PL3377518T3 - Bakterie modyfikowane do celów zmniejszenia hiperfenyloalaninemii - Google Patents
Bakterie modyfikowane do celów zmniejszenia hiperfenyloalaninemiiInfo
- Publication number
- PL3377518T3 PL3377518T3 PL16810138.4T PL16810138T PL3377518T3 PL 3377518 T3 PL3377518 T3 PL 3377518T3 PL 16810138 T PL16810138 T PL 16810138T PL 3377518 T3 PL3377518 T3 PL 3377518T3
- Authority
- PL
- Poland
- Prior art keywords
- bacteria engineered
- hyperphenylalaninemia
- reduce
- reduce hyperphenylalaninemia
- engineered
- Prior art date
Links
- 241000894006 Bacteria Species 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y104/00—Oxidoreductases acting on the CH-NH2 group of donors (1.4)
- C12Y104/03—Oxidoreductases acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
- C12Y104/03002—L-Amino-acid oxidase (1.4.3.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y403/00—Carbon-nitrogen lyases (4.3)
- C12Y403/01—Ammonia-lyases (4.3.1)
- C12Y403/01024—Phenylalanine ammonia-lyase (4.3.1.24)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/988—Lyases (4.), e.g. aldolases, heparinase, enolases, fumarase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562256052P | 2015-11-16 | 2015-11-16 | |
| PCT/US2016/032562 WO2016183531A1 (en) | 2015-05-13 | 2016-05-13 | Bacteria engineered to reduce hyperphenylalaninemia |
| PCT/US2016/062369 WO2017087580A1 (en) | 2015-11-16 | 2016-11-16 | Bacteria engineered to reduce hyperphenylalaninemia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3377518T3 true PL3377518T3 (pl) | 2022-09-26 |
Family
ID=58717781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL16810138.4T PL3377518T3 (pl) | 2015-11-16 | 2016-11-16 | Bakterie modyfikowane do celów zmniejszenia hiperfenyloalaninemii |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11618894B2 (pl) |
| EP (2) | EP4095150A1 (pl) |
| JP (4) | JP6993970B2 (pl) |
| AU (3) | AU2016356684C1 (pl) |
| ES (1) | ES2925049T3 (pl) |
| PL (1) | PL3377518T3 (pl) |
| WO (1) | WO2017087580A1 (pl) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3294760B1 (en) | 2015-05-13 | 2021-03-24 | Synlogic Operating Company, Inc. | Bacteria engineered to reduce hyperphenylalaninemia |
| AU2016356684C1 (en) * | 2015-11-16 | 2022-11-10 | Synlogic Operating Company, Inc. | Bacteria engineered to reduce hyperphenylalaninemia |
| JP7358245B2 (ja) | 2017-06-21 | 2023-10-10 | シンロジック オペレーティング カンパニー インコーポレイテッド | 障害の処置のための細菌 |
| JP2022530503A (ja) | 2019-04-29 | 2022-06-29 | シンロジック オペレーティング カンパニー インコーポレイテッド | 遺伝子操作された微生物 |
| AU2020288624B2 (en) | 2019-06-04 | 2025-09-25 | Cocoon Biotech Inc. | Silk-based products, formulations, and methods of use |
| EP3999071A1 (en) * | 2019-07-15 | 2022-05-25 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for predicting and treating cardiac dysfunction |
| CN110643585B (zh) * | 2019-11-08 | 2021-09-03 | 江南大学 | 一种利用氨基酸脱氨酶生产α-酮-β-甲基正戊酸的方法 |
| CN113493796B (zh) * | 2020-03-18 | 2023-05-30 | 苏州优信合生技术有限公司 | 苯丙酮尿症治疗用益生菌工程菌株的构建方法与应用 |
| JP2023518184A (ja) | 2020-03-20 | 2023-04-28 | シンロジック オペレーティング カンパニー インコーポレイテッド | 高フェニルアラニン血症を軽減するように遺伝子改変された微生物 |
| CN113755516A (zh) * | 2020-06-05 | 2021-12-07 | 中国医学科学院药物研究所 | 工程粪肠球菌在治疗苯丙酮尿症药物中的应用 |
| US20220031771A1 (en) * | 2020-07-31 | 2022-02-03 | Iowa State University Research Foundation, Inc. | Microencapsulated and chromosome integrated compositions for l-dopa microbiome therapy |
| CA3200887A1 (en) | 2020-12-02 | 2022-06-09 | Michael James | Engineered microorganisms |
| CN112662607A (zh) * | 2021-01-07 | 2021-04-16 | 上海陶宇晟生物技术有限责任公司 | 具备表面展示苯丙氨酸解氨酶的工程益生菌 |
| WO2023044479A1 (en) * | 2021-09-17 | 2023-03-23 | Synlogic Operating Company, Inc. | Methods for reducing hyperphenylalaninemia |
