JP7026787B2 - ヒストン脱アセチル化酵素１および／または２（ｈｄａｃ１－２）の選択的阻害剤としての新規なヘテロアリールアミド誘導体 - Google Patents

ヒストン脱アセチル化酵素１および／または２（ｈｄａｃ１－２）の選択的阻害剤としての新規なヘテロアリールアミド誘導体 Download PDF

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JP7026787B2
JP7026787B2 JP2020523052A JP2020523052A JP7026787B2 JP 7026787 B2 JP7026787 B2 JP 7026787B2 JP 2020523052 A JP2020523052 A JP 2020523052A JP 2020523052 A JP2020523052 A JP 2020523052A JP 7026787 B2 JP7026787 B2 JP 7026787B2
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amino
group
fluorophenyl
disease
nicotinamide
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JP2020527173A (ja
JP2020527173A5 (pt-PT
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フリオ、カストロ、パロミノ、ラリア
フアン、カマチョ、ゴメス
ロドルフォ、ロドリゲス、イグレシアス
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Medibiofarma SL
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Medibiofarma SL
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2020523052A 2017-07-10 2018-07-09 ヒストン脱アセチル化酵素１および／または２（ｈｄａｃ１－２）の選択的阻害剤としての新規なヘテロアリールアミド誘導体 Active JP7026787B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17382447 2017-07-10
EP17382447.5 2017-07-10
PCT/ES2018/070491 WO2019012172A1 (es) 2017-07-10 2018-07-09 Nuevos derivados heteroaryl amida como inhibidores selectivos de histona deacetilasa 1 y 2 (hdac1/2)

Publications (3)

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JP2020527173A JP2020527173A (ja) 2020-09-03
JP2020527173A5 JP2020527173A5 (pt-PT) 2021-04-15
JP7026787B2 true JP7026787B2 (ja) 2022-02-28

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Country Link
US (1) US11241428B2 (pt-PT)
EP (1) EP3653620B9 (pt-PT)
JP (1) JP7026787B2 (pt-PT)
KR (1) KR102574135B1 (pt-PT)
CN (1) CN111051300B (pt-PT)
AU (1) AU2018300123B2 (pt-PT)
BR (1) BR112020000564A2 (pt-PT)
CA (1) CA3069273A1 (pt-PT)
DK (1) DK3653620T3 (pt-PT)
EA (1) EA039144B1 (pt-PT)
ES (1) ES2911040T3 (pt-PT)
HR (1) HRP20220472T1 (pt-PT)
HU (1) HUE058353T2 (pt-PT)
LT (1) LT3653620T (pt-PT)
MX (1) MX2020000349A (pt-PT)
PL (1) PL3653620T3 (pt-PT)
PT (1) PT3653620T (pt-PT)
RS (1) RS63156B1 (pt-PT)
SI (1) SI3653620T1 (pt-PT)
WO (1) WO2019012172A1 (pt-PT)
ZA (1) ZA202000727B (pt-PT)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114380751A (zh) * 2020-03-30 2022-04-22 上海辉启生物医药科技有限公司 二氢化茚胺类衍生物、其制备方法和用途
CA3240229A1 (en) 2021-12-03 2023-06-08 Tango Therapeutics, Inc. Novel hdac inhibitors and therapeutic use thereof
CN114524799B (zh) * 2022-03-11 2023-05-26 沈阳药科大学 一种hdac抑制剂及其制备方法和用途
EP4306106A1 (en) * 2022-07-14 2024-01-17 Universidade de Aveiro Nitro-containing compounds, compositions and uses thereof
CN115463215A (zh) * 2022-07-26 2022-12-13 苏州大学 Hdac9及其抑制剂的新用途
WO2024030659A1 (en) 2022-08-05 2024-02-08 Tango Therapeutics, Inc. An hdac inhibitor for treating cancer with a modified stk11 activity or expression
CN115304513A (zh) * 2022-08-25 2022-11-08 湖北科技学院 具有抗炎活性的查尔酮类衍生物及其合成方法和应用
CN115368277B (zh) * 2022-09-15 2024-03-29 华侨大学 一种含异羟肟酸结构的联苯类化合物及其应用
CN116199636A (zh) * 2023-02-21 2023-06-02 杭州医学院 靶向肿瘤免疫激酶的2,4-二取代嘧啶衍生物、制备方法及其应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009514859A (ja) 2005-11-03 2009-04-09 メルク エンド カムパニー インコーポレーテッド 置換ニコチンアミド化合物
JP2009535333A (ja) 2006-04-26 2009-10-01 メルク エンド カムパニー インコーポレーテッド 二置換アニリン化合物
JP2010531358A (ja) 2007-06-27 2010-09-24 メルク・シャープ・エンド・ドーム・コーポレイション ヒストン脱アセチル化酵素阻害剤としてのピリジル及びピリミジニル誘導体
JP2012529435A (ja) 2009-06-08 2012-11-22 ギリアード サイエンシーズ， インコーポレイテッド アルカノイルアミノベンズアミドアニリンｈｄａｃインヒビター化合物
WO2016057779A2 (en) 2014-10-08 2016-04-14 Acetylon Pharmaceuticals, Inc. Induction of gata2 by hdac1 and hdac2 inhibitors
WO2017004522A1 (en) 2015-07-02 2017-01-05 Biomarin Pharmaceutical Inc. Histone deacetylase inhibtors

