JP7033549B2 - 細胞に基づくネオ抗原ワクチンおよびその使用 - Google Patents
細胞に基づくネオ抗原ワクチンおよびその使用 Download PDFInfo
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- JP7033549B2 JP7033549B2 JP2018557312A JP2018557312A JP7033549B2 JP 7033549 B2 JP7033549 B2 JP 7033549B2 JP 2018557312 A JP2018557312 A JP 2018557312A JP 2018557312 A JP2018557312 A JP 2018557312A JP 7033549 B2 JP7033549 B2 JP 7033549B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A—HUMAN NECESSITIES
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- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/19—Dendritic cells
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- A—HUMAN NECESSITIES
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- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/24—Antigen-presenting cells [APC]
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- A61K40/32—T-cell receptors [TCR]
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- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/255—Salmonella (G)
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- A61K2039/55527—Interleukins
- A61K2039/55538—IL-12
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2510/00—Genetically modified cells
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Public Health (AREA)
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- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Developmental Biology & Embryology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022029582A JP2022091750A (ja) | 2016-05-04 | 2022-02-28 | 細胞に基づくネオ抗原ワクチンおよびその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662331906P | 2016-05-04 | 2016-05-04 | |
| US62/331,906 | 2016-05-04 | ||
| PCT/US2017/031171 WO2017192924A1 (en) | 2016-05-04 | 2017-05-04 | Cell-based neoantigen vaccines and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022029582A Division JP2022091750A (ja) | 2016-05-04 | 2022-02-28 | 細胞に基づくネオ抗原ワクチンおよびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019514393A JP2019514393A (ja) | 2019-06-06 |
| JP2019514393A5 JP2019514393A5 (https=) | 2020-06-11 |
| JP7033549B2 true JP7033549B2 (ja) | 2022-03-10 |
Family
ID=58739362
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018557312A Active JP7033549B2 (ja) | 2016-05-04 | 2017-05-04 | 細胞に基づくネオ抗原ワクチンおよびその使用 |
| JP2022029582A Pending JP2022091750A (ja) | 2016-05-04 | 2022-02-28 | 細胞に基づくネオ抗原ワクチンおよびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022029582A Pending JP2022091750A (ja) | 2016-05-04 | 2022-02-28 | 細胞に基づくネオ抗原ワクチンおよびその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11723962B2 (https=) |
| EP (1) | EP3452082A1 (https=) |
| JP (2) | JP7033549B2 (https=) |
| CA (1) | CA3022267A1 (https=) |
| WO (1) | WO2017192924A1 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11278570B2 (en) | 2016-12-16 | 2022-03-22 | B-Mogen Biotechnologies, Inc. | Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods |
| AU2017378482B2 (en) | 2016-12-16 | 2024-06-13 | R&D Systems, Inc. | Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods |
| CA3060523A1 (en) | 2017-04-18 | 2018-10-25 | Yale University | A platform for t lymphocyte genome engineering and in vivo high-throughput screening thereof |
| MX2019013259A (es) | 2017-05-08 | 2020-01-13 | Gritstone Oncology Inc | Vectores de neoantigeno de alfavirus. |
| CN111801415A (zh) * | 2017-11-06 | 2020-10-20 | 路德维格癌症研究院 | 扩增淋巴细胞的方法 |
| EP3706770A4 (en) * | 2017-11-07 | 2021-10-27 | Nektar Therapeutics | IMMUNOTHERAPEUTIC COMBINATION FOR THE TREATMENT OF CANCER |
| WO2019147604A2 (en) * | 2018-01-23 | 2019-08-01 | Vanderbilt University | Self-antigen specific t-cells as vacines for augmenting engraftment and stability of autologous transfer |
| WO2019173441A1 (en) * | 2018-03-06 | 2019-09-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of preparing populations of cells and retroviral reagents for adoptive cell immunotherapy |
| JP2021522188A (ja) * | 2018-04-18 | 2021-08-30 | イエール ユニバーシティ | 内因性遺伝子活性化を用いる多重腫瘍ワクチン接種のための組成物および方法 |
| CN112533617A (zh) * | 2018-04-25 | 2021-03-19 | 卫理公会医院体系公司 | 癌症新抗原和其在癌症疫苗和基于tcr的癌症免疫疗法中的效用 |
