JP6974167B2 - 線維症治療剤 - Google Patents

線維症治療剤 Download PDF

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Publication number
JP6974167B2
JP6974167B2 JP2017525457A JP2017525457A JP6974167B2 JP 6974167 B2 JP6974167 B2 JP 6974167B2 JP 2017525457 A JP2017525457 A JP 2017525457A JP 2017525457 A JP2017525457 A JP 2017525457A JP 6974167 B2 JP6974167 B2 JP 6974167B2
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Japan
Prior art keywords
fibrosis
amino
present
acid
interstitial pneumonia
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JP2017525457A
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English (en)
Japanese (ja)
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JPWO2016208744A1 (ja
Inventor
秋生 藤岡
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Taiho Pharmaceutical Co Ltd
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Taiho Pharmaceutical Co Ltd
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Publication of JPWO2016208744A1 publication Critical patent/JPWO2016208744A1/ja
Priority to JP2021180108A priority Critical patent/JP7258985B2/ja
Application granted granted Critical
Publication of JP6974167B2 publication Critical patent/JP6974167B2/ja
Priority to JP2023061284A priority patent/JP7498827B2/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2017525457A 2015-06-25 2016-06-24 線維症治療剤 Active JP6974167B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021180108A JP7258985B2 (ja) 2015-06-25 2021-11-04 線維症治療剤
JP2023061284A JP7498827B2 (ja) 2015-06-25 2023-04-05 線維症治療剤

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2015127788 2015-06-25
JP2015127788 2015-06-25
PCT/JP2016/068902 WO2016208744A1 (ja) 2015-06-25 2016-06-24 線維症治療剤

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021180108A Division JP7258985B2 (ja) 2015-06-25 2021-11-04 線維症治療剤

Publications (2)

Publication Number Publication Date
JPWO2016208744A1 JPWO2016208744A1 (ja) 2018-04-12
JP6974167B2 true JP6974167B2 (ja) 2021-12-01

Family

ID=57585165

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2017525457A Active JP6974167B2 (ja) 2015-06-25 2016-06-24 線維症治療剤
JP2021180108A Active JP7258985B2 (ja) 2015-06-25 2021-11-04 線維症治療剤
JP2023061284A Active JP7498827B2 (ja) 2015-06-25 2023-04-05 線維症治療剤

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2021180108A Active JP7258985B2 (ja) 2015-06-25 2021-11-04 線維症治療剤
JP2023061284A Active JP7498827B2 (ja) 2015-06-25 2023-04-05 線維症治療剤

Country Status (20)

