JP6956307B2 - サポニンと植物抽出物の組成物 - Google Patents
サポニンと植物抽出物の組成物 Download PDFInfo
- Publication number
- JP6956307B2 JP6956307B2 JP2018555954A JP2018555954A JP6956307B2 JP 6956307 B2 JP6956307 B2 JP 6956307B2 JP 2018555954 A JP2018555954 A JP 2018555954A JP 2018555954 A JP2018555954 A JP 2018555954A JP 6956307 B2 JP6956307 B2 JP 6956307B2
- Authority
- JP
- Japan
- Prior art keywords
- extract
- styrax
- composition
- acacia
- saponin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/16—Ericaceae [Heath or Blueberry family], e.g. rhododendron, arbutus, pieris, cranberry or bilberry
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/10—Aromatic or araliphatic carboxylic acids, or thio analogues thereof; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
- A01N37/38—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system
- A01N37/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system having at least one carboxylic group or a thio analogue, or a derivative thereof, and one oxygen or sulfur atom attached to the same aromatic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/20—Fabaceae or Leguminosae [Pea or Legume family], e.g. pea, lentil, soybean, clover, acacia, honey locust, derris or millettia
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/28—Myrtaceae [Myrtle family], e.g. teatree or clove
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N2300/00—Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/22—Lamiaceae or Labiatae [Mint family], e.g. thyme, rosemary, skullcap, selfheal, lavender, perilla, pennyroyal, peppermint or spearmint
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Pest Control & Pesticides (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Botany (AREA)
- Emergency Medicine (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Dispersion Chemistry (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Description
[1]「The saponins−polar isoprenoids with important and diverse biologial activities」A.Osbournら、Nat.Prod.Rep.,2011,28,1261
[2] WO2000/072861
[3] WO1998/048768
[4] US2006/0018867
[5] WO2009/153800
[6] WO2012/07719
[7] WO2012/077120
[8] CN101085222
[9] WO2001/47481
ブドウ球菌: 局所的な皮膚感染、びまん性皮膚感染(膿痂疹)、深部及び局所感染、急性感染性心内膜炎、敗血症、壊死性肺炎、毒素症、毒素ショック症候群、ブドウ球菌食中毒、例えば心臓弁及びカテーテルなどの植されたプロテーゼの感染症、及び女性の膀胱炎;
大腸菌: 尿路感染症(UTI)、下痢、乳児の髄膜炎、旅行者下痢、出血性大腸炎、及び溶血性尿毒症症候群;
サルモネラ菌: 腸チフス型サルモネラ症、赤痢、大腸炎、例えば胃腸炎及び腸炎を伴うサルモネラ症;
から選択される。
油によるスタイラックス・トンキネンシスの抽出:
1gの粉砕されたスタイラックス・トンキネンシス(Styrax tonkinensis)樹脂を、90℃のウオーターバスで、10mlのMCT(中鎖トリグリセリド)ココナッツ由来油に溶解させた 得られた溶液を0.45ミクロンのPTFEフィルターで濾過した。
サピンドス・ムコロッシ(Sapindus mukorossi)抽出物粉末1gを蒸留水10mlに溶解させてサポニン抽出物を得た。滅菌条件下にある非保存ローション25gにサピンドス・ムコロッシ(Sapindus mukorossi)抽出物(SN)及び/又はスタイラックス・トンキネンシス(Styrax tonkinensis)抽出物(BZ−2)を滅菌条件下で添加し、十分に混合した。様々な濃度のサピンドス・ムコロッシ(Sapindus mukorossi)抽出物及び/又はスタイラックス・トンキネンシス(Styrax tonkinensis)抽出物を以下のように試験した。