| CN113969292B (zh) * | 2021-11-15 | 2023-07-07 | 山东第一医科大学(山东省医学科学院) | 治疗苯丙酮尿症的工程益生菌及其构建方法与应用 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9107305D0 (en) | 1991-04-08 | 1991-05-22 | Unilever Plc | Probiotic |
| CN1154845A (zh) | 1996-09-09 | 1997-07-23 | 首都医学院附属北京红十字朝阳医院 | 能表达活性苯丙氨酸脱氨酶的基因工程菌口服制剂 |
| US5989463A (en) | 1997-09-24 | 1999-11-23 | Alkermes Controlled Therapeutics, Inc. | Methods for fabricating polymer-based controlled release devices |
| US6203797B1 (en) | 1998-01-06 | 2001-03-20 | Stephen C. Perry | Dietary supplement and method for use as a probiotic, for alleviating the symptons associated with irritable bowel syndrome |
| WO2000032748A1 (en) | 1998-12-02 | 2000-06-08 | Trustees Of Boston University | Gene networks for control of gene expression |
| EP1034787A1 (en) | 1999-03-11 | 2000-09-13 | Société des Produits Nestlé S.A. | Lactobacillus strains preventing diarrhea caused by pathogenic bacteria |
| AUPQ899700A0 (en) | 2000-07-25 | 2000-08-17 | Borody, Thomas Julius | Probiotic recolonisation therapy |
| DE60212825T2 (de) | 2001-05-03 | 2007-01-11 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Selbsterhaltender lactococcus stamm |
| US7314974B2 (en) * | 2002-02-21 | 2008-01-01 | Monsanto Technology, Llc | Expression of microbial proteins in plants for production of plants with improved properties |
| US7731976B2 (en) | 2003-08-29 | 2010-06-08 | Cobb And Company, Llp | Treatment of irritable bowel syndrome using probiotic composition |
| JP4452914B2 (ja) | 2003-09-08 | 2010-04-21 | 味の素株式会社 | 新規トランスポータタンパク質 |
| CA2559760A1 (en) * | 2004-07-02 | 2006-07-06 | Metanomics Gmbh | Process for the production of fine chemicals |
| GB0501540D0 (en) | 2005-01-25 | 2005-03-02 | Univ Leeds | Controlled production and delivery of biologically active agents by gut bacteria |
| US20090038023A1 (en) * | 2005-03-10 | 2009-02-05 | Verenium Corporation | Lyase Enzymes, Nucleic Acids Encoding Them and Methods For Making and Using Them |
| WO2008118176A2 (en) | 2006-06-02 | 2008-10-02 | Verenium Corporation | Lase enzymes, nucleic acids encoding them and methods for making and using them |
| TW200819540A (en) | 2006-07-11 | 2008-05-01 | Genelux Corp | Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders |
| US9084434B2 (en) | 2006-09-27 | 2015-07-21 | Little Calumet Holdings Llc | Probiotic oral dosage forms |
| US20100297249A1 (en) | 2007-07-05 | 2010-11-25 | North-West University | Enhancement of the efficacy of therapeutic proteins |
| CN101586111B (zh) | 2008-05-22 | 2012-03-07 | 北京三元基因工程有限公司 | 一种活性乳酸乳球菌制品的制备方法 |
| DK3181682T3 (da) | 2008-09-29 | 2021-07-05 | Intrexon Actobiotics Nv | Reduceret kolonisering af mikrober på slimhinden |
| RU2603061C2 (ru) | 2010-03-02 | 2016-11-20 | Ренессанс Байосайенс Корп., | Функциональное улучшение микроорганизмов для минимизации продукции акриламида |
| US8129170B1 (en) | 2010-12-06 | 2012-03-06 | E.I. Du Pont De Nemours And Company | Recombinant bacteria having the ability to metabolize sucrose |
| EP2655624B1 (en) | 2010-12-23 | 2017-11-29 | Biogen MA Inc. | Linker peptides and polypeptides comprising same |
| US9017961B2 (en) | 2012-03-05 | 2015-04-28 | E.I. Du Pont De Nemours And Company | Recombinant bacteria comprising novel sucrose transporters |
| FR2990699B1 (fr) | 2012-05-21 | 2016-02-05 | Agronomique Inst Nat Rech | Cassettes d'expression procaryotes regulees par le stress |
| CN104487581B (zh) | 2012-06-22 | 2021-05-28 | 菲特吉恩公司 | 用于苯乙烯合成的酶和方法 |
| US20150246083A1 (en) | 2012-07-27 | 2015-09-03 | University Of North Texas | Genetically modified probiotic for the treatment of phenylketonuria (pku) disease |
