JP6983069B2 - 成長因子をコードする外因性ポリヌクレオチドを含む安定な神経幹細胞およびその使用の方法 - Google Patents
成長因子をコードする外因性ポリヌクレオチドを含む安定な神経幹細胞およびその使用の方法 Download PDFInfo
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- JP6983069B2 JP6983069B2 JP2017539525A JP2017539525A JP6983069B2 JP 6983069 B2 JP6983069 B2 JP 6983069B2 JP 2017539525 A JP2017539525 A JP 2017539525A JP 2017539525 A JP2017539525 A JP 2017539525A JP 6983069 B2 JP6983069 B2 JP 6983069B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Developmental Biology & Embryology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Ophthalmology & Optometry (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462066174P | 2014-10-20 | 2014-10-20 | |
| US62/066,174 | 2014-10-20 | ||
| US201562147950P | 2015-04-15 | 2015-04-15 | |
| US62/147,950 | 2015-04-15 | ||
| PCT/US2015/056226 WO2016064737A1 (en) | 2014-10-20 | 2015-10-19 | Stable neural stem cells comprising an exogenous polynucleotide coding for a growth factor and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020201316A Division JP2021045156A (ja) | 2014-10-20 | 2020-12-03 | 成長因子をコードする外因性ポリヌクレオチドを含む安定な神経幹細胞およびその使用の方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017532068A JP2017532068A (ja) | 2017-11-02 |
| JP2017532068A5 JP2017532068A5 (cg-RX-API-DMAC7.html) | 2018-10-11 |
| JP6983069B2 true JP6983069B2 (ja) | 2021-12-17 |
Family
ID=55761367
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017539525A Active JP6983069B2 (ja) | 2014-10-20 | 2015-10-19 | 成長因子をコードする外因性ポリヌクレオチドを含む安定な神経幹細胞およびその使用の方法 |
| JP2020201316A Pending JP2021045156A (ja) | 2014-10-20 | 2020-12-03 | 成長因子をコードする外因性ポリヌクレオチドを含む安定な神経幹細胞およびその使用の方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020201316A Pending JP2021045156A (ja) | 2014-10-20 | 2020-12-03 | 成長因子をコードする外因性ポリヌクレオチドを含む安定な神経幹細胞およびその使用の方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9750769B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3209306B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6983069B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR20190060016A (cg-RX-API-DMAC7.html) |
| CN (1) | CN107148275A (cg-RX-API-DMAC7.html) |
| AU (2) | AU2015336194B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2964927C (cg-RX-API-DMAC7.html) |
| MX (1) | MX382488B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016064737A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20250022877A (ko) * | 2017-01-31 | 2025-02-17 | 리젠엑스바이오 인크. | 완전히-인간 글리코실화된 인간 알파-l-이두로니다아제(idua)를 이용한 뮤코다당증 1형의 치료 |
| KR102245539B1 (ko) | 2018-02-12 | 2021-04-29 | 주식회사 지앤피바이오사이언스 | 코어-쉘 구조의 마이크로 입자를 유효성분으로 포함하는 성장인자 유전자 발현 증가용 조성물 |
| WO2019165306A1 (en) * | 2018-02-23 | 2019-08-29 | Regeneration Biomedical, Inc. | Methods, apparatuses and systems for instilling stem cells and pharmaceuticals into the human ventricular system |
| CN112469732A (zh) * | 2018-07-17 | 2021-03-09 | 赫利世弥斯株式会社 | 使用胰岛素样生长因子1-加密脱氧核糖核酸构建体及肝细胞生长因子-加密脱氧核糖核酸构建体的神经病变治疗 |
| EP3823981A4 (en) * | 2018-07-17 | 2022-04-06 | Neuromyon Inc. | TREATMENT OF NEUROPATHY WITH DNA CONSTRUCTS EXPRESSING IGF-1 ISOFORMS |
| EP3852771A4 (en) | 2018-09-19 | 2022-06-08 | Regeneration Biomedical, Inc. | WNT-ACTIVATED ADI-DERIVED STEM CELL DEVICES, METHODS AND SYSTEMS |
| KR20210077634A (ko) * | 2019-12-17 | 2021-06-25 | 코아스템(주) | 인간 만능 줄기세포로부터 3d 오가노이드를 이용하여 미세교세포를 다량 확보하는 미세교세포의 분화방법 |
| CN111388654A (zh) * | 2020-05-22 | 2020-07-10 | 南通大学 | 治疗脊髓损伤的药物、药物试剂盒及方法 |
| WO2023158214A1 (ko) * | 2022-02-15 | 2023-08-24 | 주식회사 헬릭스미스 | 인슐린-유사 성장인자-1의 이형체를 이용한 근감소증 예방 또는 치료용 조성물 |
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2015
- 2015-10-19 WO PCT/US2015/056226 patent/WO2016064737A1/en not_active Ceased
- 2015-10-19 AU AU2015336194A patent/AU2015336194B2/en active Active
- 2015-10-19 US US14/886,272 patent/US9750769B2/en active Active
- 2015-10-19 KR KR1020197015061A patent/KR20190060016A/ko not_active Withdrawn
- 2015-10-19 KR KR1020177013001A patent/KR102100021B1/ko active Active
- 2015-10-19 CA CA2964927A patent/CA2964927C/en active Active
- 2015-10-19 JP JP2017539525A patent/JP6983069B2/ja active Active
- 2015-10-19 MX MX2017005186A patent/MX382488B/es unknown
- 2015-10-19 EP EP15852516.2A patent/EP3209306B1/en active Active
- 2015-10-19 CN CN201580057196.0A patent/CN107148275A/zh active Pending
-
2017
- 2017-06-16 US US15/624,959 patent/US10702555B2/en active Active
-
2018
- 2018-12-14 AU AU2018279014A patent/AU2018279014A1/en not_active Abandoned
-
2020
- 2020-12-03 JP JP2020201316A patent/JP2021045156A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MX2017005186A (es) | 2017-07-26 |
| EP3209306A1 (en) | 2017-08-30 |
| CA2964927C (en) | 2019-07-30 |
| CA2964927A1 (en) | 2016-04-28 |
| MX382488B (es) | 2025-03-13 |
| KR20190060016A (ko) | 2019-05-31 |
| EP3209306A4 (en) | 2018-07-04 |
| AU2015336194B2 (en) | 2019-01-03 |
| US20170319625A1 (en) | 2017-11-09 |
| AU2015336194A1 (en) | 2017-05-04 |
| US20160120942A1 (en) | 2016-05-05 |
| CN107148275A (zh) | 2017-09-08 |
| JP2017532068A (ja) | 2017-11-02 |
| AU2018279014A1 (en) | 2019-01-17 |
| US10702555B2 (en) | 2020-07-07 |
| KR20170067884A (ko) | 2017-06-16 |
| EP3209306B1 (en) | 2024-04-24 |
| US9750769B2 (en) | 2017-09-05 |
| KR102100021B1 (ko) | 2020-04-13 |
| WO2016064737A1 (en) | 2016-04-28 |
| JP2021045156A (ja) | 2021-03-25 |
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