JP7046007B2 - 分子標識カウントの調節方法 - Google Patents
分子標識カウントの調節方法 Download PDFInfo
- Publication number
- JP7046007B2 JP7046007B2 JP2018561218A JP2018561218A JP7046007B2 JP 7046007 B2 JP7046007 B2 JP 7046007B2 JP 2018561218 A JP2018561218 A JP 2018561218A JP 2018561218 A JP2018561218 A JP 2018561218A JP 7046007 B2 JP7046007 B2 JP 7046007B2
- Authority
- JP
- Japan
- Prior art keywords
- sequencing
- molecular
- nucleic acid
- target
- labels
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06K—GRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
- G06K19/00—Record carriers for use with machines and with at least a part designed to carry digital markings
- G06K19/06—Record carriers for use with machines and with at least a part designed to carry digital markings characterised by the kind of the digital marking, e.g. shape, nature, code
- G06K19/06009—Record carriers for use with machines and with at least a part designed to carry digital markings characterised by the kind of the digital marking, e.g. shape, nature, code with optically detectable marking
- G06K19/06018—Record carriers for use with machines and with at least a part designed to carry digital markings characterised by the kind of the digital marking, e.g. shape, nature, code with optically detectable marking one-dimensional coding
- G06K19/06028—Record carriers for use with machines and with at least a part designed to carry digital markings characterised by the kind of the digital marking, e.g. shape, nature, code with optically detectable marking one-dimensional coding using bar codes
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/10—Signal processing, e.g. from mass spectrometry [MS] or from PCR
Landscapes
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biotechnology (AREA)
- Evolutionary Biology (AREA)
- General Health & Medical Sciences (AREA)
- Data Mining & Analysis (AREA)
- Epidemiology (AREA)
- Software Systems (AREA)
- Public Health (AREA)
- Evolutionary Computation (AREA)
- Artificial Intelligence (AREA)
- Bioethics (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Databases & Information Systems (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical & Material Sciences (AREA)
- Signal Processing (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662342137P | 2016-05-26 | 2016-05-26 | |
| US62/342,137 | 2016-05-26 | ||
| US201662381945P | 2016-08-31 | 2016-08-31 | |
| US62/381,945 | 2016-08-31 | ||
| US201662401720P | 2016-09-29 | 2016-09-29 | |
| US62/401,720 | 2016-09-29 | ||
| PCT/US2017/034576 WO2017205691A1 (en) | 2016-05-26 | 2017-05-25 | Molecular label counting adjustment methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019522268A JP2019522268A (ja) | 2019-08-08 |
| JP2019522268A5 JP2019522268A5 (enExample) | 2020-07-02 |
| JP7046007B2 true JP7046007B2 (ja) | 2022-04-01 |
Family
ID=59014820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018561218A Active JP7046007B2 (ja) | 2016-05-26 | 2017-05-25 | 分子標識カウントの調節方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11397882B2 (enExample) |
| EP (2) | EP3465502B1 (enExample) |
| JP (1) | JP7046007B2 (enExample) |
| CN (1) | CN109074430B (enExample) |
| ES (1) | ES2979395T3 (enExample) |
| WO (1) | WO2017205691A1 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| GB2513024B (en) | 2012-02-27 | 2016-08-31 | Cellular Res Inc | A clonal amplification method |
| ES2857908T3 (es) | 2013-08-28 | 2021-09-29 | Becton Dickinson Co | Análisis masivamente paralelo de células individuales |
| CN107250379B (zh) | 2015-02-19 | 2021-12-28 | 贝克顿迪金森公司 | 结合蛋白质组信息和基因组信息的高通量单细胞分析 |
| ES2836802T3 (es) | 2015-02-27 | 2021-06-28 | Becton Dickinson Co | Códigos de barras moleculares espacialmente direccionables |
| EP4180535A1 (en) | 2015-03-30 | 2023-05-17 | Becton, Dickinson and Company | Methods and compositions for combinatorial barcoding |
| EP4582556A3 (en) | 2015-04-23 | 2025-10-08 | Becton, Dickinson and Company | Methods and compositions for whole transcriptome amplification |
| US11124823B2 (en) | 2015-06-01 | 2021-09-21 | Becton, Dickinson And Company | Methods for RNA quantification |
| ES2745694T3 (es) | 2015-09-11 | 2020-03-03 | Cellular Res Inc | Métodos y composiciones para normalización de biblioteca de ácido nucleico |
| AU2017261189B2 (en) | 2016-05-02 | 2023-02-09 | Becton, Dickinson And Company | Accurate molecular barcoding |
| US10301677B2 (en) | 2016-05-25 | 2019-05-28 | Cellular Research, Inc. | Normalization of nucleic acid libraries |
| ES2979395T3 (es) | 2016-05-26 | 2024-09-25 | Becton Dickinson Co | Métodos de ajuste del recuento de etiquetas moleculares |
| US10640763B2 (en) | 2016-05-31 | 2020-05-05 | Cellular Research, Inc. | Molecular indexing of internal sequences |
| US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
| KR102522023B1 (ko) | 2016-09-26 | 2023-04-17 | 셀룰러 리서치, 인크. | 바코딩된 올리고뉴클레오티드 서열을 갖는 시약을 이용한 단백질 발현의 측정 |
| US11608497B2 (en) | 2016-11-08 | 2023-03-21 | Becton, Dickinson And Company | Methods for cell label classification |
| WO2018089378A1 (en) | 2016-11-08 | 2018-05-17 | Cellular Research, Inc. | Methods for expression profile classification |
| JP7104048B2 (ja) | 2017-01-13 | 2022-07-20 | セルラー リサーチ, インコーポレイテッド | 流体チャネルの親水性コーティング |
| EP3577232A1 (en) | 2017-02-01 | 2019-12-11 | Cellular Research, Inc. | Selective amplification using blocking oligonucleotides |
| KR102790050B1 (ko) | 2017-06-05 | 2025-04-04 | 백톤 디킨슨 앤드 컴퍼니 | 단일 세포를 위한 샘플 인덱싱 |
| EP3460071A1 (en) | 2017-09-22 | 2019-03-27 | Lexogen GmbH | Estimating pre-pcr fragment numbers from post-pcr frequencies of unique molecular identifiers |
| CN120564822A (zh) * | 2017-09-25 | 2025-08-29 | 贝克顿迪金森公司 | 免疫受体条形码错误校正 |
| CN111492068B (zh) * | 2017-12-19 | 2025-03-21 | 贝克顿迪金森公司 | 与寡核苷酸相关联的颗粒 |
| DK3746564T3 (da) | 2018-01-29 | 2023-01-30 | St Jude Childrens Res Hospital Inc | Fremgangsmåde til nukleinsyreamplifikation |
| EP4545647A3 (en) | 2018-05-03 | 2025-07-09 | Becton, Dickinson and Company | Molecular barcoding on opposite transcript ends |
| WO2019213294A1 (en) | 2018-05-03 | 2019-11-07 | Becton, Dickinson And Company | High throughput multiomics sample analysis |
