JP7000431B2 - 樹脂ビーズおよび水溶液の処理における使用 - Google Patents
樹脂ビーズおよび水溶液の処理における使用 Download PDFInfo
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- JP7000431B2 JP7000431B2 JP2019532139A JP2019532139A JP7000431B2 JP 7000431 B2 JP7000431 B2 JP 7000431B2 JP 2019532139 A JP2019532139 A JP 2019532139A JP 2019532139 A JP2019532139 A JP 2019532139A JP 7000431 B2 JP7000431 B2 JP 7000431B2
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- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
- C08F8/42—Introducing metal atoms or metal-containing groups
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1814—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns recycling of the fraction to be distributed
- B01D15/1821—Simulated moving beds
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
- B01J20/26—Synthetic macromolecular compounds
- B01J20/265—Synthetic macromolecular compounds modified or post-treated polymers
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- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
- B01J20/28004—Sorbent size or size distribution, e.g. particle size
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
- B01J20/28016—Particle form
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
- B01J20/289—Phases chemically bonded to a substrate, e.g. to silica or to polymers bonded via a spacer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/3085—Chemical treatments not covered by groups B01J20/3007 - B01J20/3078
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J45/00—Ion-exchange in which a complex or a chelate is formed; Use of material as complex or chelate forming ion-exchangers; Treatment of material for improving the complex or chelate forming ion-exchange properties
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/02—Monosaccharides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/04—Disaccharides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/12—Powdering or granulating
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L25/00—Compositions of, homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring; Compositions of derivatives of such polymers
- C08L25/02—Homopolymers or copolymers of hydrocarbons
- C08L25/04—Homopolymers or copolymers of styrene
- C08L25/08—Copolymers of styrene
-
- C—CHEMISTRY; METALLURGY
- C13—SUGAR INDUSTRY
- C13B—PRODUCTION OF SUCROSE; APPARATUS SPECIALLY ADAPTED THEREFOR
- C13B20/00—Purification of sugar juices
- C13B20/12—Purification of sugar juices using adsorption agents, e.g. active carbon
-
- C—CHEMISTRY; METALLURGY
- C13—SUGAR INDUSTRY
- C13B—PRODUCTION OF SUCROSE; APPARATUS SPECIALLY ADAPTED THEREFOR
- C13B20/00—Purification of sugar juices
- C13B20/12—Purification of sugar juices using adsorption agents, e.g. active carbon
- C13B20/126—Organic agents, e.g. polyelectrolytes
-
- C—CHEMISTRY; METALLURGY
- C13—SUGAR INDUSTRY
- C13K—SACCHARIDES OBTAINED FROM NATURAL SOURCES OR BY HYDROLYSIS OF NATURALLY OCCURRING DISACCHARIDES, OLIGOSACCHARIDES OR POLYSACCHARIDES
- C13K13/00—Sugars not otherwise provided for in this class
-
- C—CHEMISTRY; METALLURGY
- C13—SUGAR INDUSTRY
- C13K—SACCHARIDES OBTAINED FROM NATURAL SOURCES OR BY HYDROLYSIS OF NATURALLY OCCURRING DISACCHARIDES, OLIGOSACCHARIDES OR POLYSACCHARIDES
- C13K3/00—Invert sugar; Separation of glucose or fructose from invert sugar
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2220/00—Aspects relating to sorbent materials
- B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
