JP2018535678A5 - - Google Patents
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- JP2018535678A5 JP2018535678A5 JP2018526505A JP2018526505A JP2018535678A5 JP 2018535678 A5 JP2018535678 A5 JP 2018535678A5 JP 2018526505 A JP2018526505 A JP 2018526505A JP 2018526505 A JP2018526505 A JP 2018526505A JP 2018535678 A5 JP2018535678 A5 JP 2018535678A5
- Authority
- JP
- Japan
- Prior art keywords
- promoter
- phenylalanine
- gene
- pal
- bacteria
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021200761A JP7245312B2 (ja) | 2015-11-16 | 2021-12-10 | 高フェニルアラニン血症を低減させるように操作された細菌 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562256052P | 2015-11-16 | 2015-11-16 | |
| US62/256,052 | 2015-11-16 | ||
| PCT/US2016/032562 WO2016183531A1 (en) | 2015-05-13 | 2016-05-13 | Bacteria engineered to reduce hyperphenylalaninemia |
| USPCT/US2016/032562 | 2016-05-13 | ||
| PCT/US2016/062369 WO2017087580A1 (en) | 2015-11-16 | 2016-11-16 | Bacteria engineered to reduce hyperphenylalaninemia |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021200761A Division JP7245312B2 (ja) | 2015-11-16 | 2021-12-10 | 高フェニルアラニン血症を低減させるように操作された細菌 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018535678A JP2018535678A (ja) | 2018-12-06 |
| JP2018535678A5 true JP2018535678A5 (https=) | 2020-01-09 |
| JP6993970B2 JP6993970B2 (ja) | 2022-02-15 |
Family
ID=58717781
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018526505A Active JP6993970B2 (ja) | 2015-11-16 | 2016-11-16 | 高フェニルアラニン血症を低減させるように操作された細菌 |
| JP2021200761A Active JP7245312B2 (ja) | 2015-11-16 | 2021-12-10 | 高フェニルアラニン血症を低減させるように操作された細菌 |
| JP2023037499A Active JP7494345B2 (ja) | 2015-11-16 | 2023-03-10 | 高フェニルアラニン血症を低減させるように操作された細菌 |
| JP2024083082A Active JP7813312B2 (ja) | 2015-11-16 | 2024-05-22 | 高フェニルアラニン血症を低減させるように操作された細菌 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021200761A Active JP7245312B2 (ja) | 2015-11-16 | 2021-12-10 | 高フェニルアラニン血症を低減させるように操作された細菌 |
| JP2023037499A Active JP7494345B2 (ja) | 2015-11-16 | 2023-03-10 | 高フェニルアラニン血症を低減させるように操作された細菌 |
| JP2024083082A Active JP7813312B2 (ja) | 2015-11-16 | 2024-05-22 | 高フェニルアラニン血症を低減させるように操作された細菌 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11618894B2 (https=) |
| EP (2) | EP4095150A1 (https=) |
| JP (4) | JP6993970B2 (https=) |
| AU (3) | AU2016356684C1 (https=) |
| ES (1) | ES2925049T3 (https=) |
| PL (1) | PL3377518T3 (https=) |
| WO (1) | WO2017087580A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2881384T3 (es) | 2015-05-13 | 2021-11-29 | Synlogic Operating Co Inc | Bacterias manipuladas para reducir la hiperfenilalaninemia |
| ES2925049T3 (es) * | 2015-11-16 | 2022-10-13 | Synlogic Operating Co Inc | Bacterias manipuladas para reducir la hiperfenilalaninemia |
| CN111655841A (zh) | 2017-06-21 | 2020-09-11 | 同生运营公司 | 用于治疗紊乱的细菌 |
| KR20220003030A (ko) | 2019-04-29 | 2022-01-07 | 신로직 오퍼레이팅 컴퍼니, 인코포레이티드 | 살아 있는 세포 계수 기술에 의한 유전적으로 조작된 미생물의 계수 |
| CA3142608A1 (en) | 2019-06-04 | 2020-12-10 | Cocoon Biotech Inc. | Silk-based products, formulations, and methods of use |
| US20220268782A1 (en) * | 2019-07-15 | 2022-08-25 | Inserm (Institut National De La Santé Eat De La Recherche Médicale) | Methods for predicting and treating cardiac dysfunction |
| CN110643585B (zh) * | 2019-11-08 | 2021-09-03 | 江南大学 | 一种利用氨基酸脱氨酶生产α-酮-β-甲基正戊酸的方法 |
| CN113493796B (zh) * | 2020-03-18 | 2023-05-30 | 苏州优信合生技术有限公司 | 苯丙酮尿症治疗用益生菌工程菌株的构建方法与应用 |
| BR112022018571A2 (pt) | 2020-03-20 | 2022-11-01 | Synlogic Operating Co Inc | Microrganismos manipulados para reduzir a hiperfenilalaninemia |