| US20200020419A1 (en) | 2018-07-16 | 2020-01-16 | Flagship Pioneering Innovations Vi, Llc. | Methods of analyzing cells |
| EP4471156A3 (en) | 2018-10-01 | 2025-02-26 | Becton, Dickinson and Company | Determining 5' transcript sequences |
| JP7618548B2 (ja) | 2018-11-08 | 2025-01-21 | ベクトン・ディキンソン・アンド・カンパニー | ランダムプライミングを使用した単一細胞の全トランスクリプトーム解析 |
| WO2020123384A1 (en) | 2018-12-13 | 2020-06-18 | Cellular Research, Inc. | Selective extension in single cell whole transcriptome analysis |
| WO2020150356A1 (en) | 2019-01-16 | 2020-07-23 | Becton, Dickinson And Company | Polymerase chain reaction normalization through primer titration |
| ES2989967T3 (es) | 2019-01-23 | 2024-11-28 | Becton Dickinson Co | Oligonucleótidos asociados con anticuerpos |
| WO2020167830A1 (en) * | 2019-02-12 | 2020-08-20 | Becton, Dickinson And Company | Determining expressions of transcript variants and polyadenylation sites |
| US12071617B2 (en) | 2019-02-14 | 2024-08-27 | Becton, Dickinson And Company | Hybrid targeted and whole transcriptome amplification |
| CN110222745B (zh) * | 2019-05-24 | 2021-04-30 | 中南大学 | 一种基于相似性学习及其增强的细胞类型鉴定方法 |
| CN120099137A (zh) | 2019-07-22 | 2025-06-06 | 贝克顿迪金森公司 | 单细胞染色质免疫沉淀测序测定 |
| CN114746947A (zh) * | 2019-09-09 | 2022-07-12 | 格瑞尔有限责任公司 | 用于分析dna数据的读数层特定噪声模型 |
| CN114729350A (zh) | 2019-11-08 | 2022-07-08 | 贝克顿迪金森公司 | 使用随机引发获得用于免疫组库测序的全长v(d)j信息 |
| JP2021103139A (ja) * | 2019-12-25 | 2021-07-15 | ソニーグループ株式会社 | 情報処理装置、粒子測定装置、粒子測定システム、粒子分取装置、粒子分取システム、情報処理方法、及び情報処理プログラム |
| US11649497B2 (en) | 2020-01-13 | 2023-05-16 | Becton, Dickinson And Company | Methods and compositions for quantitation of proteins and RNA |
| US20230046438A1 (en) * | 2020-01-14 | 2023-02-16 | Peking University | Method for predicting cell spatial relation based on single-cell transcriptome sequencing data |
| WO2021155057A1 (en) | 2020-01-29 | 2021-08-05 | Becton, Dickinson And Company | Barcoded wells for spatial mapping of single cells through sequencing |
| WO2021173719A1 (en) | 2020-02-25 | 2021-09-02 | Becton, Dickinson And Company | Bi-specific probes to enable the use of single-cell samples as single color compensation control |
| CN111521591B (zh) * | 2020-05-09 | 2021-04-16 | 艾普拜生物科技(苏州)有限公司 | 用于微滴式数字pcr仪的计数校准装置、制备及使用方法 |
| EP4150118A1 (en) | 2020-05-14 | 2023-03-22 | Becton Dickinson and Company | Primers for immune repertoire profiling |
| EP4158055B1 (en) | 2020-06-02 | 2024-03-27 | Becton, Dickinson and Company | Oligonucleotides and beads for 5 prime gene expression assay |
| US11932901B2 (en) | 2020-07-13 | 2024-03-19 | Becton, Dickinson And Company | Target enrichment using nucleic acid probes for scRNAseq |
| WO2022026909A1 (en) | 2020-07-31 | 2022-02-03 | Becton, Dickinson And Company | Single cell assay for transposase-accessible chromatin |
| US11739443B2 (en) | 2020-11-20 | 2023-08-29 | Becton, Dickinson And Company | Profiling of highly expressed and lowly expressed proteins |
| US12392771B2 (en) | 2020-12-15 | 2025-08-19 | Becton, Dickinson And Company | Single cell secretome analysis |
| EP4263868A4 (en) * | 2021-03-12 | 2024-11-27 | Singular Genomics Systems, Inc. | NANONETWORKS AND METHODS OF USE THEREOF |
| US11884977B2 (en) | 2021-03-12 | 2024-01-30 | Singular Genomics Systems, Inc. | Nanoarrays and methods of use thereof |
| CN113096734B (zh) * | 2021-05-11 | 2021-12-14 | 中国科学院水生生物研究所 | 一种筛选用于二倍体群体亲子鉴定的分子标记组合的方法 |
| WO2023232940A1 (en) * | 2022-06-01 | 2023-12-07 | Gmendel Aps | A computer implemented method for identifying, if present, a preselected genetic disorder |
| CN116189768B (zh) * | 2023-02-10 | 2025-07-29 | 北京吉因加医学检验实验室有限公司 | 双重测序的测序深度估计方法、装置、设备及存储介质 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110160078A1 (en) | 2009-12-15 | 2011-06-30 | Affymetrix, Inc. | Digital Counting of Individual Molecules by Stochastic Attachment of Diverse Labels |
| WO2015002908A1 (en) | 2013-07-01 | 2015-01-08 | Sequenta, Inc. | Large-scale biomolecular analysis with sequence tags |
Family Cites Families (291)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4510244A (en) | 1980-04-17 | 1985-04-09 | The Board Of Trustees Of The Leland Stanford Jr. University | Cell labeling with antigen-coupled microspheres |
| US4725536A (en) | 1985-09-19 | 1988-02-16 | Genetics Institute, Inc. | Reagent polynucleotide complex with multiple target binding regions, and kit and methods |
| US6150517A (en) | 1986-11-24 | 2000-11-21 | Gen-Probe | Methods for making oligonucleotide probes for the detection and/or quantitation of non-viral organisms |
| WO1989001050A1 (en) | 1987-07-31 | 1989-02-09 | The Board Of Trustees Of The Leland Stanford Junior University | Selective amplification of target polynucleotide sequences |
| US5149625A (en) | 1987-08-11 | 1992-09-22 | President And Fellows Of Harvard College | Multiplex analysis of DNA |
| US5656731A (en) | 1987-10-15 | 1997-08-12 | Chiron Corporation | Nucleic acid-amplified immunoassay probes |
| US5124246A (en) | 1987-10-15 | 1992-06-23 | Chiron Corporation | Nucleic acid multimers and amplified nucleic acid hybridization assays using same |
| JPH04501353A (ja) | 1988-07-26 | 1992-03-12 | ジエネラブス・テクノロジーズ・インコーポレイテツド | Rna及びdna増幅法 |
| US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| US5871928A (en) | 1989-06-07 | 1999-02-16 | Fodor; Stephen P. A. | Methods for nucleic acid analysis |
| US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| US5424186A (en) | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
| US6309822B1 (en) | 1989-06-07 | 2001-10-30 | Affymetrix, Inc. | Method for comparing copy number of nucleic acid sequences |
| US5925525A (en) | 1989-06-07 | 1999-07-20 | Affymetrix, Inc. | Method of identifying nucleotide differences |
| US6551784B2 (en) | 1989-06-07 | 2003-04-22 | Affymetrix Inc | Method of comparing nucleic acid sequences |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5200314A (en) | 1990-03-23 | 1993-04-06 | Chiron Corporation | Polynucleotide capture assay employing in vitro amplification |
| US5119316A (en) | 1990-06-29 | 1992-06-02 | E. I. Du Pont De Nemours And Company | Method for determining dna sequences |
| DK0834575T3 (da) | 1990-12-06 | 2002-04-02 | Affymetrix Inc A Delaware Corp | Identifikation af nucleinsyrer i prøver |
