JP2019514393A5 - - Google Patents

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JP2019514393A5
JP2019514393A5 JP2018557312A JP2018557312A JP2019514393A5 JP 2019514393 A5 JP2019514393 A5 JP 2019514393A5 JP 2018557312 A JP2018557312 A JP 2018557312A JP 2018557312 A JP2018557312 A JP 2018557312A JP 2019514393 A5 JP2019514393 A5 JP 2019514393A5
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cell
nucleic acid
acid molecule
composition
agonist
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JP2018557312A
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JP2019514393A (ja
JP7033549B2 (ja
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Priority claimed from PCT/US2017/031171 external-priority patent/WO2017192924A1/en
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JP2018557312A 2016-05-04 2017-05-04 細胞に基づくネオ抗原ワクチンおよびその使用 Active JP7033549B2 (ja)

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JP2022029582A JP2022091750A (ja) 2016-05-04 2022-02-28 細胞に基づくネオ抗原ワクチンおよびその使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662331906P 2016-05-04 2016-05-04
US62/331,906 2016-05-04
PCT/US2017/031171 WO2017192924A1 (en) 2016-05-04 2017-05-04 Cell-based neoantigen vaccines and uses thereof

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JP2022029582A Division JP2022091750A (ja) 2016-05-04 2022-02-28 細胞に基づくネオ抗原ワクチンおよびその使用

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JP2019514393A JP2019514393A (ja) 2019-06-06
JP2019514393A5 true JP2019514393A5 (https=) 2020-06-11
JP7033549B2 JP7033549B2 (ja) 2022-03-10

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JP2018557312A Active JP7033549B2 (ja) 2016-05-04 2017-05-04 細胞に基づくネオ抗原ワクチンおよびその使用
JP2022029582A Pending JP2022091750A (ja) 2016-05-04 2022-02-28 細胞に基づくネオ抗原ワクチンおよびその使用