- B01J2220/52—Sorbents specially adapted for preparative chromatography
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2205/00—Foams characterised by their properties
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- C08L2201/00—Properties
- C08L2201/54—Aqueous solutions or dispersions
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- Chemical & Material Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Polymers & Plastics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Electrochemistry (AREA)
- Sustainable Development (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
- Treatments Of Macromolecular Shaped Articles (AREA)
Description
を有する一価の基である)
の官能基を含む樹脂ビーズであり、ここで、多価原子カチオンの-X-基に対するモル比は、0:1または0.01:1以下のいずれかである。
を有する一価の基である)
の官能基を含む、方法である。
を有する。ビニルモノマーは、フリーラジカル重合してポリマーを形成することが可能である。ビニルポリマーは、ビニルモノマーの集合体の二重結合を重合させた反応生成物である。
を有する、ビニルモノマーである。
の1つを有する、ビニルモノマーである。
を有する一価の基である)
を有する樹脂ビーズである。
を有する。nは、好ましくは、2以上;より好ましくは4以上;より好ましくは6以上である。nは、好ましくは、14以下;より好ましくは12以下;より好ましくは10以下;より好ましくは8以下である。構造(S10)は、1つまたは複数の-G-基が直線状に結合されていることを示す。nが1より大きい場合、すべての-G-基が相互に同じものであり得、または-G-基のいくつかが相互に異なり、かつ-G-基のいくつかが相互に同じであり得、またはn個の異なる-G-基が存在し得る。好ましい-G-基は、(S11)、(S12)、(S13)および(S14):
を有することが好ましい。それぞれの-Z-基およびそれぞれの-J-基は、相互に独立して選択される二価の化学基である。好ましくは、それぞれの-Z-基およびそれぞれの-J-基は、先に定義されたような(S11)、(S12)および(S13)から選択されることが好ましく、ここで、それぞれの-Z-基およびそれぞれの-J-基中において、-R4、-R5および-R6のそれぞれは、相互に独立して、水素、ヒドロキシル、アミノ、N置換されたアミノ、非置換のアルキルまたは置換されたアルキルである。
から選択される)
から選択されることが好ましい。-R1および-R2の1つまたは複数は、水素であることが好ましく、-R1および-R2の両方は、水素であることがより好ましい。
を含有する。-X-と-YRとの間の結合は、共有結合、イオン結合または配位結合であり得る。いくつかのY置換不純物としては、以下のものが挙げられる:塩化鉄分子;遷移金属の原子カチオン;亜鉛、カドミウムおよび水銀の原子カチオン;ならびにすべてのタイプの多価原子カチオン。好ましくは、それぞれのタイプのY置換不純物は、存在しないか、または存在する場合には比較的少ない量で存在するかのいずれかであることが好ましい。
RAB=2(tB-tA)/(WA+WB)
である。
樹脂ビーズDOWEX(商標)BSR-1を使用した。これらのビーズは、マクロポーラスであり、スチレン/ジビニルベンゼンコポリマーを含有し、構造(S18):
下記の溶質についてパルス試験を実施した。
以下の比較例樹脂を試験した。
Claims (7)
- 水溶液を処理する方法であって、
前記水溶液は、1つもしくは複数の溶解された糖、1つもしくは複数の溶解された糖アルコールまたはそれらの混合物を含み、
前記方法は、前記水溶液を樹脂ビーズの集合体と接触させることを含み、前記樹脂ビーズは、構造(S1)
を有する一価の基である)
の官能基を含み、
-X-は、1つの構造(S14)と2~10の構造(S13):
を含む、方法。 - 前記水溶液は、6未満のpHを有する、請求項1に記載の方法。
- 前記溶解された糖は、前記水溶液の重量を基準にして重量で5%~60%の量において存在する、請求項1に記載の方法。
- 前記樹脂ビーズの集合体は、200μm以上の調和平均直径を有する、請求項1に記載の方法。
- 前記樹脂ビーズの集合体は、1.02以上の均等係数を有する、請求項1に記載の方法。
- 構造(S14)中の-R7、-R8、-R9、-R10および-R11の1以上は、水素、ヒドロキシルまたは非置換のアルキルであるが、ただし、その1つは、構造(S13)または樹脂の主鎖との間の接続結合である、請求項1に記載の方法。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/KR2016/015589 WO2018124349A1 (en) | 2016-12-30 | 2016-12-30 | Resin beads and use in processing of aqueous solutions |
Publications (2)
Publication Number | Publication Date |
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JP2020504668A JP2020504668A (ja) | 2020-02-13 |
JP7000431B2 true JP7000431B2 (ja) | 2022-01-19 |
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ID=62709943
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Application Number | Title | Priority Date | Filing Date |
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JP2019532139A Active JP7000431B2 (ja) | 2016-12-30 | 2016-12-30 | 樹脂ビーズおよび水溶液の処理における使用 |
Country Status (11)
Country | Link |
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US (1) | US11370853B2 (ja) |
EP (1) | EP3562867B1 (ja) |
JP (1) | JP7000431B2 (ja) |
KR (1) | KR102589387B1 (ja) |
CN (1) | CN110088172B (ja) |
AU (1) | AU2016433970B2 (ja) |
BR (1) | BR112019012117B1 (ja) |
CA (1) | CA3048607C (ja) |
IL (1) | IL267489B (ja) |
WO (1) | WO2018124349A1 (ja) |
ZA (1) | ZA201903462B (ja) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103864858A (zh) | 2014-03-11 | 2014-06-18 | 江南大学 | 一种乳果糖的制备方法 |