| US5981179A (en) | 1991-11-14 | 1999-11-09 | Digene Diagnostics, Inc. | Continuous amplification reaction |
| US5424413A (en) | 1992-01-22 | 1995-06-13 | Gen-Probe Incorporated | Branched nucleic acid probes |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| US5981176A (en) | 1992-06-17 | 1999-11-09 | City Of Hope | Method of detecting and discriminating between nucleic acid sequences |
| EP0705271B1 (en) | 1993-06-25 | 2002-11-13 | Affymetrix, Inc. (a Delaware Corporation) | Hybridization and sequencing of nucleic acids |
| US5500356A (en) | 1993-08-10 | 1996-03-19 | Life Technologies, Inc. | Method of nucleic acid sequence selection |
| US6309823B1 (en) | 1993-10-26 | 2001-10-30 | Affymetrix, Inc. | Arrays of nucleic acid probes for analyzing biotransformation genes and methods of using the same |
| US5681697A (en) | 1993-12-08 | 1997-10-28 | Chiron Corporation | Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor |
| US5714330A (en) | 1994-04-04 | 1998-02-03 | Lynx Therapeutics, Inc. | DNA sequencing by stepwise ligation and cleavage |
| US5695934A (en) | 1994-10-13 | 1997-12-09 | Lynx Therapeutics, Inc. | Massively parallel sequencing of sorted polynucleotides |
| US6013445A (en) | 1996-06-06 | 2000-01-11 | Lynx Therapeutics, Inc. | Massively parallel signature sequencing by ligation of encoded adaptors |
| US5846719A (en) | 1994-10-13 | 1998-12-08 | Lynx Therapeutics, Inc. | Oligonucleotide tags for sorting and identification |
| US5604097A (en) | 1994-10-13 | 1997-02-18 | Spectragen, Inc. | Methods for sorting polynucleotides using oligonucleotide tags |
| US6600996B2 (en) | 1994-10-21 | 2003-07-29 | Affymetrix, Inc. | Computer-aided techniques for analyzing biological sequences |
| EP0709466B1 (en) | 1994-10-28 | 2006-09-27 | Gen-Probe Incorporated | Compositions and methods for the simultaneous detection and quantification of multiple specific nucleic acid sequences |
| AU707444B2 (en) | 1995-04-25 | 1999-07-08 | Irori | Remotely programmable matrices with memories and uses thereof |
| US5648245A (en) | 1995-05-09 | 1997-07-15 | Carnegie Institution Of Washington | Method for constructing an oligonucleotide concatamer library by rolling circle replication |
| US5968740A (en) | 1995-07-24 | 1999-10-19 | Affymetrix, Inc. | Method of Identifying a Base in a Nucleic Acid |
| US5763175A (en) | 1995-11-17 | 1998-06-09 | Lynx Therapeutics, Inc. | Simultaneous sequencing of tagged polynucleotides |
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| US5962271A (en) | 1996-01-03 | 1999-10-05 | Cloutech Laboratories, Inc. | Methods and compositions for generating full-length cDNA having arbitrary nucleotide sequence at the 3'-end |
| US6458530B1 (en) | 1996-04-04 | 2002-10-01 | Affymetrix Inc. | Selecting tag nucleic acids |
| EP0912761A4 (en) | 1996-05-29 | 2004-06-09 | Cornell Res Foundation Inc | DETERMINATION OF DIFFERENCES IN THE NUCLEIC ACID SEQUENCE BY MEANS OF A COMBINATION OF LIGASE DETERMINATION AND POLYMERASE CHAIN REACTION |
| JPH1021373A (ja) | 1996-07-05 | 1998-01-23 | Fuji Photo Film Co Ltd | 画像解析装置 |
| US5935793A (en) | 1996-09-27 | 1999-08-10 | The Chinese University Of Hong Kong | Parallel polynucleotide sequencing method using tagged primers |
| US6124092A (en) | 1996-10-04 | 2000-09-26 | The Perkin-Elmer Corporation | Multiplex polynucleotide capture methods and compositions |
| US6117631A (en) | 1996-10-29 | 2000-09-12 | Polyprobe, Inc. | Detection of antigens via oligonucleotide antibody conjugates |
| US6046005A (en) | 1997-01-15 | 2000-04-04 | Incyte Pharmaceuticals, Inc. | Nucleic acid sequencing with solid phase capturable terminators comprising a cleavable linking group |
| JP4294740B2 (ja) | 1997-05-23 | 2009-07-15 | ソレクサ・インコーポレイテッド | 分析物の系列的プロセシングのためのシステムおよび装置 |
| US6399334B1 (en) | 1997-09-24 | 2002-06-04 | Invitrogen Corporation | Normalized nucleic acid libraries and methods of production thereof |
| WO1999028505A1 (en) | 1997-12-03 | 1999-06-10 | Curagen Corporation | Methods and devices for measuring differential gene expression |
| US6265163B1 (en) | 1998-01-09 | 2001-07-24 | Lynx Therapeutics, Inc. | Solid phase selection of differentially expressed genes |
| US6787308B2 (en) | 1998-07-30 | 2004-09-07 | Solexa Ltd. | Arrayed biomolecules and their use in sequencing |
| US6653077B1 (en) | 1998-09-04 | 2003-11-25 | Lynx Therapeutics, Inc. | Method of screening for genetic polymorphism |
| US6480791B1 (en) | 1998-10-28 | 2002-11-12 | Michael P. Strathmann | Parallel methods for genomic analysis |
| US6197554B1 (en) | 1998-11-20 | 2001-03-06 | Shi-Lung Lin | Method for generating full-length cDNA library from single cells |
| US6629040B1 (en) | 1999-03-19 | 2003-09-30 | University Of Washington | Isotope distribution encoded tags for protein identification |
| JP2002539849A (ja) | 1999-03-26 | 2002-11-26 | ホワイトヘッド インスチチュート フォアー バイオメディカル リサーチ | ユニバーサルアレイ |
| EP1046717B1 (en) | 1999-04-20 | 2010-10-06 | National Institute of Advanced Industrial Science and Technology | Method and probes for determining a concentration of target nucleic acid molecules and method for analyzing data obtained by the method |
| US6355431B1 (en) | 1999-04-20 | 2002-03-12 | Illumina, Inc. | Detection of nucleic acid amplification reactions using bead arrays |
| US6326148B1 (en) | 1999-07-12 | 2001-12-04 | The Regents Of The University Of California | Detection of copy number changes in colon cancer |
| US6440706B1 (en) | 1999-08-02 | 2002-08-27 | Johns Hopkins University | Digital amplification |
| SE9903988D0 (sv) | 1999-11-03 | 1999-11-03 | Amersham Pharm Biotech Ab | Method of analysis |
| US6489114B2 (en) | 1999-12-17 | 2002-12-03 | Bio Merieux | Process for labeling a ribonucleic acid, and labeled RNA fragments which are obtained thereby |
| US6235483B1 (en) | 2000-01-31 | 2001-05-22 | Agilent Technologies, Inc. | Methods and kits for indirect labeling of nucleic acids |
| DE60136166D1 (de) | 2000-02-07 | 2008-11-27 | Illumina Inc | Nukleinsäure-nachweisverfahren mit universellem priming |
| GB2364054B (en) | 2000-03-24 | 2002-05-29 | Smithkline Beecham Corp | Method of amplifying quinolone-resistance-determining-regions and identifying polymorphic variants thereof |
