JP6993402B2 - 抗ｋｒａｓ－ｇ１２ｄ ｔ細胞受容体 - Google Patents

抗ｋｒａｓ－ｇ１２ｄ ｔ細胞受容体 Download PDF

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JP6993402B2
JP6993402B2 JP2019505220A JP2019505220A JP6993402B2 JP 6993402 B2 JP6993402 B2 JP 6993402B2 JP 2019505220 A JP2019505220 A JP 2019505220A JP 2019505220 A JP2019505220 A JP 2019505220A JP 6993402 B2 JP6993402 B2 JP 6993402B2
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amino acid
acid sequence
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amino acids
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JP2019527555A (ja
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トラン、エリック
ルー、ヨン－チェン
パセット、アンナ
エフ． ロビンズ、ポール
エイ． ローゼンバーグ、スティーヴン
チェン、ジリ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57557—Immunoassay; Biospecific binding assay; Materials therefor for cancer of other specific parts of the body, e.g. brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C12N2015/8518—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic expressing industrially exogenous proteins, e.g. for pharmaceutical use, human insulin, blood factors, immunoglobulins, pseudoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/7051—T-cell receptor (TcR)-CD3 complex

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  • Life Sciences & Earth Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Gastroenterology & Hepatology (AREA)
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  • Hematology (AREA)
  • Urology & Nephrology (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
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JP2019505220A 2016-08-02 2017-07-31 抗ｋｒａｓ－ｇ１２ｄ ｔ細胞受容体 Active JP6993402B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2021199878A JP7413338B2 (ja) 2016-08-02 2021-12-09 抗ｋｒａｓ－ｇ１２ｄ ｔ細胞受容体
JP2023221526A JP7649370B2 (ja) 2016-08-02 2023-12-27 抗ｋｒａｓ－ｇ１２ｄ ｔ細胞受容体
JP2025036871A JP2025090690A (ja) 2016-08-02 2025-03-07 抗ｋｒａｓ－ｇ１２ｄ ｔ細胞受容体

Applications Claiming Priority (3)

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US201662369883P 2016-08-02 2016-08-02
US62/369,883 2016-08-02
PCT/US2017/044615 WO2018026691A1 (en) 2016-08-02 2017-07-31 Anti-kras-g12d t cell receptors

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JP2019527555A JP2019527555A (ja) 2019-10-03
JP2019527555A5 JP2019527555A5 (https=) 2020-09-10
JP6993402B2 true JP6993402B2 (ja) 2022-02-03

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JP2021199878A Active JP7413338B2 (ja) 2016-08-02 2021-12-09 抗ｋｒａｓ－ｇ１２ｄ ｔ細胞受容体
JP2023221526A Active JP7649370B2 (ja) 2016-08-02 2023-12-27 抗ｋｒａｓ－ｇ１２ｄ ｔ細胞受容体
JP2025036871A Pending JP2025090690A (ja) 2016-08-02 2025-03-07 抗ｋｒａｓ－ｇ１２ｄ ｔ細胞受容体

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JP2023221526A Active JP7649370B2 (ja) 2016-08-02 2023-12-27 抗ｋｒａｓ－ｇ１２ｄ ｔ細胞受容体
JP2025036871A Pending JP2025090690A (ja) 2016-08-02 2025-03-07 抗ｋｒａｓ－ｇ１２ｄ ｔ細胞受容体

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US (6) US10611816B2 (https=)
EP (2) EP3494133B1 (https=)
JP (4) JP6993402B2 (https=)
KR (1) KR102527052B1 (https=)
CN (2) CN109790211B (https=)
AU (3) AU2017306038B2 (https=)
CY (1) CY1125601T1 (https=)
DK (1) DK3494133T3 (https=)
ES (1) ES2928051T3 (https=)
HR (1) HRP20221183T1 (https=)
HU (1) HUE060121T2 (https=)
IL (2) IL264425B2 (https=)
LT (1) LT3494133T (https=)
PL (1) PL3494133T3 (https=)
PT (1) PT3494133T (https=)
RS (1) RS63615B1 (https=)
SG (2) SG10201913959WA (https=)
SI (1) SI3494133T1 (https=)
SM (1) SMT202200379T1 (https=)
WO (1) WO2018026691A1 (https=)