CN104098734A (zh) | 2013-04-09 | 2014-10-15 | 江南大学 | 苯硼酸基团修饰大孔树脂的制备方法及其在莱鲍迪苷a和甜菊苷分离中的应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS59219357A (ja) * | 1983-05-28 | 1984-12-10 | Sankyo Yuki Gosei Kk | 安定化されたハロゲン含有樹脂組成物 |
IT1206140B (it) * | 1984-03-22 | 1989-04-14 | Sirac Srl | Procedimento per la purificazione di lattulosio. |
JPS6312282A (ja) * | 1986-07-03 | 1988-01-19 | Takuma Co Ltd | 包括固定化方法 |
JPH03152455A (ja) * | 1989-11-10 | 1991-06-28 | Nippon Paint Co Ltd | クロマトグラフィー用吸着体及びその使用方法 |
IL117849A (en) * | 1995-04-14 | 2002-07-25 | Lepetit Spa | Chromatographic process for clearing glycoproteins |
US5981716A (en) | 1995-06-07 | 1999-11-09 | Gruppo Lepettit, S.P.A. | Process for the purification of proteins |
CA2356455A1 (en) * | 2000-08-31 | 2002-02-28 | University Of Alberta | Preparation and uses of conjugated solid supports for boronic acids |
US9493499B2 (en) | 2007-06-12 | 2016-11-15 | Novo Nordisk A/S | Process for the production of purified cytidinemonophosphate-sialic acid-polyalkylene oxide (CMP-SA-PEG) as modified nucleotide sugars via anion exchange chromatography |
WO2018124350A1 (en) * | 2016-12-30 | 2018-07-05 | Dow Global Technologies Llc | Resin beads and use in processing of aqueous solutions |
-
2016
- 2016-12-30 IL IL267489A patent/IL267489B/en unknown
- 2016-12-30 AU AU2016433970A patent/AU2016433970B2/en active Active
- 2016-12-30 JP JP2019532139A patent/JP7000431B2/ja active Active
- 2016-12-30 CA CA3048607A patent/CA3048607C/en active Active
- 2016-12-30 US US16/461,839 patent/US11370853B2/en active Active
- 2016-12-30 CN CN201680091747.XA patent/CN110088172B/zh active Active
- 2016-12-30 WO PCT/KR2016/015589 patent/WO2018124349A1/en unknown
- 2016-12-30 EP EP16925463.8A patent/EP3562867B1/en active Active
- 2016-12-30 KR KR1020197019090A patent/KR102589387B1/ko active IP Right Grant
- 2016-12-30 BR BR112019012117-0A patent/BR112019012117B1/pt active IP Right Grant
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2019
- 2019-05-30 ZA ZA2019/03462A patent/ZA201903462B/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104098734A (zh) | 2013-04-09 | 2014-10-15 | 江南大学 | 苯硼酸基团修饰大孔树脂的制备方法及其在莱鲍迪苷a和甜菊苷分离中的应用 |
CN103864858A (zh) | 2014-03-11 | 2014-06-18 | 江南大学 | 一种乳果糖的制备方法 |
Non-Patent Citations (2)
Title |
---|
Sorption and Separation of Sugars with Adsorbents Based on Reversible Chemical Interaction,Adsorption Science & Technology,2006年,Vol.24, No.9,P.771-780 |
STUDY OF THE INTERACTION OF POLYOLS WITH POLYMERS CONTAINING N-SUBSTITUTED [(4-BORONOPHENYL)METHYL]-AMMONIO GROUPS,Carbohydrate Research,1975年,Vol.43,P.215-224 |
Also Published As
Publication number | Publication date |
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JP2020504668A (ja) | 2020-02-13 |
CA3048607A1 (en) | 2018-07-05 |
CA3048607C (en) | 2023-09-05 |
AU2016433970B2 (en) | 2022-07-28 |
ZA201903462B (en) | 2020-09-30 |
CN110088172A (zh) | 2019-08-02 |
AU2016433970A1 (en) | 2019-06-20 |
IL267489B (en) | 2022-09-01 |
US20190366233A1 (en) | 2019-12-05 |
WO2018124349A1 (en) | 2018-07-05 |
KR102589387B1 (ko) | 2023-10-16 |
IL267489A (en) | 2019-08-29 |
EP3562867A1 (en) | 2019-11-06 |
BR112019012117A2 (pt) | 2019-11-05 |
EP3562867A4 (en) | 2020-08-12 |
US11370853B2 (en) | 2022-06-28 |
EP3562867B1 (en) | 2023-04-05 |
KR20190099441A (ko) | 2019-08-27 |
CN110088172B (zh) | 2022-06-17 |
BR112019012117B1 (pt) | 2022-08-16 |
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