| EP2278029B1 (en) | 2000-04-10 | 2016-07-13 | Taxon Biosciences, Inc. | Methods for the survey and genetic analysis of populations |
| US20030207300A1 (en) | 2000-04-28 | 2003-11-06 | Matray Tracy J. | Multiplex analytical platform using molecular tags |
| US7630063B2 (en) | 2000-08-02 | 2009-12-08 | Honeywell International Inc. | Miniaturized cytometer for detecting multiple species in a sample |
| AU2001282881B2 (en) | 2000-07-07 | 2007-06-14 | Visigen Biotechnologies, Inc. | Real-time sequence determination |
| CA2426824A1 (en) | 2000-10-24 | 2002-07-25 | The Board Of Trustees Of The Leland Stanford Junior University | Direct multiplex characterization of genomic dna |
| US20020142345A1 (en) | 2000-12-22 | 2002-10-03 | Nelsen Anita J. | Methods for encoding and decoding complex mixtures in arrayed assays |
| US20030049616A1 (en) | 2001-01-08 | 2003-03-13 | Sydney Brenner | Enzymatic synthesis of oligonucleotide tags |
| AU2002249116A1 (en) | 2001-01-11 | 2002-09-19 | Lion Bioscience Ag | Gene library for screening methods |
| WO2002059354A2 (en) | 2001-01-25 | 2002-08-01 | Tm Bioscience Corporation | Polynucleotides for use as tags and tag complements, manufacture and use thereof |
| US7027932B2 (en) | 2001-03-21 | 2006-04-11 | Olympus Optical Co., Ltd. | Biochemical examination method |
| US6849404B2 (en) | 2001-05-07 | 2005-02-01 | Bioneer Corporation | Polymerase chain reaction of DNA of which base sequence is completely unidentified |
| US6905827B2 (en) | 2001-06-08 | 2005-06-14 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases |
| US6830931B2 (en) | 2001-07-12 | 2004-12-14 | Automated Cell, Inc. | Method and apparatus for monitoring of proteins and cells |
| US20060141493A1 (en) | 2001-11-09 | 2006-06-29 | Duke University Office Of Science And Technology | Atherosclerotic phenotype determinative genes and methods for using the same |
| EP1476569A2 (en) | 2002-01-29 | 2004-11-17 | Global Genomics AB | Methods and means for manipulating nucleic acid |
| US20030186251A1 (en) | 2002-04-01 | 2003-10-02 | Brookhaven Science Associates, Llc | Genome sequence tags |
| US20070178478A1 (en) | 2002-05-08 | 2007-08-02 | Dhallan Ravinder S | Methods for detection of genetic disorders |
| US7955800B2 (en) | 2002-06-25 | 2011-06-07 | Advpharma Inc. | Metastasis-associated gene profiling for identification of tumor tissue, subtyping, and prediction of prognosis of patients |
| AU2003256285A1 (en) | 2002-06-28 | 2004-01-19 | Igen International, Inc. | Improved assay systems and components |
| US20050019776A1 (en) | 2002-06-28 | 2005-01-27 | Callow Matthew James | Universal selective genome amplification and universal genotyping system |
| JP2006515065A (ja) | 2002-08-16 | 2006-05-18 | ディシジョン バイオマーカーズ インコーポレイテッド | 蛍光配列の読み取り |
| US7361821B2 (en) | 2002-09-20 | 2008-04-22 | Intel Corporation | Controlled alignment of nanobarcodes encoding specific information for scanning probe microscopy (SPM) reading |
| US7919235B2 (en) | 2002-09-30 | 2011-04-05 | F. Hoffman-La Roche Ag | Oligonucleotides for genotyping thymidylate synthase gene |
| EP1546412B1 (en) | 2002-10-02 | 2014-05-21 | California Institute Of Technology | Microfluidic nucleic acid analysis |
| US7822555B2 (en) | 2002-11-11 | 2010-10-26 | Affymetrix, Inc. | Methods for identifying DNA copy number changes |
| AU2003291481A1 (en) | 2002-11-11 | 2004-06-03 | Affymetrix, Inc. | Methods for identifying dna copy number changes |
| US7704687B2 (en) | 2002-11-15 | 2010-04-27 | The Johns Hopkins University | Digital karyotyping |
| US7269518B2 (en) | 2003-04-30 | 2007-09-11 | Agilent Technologies, Inc. | Chemical array reading |
| US20060078941A1 (en) | 2003-06-09 | 2006-04-13 | Santin Alessandro D | Gene expression profiling in primary ovarian serous papillary tumors and normal ovarian epithelium |
| US20040259118A1 (en) | 2003-06-23 | 2004-12-23 | Macevicz Stephen C. | Methods and compositions for nucleic acid sequence analysis |
| EP2918595B1 (en) | 2003-07-05 | 2019-12-11 | The Johns-Hopkins University | Method and compositions for detection and enumeration of genetic variations |
| GB0319332D0 (en) | 2003-08-16 | 2003-09-17 | Astrazeneca Ab | Amplification |
| US20050048498A1 (en) | 2003-08-29 | 2005-03-03 | Applera Corporation | Compositions, methods, and kits for assembling probes |
| US7354706B2 (en) | 2003-09-09 | 2008-04-08 | The Regents Of The University Of Colorado, A Body Corporate | Use of photopolymerization for amplification and detection of a molecular recognition event |
| EP1660674B1 (en) | 2003-09-10 | 2010-03-17 | Althea Technologies, Inc. | Expression profiling using microarrays |
| EP1694869A2 (en) | 2003-11-10 | 2006-08-30 | Investigen, Inc. | Methods of preparing nucleic acid for detection |
| EP1709203A2 (en) | 2004-01-23 | 2006-10-11 | Lingvitae AS | Improving polynucleotide ligation reactions |
| DE602005018166D1 (de) | 2004-02-12 | 2010-01-21 | Population Genetics Technologi | Genetische analyse mittels sequenzspezifischem sortieren |
| US20100216153A1 (en) | 2004-02-27 | 2010-08-26 | Helicos Biosciences Corporation | Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities |
| WO2005113816A2 (en) | 2004-05-07 | 2005-12-01 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Methods of diagnosing or treating prostate cancer using the erg gene, alone or in combination with other over or under expressed genes in prostate cancer |
| US20050250147A1 (en) | 2004-05-10 | 2005-11-10 | Macevicz Stephen C | Digital profiling of polynucleotide populations |
| EP1771249A4 (en) | 2004-06-07 | 2010-02-24 | Irm Llc | DISTRIBUTION SYSTEMS, SOFTWARE AND ASSOCIATED METHODS |
| US20060035258A1 (en) | 2004-08-06 | 2006-02-16 | Affymetrix, Inc. | Methods for identifying DNA copy number changes |
| US20060041385A1 (en) | 2004-08-18 | 2006-02-23 | Bauer Kenneth D | Method of quantitating proteins and genes in cells using a combination of immunohistochemistry and in situ hybridization |
| EP1647600A3 (en) | 2004-09-17 | 2006-06-28 | Affymetrix, Inc. (A US Entity) | Methods for identifying biological samples by addition of nucleic acid bar-code tags |