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US9603950B1 (en) * 2015-10-25 2017-03-28 Institute Of Nuclear Energy Research Compounds of imaging agent with HDAC inhibitor for treatment of Alzheimer syndrome and method of synthesis thereof

Patent Citations (6)

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Publication number Priority date Publication date Assignee Title
JP2009514859A (ja) 2005-11-03 2009-04-09 メルク エンド カムパニー インコーポレーテッド 置換ニコチンアミド化合物
JP2009535333A (ja) 2006-04-26 2009-10-01 メルク エンド カムパニー インコーポレーテッド 二置換アニリン化合物
JP2010531358A (ja) 2007-06-27 2010-09-24 メルク・シャープ・エンド・ドーム・コーポレイション ヒストン脱アセチル化酵素阻害剤としてのピリジル及びピリミジニル誘導体
JP2012529435A (ja) 2009-06-08 2012-11-22 ギリアード サイエンシーズ， インコーポレイテッド アルカノイルアミノベンズアミドアニリンｈｄａｃインヒビター化合物
WO2016057779A2 (en) 2014-10-08 2016-04-14 Acetylon Pharmaceuticals, Inc. Induction of gata2 by hdac1 and hdac2 inhibitors
WO2017004522A1 (en) 2015-07-02 2017-01-05 Biomarin Pharmaceutical Inc. Histone deacetylase inhibtors

Non-Patent Citations (2)

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Title
BRESSI,J.C. et al.，Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides，Bioorganic & Medicinal Chemistry Letters，2010年，Vol.20, No.10，p.3142-3145
METHOT,J.L. et al.，Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2)，Bioorganic & Medicinal Chemistry Letters，2008年，Vol.18, No.3，p.973-978

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Publication number Publication date
CN111051300A (zh) 2020-04-21
ES2911040T3 (es) 2022-05-17
PL3653620T3 (pl) 2022-06-20
CA3069273A1 (en) 2019-01-17
HRP20220472T1 (hr) 2022-05-27
LT3653620T (lt) 2022-05-10
CN111051300B (zh) 2022-12-23
BR112020000564A2 (pt) 2020-07-21
EP3653620B1 (en) 2022-02-02
EA202090259A1 (ru) 2020-05-25
AU2018300123B2 (en) 2022-03-17
JP2020527173A (ja) 2020-09-03
AU2018300123A1 (en) 2020-02-13
KR102574135B1 (ko) 2023-09-01
US20200138808A1 (en) 2020-05-07
RS63156B1 (sr) 2022-05-31
DK3653620T3 (da) 2022-03-28
EA039144B1 (ru) 2021-12-09
HUE058353T2 (hu) 2022-07-28
US11241428B2 (en) 2022-02-08
ZA202000727B (en) 2022-07-27
EP3653620A1 (en) 2020-05-20
PT3653620T (pt) 2022-04-22
MX2020000349A (es) 2020-08-17
WO2019012172A1 (es) 2019-01-17
KR20200038473A (ko) 2020-04-13
EP3653620B9 (en) 2022-03-23
SI3653620T1 (sl) 2022-05-31

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