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US (1) US11723962B2 (https=)
EP (1) EP3452082A1 (https=)
JP (2) JP7033549B2 (https=)
CA (1) CA3022267A1 (https=)
WO (1) WO2017192924A1 (https=)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11278570B2 (en) 2016-12-16 2022-03-22 B-Mogen Biotechnologies, Inc. Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods
AU2017378482B2 (en) 2016-12-16 2024-06-13 R&D Systems, Inc. Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods
CA3060523A1 (en) 2017-04-18 2018-10-25 Yale University A platform for t lymphocyte genome engineering and in vivo high-throughput screening thereof
MX2019013259A (es) 2017-05-08 2020-01-13 Gritstone Oncology Inc Vectores de neoantigeno de alfavirus.
CN111801415A (zh) * 2017-11-06 2020-10-20 路德维格癌症研究院 扩增淋巴细胞的方法
EP3706770A4 (en) * 2017-11-07 2021-10-27 Nektar Therapeutics IMMUNOTHERAPEUTIC COMBINATION FOR THE TREATMENT OF CANCER
WO2019147604A2 (en) * 2018-01-23 2019-08-01 Vanderbilt University Self-antigen specific t-cells as vacines for augmenting engraftment and stability of autologous transfer
WO2019173441A1 (en) * 2018-03-06 2019-09-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of preparing populations of cells and retroviral reagents for adoptive cell immunotherapy
JP2021522188A (ja) * 2018-04-18 2021-08-30 イエール ユニバーシティ 内因性遺伝子活性化を用いる多重腫瘍ワクチン接種のための組成物および方法
CN112533617A (zh) * 2018-04-25 2021-03-19 卫理公会医院体系公司 癌症新抗原和其在癌症疫苗和基于tcr的癌症免疫疗法中的效用
EP3796930A4 (en) * 2018-05-23 2022-05-04 Gritstone bio, Inc. IMMUNE CHECKPOINT INHIBITOR KO-EXPRESSION VECTORS
US12528848B2 (en) * 2018-05-25 2026-01-20 The Wistar Institute Of Anatomy And Biology Tumor-specific neoantigens and methods of using the same
AU2019288669B2 (en) 2018-06-21 2025-06-26 R&D Systems, Inc. Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods
MX2021001938A (es) 2018-08-22 2021-04-19 Fred Hutchinson Cancer Center Inmunoterapia dirigida a antigenos kras o her2.
KR20210102231A (ko) 2018-11-09 2021-08-19 프레드 헛친슨 켄서 리서치 센터 메소텔린에 특이적인 t 세포 수용체 및 면역요법에서의 그의 용도
US12227551B2 (en) 2018-12-11 2025-02-18 Obsidian Therapeutics, Inc. Membrane bound IL12 compositions and methods for tunable regulation
CN113164578B (zh) * 2019-01-03 2024-04-30 南京传奇生物科技有限公司 表达鞭毛蛋白多肽的经修饰的免疫细胞
CN111454358A (zh) * 2019-01-18 2020-07-28 四川科伦博泰生物医药股份有限公司 一种嵌合抗原受体及其应用
WO2020172332A1 (en) 2019-02-20 2020-08-27 Fred Hutchinson Cancer Research Center Binding proteins specific for ras neoantigens and uses thereof
MX2021014525A (es) 2019-05-30 2022-03-17 Gritstone Bio Inc Adenovirus modificados.
EP3983537A1 (en) 2019-06-12 2022-04-20 Obsidian Therapeutics, Inc. Ca2 compositions and methods for tunable regulation
EP4025244A1 (en) * 2019-09-02 2022-07-13 Institut Curie Immunotherapy targeting tumor neoantigenic peptides
CN110804594B (zh) * 2019-11-21 2020-11-20 启辰生生物科技(珠海)有限公司 工程化抗原递呈细胞及其在用于活化cd3+免疫细胞中的应用
CN113318225B (zh) * 2020-02-28 2024-01-19 无锡派列博生物医药科技有限公司 肿瘤免疫增强剂及其制法和应用
AU2021253641A1 (en) * 2020-04-07 2022-10-27 Evaxion Biotech A/S Neoepitope immunotherapy with APC targeting unit
GB202006254D0 (en) * 2020-04-28 2020-06-10 Institute Of Cancer Res Anti-cancer vaccines and related therapy
CN111690609B (zh) * 2020-06-30 2022-04-05 深圳裕泰抗原科技有限公司 一种新生抗原免疫原性的测试方法
WO2022023521A2 (en) * 2020-07-30 2022-02-03 Evaxion Biotech A/S Process for preparation of neopepitope-containing vaccine agents
KR20230046313A (ko) 2020-08-06 2023-04-05 그릿스톤 바이오, 인코포레이티드 다중에피토프 백신 카세트
WO2022067038A1 (en) * 2020-09-25 2022-03-31 President And Fellows Of Harvard College Immunotherapeutic virus for the treatment of cancer
AR124826A1 (es) * 2021-02-08 2023-05-10 Hutchinson Fred Cancer Res Sistema y métodos para vincular la señalización de cd40 a la unión del antígeno
CA3245584A1 (en) 2022-03-10 2023-09-14 City Of Hope IL-12 Bound to the Membrane for Cellular Immunotherapy
WO2024118634A2 (en) * 2022-11-28 2024-06-06 The Trustees Of The University Of Pennsylvania In vivo expansion of car t cells and delivery of car target antigen to tumors using mrna lipid nanoparticles
CN117338914B (zh) * 2023-10-27 2024-09-06 中山市珈钰生物医药有限公司 一种同种异体树突细胞肿瘤疫苗及其制备方法和应用
US20250144143A1 (en) * 2023-11-06 2025-05-08 Immunitybio, Inc. Virally Educated T cells
WO2025185599A1 (zh) * 2024-03-04 2025-09-12 清华大学 编码膜型IL-12细胞因子佐剂的mRNA肿瘤疫苗及其用途
CN119823283B (zh) * 2025-01-08 2025-08-26 国科明耀(山东)医学科技有限公司 一种il-12-cd137嵌合蛋白、一种功能增强型工程化nk细胞、其制备及应用