| US8883487B2 (en) | 2004-12-23 | 2014-11-11 | Abbott Point Of Care Inc. | Molecular diagnostics system and methods |
| US20080003602A1 (en) | 2004-12-23 | 2008-01-03 | Ge Healthcare Bio-Sciences Corp. | Ligation-Based Rna Amplification |
| US7393665B2 (en) | 2005-02-10 | 2008-07-01 | Population Genetics Technologies Ltd | Methods and compositions for tagging and identifying polynucleotides |
| EP1845160A4 (en) | 2005-02-10 | 2009-07-01 | Riken | NUCLEOTIDE-amplification |
| EP1856293A2 (en) | 2005-03-16 | 2007-11-21 | Compass Genetics, Llc | Methods and compositions for assay readouts on multiple analytical platforms |
| EP2371453A1 (en) | 2005-03-18 | 2011-10-05 | Fluidigm Corporation | Microfluidic device |
| US7695886B2 (en) | 2005-05-19 | 2010-04-13 | Fuji Xerox Co., Ltd. | Process for producing resin particle liquid dispersion for electrostatic image developing toner, electrostatic image developing toner and production process thereof |
| US20060263789A1 (en) | 2005-05-19 | 2006-11-23 | Robert Kincaid | Unique identifiers for indicating properties associated with entities to which they are attached, and methods for using |
| US8407013B2 (en) | 2005-06-07 | 2013-03-26 | Peter K. Rogan | AB initio generation of single copy genomic probes |
| US7796815B2 (en) | 2005-06-10 | 2010-09-14 | The Cleveland Clinic Foundation | Image analysis of biological objects |
| US20070020640A1 (en) | 2005-07-21 | 2007-01-25 | Mccloskey Megan L | Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis |
| WO2007035742A2 (en) | 2005-09-16 | 2007-03-29 | 454 Life Sciences Corporation | Cdna library preparation |
| EP1949070A4 (en) | 2005-11-01 | 2009-11-18 | Symyx Technologies Inc | LIQUID DISPENSER FOR HIGH-PERFORMANCE EXPERIMENTS |
| US7375211B2 (en) | 2005-11-18 | 2008-05-20 | Kou Zhong C | Method for detection and quantification of T-cell receptor Vβ repertoire |
| US20080070303A1 (en) | 2005-11-21 | 2008-03-20 | West Michael D | Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby |
| US7636465B2 (en) | 2005-12-09 | 2009-12-22 | Cytyc Corporation | Cross-frame object reconstruction for image-based cytology applications |
| WO2007087312A2 (en) | 2006-01-23 | 2007-08-02 | Population Genetics Technologies Ltd. | Molecular counting |
| EP1987162A4 (en) | 2006-01-23 | 2009-11-25 | Population Genetics Technologi | NUCLEIC ACID ANALYSIS ABOUT SEQUENCE TOKENS |
| JP5180845B2 (ja) * | 2006-02-24 | 2013-04-10 | カリダ・ジェノミックス・インコーポレイテッド | Dnaアレイ上でのハイスループットゲノム配列決定 |
| US20080038727A1 (en) | 2006-03-10 | 2008-02-14 | Applera Corporation | MicroRNA and Messenger RNA Detection on Arrays |
| US7752233B2 (en) | 2006-03-29 | 2010-07-06 | Massachusetts Institute Of Technology | Techniques for clustering a set of objects |
| US7880142B2 (en) | 2006-04-04 | 2011-02-01 | Sidec Technologies Ab | Extended electron tomography |
| US20080194414A1 (en) | 2006-04-24 | 2008-08-14 | Albert Thomas J | Enrichment and sequence analysis of genomic regions |
| WO2007136874A2 (en) | 2006-05-18 | 2007-11-29 | President And Fellows Of Harvard College | Genomic library construction |
| AU2007260676A1 (en) | 2006-06-14 | 2007-12-21 | Artemis Health, Inc. | Rare cell analysis using sample splitting and DNA tags |
| CA2669728C (en) | 2006-11-15 | 2017-04-11 | Biospherex Llc | Multitag sequencing and ecogenomics analysis |
| US8050476B2 (en) | 2006-11-22 | 2011-11-01 | General Electric Company | Heart rate demodulation of periodic movement in ultrasound data for object identification |
| EP2677309B9 (en) | 2006-12-14 | 2014-11-19 | Life Technologies Corporation | Methods for sequencing a nucleic acid using large scale FET arrays, configured to measure a limited pH range |
| JP5489469B2 (ja) | 2007-01-16 | 2014-05-14 | オリンパス株式会社 | 蛍光信号解析装置および蛍光信号解析方法 |
| US9063133B2 (en) | 2007-01-30 | 2015-06-23 | The Regents Of The University Of California | Methods and devices for biomolecular arrays |
| US20080269068A1 (en) | 2007-02-06 | 2008-10-30 | President And Fellows Of Harvard College | Multiplex decoding of sequence tags in barcodes |
| WO2008096318A2 (en) | 2007-02-09 | 2008-08-14 | Koninklijke Philips Electronics N.V. | Identification system |
| KR100882711B1 (ko) | 2007-03-12 | 2009-02-06 | 성균관대학교산학협력단 | 사이크로박터 스피시스 hj147 균주 유래의 우라실-dna글리코실라제 및 이의 용도 |
| US20080274458A1 (en) | 2007-05-01 | 2008-11-06 | Latham Gary J | Nucleic acid quantitation methods |
| US20090061513A1 (en) | 2007-05-15 | 2009-03-05 | Picovitro Ab | Cell sorting and cell cultivation methods |
| EP2164985A4 (en) | 2007-06-01 | 2014-05-14 | 454 Life Sciences Corp | SYSTEM AND METHOD FOR IDENTIFYING INDIVIDUAL SAMPLES FROM A MULTIPLEX MIXTURE |
| EP2395113A1 (en) | 2007-06-29 | 2011-12-14 | Population Genetics Technologies Ltd. | Methods and compositions for isolating nucleic acid sequence variants |
| CA2720747A1 (en) | 2008-02-21 | 2009-08-27 | Gentel Biosciences, Inc. | Substrates for multiplexed assays and uses thereof |
| US8687189B2 (en) | 2008-03-03 | 2014-04-01 | Ajjer, Llc | Analysis of arrays by laser induced breakdown spectroscopy |
| DE102008025656B4 (de) | 2008-05-28 | 2016-07-28 | Genxpro Gmbh | Verfahren zur quantitativen Analyse von Nukleinsäuren, Marker dafür und deren Verwendung |
| US20090298709A1 (en) | 2008-05-28 | 2009-12-03 | Affymetrix, Inc. | Assays for determining telomere length and repeated sequence copy number |
| WO2009148560A2 (en) | 2008-05-30 | 2009-12-10 | Board Of Regents, The Universtiy Of Texas System | Methods and compositions for nucleic acid sequencing |
| US9175303B2 (en) | 2008-07-17 | 2015-11-03 | Basf Plant Science Gmbh | Plants having enhanced yield-related traits and a method for making the same |
| WO2010021936A1 (en) | 2008-08-16 | 2010-02-25 | The Board Of Trustees Of The Leland Stanford Junior University | Digital pcr calibration for high throughput sequencing |
| US8476013B2 (en) | 2008-09-16 | 2013-07-02 | Sequenom, Inc. | Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
| MX2011004588A (es) | 2008-10-31 | 2011-08-03 | Abbott Lab | Clasificacion genomica de carcinoma de pulmon de celulas no pequeñas basadas en patrones de alteraciones de numero de copias de gene. |
