JP6982664B2 - 冬虫夏草cs−100菌株及びそれを用いて神経細胞内の異常タンパク質に関連する疾患を治療又は予防する用途 - Google Patents
冬虫夏草cs−100菌株及びそれを用いて神経細胞内の異常タンパク質に関連する疾患を治療又は予防する用途 Download PDFInfo
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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Description
Claims (6)
- 中国微生物菌種保蔵管理委員会普通微生物センターに寄託番号CGMCC No.14350として2017年7月7日に寄託された、新規冬虫夏草CS−100菌株であって、
前記新規冬虫夏草CS−100菌株は、神経細胞内でのQN1タンパク質、TDP−43タンパク質、アミロイドβタンパク質、又はそれらの少なくとも任意の2つの組み合わせの蓄積を抑制する活性、並びにシナプスの成長を促進する活性を有し、
前記QN1タンパク質は、TDP−43タンパク質のQN1ペプチドである新規冬虫夏草CS−100菌株。 - 前記新規冬虫夏草CS−100菌株のrDNA配列は、SEQ ID No.1に示す配列を含む、請求項1に記載の新規冬虫夏草CS−100菌株。
- 冬虫夏草CS−100菌株又はその菌糸体抽出液を含む筋萎縮性側索硬化症を治療又は予防するための組成物であって、そのうち、前記冬虫夏草CS−100菌株は中国微生物菌種保蔵管理委員会普通微生物センターに寄託番号CGMCC No.14350として2017年7月7日に寄託されたものである、組成物。
- 前記冬虫夏草CS−100菌株の菌糸体抽出液の濃度は少なくとも1.7ppmである、請求項3に記載の組成物。
- 冬虫夏草CS−100菌株又はその菌糸体抽出液を含む神経細胞内でのQN1タンパク質、TDP−43タンパク質、アミロイドβタンパク質、又はそれらの少なくとも任意の2つの組み合わせの蓄積を抑制するための組成物であって、そのうち、
前記冬虫夏草CS−100菌株は、中国微生物菌種保蔵管理委員会普通微生物センターに寄託番号CGMCC No.14350として2017年7月7日に寄託されたものであり、
前記QN1タンパク質は、TDP−43タンパク質のQN1ペプチドである、組成物。 - 冬虫夏草CS−100菌株又はその菌糸体抽出液を含むシナプスの成長を促進するための組成物であって、そのうち、前記冬虫夏草CS−100菌株は中国微生物菌種保蔵管理委員会普通微生物センターに寄託番号CGMCC No.14350として2017年7月7日に寄託されたものである、組成物。
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TW108126441A TWI768224B (zh) | 2019-07-25 | 2019-07-25 | 冬蟲夏草cs-100菌株用於促進神經細胞生長之用途 |
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CN102373190B (zh) * | 2011-09-09 | 2012-12-12 | 浙江工业大学 | 冬虫夏草中国被毛孢合成代谢甘露醇相关酶、基因及应用 |
CN103789212B (zh) * | 2012-11-02 | 2015-10-28 | 中国科学院微生物研究所 | 一株高产孢冬虫夏草菌株 |
CN104922164B (zh) * | 2014-12-12 | 2020-06-02 | 中国医科大学 | 一种治疗阿尔茨海默病的药物复合制剂 |
US10092609B2 (en) * | 2015-01-16 | 2018-10-09 | James A. Wieser | Process for preparing medicinal mycological preparations |
CN106010972B (zh) * | 2015-03-23 | 2020-01-17 | 慕求生技股份有限公司 | 台湾冬虫夏草分离株及其用途 |
TWI577383B (zh) * | 2015-03-24 | 2017-04-11 | 慕求生技股份有限公司 | 台灣冬蟲夏草分離株及其用途 |
CN105624200B (zh) * | 2016-02-05 | 2019-06-14 | 浙江工业大学 | 一种中国被毛孢发酵滤液的回收利用方法 |
TWI631952B (zh) * | 2017-04-24 | 2018-08-11 | 大葉大學 | 保護類神經細胞之冬蟲夏草發酵製備物及其產製方法 |
TWI643627B (zh) * | 2017-04-24 | 2018-12-11 | 大葉大學 | 冬蟲夏草菌絲體萃取物抗發炎之用途及其製法 |
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