JP6993970B2 - 高フェニルアラニン血症を低減させるように操作された細菌 - Google Patents

高フェニルアラニン血症を低減させるように操作された細菌 Download PDF

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JP6993970B2
JP6993970B2 JP2018526505A JP2018526505A JP6993970B2 JP 6993970 B2 JP6993970 B2 JP 6993970B2 JP 2018526505 A JP2018526505 A JP 2018526505A JP 2018526505 A JP2018526505 A JP 2018526505A JP 6993970 B2 JP6993970 B2 JP 6993970B2
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phenylalanine
gene
pal
bacterium
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JP2018535678A (ja
JP2018535678A5 (https=
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ファルブ ディーン
エム イザベラ ビンセント
ダブリュー コツラ ジョナサン
エフ ミラー ポール
ロウ サラ
ミレー イブ
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Synlogic Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y104/00—Oxidoreductases acting on the CH-NH2 group of donors (1.4)
    • C12Y104/03—Oxidoreductases acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C12Y104/03002—L-Amino-acid oxidase (1.4.3.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y403/00—Carbon-nitrogen lyases (4.3)
    • C12Y403/01—Ammonia-lyases (4.3.1)
    • C12Y403/01024—Phenylalanine ammonia-lyase (4.3.1.24)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/988—Lyases (4.), e.g. aldolases, heparinase, enolases, fumarase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Physics & Mathematics (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2018526505A 2015-11-16 2016-11-16 高フェニルアラニン血症を低減させるように操作された細菌 Active JP6993970B2 (ja)

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US201562256052P 2015-11-16 2015-11-16
US62/256,052 2015-11-16
PCT/US2016/032562 WO2016183531A1 (en) 2015-05-13 2016-05-13 Bacteria engineered to reduce hyperphenylalaninemia
USPCT/US2016/032562 2016-05-13
PCT/US2016/062369 WO2017087580A1 (en) 2015-11-16 2016-11-16 Bacteria engineered to reduce hyperphenylalaninemia

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JP2018535678A5 JP2018535678A5 (https=) 2020-01-09
JP6993970B2 true JP6993970B2 (ja) 2022-02-15

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JP2021200761A Active JP7245312B2 (ja) 2015-11-16 2021-12-10 高フェニルアラニン血症を低減させるように操作された細菌
JP2023037499A Active JP7494345B2 (ja) 2015-11-16 2023-03-10 高フェニルアラニン血症を低減させるように操作された細菌
JP2024083082A Active JP7813312B2 (ja) 2015-11-16 2024-05-22 高フェニルアラニン血症を低減させるように操作された細菌

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JP2023037499A Active JP7494345B2 (ja) 2015-11-16 2023-03-10 高フェニルアラニン血症を低減させるように操作された細菌
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US (2) US11618894B2 (https=)
EP (2) EP3377518B1 (https=)
JP (4) JP6993970B2 (https=)
AU (3) AU2016356684C1 (https=)
ES (1) ES2925049T3 (https=)
PL (1) PL3377518T3 (https=)
WO (1) WO2017087580A1 (https=)

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CN111655841A (zh) 2017-06-21 2020-09-11 同生运营公司 用于治疗紊乱的细菌
WO2020223345A1 (en) 2019-04-29 2020-11-05 Antipov Eugene Enumeration of genetically engineered microorganisms by live cell counting techniques
AU2020288624B2 (en) 2019-06-04 2025-09-25 Cocoon Biotech Inc. Silk-based products, formulations, and methods of use
WO2021009091A1 (en) * 2019-07-15 2021-01-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting and treating cardiac dysfunction
CN110643585B (zh) * 2019-11-08 2021-09-03 江南大学 一种利用氨基酸脱氨酶生产α-酮-β-甲基正戊酸的方法
CN113493796B (zh) * 2020-03-18 2023-05-30 苏州优信合生技术有限公司 苯丙酮尿症治疗用益生菌工程菌株的构建方法与应用
CN115298308A (zh) 2020-03-20 2022-11-04 同生运营公司 经工程化以减轻高苯丙氨酸血症的微生物
CN113755516B (zh) * 2020-06-05 2026-03-20 中国医学科学院药物研究所 工程粪肠球菌在治疗苯丙酮尿症药物中的应用
US20220031771A1 (en) * 2020-07-31 2022-02-03 Iowa State University Research Foundation, Inc. Microencapsulated and chromosome integrated compositions for l-dopa microbiome therapy
WO2022120028A2 (en) 2020-12-02 2022-06-09 Synlogic Operating Company, Inc. Engineered microorganisms
CN112662607A (zh) * 2021-01-07 2021-04-16 上海陶宇晟生物技术有限责任公司 具备表面展示苯丙氨酸解氨酶的工程益生菌
WO2023044479A1 (en) * 2021-09-17 2023-03-23 Synlogic Operating Company, Inc. Methods for reducing hyperphenylalaninemia
CN113969292B (zh) * 2021-11-15 2023-07-07 山东第一医科大学(山东省医学科学院) 治疗苯丙酮尿症的工程益生菌及其构建方法与应用

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JP7245312B2 (ja) 2023-03-23
AU2025202726A9 (en) 2026-03-05
JP2024112925A (ja) 2024-08-21
JP7813312B2 (ja) 2026-02-12
JP2018535678A (ja) 2018-12-06
JP7494345B2 (ja) 2024-06-03
US20180320161A1 (en) 2018-11-08
AU2025202726A1 (en) 2025-05-08
CA3005451A1 (en) 2017-05-26
WO2017087580A1 (en) 2017-05-26
JP2022046527A (ja) 2022-03-23
AU2022201838B2 (en) 2025-01-23
US11618894B2 (en) 2023-04-04
AU2022201838A1 (en) 2022-04-07
AU2016356684B2 (en) 2021-12-16
ES2925049T3 (es) 2022-10-13
US20240076645A1 (en) 2024-03-07
PL3377518T3 (pl) 2022-09-26
EP4095150A1 (en) 2022-11-30
EP3377518B1 (en) 2022-04-13
AU2016356684A1 (en) 2018-05-31
EP3377518A1 (en) 2018-09-26
JP2023085294A (ja) 2023-06-20
AU2016356684C1 (en) 2022-11-10

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