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KR20250037592A (ko) 2017-09-20 2025-03-17 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 돌연변이된 ras에 대한 hla 클래스 ii-제한된 t 세포 수용체
AU2018345400B2 (en) 2017-10-05 2024-06-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods for selectively expanding cells expressing a TCR with a murine constant region
MX2020014243A (es) 2018-06-19 2021-05-12 Biontech Us Inc Neoantigenos y usos de los mismos.
WO2020154617A1 (en) * 2019-01-25 2020-07-30 The Trustees Of The University Of Pennsylvania Compositions and methods for targeting mutant ras
CN114026116A (zh) * 2019-02-20 2022-02-08 弗雷德哈钦森癌症研究中心 Ras新抗原特异性结合蛋白及其用途
CN110172089B (zh) * 2019-06-11 2020-01-07 北京鼎成肽源生物技术有限公司 一种kras突变多抗原组合、靶向kras突变肿瘤ctl及其应用
CN112110995A (zh) * 2019-06-19 2020-12-22 上海交通大学医学院 肿瘤新抗原多肽及其用途
CN112760290A (zh) * 2019-10-21 2021-05-07 郑州大学 携带突变的肿瘤驱动基因的干细胞及其用途
CN112759641B (zh) * 2019-11-01 2023-01-20 香雪生命科学技术（广东）有限公司 一种识别Kras G12V的高亲和力TCR
CN115151274B (zh) * 2019-11-05 2026-03-27 得克萨斯州大学系统董事会 Hla限制性hormad1 t细胞受体及其用途
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KR102842684B1 (ko) * 2019-12-30 2025-08-05 브리스타 이뮤노테크 리미티드 향상된 t-세포 수용체 star 및 이의 적용
US20240294598A1 (en) * 2020-05-25 2024-09-05 China Immunotech (Beijing) Biotechnology Co., Ltd Enhanced synthetic t-cell receptor and antigen receptor
EP4178976A1 (en) * 2020-07-13 2023-05-17 The United States of America, as represented by the Secretary, Department of Health and Human Services Hla class ii?restricted drb t cell receptors against ras with g12d mutation
TW202229327A (zh) * 2020-10-02 2022-08-01 美國衛生與公眾服務部 針對含有g13d突變之ras之hla第ii類限制性dq t細胞受體
EP4247401A4 (en) * 2020-11-20 2025-06-11 Think Therapeutics, Inc. COMPOSITIONS AND METHODS FOR OPTIMIZED PEPTIDE VACCINES
WO2022115641A2 (en) * 2020-11-25 2022-06-02 Geneius Biotechnology, Inc. Antigen specific t cells and methods of making and using same
WO2022183167A1 (en) 2021-02-25 2022-09-01 Alaunos Therapeutics, Inc. Recombinant vectors comprising polycistronic expression cassettes and methods of use thereof
WO2022233956A1 (en) 2021-05-05 2022-11-10 Immatics Biotechnologies Gmbh Antigen binding proteins specifically binding prame
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US20260021183A1 (en) * 2022-07-22 2026-01-22 Board Of Regents, The University Of Texas System Cd3-expressing natural killer cells with enhanced function for adoptive immunotherapy
CN115850444B (zh) * 2022-09-15 2025-01-28 重庆医科大学 Tcr或其抗原结合片段及其应用
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CN120693174A (zh) * 2022-12-13 2025-09-23 百欧恩泰美国公司 T细胞受体构建体及其用途
AU2024309123A1 (en) 2023-06-28 2026-01-15 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T cell receptors targeting ras with g12d, g12r, or g12v mutation
CN120157754A (zh) * 2023-12-14 2025-06-17 新景智源生物科技(苏州)有限公司 Kras_g12d突变抗原特异性tcr及其与cd8共表达重定向cd4 t细胞
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CY1125601T1 (el) 2026-02-25
AU2023233125B2 (en) 2025-10-16
EP4159751A1 (en) 2023-04-05
CN118063591A (zh) 2024-05-24
PL3494133T3 (pl) 2022-11-21
JP2019527555A (ja) 2019-10-03
AU2026200276A1 (en) 2026-02-19
US20220089677A1 (en) 2022-03-24
JP2022050400A (ja) 2022-03-30
IL301894B2 (en) 2025-02-01
SI3494133T1 (sl) 2022-11-30
DK3494133T3 (da) 2022-09-19
AU2017306038A1 (en) 2019-02-14
WO2018026691A1 (en) 2018-02-08
US11208456B2 (en) 2021-12-28
US20210300988A1 (en) 2021-09-30
PT3494133T (pt) 2022-09-28
JP7413338B2 (ja) 2024-01-15
US20190177395A1 (en) 2019-06-13
IL301894B1 (en) 2024-10-01
IL264425A (https=) 2019-03-31
SMT202200379T1 (it) 2022-11-18
CN109790211B (zh) 2024-03-26
US11897933B2 (en) 2024-02-13
LT3494133T (lt) 2022-12-12
RS63615B1 (sr) 2022-10-31
US10611816B2 (en) 2020-04-07
SG11201900654QA (en) 2019-02-27
HUE060121T2 (hu) 2023-01-28
US11840561B2 (en) 2023-12-12
ES2928051T3 (es) 2022-11-15
JP2025090690A (ja) 2025-06-17
IL301894A (en) 2023-06-01
AU2017306038B2 (en) 2023-06-22
JP7649370B2 (ja) 2025-03-19
AU2023233125A1 (en) 2023-10-12
CN109790211A (zh) 2019-05-21
US20250340611A1 (en) 2025-11-06
CA3032870A1 (en) 2018-02-08
HRP20221183T1 (hr) 2022-12-09
EP3494133A1 (en) 2019-06-12
US20240209059A1 (en) 2024-06-27
SG10201913959WA (en) 2020-03-30
EP3494133B1 (en) 2022-07-06
IL264425B2 (en) 2023-09-01
KR20190064566A (ko) 2019-06-10
US12391742B2 (en) 2025-08-19
US20200247869A1 (en) 2020-08-06
IL264425B1 (en) 2023-05-01
JP2024045139A (ja) 2024-04-02
KR102527052B1 (ko) 2023-04-27

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