CN109890826A - 一种含有氮杂环螺旋结构的高效ido/tdo双抑制剂 - Google Patents

一种含有氮杂环螺旋结构的高效ido/tdo双抑制剂 Download PDF

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Publication number
CN109890826A
CN109890826A CN201780064706.6A CN201780064706A CN109890826A CN 109890826 A CN109890826 A CN 109890826A CN 201780064706 A CN201780064706 A CN 201780064706A CN 109890826 A CN109890826 A CN 109890826A
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indoles
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base
spiral shell
cyclobutane
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CN201780064706.6A
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English (en)
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王召印
郭巍
朱继东
胡新波
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Shanghai Institute of Organic Chemistry of CAS
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Shanghai Institute of Organic Chemistry of CAS
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Publication of CN109890826A publication Critical patent/CN109890826A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明公开了一种含有氮杂环螺旋结构的高效IDO/TDO双抑制剂，具体地，涉及一种式(I)化合物或其药学上可接受的盐、其立体异构体、或其互变异构体、或其前药。本发明的式(I)化合物，可以作为吲哚胺‑2,3‑双加氧酶抑制剂和色氨酸‑2,3‑双加氧酶，用于制备预防和/或治疗吲哚胺‑2,3‑双加氧酶和色氨酸‑2,3‑双加氧酶介导的疾病的药物，

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN201780064706.6A 2016-11-01 2017-11-01 一种含有氮杂环螺旋结构的高效ido/tdo双抑制剂 Pending CN109890826A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610937361.8A CN108017643A (zh) 2016-11-01 2016-11-01 一种含有氮杂环螺旋结构的高效ido/tdo双抑制剂
CN2016109373618 2016-11-01
PCT/CN2017/108941 WO2018082567A1 (zh) 2016-11-01 2017-11-01 一种含有氮杂环螺旋结构的高效ido/tdo双抑制剂

Publications (1)

Publication Number Publication Date
CN109890826A true CN109890826A (zh) 2019-06-14

Family

ID=62070572

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201610937361.8A Pending CN108017643A (zh) 2016-11-01 2016-11-01 一种含有氮杂环螺旋结构的高效ido/tdo双抑制剂
CN201780064706.6A Pending CN109890826A (zh) 2016-11-01 2017-11-01 一种含有氮杂环螺旋结构的高效ido/tdo双抑制剂

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201610937361.8A Pending CN108017643A (zh) 2016-11-01 2016-11-01 一种含有氮杂环螺旋结构的高效ido/tdo双抑制剂

Country Status (2)

Country Link
CN (2) CN108017643A (zh)
WO (1) WO2018082567A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12091405B2 (en) 2018-11-01 2024-09-17 Merck Sharp & Dohme Llc Substituted pyrazole compounds as indoleamine 2,3-dioxygenase inhibitors
CN110628736B (zh) * 2019-10-09 2021-05-11 扬州大学 色氨酸2,3双加氧酶突变体及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3835138A (en) * 1972-10-13 1974-09-10 Dow Chemical Co Bronchodilator 5,6-dihydro-tetrazolo(1,5-c) quinazolines
WO2008046084A2 (en) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Spiroheterocyclic compounds and their uses as therapeutic agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3835138A (en) * 1972-10-13 1974-09-10 Dow Chemical Co Bronchodilator 5,6-dihydro-tetrazolo(1,5-c) quinazolines
WO2008046084A2 (en) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Spiroheterocyclic compounds and their uses as therapeutic agents

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Publication number Publication date
WO2018082567A1 (zh) 2018-05-11
CN108017643A (zh) 2018-05-11

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Application publication date: 20190614

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