JP6987742B2 - 抗ヒトｈｅｒ３抗体及びその使用 - Google Patents

抗ヒトｈｅｒ３抗体及びその使用 Download PDF

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Publication number
JP6987742B2
JP6987742B2 JP2018509977A JP2018509977A JP6987742B2 JP 6987742 B2 JP6987742 B2 JP 6987742B2 JP 2018509977 A JP2018509977 A JP 2018509977A JP 2018509977 A JP2018509977 A JP 2018509977A JP 6987742 B2 JP6987742 B2 JP 6987742B2
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Prior art keywords
antibody
cancer
seq
set forth
sequence set
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Expired - Fee Related
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JP2018509977A
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English (en)
Japanese (ja)
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JP2018515137A5 (OSRAM
JP2018515137A (ja
Inventor
シャルド，ティエリー
デュブレイユ，オリヴィエ
ペルグラン，アンドレ
ラルブレ，クリステル
プロスト，ジャン−フランソワ
バレ，ジャン−マルク
ドゥゴーヴ，ステファーヌ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Regional du Cancer de Montpellier
Gamamabs Pharma SA
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Institut Regional du Cancer de Montpellier
Gamamabs Pharma SA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
JP2018509977A 2015-05-06 2016-05-02 抗ヒトｈｅｒ３抗体及びその使用 Expired - Fee Related JP6987742B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15305695.7A EP3091033A1 (en) 2015-05-06 2015-05-06 Anti-human-her3 antibodies and uses thereof
EP15305695.7 2015-05-06
PCT/EP2016/059739 WO2016177664A1 (en) 2015-05-06 2016-05-02 Anti-human-her3 antibodies and uses thereof

Publications (3)

Publication Number Publication Date
JP2018515137A JP2018515137A (ja) 2018-06-14
JP2018515137A5 JP2018515137A5 (OSRAM) 2019-05-30
JP6987742B2 true JP6987742B2 (ja) 2022-01-05

Family

ID=53059029

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018509977A Expired - Fee Related JP6987742B2 (ja) 2015-05-06 2016-05-02 抗ヒトｈｅｒ３抗体及びその使用

Country Status (12)

Country Link
US (1) US11001634B2 (OSRAM)
EP (2) EP3091033A1 (OSRAM)
JP (1) JP6987742B2 (OSRAM)
CN (1) CN107771183A (OSRAM)
BR (1) BR112017023874A2 (OSRAM)
CA (1) CA2985143C (OSRAM)
ES (1) ES2905531T3 (OSRAM)
PL (1) PL3292154T3 (OSRAM)
PT (1) PT3292154T (OSRAM)
RS (1) RS62912B1 (OSRAM)
RU (1) RU2017138468A (OSRAM)
WO (1) WO2016177664A1 (OSRAM)

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CN110724194B (zh) * 2018-07-17 2021-03-19 上海生物制品研究所有限责任公司 抗her3人源化单克隆抗体及其制剂
EP3849538A4 (en) 2018-09-10 2022-06-29 Mirati Therapeutics, Inc. Combination therapies
GB201913079D0 (en) * 2019-09-11 2019-10-23 Hummingbird Bioscience Holdings Pte Ltd Treatment and prevention of cancer using her3 antigen-binding molecules
CN113135995B (zh) * 2020-01-17 2022-08-12 上海生物制品研究所有限责任公司 抗her3单克隆抗体及其应用
EP4257153B1 (en) * 2020-12-04 2025-11-12 Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. Antibody-drug conjugate, and intermediate thereof, preparation method therefor, and application thereof
US20240293565A1 (en) * 2021-06-15 2024-09-05 Beijing Sinotau Bio-Pharmaceuticals Technology Co., Ltd. Anti-her3 antibody, antibody drug conjugate containing the same, and use thereof
WO2023143263A1 (zh) * 2022-01-25 2023-08-03 苏州宜联生物医药有限公司 一种针对Her3的抗体，偶联物及其用途
CN115724979B (zh) * 2022-10-13 2025-09-30 深圳市百士通科技开发有限公司 一种多功能重组抗体及其制备方法和应用
CN116444672B (zh) * 2023-06-13 2023-11-03 上海偌妥生物科技有限公司 人表皮生长因子3的抗体、其制备方法及其应用

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Also Published As

Publication number Publication date
EP3292154A1 (en) 2018-03-14
US20180155433A1 (en) 2018-06-07
RU2017138468A3 (OSRAM) 2019-09-03
US11001634B2 (en) 2021-05-11
CN107771183A (zh) 2018-03-06
EP3292154B1 (en) 2021-11-03
CA2985143A1 (en) 2016-11-10
JP2018515137A (ja) 2018-06-14
PT3292154T (pt) 2022-01-26
RU2017138468A (ru) 2019-06-06
EP3091033A1 (en) 2016-11-09
ES2905531T3 (es) 2022-04-11
CA2985143C (en) 2023-10-17
WO2016177664A1 (en) 2016-11-10
RS62912B1 (sr) 2022-03-31
PL3292154T3 (pl) 2022-04-19
BR112017023874A2 (pt) 2018-07-24

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