| WO2014066945A1 (en) | 2012-11-01 | 2014-05-08 | The Sydney Children's Hospital Network (Randwick & Westmead) | Genetically-modified probiotic for treatment of phenylketonuria |
| WO2014093852A1 (en) | 2012-12-13 | 2014-06-19 | Massachusetts Institute Of Technology | Recombinase-based logic and memory systems |
| WO2014138324A1 (en) | 2013-03-07 | 2014-09-12 | The General Hospital Corporation | Compositions and methods for bacterial delivery of polypeptides |
| US9688967B2 (en) * | 2014-12-05 | 2017-06-27 | Synlogic, Inc. | Bacteria engineered to treat diseases associated with hyperammonemia |
| EP3294757B1 (en) * | 2015-05-13 | 2023-12-27 | Synlogic Operating Company, Inc. | Bacteria engineered to treat a disease or disorder |
| EP3294760B1 (en) | 2015-05-13 | 2021-03-24 | Synlogic Operating Company, Inc. | Bacteria engineered to reduce hyperphenylalaninemia |
| EP3307870B1 (en) * | 2015-06-10 | 2023-08-02 | Synlogic Operating Company, Inc. | Bacteria engineered to treat disorders involving the catabolism of a branched chain amino acid |
| WO2016210373A2 (en) * | 2015-06-24 | 2016-12-29 | Synlogic, Inc. | Recombinant bacteria engineered for biosafety, pharmaceutical compositions, and methods of use thereof |
| US20170216370A1 (en) * | 2015-07-31 | 2017-08-03 | Synlogic, Inc. | Bacteria engineered to treat disorders involving propionate catabolism |
| AU2016356684C1 (en) * | 2015-11-16 | 2022-11-10 | Synlogic Operating Company, Inc. | Bacteria engineered to reduce hyperphenylalaninemia |
| EP3606544B1 (en) * | 2017-04-05 | 2025-06-04 | University of Massachusetts | Minigene therapy |
| SK289101B6 (sk) * | 2020-12-17 | 2023-08-09 | Ústav molekulárnej biológie Slovenskej akadémie vied, verejná výskumná inštitúcia | Antimikrobiálny proteín, antimikrobiálny rekombinantný proteín s lytickými vlastnosťami, expresný vektor, spôsob ich prípravy a použitie |
-
2016
- 2016-11-16 AU AU2016356684A patent/AU2016356684C1/en active Active
- 2016-11-16 PL PL16810138.4T patent/PL3377518T3/pl unknown
- 2016-11-16 JP JP2018526505A patent/JP6993970B2/ja active Active
- 2016-11-16 EP EP22167588.7A patent/EP4095150A1/en active Pending
- 2016-11-16 US US15/775,936 patent/US11618894B2/en active Active
- 2016-11-16 ES ES16810138T patent/ES2925049T3/es active Active
- 2016-11-16 WO PCT/US2016/062369 patent/WO2017087580A1/en not_active Ceased
- 2016-11-16 EP EP16810138.4A patent/EP3377518B1/en active Active
-
2021
- 2021-12-10 JP JP2021200761A patent/JP7245312B2/ja active Active
-
2022
- 2022-03-16 AU AU2022201838A patent/AU2022201838B2/en active Active
- 2022-12-19 US US18/068,004 patent/US20240076645A1/en active Pending
-
2023
- 2023-03-10 JP JP2023037499A patent/JP7494345B2/ja active Active
-
2024
- 2024-05-22 JP JP2024083082A patent/JP2024112925A/ja active Pending
-
2025
- 2025-04-17 AU AU2025202726A patent/AU2025202726A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2022201838A1 (en) | 2022-04-07 |
| EP3377518A1 (en) | 2018-09-26 |
| US20240076645A1 (en) | 2024-03-07 |
| JP2018535678A (ja) | 2018-12-06 |
| JP2024112925A (ja) | 2024-08-21 |
| JP7245312B2 (ja) | 2023-03-23 |
| AU2016356684A1 (en) | 2018-05-31 |
| EP4095150A1 (en) | 2022-11-30 |
| AU2016356684B2 (en) | 2021-12-16 |
| JP7494345B2 (ja) | 2024-06-03 |
| AU2022201838B2 (en) | 2025-01-23 |
| AU2025202726A1 (en) | 2025-05-08 |
| US20180320161A1 (en) | 2018-11-08 |
| JP2023085294A (ja) | 2023-06-20 |
| ES2925049T3 (es) | 2022-10-13 |
| EP3377518B1 (en) | 2022-04-13 |
| CA3005451A1 (en) | 2017-05-26 |
| JP2022046527A (ja) | 2022-03-23 |
| JP6993970B2 (ja) | 2022-02-15 |
| WO2017087580A1 (en) | 2017-05-26 |
| US11618894B2 (en) | 2023-04-04 |
| AU2016356684C1 (en) | 2022-11-10 |
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