Country Link
US (4) US10449189B2 (https=)
EP (2) EP3973962A1 (https=)
JP (3) JP6974167B2 (https=)
KR (1) KR102647942B1 (https=)
CN (2) CN112716952A (https=)
AU (1) AU2016284531B2 (https=)
BR (1) BR112017028137B1 (https=)
CA (1) CA2990791A1 (https=)
DK (1) DK3315131T3 (https=)
ES (1) ES2928684T3 (https=)
HU (1) HUE060732T2 (https=)
MA (1) MA42266A (https=)
MX (2) MX381792B (https=)
MY (1) MY191219A (https=)
PH (1) PH12017502322B1 (https=)
PL (1) PL3315131T3 (https=)
PT (1) PT3315131T (https=)
RU (1) RU2729630C2 (https=)
SG (2) SG11201709260TA (https=)
WO (1) WO2016208744A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007139608A1 (en) 2006-03-14 2007-12-06 Ceres, Inc. Nucleotide sequences and corresponding polypeptides conferring modulated growth rate and biomass in plants grown in saline conditions
US12152246B2 (en) 2006-03-14 2024-11-26 Ceres, Inc. Nucleotide sequences and corresponding polypeptides conferring modulated growth rate and biomass in plants grown in saline conditions
MA42266A (fr) * 2015-06-25 2018-05-02 Taiho Pharmaceutical Co Ltd Agent thérapeutique contre la fibrose
HUE068810T2 (hu) 2017-02-15 2025-01-28 Taiho Pharmaceutical Co Ltd Gyógyászati készítmény
MA50251A (fr) 2017-09-08 2021-06-02 Taiho Pharmaceutical Co Ltd Agent antitumoral et potentialisateur d'effet antitumoral
US20210369739A1 (en) 2018-09-18 2021-12-02 Taiho Pharmaceutical Co., Ltd. Combination therapy of acylthiourea compound and abiraterone
TWI872203B (zh) * 2020-02-14 2025-02-11 日商大鵬藥品工業股份有限公司 醯基硫脲化合物的製造方法
CN115177636A (zh) * 2022-07-18 2022-10-14 陕西科美致尚生物科技有限公司 一种用于治疗前列腺钙化的组合物及其制备方法与应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69939586D1 (de) 1998-04-28 2008-10-30 Toshikazu Nakamura Inhibitoren für die gefässneubildung
JP2003238592A (ja) * 2001-12-13 2003-08-27 Japan Tobacco Inc 組織及び血管の再生のための医薬及びその方法
WO2007005668A2 (en) 2005-06-30 2007-01-11 Amgen Inc. Bis-aryl kinase inhibitors and their use in the treatment of inflammation, angiogenesis and cancer
CN101360748B (zh) * 2005-11-30 2012-05-30 沃泰克斯药物股份有限公司 c-MET抑制剂及其应用
KR20080080584A (ko) 2005-11-30 2008-09-04 버텍스 파마슈티칼스 인코포레이티드 ｃ-Ｍｅｔ의 억제제 및 이의 용도
AU2008219166B2 (en) 2007-02-16 2013-05-16 Amgen Inc. Nitrogen-containing heterocyclyl ketones and their use as c-Met inhibitors
ATE523508T1 (de) 2007-10-25 2011-09-15 Astrazeneca Ab Für die behandlung von zellproliferativen erkrankungen geeignete pyridin- und pyrazinderivate
KR101414931B1 (ko) * 2008-04-10 2014-07-04 다이호야쿠힌고교 가부시키가이샤 아실티오우레아 화합물 또는 그 염 및 그 용도
UY32049A (es) * 2008-08-14 2010-03-26 Takeda Pharmaceutical Inhibidores de cmet
EA025304B1 (ru) * 2010-02-03 2016-12-30 Инсайт Холдингс Корпорейшн ИМИДАЗО[1,2-b][1,2,4]ТРИАЗИНЫ В КАЧЕСТВЕ c-Met ИНГИБИТОРОВ
JP5960688B2 (ja) 2010-05-17 2016-08-02 インコゼン セラピューティクス プライベート リミテッド プロテインキナーゼ調節物質としての新規３，５−二置換−３ｈ−［１，２，３］トリアゾロ［４，５−ｂ］ピリジン化合物
TWI594986B (zh) 2011-12-28 2017-08-11 Taiho Pharmaceutical Co Ltd Antineoplastic agent effect enhancer
RU2494470C1 (ru) * 2012-04-04 2013-09-27 Общество с ограниченной ответственностью "Саентифик Фьючер Менеджмент" (ООО "Саентифик Фьючер Менеджмент") Способ лечения фиброза легких
US9149471B2 (en) 2013-09-30 2015-10-06 National University Corporation Tokyo University Of Agriculture And Technology Therapeutic agent for osteoporosis
MA42266A (fr) * 2015-06-25 2018-05-02 Taiho Pharmaceutical Co Ltd Agent thérapeutique contre la fibrose

Also Published As

Publication number Publication date
BR112017028137B1 (pt) 2023-04-04
JP2022009994A (ja) 2022-01-14
SG11201709260TA (en) 2018-01-30
US20200009128A1 (en) 2020-01-09
ES2928684T3 (es) 2022-11-21
MX381792B (es) 2025-03-13
JP2023076632A (ja) 2023-06-01
EP3315131A1 (en) 2018-05-02
SG10201912684TA (en) 2020-03-30
MX2020012989A (es) 2021-02-16
HK1245639A1 (zh) 2018-08-31
US20220047572A1 (en) 2022-02-17
EP3315131A4 (en) 2019-02-27
US11690838B2 (en) 2023-07-04
MA42266A (fr) 2018-05-02
PH12017502322B1 (en) 2023-08-30
JP7258985B2 (ja) 2023-04-17
PT3315131T (pt) 2022-10-26
KR20180021682A (ko) 2018-03-05
DK3315131T3 (da) 2022-11-14
MX2017016774A (es) 2018-05-14
RU2017145271A (ru) 2019-07-25
US20200297716A1 (en) 2020-09-24
HUE060732T2 (hu) 2023-04-28
JPWO2016208744A1 (ja) 2018-04-12
CN107708697A (zh) 2018-02-16
US11191759B2 (en) 2021-12-07
MY191219A (en) 2022-06-09
CA2990791A1 (en) 2016-12-29
CN112716952A (zh) 2021-04-30
US10695340B2 (en) 2020-06-30
EP3315131B1 (en) 2022-09-14
AU2016284531A1 (en) 2017-11-30
KR102647942B1 (ko) 2024-03-14
CN107708697B (zh) 2021-02-09
JP7498827B2 (ja) 2024-06-12
EP3973962A1 (en) 2022-03-30
RU2017145271A3 (https=) 2019-12-02
AU2016284531B2 (en) 2020-06-04
PH12017502322A1 (en) 2018-06-25
RU2729630C2 (ru) 2020-08-11
BR112017028137A2 (pt) 2018-08-28
US20180289690A1 (en) 2018-10-11
PL3315131T3 (pl) 2022-12-12
WO2016208744A1 (ja) 2016-12-29
US10449189B2 (en) 2019-10-22

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