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5283173A (en) 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
US7067318B2 (en) 1995-06-07 2006-06-27 The Regents Of The University Of Michigan Methods for transfecting T cells
GB9518220D0 (en) 1995-09-06 1995-11-08 Medical Res Council Checkpoint gene
US5853719A (en) 1996-04-30 1998-12-29 Duke University Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA
US20020155093A1 (en) 1997-02-18 2002-10-24 Houghton Alan N. Method for stimulation of an immune response to a differentiation antigen stimulated by an altered antigen
GB0224442D0 (en) 2002-10-21 2002-11-27 Molmed Spa A delivery system
JP2006506072A (ja) * 2002-11-12 2006-02-23 デイッセロース,アルバート,ビー アデノウイルスベクターワクチン
US20050129671A1 (en) 2003-03-11 2005-06-16 City Of Hope Mammalian antigen-presenting T cells and bi-specific T cells
EP1755668A2 (en) 2004-05-07 2007-02-28 Hans-Gustaf Ljunggren Adjuvants
JP2008527001A (ja) 2005-01-13 2008-07-24 ザ ジョンズ ホプキンス ユニバーシティー 前立腺幹細胞抗原ワクチンおよびその使用
US20090263421A1 (en) 2005-05-10 2009-10-22 Anna-Lena Spetz-Holmgren Cellular vaccine
US20090324630A1 (en) 2008-04-21 2009-12-31 Jensen Michael C Fusion multiviral chimeric antigen
EP2258719A1 (en) 2009-05-19 2010-12-08 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Multiple target T cell receptor
CN110200997A (zh) 2011-03-23 2019-09-06 弗雷德哈钦森癌症研究中心 用于细胞免疫治疗的方法和组合物
EP2697367B1 (en) 2011-04-13 2018-12-19 Immunicum AB Method for proliferation of antigen-specific t cells
JP6117515B2 (ja) 2011-11-01 2017-04-19 国立大学法人名古屋大学 髄膜腫治療用医薬組成物
PT2961831T (pt) 2013-02-26 2020-10-12 Memorial Sloan Kettering Cancer Center Composições e métodos para imunoterapêutica
UY35468A (es) 2013-03-16 2014-10-31 Novartis Ag Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19
AU2014248119B2 (en) 2013-04-03 2019-06-20 Memorial Sloan-Kettering Cancer Center Effective generation of tumor-targeted T-cells derived from pluripotent stem cells
CN118750591A (zh) 2013-04-07 2024-10-11 博德研究所 用于个性化瘤形成疫苗的组合物和方法
BR112016021345A8 (pt) 2014-03-17 2022-07-05 Tapimmune Inc Composições de vacina de molécula de ácido nucleico e usos das mesmas
EP3193892A4 (en) 2014-09-14 2018-09-12 Washington University Personalized cancer vaccines and methods therefor
AU2015327868A1 (en) 2014-10-03 2017-04-20 Novartis Ag Combination therapies
JP2017531427A (ja) 2014-10-03 2017-10-26 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド グルココルチコイド誘導腫瘍壊死因子受容体(gitr)抗体およびその使用法
MX389823B (es) 2014-10-27 2025-03-20 Fred Hutchinson Cancer Center Composiciones y metodos para reforzar la eficacia de inmunoterapia celular adoptiva.
WO2016069641A1 (en) 2014-10-28 2016-05-06 Thomas Jefferson University COMPOSITIONS AND METHODS OF USING TRANSFER RNAS (tRNAs)
AU2016261358B2 (en) 2015-05-11 2021-09-16 Editas Medicine, Inc. Optimized CRISPR/Cas9 systems and methods for gene editing in stem cells
WO2017059186A1 (en) 2015-10-01 2017-04-06 QXMedical, LLC. Catheter structure with improved support and related systems, methods and devices
US20180311257A1 (en) 2015-11-03 2018-11-01 Hochschule Darmstadt Selective hdac8 inhibitors and their uses

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