| US20100159533A1 (en) | 2008-11-24 | 2010-06-24 | Helicos Biosciences Corporation | Simplified sample preparation for rna analysis |
| US8492096B2 (en) | 2008-12-24 | 2013-07-23 | Boris Pasche | TGFBR1 expression modifies risk for colorectal cancer |
| EP3020830A1 (en) | 2009-01-20 | 2016-05-18 | The Board Of Trustees Of The Leland Stanford Junior University | Single cell gene expression for diagnosis, prognosis and identification of drug targets |
| US20100323348A1 (en) | 2009-01-31 | 2010-12-23 | The Regents Of The University Of Colorado, A Body Corporate | Methods and Compositions for Using Error-Detecting and/or Error-Correcting Barcodes in Nucleic Acid Amplification Process |
| SG172469A1 (en) | 2009-03-05 | 2011-08-29 | Daiichi Sankyo Co Ltd | Pyridine derivative |
| EP2230312A1 (en) | 2009-03-19 | 2010-09-22 | Helmholtz-Zentrum für Infektionsforschung GmbH | Probe compound for detecting and isolating enzymes and means and methods using the same |
| US20120010091A1 (en) | 2009-03-30 | 2012-01-12 | Illumina, Inc. | Gene expression analysis in single cells |
| US8691509B2 (en) | 2009-04-02 | 2014-04-08 | Fluidigm Corporation | Multi-primer amplification method for barcoding of target nucleic acids |
| WO2010127186A1 (en) | 2009-04-30 | 2010-11-04 | Prognosys Biosciences, Inc. | Nucleic acid constructs and methods of use |
| FR2945545B1 (fr) | 2009-05-14 | 2011-08-05 | Univ Aix Marseille Ii | Methode de detection d'adn procaryote extrait d'un echantillon de selles |
| GB0909923D0 (en) | 2009-06-09 | 2009-07-22 | Oxford Gene Tech Ip Ltd | Picowell capture devices for analysing single cells or other particles |
| JP5785942B2 (ja) | 2009-06-29 | 2015-09-30 | ルミネックス コーポレーション | ヘアピンコンフォメーションを有するキメラプライマーおよびその使用法 |
| US8330957B2 (en) | 2009-06-29 | 2012-12-11 | Hager Enviromental and Atmospheric Technologies, LLC | Device and method for quantification of gases in plumes by remote sensing |
| EP3029141A1 (en) | 2009-08-20 | 2016-06-08 | Population Genetics Technologies Ltd. | Compositions and methods for intramolecular nucleic acid rearrangement |
| BR112012004382A2 (pt) | 2009-09-01 | 2016-03-22 | Koninkl Philips Electronics Nv | dispositivo para a seleção específica de moléculas-alvo, método para selecionar especificamente moléculas-alvo e uso de um dispositivo |
| US8936762B2 (en) | 2009-09-01 | 2015-01-20 | Trustees Of Boston University | High throughput multichannel reader and uses thereof |
| US9625454B2 (en) | 2009-09-04 | 2017-04-18 | The Research Foundation For The State University Of New York | Rapid and continuous analyte processing in droplet microfluidic devices |
| US20120184048A1 (en) * | 2009-09-28 | 2012-07-19 | Koninklijke Philips Electronics N.V. | Method for characterization of biological bonds |
| US9488656B2 (en) | 2009-09-30 | 2016-11-08 | Quest Diagnostics Investments Incorporated | BCR-ABL truncation mutations |
| US9315857B2 (en) * | 2009-12-15 | 2016-04-19 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse label-tags |
| US10662474B2 (en) | 2010-01-19 | 2020-05-26 | Verinata Health, Inc. | Identification of polymorphic sequences in mixtures of genomic DNA by whole genome sequencing |
| EP3006573B1 (en) | 2010-01-19 | 2018-03-07 | Verinata Health, Inc | Methods for determining fraction of fetal nucleic acids in maternal samples |
| WO2011091393A1 (en) * | 2010-01-25 | 2011-07-28 | Rd Biosciences, Inc. | Self-folding amplification of target nucleic acid |
| JP5934657B2 (ja) | 2010-02-12 | 2016-06-15 | レインダンス テクノロジーズ, インコーポレイテッド | デジタル検体分析 |
| JP5901046B2 (ja) | 2010-02-19 | 2016-04-06 | 国立大学法人 千葉大学 | OATP1B3mRNAの新規な選択的スプライシングバリアント |
| WO2011123246A2 (en) | 2010-04-01 | 2011-10-06 | Illumina, Inc. | Solid-phase clonal amplification and related methods |
| US20140227691A1 (en) | 2010-05-14 | 2014-08-14 | Fluidigm, Inc. | Nucleic acid isolation methods |
| US8828688B2 (en) | 2010-05-27 | 2014-09-09 | Affymetrix, Inc. | Multiplex amplification methods |
| EP3425062B1 (en) | 2010-06-09 | 2023-08-02 | Keygene N.V. | Combinatorial sequence barcodes for high throughput screening |
| EP2407242A1 (en) | 2010-07-13 | 2012-01-18 | Dublin City University | Direct clone analysis and selection technology |
| US20120040843A1 (en) | 2010-08-12 | 2012-02-16 | Dublin City University | Centrifugal capture system |
| ES2690753T3 (es) | 2010-09-21 | 2018-11-22 | Agilent Technologies, Inc. | Aumento de la confianza en las identificaciones de alelos con el recuento molecular |
| WO2012042374A2 (en) | 2010-10-01 | 2012-04-05 | Anssi Jussi Nikolai Taipale | Method of determining number or concentration of molecules |
| US20120088691A1 (en) | 2010-10-08 | 2012-04-12 | Gao Chen | Highly multiplexed real-time pcr using encoded microbeads |
| EP2625320B1 (en) | 2010-10-08 | 2019-03-27 | President and Fellows of Harvard College | High-throughput single cell barcoding |
| US20130225623A1 (en) | 2010-10-27 | 2013-08-29 | Mount Sinai School Of Medicine | Methods of Treating Psychiatric or Neurological Disorders with MGLUR Antagonists |
| CN103649713B (zh) | 2010-11-29 | 2017-03-01 | 丹麦达科有限公司 | 由可编程性定量检定所处理的样本的图像分析方法和体系 |
| CN103403545B (zh) | 2010-12-09 | 2018-06-22 | 阿科尼生物系统公司 | 样本分析系统 |
| DK2652155T3 (en) | 2010-12-16 | 2017-02-13 | Gigagen Inc | Methods for Massive Parallel Analysis of Nucleic Acids in Single Cells |
| US10241075B2 (en) | 2010-12-30 | 2019-03-26 | Life Technologies Corporation | Methods, systems, and computer readable media for nucleic acid sequencing |
| WO2012103031A2 (en) | 2011-01-25 | 2012-08-02 | Ariosa Diagnostics, Inc. | Detection of genetic abnormalities |
| US9365897B2 (en) | 2011-02-08 | 2016-06-14 | Illumina, Inc. | Selective enrichment of nucleic acids |
| US9150852B2 (en) | 2011-02-18 | 2015-10-06 | Raindance Technologies, Inc. | Compositions and methods for molecular labeling |
| WO2012129363A2 (en) * | 2011-03-24 | 2012-09-27 | President And Fellows Of Harvard College | Single cell nucleic acid detection and analysis |
| KR20120110431A (ko) | 2011-03-29 | 2012-10-10 | 에스케이하이닉스 주식회사 | 반도체 메모리 장치 |
| GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
| CN110016499B (zh) | 2011-04-15 | 2023-11-14 | 约翰·霍普金斯大学 | 安全测序系统 |
| EP3395957B1 (en) | 2011-04-25 | 2020-08-12 | Bio-Rad Laboratories, Inc. | Methods and compositions for nucleic acid analysis |