| CN113755516B (zh) * | 2020-06-05 | 2026-03-20 | 中国医学科学院药物研究所 | 工程粪肠球菌在治疗苯丙酮尿症药物中的应用 |
| US20220031771A1 (en) * | 2020-07-31 | 2022-02-03 | Iowa State University Research Foundation, Inc. | Microencapsulated and chromosome integrated compositions for l-dopa microbiome therapy |
| EP4256039A2 (en) | 2020-12-02 | 2023-10-11 | Synlogic Operating Company, Inc. | Engineered microorganisms |
| CN112662607A (zh) * | 2021-01-07 | 2021-04-16 | 上海陶宇晟生物技术有限责任公司 | 具备表面展示苯丙氨酸解氨酶的工程益生菌 |
| WO2023044479A1 (en) * | 2021-09-17 | 2023-03-23 | Synlogic Operating Company, Inc. | Methods for reducing hyperphenylalaninemia |
| CN113969292B (zh) * | 2021-11-15 | 2023-07-07 | 山东第一医科大学(山东省医学科学院) | 治疗苯丙酮尿症的工程益生菌及其构建方法与应用 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9107305D0 (en) | 1991-04-08 | 1991-05-22 | Unilever Plc | Probiotic |
| CN1154845A (zh) | 1996-09-09 | 1997-07-23 | 首都医学院附属北京红十字朝阳医院 | 能表达活性苯丙氨酸脱氨酶的基因工程菌口服制剂 |
| US5989463A (en) | 1997-09-24 | 1999-11-23 | Alkermes Controlled Therapeutics, Inc. | Methods for fabricating polymer-based controlled release devices |
| US6203797B1 (en) | 1998-01-06 | 2001-03-20 | Stephen C. Perry | Dietary supplement and method for use as a probiotic, for alleviating the symptons associated with irritable bowel syndrome |
| AU3108400A (en) | 1998-12-02 | 2000-06-19 | Trustees Of Boston University | Gene networks for control of gene expression |
| EP1034787A1 (en) | 1999-03-11 | 2000-09-13 | Société des Produits Nestlé S.A. | Lactobacillus strains preventing diarrhea caused by pathogenic bacteria |
| AUPQ899700A0 (en) | 2000-07-25 | 2000-08-17 | Borody, Thomas Julius | Probiotic recolonisation therapy |
| DK1383897T3 (da) | 2001-05-03 | 2006-10-30 | Vlaams Interuniv Inst Biotech | Selv-containing Lactococcus-stamme |
| US7314974B2 (en) * | 2002-02-21 | 2008-01-01 | Monsanto Technology, Llc | Expression of microbial proteins in plants for production of plants with improved properties |
| US7731976B2 (en) | 2003-08-29 | 2010-06-08 | Cobb And Company, Llp | Treatment of irritable bowel syndrome using probiotic composition |
| JP4452914B2 (ja) | 2003-09-08 | 2010-04-21 | 味の素株式会社 | 新規トランスポータタンパク質 |
| EP2080769A3 (en) * | 2004-07-02 | 2010-12-01 | Metanomics GmbH | Process for the production of fine chemicals |
| GB0501540D0 (en) | 2005-01-25 | 2005-03-02 | Univ Leeds | Controlled production and delivery of biologically active agents by gut bacteria |
| EP2886658A1 (en) * | 2005-03-10 | 2015-06-24 | BASF Enzymes LLC | Lyase enzymes, nucleic acids encoding them and methods for making and using them |
| WO2008118176A2 (en) | 2006-06-02 | 2008-10-02 | Verenium Corporation | Lase enzymes, nucleic acids encoding them and methods for making and using them |
| TW200819540A (en) | 2006-07-11 | 2008-05-01 | Genelux Corp | Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders |
| US9084434B2 (en) | 2006-09-27 | 2015-07-21 | Little Calumet Holdings Llc | Probiotic oral dosage forms |
| US20100297249A1 (en) * | 2007-07-05 | 2010-11-25 | North-West University | Enhancement of the efficacy of therapeutic proteins |
| CN101586111B (zh) | 2008-05-22 | 2012-03-07 | 北京三元基因工程有限公司 | 一种活性乳酸乳球菌制品的制备方法 |
| EP3181682B1 (en) | 2008-09-29 | 2021-04-21 | Intrexon Actobiotics NV | Reduced colonization of microbes at the mucosa |
| BR112012022054A2 (pt) | 2010-03-02 | 2015-09-15 | Functional Technologies Corp | microorganismo transformado, método de redução de asparagina durante o preparo ou processamento de alimento, médtodo de redução de acrilamidia em um produto alimentício, e, produto alimentício |
