JP6995751B2 - ガイド核酸を作製および使用するための方法および組成物 - Google Patents

ガイド核酸を作製および使用するための方法および組成物 Download PDF

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JP6995751B2
JP6995751B2 JP2018529124A JP2018529124A JP6995751B2 JP 6995751 B2 JP6995751 B2 JP 6995751B2 JP 2018529124 A JP2018529124 A JP 2018529124A JP 2018529124 A JP2018529124 A JP 2018529124A JP 6995751 B2 JP6995751 B2 JP 6995751B2
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ステファン ビー． グーギュッチョン，
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アーク バイオ， エルエルシー
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    • C40—COMBINATORIAL TECHNOLOGY
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    • C40B40/00—Libraries per se, e.g. arrays, mixtures
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    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
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    • C12N2800/70—Vectors containing special elements for cloning, e.g. topoisomerase, adaptor sites

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JP2018529124A 2015-12-07 2016-12-07 ガイド核酸を作製および使用するための方法および組成物 Active JP6995751B2 (ja)

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JP2021103316A JP2021141904A (ja) 2015-12-07 2021-06-22 ガイド核酸を作製および使用するための方法および組成物
JP2024030061A JP2024051149A (ja) 2015-12-07 2024-02-29 ガイド核酸を作製および使用するための方法および組成物

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US201562264262P 2015-12-07 2015-12-07
US62/264,262 2015-12-07
US201662298963P 2016-02-23 2016-02-23
US62/298,963 2016-02-23
PCT/US2016/065420 WO2017100343A1 (en) 2015-12-07 2016-12-07 Methods and compositions for the making and using of guide nucleic acids

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