| SG194745A1 (en) | 2011-05-20 | 2013-12-30 | Fluidigm Corp | Nucleic acid encoding reactions |
| LT3892295T (lt) | 2011-05-24 | 2023-07-10 | BioNTech SE | Individualizuotos vakcinos nuo vėžio |
| WO2012162621A1 (en) | 2011-05-26 | 2012-11-29 | Brandeis University | Methods for suppression pcr |
| US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
| US9752176B2 (en) | 2011-06-15 | 2017-09-05 | Ginkgo Bioworks, Inc. | Methods for preparative in vitro cloning |
| EP2724160A2 (en) | 2011-06-27 | 2014-04-30 | Life Technologies Corporation | Acoustic cytometry methods and protocols |
| KR101454886B1 (ko) | 2011-08-01 | 2014-11-03 | 주식회사 셀레믹스 | 핵산분자의 제조방법 |
| KR101337094B1 (ko) | 2011-11-30 | 2013-12-05 | 삼성에스디에스 주식회사 | 염기 서열 정렬 장치 및 그 방법 |
| WO2013117595A2 (en) | 2012-02-07 | 2013-08-15 | Illumina Cambridge Limited | Targeted enrichment and amplification of nucleic acids on a support |
| EP2823303A4 (en) | 2012-02-10 | 2015-09-30 | Raindance Technologies Inc | MOLECULAR DIAGNOSTIC SCREENING TEST |
| WO2013126741A1 (en) | 2012-02-24 | 2013-08-29 | Raindance Technologies, Inc. | Labeling and sample preparation for sequencing |
| WO2013130512A2 (en) | 2012-02-27 | 2013-09-06 | The University Of North Carolina At Chapel Hill | Methods and uses for molecular tags |
| GB2513024B (en) | 2012-02-27 | 2016-08-31 | Cellular Res Inc | A clonal amplification method |
| ES2899687T3 (es) | 2012-05-14 | 2022-03-14 | Irepertoire Inc | Método para aumentar la precisión en la detección cuantitativa de polinucleótidos |
| EP2852682B1 (en) | 2012-05-21 | 2017-10-04 | Fluidigm Corporation | Single-particle analysis of particle populations |
| CN108587867B (zh) | 2012-05-25 | 2021-12-17 | 北卡罗来纳-查佩尔山大学 | 微流体装置、用于试剂的固体支持体和相关方法 |
| CA2876209A1 (en) | 2012-06-15 | 2013-12-19 | Adaptive Biotechnologies Corporation | Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set |
| DK2861760T3 (da) | 2012-06-15 | 2020-03-09 | Univ Texas | Sekventering med høj kapacitet af flere udskrifter af en enkelt celle |
| US9957549B2 (en) | 2012-06-18 | 2018-05-01 | Nugen Technologies, Inc. | Compositions and methods for negative selection of non-desired nucleic acid sequences |
| CN104812947B (zh) | 2012-07-17 | 2018-04-27 | 考希尔股份有限公司 | 检测遗传变异的系统和方法 |
| WO2014015098A1 (en) | 2012-07-18 | 2014-01-23 | Siemens Healthcare Diagnostics Inc. | A method of normalizing biological samples |
| SG11201500313YA (en) | 2012-07-24 | 2015-02-27 | Sequenta Inc | Single cell analysis using sequence tags |
| US20140378349A1 (en) | 2012-08-14 | 2014-12-25 | 10X Technologies, Inc. | Compositions and methods for sample processing |
| US20140378345A1 (en) | 2012-08-14 | 2014-12-25 | 10X Technologies, Inc. | Compositions and methods for sample processing |
| US20150005199A1 (en) | 2012-08-14 | 2015-01-01 | 10X Technologies, Inc. | Compositions and methods for sample processing |
| US9951386B2 (en) | 2014-06-26 | 2018-04-24 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| CN111748607B (zh) | 2012-08-14 | 2024-04-30 | 10X基因组学有限公司 | 微胶囊组合物及方法 |
| US20140378322A1 (en) | 2012-08-14 | 2014-12-25 | 10X Technologies, Inc. | Compositions and methods for sample processing |
| US10221442B2 (en) | 2012-08-14 | 2019-03-05 | 10X Genomics, Inc. | Compositions and methods for sample processing |
| US20150005200A1 (en) | 2012-08-14 | 2015-01-01 | 10X Technologies, Inc. | Compositions and methods for sample processing |
| EP2914745B1 (en) | 2012-11-05 | 2017-09-06 | Rubicon Genomics, Inc. | Barcoding nucleic acids |
| US9489627B2 (en) | 2012-11-19 | 2016-11-08 | Bottomline Technologies (De), Inc. | Hybrid clustering for data analytics |
| CA2894694C (en) | 2012-12-14 | 2023-04-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| WO2014108850A2 (en) | 2013-01-09 | 2014-07-17 | Yeda Research And Development Co. Ltd. | High throughput transcriptome analysis |
| WO2014116729A2 (en) | 2013-01-22 | 2014-07-31 | The Board Of Trustees Of The Leland Stanford Junior University | Haplotying of hla loci with ultra-deep shotgun sequencing |
| WO2014116979A1 (en) | 2013-01-24 | 2014-07-31 | Sabic Innovative Plastics Ip B.V. | Microwell plate made from a polyester-polycarbonate |
| CN104969056B (zh) | 2013-02-01 | 2018-05-01 | 贝克顿迪金森公司 | 评估流式细胞仪中样品行为的方法和系统 |
| WO2014124338A1 (en) | 2013-02-08 | 2014-08-14 | 10X Technologies, Inc. | Polynucleotide barcode generation |
| WO2014126937A1 (en) | 2013-02-14 | 2014-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | Suspension arrays and multiplexed assays based thereon |
| US20140274811A1 (en) | 2013-03-14 | 2014-09-18 | Lyle J. Arnold | Methods for Amplifying a Complete Genome or Transcriptome |
| GB2525568B (en) | 2013-03-15 | 2020-10-14 | Abvitro Llc | Single cell barcoding for antibody discovery |
| US9856525B2 (en) * | 2013-03-15 | 2018-01-02 | Bio-Rad Laboratories, Inc. | Digital assays with associated targets |
| US9799041B2 (en) | 2013-03-15 | 2017-10-24 | The Nielsen Company (Us), Llc | Method and apparatus for interactive evolutionary optimization of concepts |
| US20140303005A1 (en) | 2013-04-05 | 2014-10-09 | Raindance Technologies, Inc. | Rare cell analysis after negative selection |
| EP2805769A1 (en) | 2013-05-24 | 2014-11-26 | European Molecular Biology Laboratory | Methods for nano-scale single cell analysis |
| WO2014201273A1 (en) | 2013-06-12 | 2014-12-18 | The Broad Institute, Inc. | High-throughput rna-seq |
| KR102366116B1 (ko) | 2013-06-27 | 2022-02-23 | 10엑스 제노믹스, 인크. | 샘플 처리를 위한 조성물 및 방법 |
| ES2857908T3 (es) | 2013-08-28 | 2021-09-29 | Becton Dickinson Co | Análisis masivamente paralelo de células individuales |
| US10395758B2 (en) | 2013-08-30 | 2019-08-27 | 10X Genomics, Inc. | Sequencing methods |
| CN105683397A (zh) | 2013-09-04 | 2016-06-15 | 富鲁达公司 | 用于检测单细胞中的核酸和蛋白的邻近测定 |
| US10633691B2 (en) | 2013-09-30 | 2020-04-28 | Di Wu | Methods to profile molecular complexes or single cells via proximity dependant barcoding |
| GB201317301D0 (en) | 2013-09-30 | 2013-11-13 | Linnarsson Sten | Method for capturing and encoding nucleic acid from a plurality of single cells |