| US8129170B1 (en) | 2010-12-06 | 2012-03-06 | E.I. Du Pont De Nemours And Company | Recombinant bacteria having the ability to metabolize sucrose |
| EP2655624B1 (en) | 2010-12-23 | 2017-11-29 | Biogen MA Inc. | Linker peptides and polypeptides comprising same |
| US9017961B2 (en) | 2012-03-05 | 2015-04-28 | E.I. Du Pont De Nemours And Company | Recombinant bacteria comprising novel sucrose transporters |
| FR2990699B1 (fr) | 2012-05-21 | 2016-02-05 | Agronomique Inst Nat Rech | Cassettes d'expression procaryotes regulees par le stress |
| US20150337336A1 (en) * | 2012-06-22 | 2015-11-26 | Phytogene, Inc. | Enzymes and methods for styrene synthesis |
| AU2013295621A1 (en) | 2012-07-27 | 2015-03-12 | University Of North Texas | Genetically modified probiotic for the treatment of phenylketonuria (PKU) disease |
| WO2014066945A1 (en) * | 2012-11-01 | 2014-05-08 | The Sydney Children's Hospital Network (Randwick & Westmead) | Genetically-modified probiotic for treatment of phenylketonuria |
| CN105144204B (zh) | 2012-12-13 | 2018-02-27 | 麻省理工学院 | 基于重组酶的逻辑与存储系统 |
| JP6283040B2 (ja) | 2013-03-07 | 2018-02-21 | ザ ジェネラル ホスピタル コーポレイション | 細菌によるポリペプチド送達のための組成物および方法 |
| US9688967B2 (en) * | 2014-12-05 | 2017-06-27 | Synlogic, Inc. | Bacteria engineered to treat diseases associated with hyperammonemia |
| WO2016183532A1 (en) | 2015-05-13 | 2016-11-17 | Synlogic, Inc. | Bacteria engineered to treat a disease or disorder |
| ES2881384T3 (es) * | 2015-05-13 | 2021-11-29 | Synlogic Operating Co Inc | Bacterias manipuladas para reducir la hiperfenilalaninemia |
| AU2016276973B2 (en) * | 2015-06-10 | 2022-09-01 | Synlogic Operating Company, Inc. | Bacteria engineered to treat disorders involving the catabolism of a branched chain amino acid |
| WO2016210373A2 (en) * | 2015-06-24 | 2016-12-29 | Synlogic, Inc. | Recombinant bacteria engineered for biosafety, pharmaceutical compositions, and methods of use thereof |
| US20170216370A1 (en) * | 2015-07-31 | 2017-08-03 | Synlogic, Inc. | Bacteria engineered to treat disorders involving propionate catabolism |
| ES2925049T3 (es) * | 2015-11-16 | 2022-10-13 | Synlogic Operating Co Inc | Bacterias manipuladas para reducir la hiperfenilalaninemia |
| CN110709095B (zh) * | 2017-04-05 | 2024-05-03 | 马萨诸塞大学 | 小基因治疗 |
| SK289101B6 (sk) * | 2020-12-17 | 2023-08-09 | Ústav molekulárnej biológie Slovenskej akadémie vied, verejná výskumná inštitúcia | Antimikrobiálny proteín, antimikrobiálny rekombinantný proteín s lytickými vlastnosťami, expresný vektor, spôsob ich prípravy a použitie |
-
2016
- 2016-11-16 ES ES16810138T patent/ES2925049T3/es active Active
- 2016-11-16 US US15/775,936 patent/US11618894B2/en active Active
- 2016-11-16 EP EP22167588.7A patent/EP4095150A1/en active Pending
- 2016-11-16 JP JP2018526505A patent/JP6993970B2/ja active Active
- 2016-11-16 AU AU2016356684A patent/AU2016356684C1/en active Active
- 2016-11-16 WO PCT/US2016/062369 patent/WO2017087580A1/en not_active Ceased
- 2016-11-16 EP EP16810138.4A patent/EP3377518B1/en active Active
- 2016-11-16 PL PL16810138.4T patent/PL3377518T3/pl unknown
-
2021
- 2021-12-10 JP JP2021200761A patent/JP7245312B2/ja active Active
-
2022
- 2022-03-16 AU AU2022201838A patent/AU2022201838B2/en active Active
- 2022-12-19 US US18/068,004 patent/US20240076645A1/en active Pending
-
2023
- 2023-03-10 JP JP2023037499A patent/JP7494345B2/ja active Active
-
2024
- 2024-05-22 JP JP2024083082A patent/JP7813312B2/ja active Active
-
2025
- 2025-04-17 AU AU2025202726A patent/AU2025202726A1/en active Pending
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