JP7055802B2 - 正常眼圧緑内障を処置するための一酸化窒素放出プロスタグランジン誘導体 - Google Patents

正常眼圧緑内障を処置するための一酸化窒素放出プロスタグランジン誘導体 Download PDF

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Publication number
JP7055802B2
JP7055802B2 JP2019523710A JP2019523710A JP7055802B2 JP 7055802 B2 JP7055802 B2 JP 7055802B2 JP 2019523710 A JP2019523710 A JP 2019523710A JP 2019523710 A JP2019523710 A JP 2019523710A JP 7055802 B2 JP7055802 B2 JP 7055802B2
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compound
formula
pharmaceutical composition
iop
composition according
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Japanese (ja)
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JP2019534296A (ja
JP2019534296A5 (https=
Inventor
ヴィティトウ，ジェイソン・ラマー
キャヴェット，メーガン・エリザベス
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Bausch and Lomb Inc
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Bausch and Lomb Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2019523710A 2016-11-08 2017-11-07 正常眼圧緑内障を処置するための一酸化窒素放出プロスタグランジン誘導体 Active JP7055802B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662419153P 2016-11-08 2016-11-08
US62/419,153 2016-11-08
PCT/EP2017/078486 WO2018087092A1 (en) 2016-11-08 2017-11-07 Nitric oxide releasing prostaglandin derivatives for treating normal tension glaucoma

Publications (3)

Publication Number Publication Date
JP2019534296A JP2019534296A (ja) 2019-11-28
JP2019534296A5 JP2019534296A5 (https=) 2020-12-10
JP7055802B2 true JP7055802B2 (ja) 2022-04-18

Family

ID=60421748

Family Applications (1)

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JP2019523710A Active JP7055802B2 (ja) 2016-11-08 2017-11-07 正常眼圧緑内障を処置するための一酸化窒素放出プロスタグランジン誘導体

Country Status (7)

Country Link
US (1) US11058691B2 (https=)
JP (1) JP7055802B2 (https=)
KR (1) KR20190104993A (https=)
BR (1) BR112019009330A2 (https=)
CA (1) CA3043000A1 (https=)
MX (1) MX2019005321A (https=)
WO (1) WO2018087092A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6750473B2 (ja) * 2016-11-22 2020-09-02 沖電気工業株式会社 自動取引装置及び自動取引システム
EP4404936A1 (en) 2021-09-20 2024-07-31 Nicox SA Nitric oxide releasing prostamide as neuroprotective agent
CA3195291A1 (en) * 2022-04-13 2023-10-13 Caravel Therapeutics, Inc. Preservative-free ophthalmic pharmaceutical emulsion and its application
WO2024121867A1 (en) * 2022-12-09 2024-06-13 Sentiss Pharma Private Limited Pharmaceutical composition for glaucoma and ocular hypertension

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007518716A (ja) 2004-01-05 2007-07-12 ニコックス，ソシエテ アノニム プロスタグランヂンニトロオキシ誘導体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4952581A (en) 1987-04-03 1990-08-28 The Trustees Of Columbia University In The City Of New York Use of a prostaglandin in combination with an adrenergic blocking agent for reduction of intraocular pressure
WO1994008585A1 (en) 1992-10-13 1994-04-28 Alcon Laboratories, Inc. Combinations of prostaglandins and clonidine derivatives for the treatment of glaucoma
IT1295694B1 (it) 1996-11-14 1999-05-27 Nicox Sa Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica
JP2009501150A (ja) 2005-06-29 2009-01-15 ファイザー・インク プロスタグランジン誘導体
EP1917239A1 (en) 2005-06-29 2008-05-07 Pfizer, Inc. Fluoroprostaglandins nitroderivatives
AR076731A1 (es) 2008-05-09 2011-07-06 Pfizer Prostamidas donadoras de oxido nitrico, uso de los mismos y composiciones farmaceuticas

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007518716A (ja) 2004-01-05 2007-07-12 ニコックス，ソシエテ アノニム プロスタグランヂンニトロオキシ誘導体

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Clinical Ophthalmology，2016年，10，pp.2035-2050

Also Published As

Publication number Publication date
US11058691B2 (en) 2021-07-13
JP2019534296A (ja) 2019-11-28
KR20190104993A (ko) 2019-09-11
MX2019005321A (es) 2019-10-14
WO2018087092A1 (en) 2018-05-17
CA3043000A1 (en) 2018-05-17
US20200179401A1 (en) 2020-06-11
BR112019009330A2 (pt) 2019-07-30

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