| WO2015054292A1 (en) | 2013-10-07 | 2015-04-16 | Cellular Research, Inc. | Methods and systems for digitally counting features on arrays |
| CN111534580B (zh) | 2013-12-28 | 2024-06-04 | 夸登特健康公司 | 用于检测遗传变异的方法和系统 |
| SG11201605344YA (en) | 2013-12-30 | 2016-07-28 | Atreca Inc | Analysis of nucleic acids associated with single cells using nucleic acid barcodes |
| AU2015227054A1 (en) | 2014-03-05 | 2016-09-22 | Adaptive Biotechnologies Corporation | Methods using randomer-containing synthetic molecules |
| US20150298091A1 (en) | 2014-04-21 | 2015-10-22 | President And Fellows Of Harvard College | Systems and methods for barcoding nucleic acids |
| GB201409282D0 (en) | 2014-05-23 | 2014-07-09 | Univ Sydney Tech | Sequencing process |
| CN106536756A (zh) | 2014-06-26 | 2017-03-22 | 10X基因组学有限公司 | 核酸序列的分析 |
| CN113249435B (zh) | 2014-06-26 | 2024-09-03 | 10X基因组学有限公司 | 分析来自单个细胞或细胞群体的核酸的方法 |
| JP6125731B2 (ja) | 2014-07-02 | 2017-05-10 | 株式会社Dnaチップ研究所 | 核酸分子数計測法 |
| WO2016040524A1 (en) * | 2014-09-09 | 2016-03-17 | Igenomx International Genomics Corporation | Methods and compositions for rapid nucleic acid library preparation |
| CN107873054B (zh) | 2014-09-09 | 2022-07-12 | 博德研究所 | 用于复合单细胞核酸分析的基于微滴的方法和设备 |
| EP3248018B1 (en) | 2015-01-22 | 2020-01-08 | Becton, Dickinson and Company | Devices and systems for molecular barcoding of nucleic acid targets in single cells |
| CN107250379B (zh) | 2015-02-19 | 2021-12-28 | 贝克顿迪金森公司 | 结合蛋白质组信息和基因组信息的高通量单细胞分析 |
| ES2836802T3 (es) | 2015-02-27 | 2021-06-28 | Becton Dickinson Co | Códigos de barras moleculares espacialmente direccionables |
| WO2016138500A1 (en) | 2015-02-27 | 2016-09-01 | Cellular Research, Inc. | Methods and compositions for barcoding nucleic acids for sequencing |
| WO2016149418A1 (en) | 2015-03-18 | 2016-09-22 | Cellular Research, Inc. | Methods and compositions for labeling targets and haplotype phasing |
| EP4180535A1 (en) | 2015-03-30 | 2023-05-17 | Becton, Dickinson and Company | Methods and compositions for combinatorial barcoding |
| HK1250245A1 (zh) | 2015-04-10 | 2018-12-07 | Spatial Transcriptomics Ab | 生物样本的空间区别、多重核酸分析 |
| EP4582556A3 (en) | 2015-04-23 | 2025-10-08 | Becton, Dickinson and Company | Methods and compositions for whole transcriptome amplification |
| US9618871B2 (en) | 2015-04-28 | 2017-04-11 | Kyocera Document Solutions Inc. | Image forming apparatus |
| ES2745694T3 (es) | 2015-09-11 | 2020-03-03 | Cellular Res Inc | Métodos y composiciones para normalización de biblioteca de ácido nucleico |
| US12060412B2 (en) | 2016-03-21 | 2024-08-13 | The Broad Institute, Inc. | Methods for determining spatial and temporal gene expression dynamics in single cells |
| AU2017261189B2 (en) | 2016-05-02 | 2023-02-09 | Becton, Dickinson And Company | Accurate molecular barcoding |
| ES2979395T3 (es) | 2016-05-26 | 2024-09-25 | Becton Dickinson Co | Métodos de ajuste del recuento de etiquetas moleculares |
| TWI600309B (zh) | 2016-05-28 | 2017-09-21 | Hon Hai Prec Ind Co Ltd | 角度調整機構 |
| US10640763B2 (en) | 2016-05-31 | 2020-05-05 | Cellular Research, Inc. | Molecular indexing of internal sequences |
| US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
| US20180037942A1 (en) | 2016-08-03 | 2018-02-08 | Cellular Research, Inc. | Enzyme-independent molecular indexing |
| WO2018089378A1 (en) | 2016-11-08 | 2018-05-17 | Cellular Research, Inc. | Methods for expression profile classification |
| US11608497B2 (en) | 2016-11-08 | 2023-03-21 | Becton, Dickinson And Company | Methods for cell label classification |
| WO2018175458A2 (en) | 2017-03-24 | 2018-09-27 | Cellular Research, Inc. | Synthetic multiplets for multiplets determination |
| JP6518720B2 (ja) | 2017-06-07 | 2019-05-22 | 日立ジョンソンコントロールズ空調株式会社 | 永久磁石式回転電機及びそれを用いた圧縮機 |
| CN120564822A (zh) | 2017-09-25 | 2025-08-29 | 贝克顿迪金森公司 | 免疫受体条形码错误校正 |
-
2017
- 2017-05-25 ES ES17728398T patent/ES2979395T3/es active Active
- 2017-05-25 WO PCT/US2017/034576 patent/WO2017205691A1/en not_active Ceased
- 2017-05-25 US US15/605,874 patent/US11397882B2/en active Active
- 2017-05-25 CN CN201780028283.2A patent/CN109074430B/zh active Active
- 2017-05-25 EP EP17728398.3A patent/EP3465502B1/en active Active
- 2017-05-25 JP JP2018561218A patent/JP7046007B2/ja active Active
- 2017-05-25 EP EP24169193.0A patent/EP4407625A3/en active Pending
-
2022
- 2022-07-21 US US17/814,042 patent/US20230065324A1/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110160078A1 (en) | 2009-12-15 | 2011-06-30 | Affymetrix, Inc. | Digital Counting of Individual Molecules by Stochastic Attachment of Diverse Labels |
| WO2015002908A1 (en) | 2013-07-01 | 2015-01-08 | Sequenta, Inc. | Large-scale biomolecular analysis with sequence tags |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3465502A1 (en) | 2019-04-10 |
| EP4407625A2 (en) | 2024-07-31 |
| EP3465502B1 (en) | 2024-04-10 |
| ES2979395T3 (es) | 2024-09-25 |
| EP4407625A3 (en) | 2024-10-23 |
| US20230065324A1 (en) | 2023-03-02 |
| JP2019522268A (ja) | 2019-08-08 |
| CN109074430B (zh) | 2022-03-29 |
| US11397882B2 (en) | 2022-07-26 |
| CN109074430A (zh) | 2018-12-21 |
| US20170344866A1 (en) | 2017-11-30 |
| WO2017205691A1 (en) | 2017-11-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7046007B2 (ja) | 分子標識カウントの調節方法 | |
| JP7615109B2 (ja) | マルチプレットを決定するための合成マルチプレット | |
| JP7706485B2 (ja) | 細胞標識分類の方法 | |
| JP7637169B2 (ja) | 発現プロファイル分類の方法 | |
| CN111247589A (zh) | 免疫受体条形码错误校正 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7423 Effective date: 20190926 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20191002 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200525 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20200525 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20210708 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20211007 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20211208 |
|
| A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20211208 |
|
| A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20211215 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20220221 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20220322 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 7046007 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |