JP6963385B2 - 抗CTLA−4抗体又は抗PD−1抗体との併用におけるIL−2Rβ選択的作動薬 - Google Patents
抗CTLA−4抗体又は抗PD−1抗体との併用におけるIL−2Rβ選択的作動薬 Download PDFInfo
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- JP6963385B2 JP6963385B2 JP2016570201A JP2016570201A JP6963385B2 JP 6963385 B2 JP6963385 B2 JP 6963385B2 JP 2016570201 A JP2016570201 A JP 2016570201A JP 2016570201 A JP2016570201 A JP 2016570201A JP 6963385 B2 JP6963385 B2 JP 6963385B2
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- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
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- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/3046—Stomach, Intestines
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- Endocrinology (AREA)
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- Reproductive Health (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN499/DEL/2014 | 2014-02-21 | ||
| IN499DE2014 | 2014-02-21 | ||
| IN3087DE2014 | 2014-10-29 | ||
| IN3087/DEL/2014 | 2014-10-29 | ||
| PCT/IN2015/000099 WO2015125159A1 (en) | 2014-02-21 | 2015-02-20 | Il-2rbeta-selective agonists in combination with an anti-ctla-4 antibody or an an anti-pd-1 antibody |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019016875A Division JP2019077723A (ja) | 2014-02-21 | 2019-02-01 | 抗CTLA−4抗体又は抗PD−1抗体との併用におけるIL−2Rβ選択的作動薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017506264A JP2017506264A (ja) | 2017-03-02 |
| JP2017506264A5 JP2017506264A5 (OSRAM) | 2018-01-18 |
| JP6963385B2 true JP6963385B2 (ja) | 2021-11-10 |
Family
ID=53055076
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016570201A Active JP6963385B2 (ja) | 2014-02-21 | 2015-02-20 | 抗CTLA−4抗体又は抗PD−1抗体との併用におけるIL−2Rβ選択的作動薬 |
| JP2019016875A Withdrawn JP2019077723A (ja) | 2014-02-21 | 2019-02-01 | 抗CTLA−4抗体又は抗PD−1抗体との併用におけるIL−2Rβ選択的作動薬 |
| JP2021018007A Withdrawn JP2021073296A (ja) | 2014-02-21 | 2021-02-08 | 抗CTLA−4抗体又は抗PD−1抗体との併用におけるIL−2Rβ選択的作動薬 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019016875A Withdrawn JP2019077723A (ja) | 2014-02-21 | 2019-02-01 | 抗CTLA−4抗体又は抗PD−1抗体との併用におけるIL−2Rβ選択的作動薬 |
| JP2021018007A Withdrawn JP2021073296A (ja) | 2014-02-21 | 2021-02-08 | 抗CTLA−4抗体又は抗PD−1抗体との併用におけるIL−2Rβ選択的作動薬 |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US10010587B2 (OSRAM) |
| EP (2) | EP3834838A1 (OSRAM) |
| JP (3) | JP6963385B2 (OSRAM) |
| KR (1) | KR102410090B1 (OSRAM) |
| CN (1) | CN106132438B (OSRAM) |
| AU (3) | AU2015220408B2 (OSRAM) |
| CA (1) | CA2937660A1 (OSRAM) |
| CY (1) | CY1124226T1 (OSRAM) |
| DK (1) | DK3134123T3 (OSRAM) |
| ES (1) | ES2872848T3 (OSRAM) |
| HR (1) | HRP20210377T1 (OSRAM) |
| HU (1) | HUE053982T2 (OSRAM) |
| IL (1) | IL247320B (OSRAM) |
| LT (1) | LT3134123T (OSRAM) |
| MX (2) | MX385194B (OSRAM) |
| PL (1) | PL3134123T3 (OSRAM) |
| PT (1) | PT3134123T (OSRAM) |
| RS (1) | RS61661B1 (OSRAM) |
| SI (1) | SI3134123T1 (OSRAM) |
| SM (1) | SMT202100191T1 (OSRAM) |
| WO (1) | WO2015125159A1 (OSRAM) |
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| WO2012088446A1 (en) | 2010-12-22 | 2012-06-28 | Board Of Trustees Of The Leland Stanford Junior University | Superagonists and antagonists of interleukin-2 |
| MX390311B (es) | 2013-12-05 | 2025-03-20 | Rfemb Holdings Llc | Presentacion de antigeno de cancer mejorado a celulas que presentan por la descomposicion electrica de membrana por radiofrecuencia (rf-rmb) como un mecanismo adyuvante para la inmunoterapia. |
| PE20160953A1 (es) | 2013-12-12 | 2016-09-26 | Shanghai hengrui pharmaceutical co ltd | Anticuerpo pd-1, fragmento de union al antigeno de este y uso medico de este |
