 山东新时代药业有限公司 | 双特异性抗体及其用途 |
| CA3122914A1 (en) * | 2018-12-21 | 2020-06-25 | Ose Immunotherapeutics | Bifunctional anti-pd-1/sirp.alpha. molecule |
| CN111484558B (zh) * | 2019-01-28 | 2023-02-17 | 上海交通大学 | 信号调节蛋白α片段-抗FcRn单链抗体融合蛋白及其制备与应用 |
| CN111423515A (zh) * | 2020-03-23 | 2020-07-17 | 倍而达药业（苏州）有限公司 | 一种cd20/cd47双特异性抗体及应用 |
| CN113896802A (zh) * | 2021-10-09 | 2022-01-07 | 宜明昂科生物医药技术（上海）有限公司 | 靶向cd47和cd38的重组融合蛋白及其制备和用途 |
| CN113956363B (zh) | 2021-10-13 | 2023-03-31 | 宜明昂科生物医药技术（上海）股份有限公司 | 靶向cd47和cd24的重组融合蛋白及其制备和用途 |
| WO2023072217A1 (en) * | 2021-10-28 | 2023-05-04 | Guangzhou Lintonpharm Co., Ltd. | Fusion proteins targeting cd3 and cd47 |
| CN119584987A (zh) * | 2023-03-01 | 2025-03-07 | 上海津曼特生物科技有限公司 | 包含cd20/cd47阻断双功能融合蛋白的联合用药物及其用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2016022971A1 (en) | 2014-08-08 | 2016-02-11 | The Board Of Trustees Of The Leland Stanford Junior University | Sirp alpha-antibody fusion proteins |
| WO2016024021A1 (en) | 2014-08-15 | 2016-02-18 | Merck Patent Gmbh | Sirp-alpha immunoglobulin fusion proteins |
| JP2016514676A (ja) | 2013-03-15 | 2016-05-23 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | 四価二重特異性抗体 |
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| WO2016187226A1 (en) * | 2015-05-18 | 2016-11-24 | Ab Initio Biotherapeutics, Inc. | Sirp polypeptide compositions and methods of use |
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| JP2016514676A (ja) | 2013-03-15 | 2016-05-23 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | 四価二重特異性抗体 |
| WO2016022971A1 (en) | 2014-08-08 | 2016-02-11 | The Board Of Trustees Of The Leland Stanford Junior University | Sirp alpha-antibody fusion proteins |
| WO2016024021A1 (en) | 2014-08-15 | 2016-02-18 | Merck Patent Gmbh | Sirp-alpha immunoglobulin fusion proteins |
Non-Patent Citations (2)
| Title |
|---|
| Clin Cancer Res, 2016 Apr 28, vol. 22, no. 20, pp. 5109-5119 |
| mAbs, 2015.08.26, vol. 7, no. 5, pp. 946-956 |
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| US11407841B2 (en) | 2022-08-09 |
| CN110300766A (zh) | 2019-10-01 |
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