JP7023108B2 - 組み換えａａｖバリアントおよびその使用 - Google Patents

組み換えａａｖバリアントおよびその使用 Download PDF

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JP7023108B2
JP7023108B2 JP2017521515A JP2017521515A JP7023108B2 JP 7023108 B2 JP7023108 B2 JP 7023108B2 JP 2017521515 A JP2017521515 A JP 2017521515A JP 2017521515 A JP2017521515 A JP 2017521515A JP 7023108 B2 JP7023108 B2 JP 7023108B2
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hsa
mir
aav
raav
disease
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JP2017532966A5 (enExample
JP2017532966A (ja
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ガオ，グアンピン
シエ，ジュン
フロット，テレンス
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ユニバーシティ オブ マサチューセッツ
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A01K2217/00—Genetically modified animals
    • A01K2217/20—Animal model comprising regulated expression system
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
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    • C12N2750/14011—Parvoviridae
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    • C12N2750/14011—Parvoviridae
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    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
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JP2017521515A 2014-10-21 2015-10-21 組み換えａａｖバリアントおよびその使用 Active JP7023108B2 (ja)

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US201462066856P 2014-10-21 2014-10-21
US62/066,856 2014-10-21
PCT/US2015/056659 WO2016065001A1 (en) 2014-10-21 2015-10-21 Recombinant aav variants and uses thereof

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JP2017532966A5 JP2017532966A5 (enExample) 2018-11-29
JP7023108B2 true JP7023108B2 (ja) 2022-02-21

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EP (1) EP3209311B1 (enExample)
JP (2) JP7023108B2 (enExample)
CN (1) CN107073051B (enExample)
AU (2) AU2015335923B2 (enExample)
BR (1) BR112017007737A2 (enExample)
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Cited By (2)

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JP2021010372A (ja) * 2014-10-21 2021-02-04 ユニバーシティ オブ マサチューセッツ 組み換えａａｖバリアントおよびその使用
US11834474B2 (en) 2009-05-28 2023-12-05 University Of Massachusetts AAV's and uses thereof

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US10072251B2 (en) 2014-02-19 2018-09-11 University Of Massachusetts Recombinant AAVS having useful transcytosis properties
AU2015231294B2 (en) 2014-03-18 2020-10-29 University Of Massachusetts rAAV-based compositions and methods for treating amyotrophic lateral sclerosis
WO2015164786A1 (en) 2014-04-25 2015-10-29 University Of Massachusetts Recombinant aav vectors useful for reducing immunity against transgene products
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CN112553229A (zh) 2014-11-05 2021-03-26 沃雅戈治疗公司 用于治疗帕金森病的aadc多核苷酸
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JP7064214B2 (ja) 2015-09-28 2022-05-10 ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル 抗体回避性ウイルスベクターのための方法および組成物
WO2017070525A1 (en) 2015-10-22 2017-04-27 University Of Massachusetts Methods and compositions for treating metabolic imbalance in neurodegenerative disease
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