| EP3796930A4 (en) * | 2018-05-23 | 2022-05-04 | Gritstone bio, Inc. | IMMUNE CHECKPOINT INHIBITOR KO-EXPRESSION VECTORS |
| US12528848B2 (en) * | 2018-05-25 | 2026-01-20 | The Wistar Institute Of Anatomy And Biology | Tumor-specific neoantigens and methods of using the same |
| AU2019288669B2 (en) | 2018-06-21 | 2025-06-26 | R&D Systems, Inc. | Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods |
| MX2021001938A (es) | 2018-08-22 | 2021-04-19 | Fred Hutchinson Cancer Center | Inmunoterapia dirigida a antigenos kras o her2. |
| KR20210102231A (ko) | 2018-11-09 | 2021-08-19 | 프레드 헛친슨 켄서 리서치 센터 | 메소텔린에 특이적인 t 세포 수용체 및 면역요법에서의 그의 용도 |
| US12227551B2 (en) | 2018-12-11 | 2025-02-18 | Obsidian Therapeutics, Inc. | Membrane bound IL12 compositions and methods for tunable regulation |
| CN113164578B (zh) * | 2019-01-03 | 2024-04-30 | 南京传奇生物科技有限公司 | 表达鞭毛蛋白多肽的经修饰的免疫细胞 |
| CN111454358A (zh) * | 2019-01-18 | 2020-07-28 | 四川科伦博泰生物医药股份有限公司 | 一种嵌合抗原受体及其应用 |
| WO2020172332A1 (en) | 2019-02-20 | 2020-08-27 | Fred Hutchinson Cancer Research Center | Binding proteins specific for ras neoantigens and uses thereof |
| MX2021014525A (es) | 2019-05-30 | 2022-03-17 | Gritstone Bio Inc | Adenovirus modificados. |
| EP3983537A1 (en) | 2019-06-12 | 2022-04-20 | Obsidian Therapeutics, Inc. | Ca2 compositions and methods for tunable regulation |
| EP4025244A1 (en) * | 2019-09-02 | 2022-07-13 | Institut Curie | Immunotherapy targeting tumor neoantigenic peptides |
| CN110804594B (zh) * | 2019-11-21 | 2020-11-20 | 启辰生生物科技(珠海)有限公司 | 工程化抗原递呈细胞及其在用于活化cd3+免疫细胞中的应用 |
| CN113318225B (zh) * | 2020-02-28 | 2024-01-19 | 无锡派列博生物医药科技有限公司 | 肿瘤免疫增强剂及其制法和应用 |
| AU2021253641A1 (en) * | 2020-04-07 | 2022-10-27 | Evaxion Biotech A/S | Neoepitope immunotherapy with APC targeting unit |
| GB202006254D0 (en) * | 2020-04-28 | 2020-06-10 | Institute Of Cancer Res | Anti-cancer vaccines and related therapy |
| CN111690609B (zh) * | 2020-06-30 | 2022-04-05 | 深圳裕泰抗原科技有限公司 | 一种新生抗原免疫原性的测试方法 |
| WO2022023521A2 (en) * | 2020-07-30 | 2022-02-03 | Evaxion Biotech A/S | Process for preparation of neopepitope-containing vaccine agents |
| KR20230046313A (ko) | 2020-08-06 | 2023-04-05 | 그릿스톤 바이오, 인코포레이티드 | 다중에피토프 백신 카세트 |
| WO2022067038A1 (en) * | 2020-09-25 | 2022-03-31 | President And Fellows Of Harvard College | Immunotherapeutic virus for the treatment of cancer |
| AR124826A1 (es) * | 2021-02-08 | 2023-05-10 | Hutchinson Fred Cancer Res | Sistema y métodos para vincular la señalización de cd40 a la unión del antígeno |
| CA3245584A1 (en) | 2022-03-10 | 2023-09-14 | City Of Hope | IL-12 Bound to the Membrane for Cellular Immunotherapy |
| WO2024118634A2 (en) * | 2022-11-28 | 2024-06-06 | The Trustees Of The University Of Pennsylvania | In vivo expansion of car t cells and delivery of car target antigen to tumors using mrna lipid nanoparticles |
| CN117338914B (zh) * | 2023-10-27 | 2024-09-06 | 中山市珈钰生物医药有限公司 | 一种同种异体树突细胞肿瘤疫苗及其制备方法和应用 |
| US20250144143A1 (en) * | 2023-11-06 | 2025-05-08 | Immunitybio, Inc. | Virally Educated T cells |
| WO2025185599A1 (zh) * | 2024-03-04 | 2025-09-12 | 清华大学 | 编码膜型IL-12细胞因子佐剂的mRNA肿瘤疫苗及其用途 |
| CN119823283B (zh) * | 2025-01-08 | 2025-08-26 | 国科明耀(山东)医学科技有限公司 | 一种il-12-cd137嵌合蛋白、一种功能增强型工程化nk细胞、其制备及应用 |
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| JP2007535924A (ja) | 2004-05-07 | 2007-12-13 | − グスタフ ユングレン、ハンス | ワクチン用アジュバントとしてのフラジェリンの使用 |
| JP2008539751A (ja) | 2005-05-10 | 2008-11-20 | アヴァリス・アーベー | 新規組成物およびその使用 |
| WO2016040900A1 (en) | 2014-09-14 | 2016-03-17 | Washington University | Personalized cancer vaccines and methods therefor |
| WO2016054555A2 (en) | 2014-10-03 | 2016-04-07 | Novartis Ag | Combination therapies |
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| CA3022267A1 (en) | 2017-11-09 |
| JP2022091750A (ja) | 2022-06-21 |
| US20190224236A1 (en) | 2019-07-25 |
| JP2019514393A (ja) | 2019-06-06 |
| EP3452082A1 (en) | 2019-03-13 |
| US11723962B2 (en) | 2023-08-15 |
| WO2017192924A1 (en) | 2017-11-09 |
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