| SMT202100191T1 (it) * | 2014-02-21 | 2021-05-07 | Nektar Therapeutics | Agonisti selettivi per il-2rbeta in combinazione con un anticorpo anti.ctla-4 o un anticorpo anti-pd-1 |
| JP6592505B2 (ja) | 2014-04-24 | 2019-10-16 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | インターロイキン−2のスーパーアンタゴニスト、パーシャルアゴニスト及びアンタゴニスト |
| CA2975123A1 (en) | 2015-01-30 | 2016-08-04 | Rfemb Holdings, Llc | Radio frequency electrical membrane breakdown for the treatment of high risk and recurrent prostate cancer, unresectable pancreatic cancer, tumors of the breast, melanoma or other skin malignancies, sarcoma, soft tissue tumors, ductal carcinoma, neoplasia, and intra and extra luminal abnormal tissue |
| HK1248115A1 (zh) | 2015-07-16 | 2018-10-12 | Bioxcel Therapeutics, Inc. | 一种使用免疫调节治疗癌症的新颖方法 |
| AU2016333538B2 (en) | 2015-10-02 | 2022-03-31 | Julius-Maximilians-Universität Würzburg | GDF-15 as a diagnostic marker to predict the clinical outcome of a treatment with immune checkpoint blockers |
| US12233104B2 (en) * | 2015-10-08 | 2025-02-25 | Nektar Therapeutics | Combination of an IL-2RBETA-selective agonist and a long-acting IL-15 agonist |
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| JP7069032B2 (ja) | 2016-03-24 | 2022-05-17 | ミレニアム ファーマシューティカルズ, インコーポレイテッド | がん免疫治療における胃腸の免疫関連有害事象の治療方法 |
| TW201735949A (zh) | 2016-03-24 | 2017-10-16 | 千禧製藥公司 | 治療抗ctla4及抗pd-1組合治療中的胃腸道免疫相關不良事件之方法 |
| CN109890405A (zh) * | 2016-08-19 | 2019-06-14 | 布鲁克林免疫治疗有限公司 | Pd-1/pd-l1抑制剂和/或ctla-4抑制剂与含有多种细胞因子组分的生物制剂用于治疗癌症的用途 |
| KR20190105568A (ko) * | 2016-11-10 | 2019-09-17 | 넥타르 테라퓨틱스 | 종양의 면역 요법적 치료 방법 |
| KR102619747B1 (ko) | 2017-01-10 | 2023-12-29 | 넥타르 테라퓨틱스 | Tlr 효현제 화합물의 다중-아암 중합체 컨쥬게이트 및 관련 면역 요법적 치료 방법 |
| AU2018227810A1 (en) * | 2017-03-01 | 2019-08-29 | Nektar Therapeutics | Immunotherapeutic tumor treatment method using an interleukin-2 receptor alpha, beta-selective agonist in combination with adoptive cell transfer therapy |
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| WO2019104092A1 (en) | 2017-11-21 | 2019-05-31 | The Board Of Trustees Of The Leland Stanford Junior University | Partial agonists of interleukin-2 |
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| CN115666724A (zh) * | 2020-05-26 | 2023-01-31 | 瑞泽恩制药公司 | 通过施用pd-1抑制剂抗体西米普利单抗来治疗宫颈癌的方法 |
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| US20240376224A1 (en) | 2021-04-02 | 2024-11-14 | The Regents Of The University Of California | Antibodies against cleaved cdcp1 and uses thereof |
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| EP1206265B1 (en) * | 1999-06-30 | 2003-11-12 | Merck & Co., Inc. | Src kinase inhibitor compounds |
| SI1758610T1 (sl) * | 2004-05-20 | 2012-11-30 | Zymogenetics Inc | Postopek za tretiranje raka z uporabo il in terapije z monoklonalnimi protitelesi |
| CN109485727A (zh) | 2005-05-09 | 2019-03-19 | 小野药品工业株式会社 | 程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法 |
| WO2006138572A2 (en) | 2005-06-16 | 2006-12-28 | Nektar Therapeutics Al, Corporation | Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates |
| AU2011325982C1 (en) | 2010-11-12 | 2015-08-20 | Endocyte, Inc. | Methods of treating cancer |
| KR20200070407A (ko) | 2010-11-12 | 2020-06-17 | 넥타르 테라퓨틱스 | Il-2 부분 및 중합체의 접합체 |
| US9107887B2 (en) * | 2011-03-10 | 2015-08-18 | Provectus Pharmaceuticals, Inc. | Combination of local and systemic immunomodulative therapies for enhanced treatment of cancer |
| SMT202100191T1 (it) * | 2014-02-21 | 2021-05-07 | Nektar Therapeutics | Agonisti selettivi per il-2rbeta in combinazione con un anticorpo anti.ctla-4 o un anticorpo anti-pd-1 |
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