種々のローション又はクレンジング配合物を、以下に記載するように、適切な微生物(細菌及び酵母)によって汚染させた。 このように調製したサンプルを以下に記載のようにインキュベートした。連続希釈法及びプレートカウントを使用して、インキュベーション期間中にアリコートを採取して、微生物数を決定した。
フェノキシエタノールに溶解した液状無菌性のメチルパラベン、エチルパラベン、プロピルパラベン、プロピレングリコール、であるSharomixを陰性対照として用いた。
試験結果を表1に示す。
この試験は、濃度が異なるSN及び/又はBZ−2を含む、25gのローション調製物のサンプルについて行った。すべての処方は、BZ−2+SNの混合物を異なる濃度で含んでいた。サピンドゥス・ムコロッシ(Sapindus mukorossi)抽出物(SN)と、スタイラックス・トンキネンシス(Styrax tonkinensis)抽出物(BZ−2)を用いた。
実施例1に記載の方法に従って、スタイラックス・パラレオネウルス(Styrax paralleoneurus)(スマトラ安息香;Sumatra benzoin)と及びスタイラックス・トンキネンシス(Styrax tonkinensis)(シャム安息香;Siam benzoin)のMCT抽出物中の10重量%を調製した。
スマトラ安息香(Benzoin Sumatra)抽出物は種々の源から得ることができた。 樹脂を粉砕し、MCT/樹脂比9:1(w/w)で抽出した。様々な抽出物の抗菌活性を、サポニン抽出物(サピンドス・ムコロッシ(Sapindus mukorossi)抽出物(SN))有り又は無しで、またワサビ(WS)有り又は無しで、非保存クリームで試験した。サンプルに黄色ブドウ球菌(S. aureus)(ATCC 6538)を植菌した(1×106)。結果を表4−1及び4−2に示す。
成分を水に溶解させることにより、0.72gのアルギニン(A)、0.6gのサリチル酸(S)、1.2gのグルコース(G)及び0.108gのトレハロース(T)の混合物を調製した。水中の混合物の最終濃度は10重量%であった。
MCT抽出物中の10%のシャム安息香(Siam benzoin)を実施例1のように調製した。ASGTの10%水混合物を実施例5に従って調製した。
MCT抽出物中の10%のシャム安息香(Siam Benzoin)を実施例1と同様に調製した。アラビアゴムノキ(Acacia arabica)(バブール:Ac、babool)果実の抽出物を以下の手順に従って調製した。
MCT抽出物中の10%シャム安息香(Siam Benzoin)を実施例1と同様に調製した。オレア・オイローパエア(Olea Europaea)(OE)葉の市販の抽出物を使用した。
MCT抽出物中の10%のシャム安息香(Siam benzoin)(BZ-2)を実施例1と同様に調製した。25重量%のヒビタキ(Terminalia bellerica)(TB)果実の市販抽出物を使用した。
MCT抽出物中の10%のスマトラ安息香(Sumatra benzoin)(BZ-1)を実施例1と同様に調製した。25重量%のワサビア・ジャポニカ(Wasabia japonica)(WS)根の市販抽出物を使用した。
MCT抽出物中の10%のスマトラ安息香(Sumatra benzoin)(BZ-1)を実施例1と同様に調製した。
本発明の組成物と比較すると、抗菌活性を有することが知られている植物ベースの抽出物のいずれも、サポニンと組み合わせた場合、抗菌活性が増加するとは限らないことに留意されたい。
Claims (20)
- 抗菌活性を有する組成物において、前記組成物が、サポニン抽出物と、エゴノキ属の少なくとも一の植物種の樹脂及び/又は樹皮からのスタイラックス抽出物とを含む組成物において、前記サポニン抽出物が前記エゴノキ属植物種とは異なるサポニン源由来であって、前記スタイラックス抽出物が、ケイ皮酸、ケイ皮酸誘導体及び/又は安息香酸誘導体の少なくとも一つを含むことを特徴とする組成物。
- 請求項1に記載の組成物において、前記スタイラックス抽出物中の桂皮酸、ケイ皮酸誘導体及び安息香酸誘導体の合計量が0.1〜10重量%であることを特徴とする組成物。
- 請求項1に記載の組成物において、前記ケイ皮酸誘導体が、桂皮酸P−クマリル、ケイ皮酸コニフェリル、ケイ皮酸シンナミル、ケイ皮酸ベンジル、ケイ皮酸エステル、及びこれらの組み合わせからなる群から選択され、及び/又は前記安息香酸誘導体が、安息香酸コニフェリル、安息香酸シンナミル、安息香酸P−クマリル、安息香酸エステル、及びそれらの組み合わせからなる群から選択されることを特徴とする組成物。
- 請求項1に記載の組成物において、前記サポニン抽出物が、前記エゴノキ属植物種とは異なるサポニン源由来であることを特徴とする組成物。
- 請求項1に記載の組成物において、前記スタイラックス抽出物が、スタイラックス・パラレオネウルス(Styrax paralleoneurus)(スマトラ安息香;Sumatra benzoin)、スタイラックス・トンキネンシス(Styrax tonkinensis)(シャム安息香;Siam Benzoin)、及びそれらの混合物の抽出物であることを特徴とする組成物。
- 請求項1に記載の組成物において、前記サポニン抽出物と、前記エゴノキ属の少なくとも一の植物種由来の抽出物との重量比が、1:50乃至50:1であることを特徴とする組成物。
- 請求項1に記載の組成物において、少なくとも一の追加の植物抽出物をさらに含むことを特徴とする組成物。
- 請求項7に記載の組成物において、前記追加の植物抽出物が、ワサビ(Wasabia)、アカシア(Acacia)、モモタマナ(Terminalia)、オリーブ(Olea)、及びそれらの混合物の抽出物から選択されることを特徴とする組成物。
- 請求項7に記載の組成物において、前記追加の植物抽出物と前記スタイラックス抽出物との間の重量比が、1:400〜400:1の間であることを特徴とする組成物。
- 請求項1に記載の組成物において、前記サポニン抽出物が、シカカイ、大豆、豆、エンドウ豆(Pisum sativum)、ルーサン、茶、ほうれん草、テンサイ、キノア、甘草、ヒマワリ、セイヨウトチノキ、人参、オート麦、トウガラシ、茄子、トマト種子、アリウム、アスパラガス、ヤムイモ、フェヌグリーク、ユッカ及びチョウセンニンジン、ルーサン、緑豆、ミシマサイコ(Bupleurum falcatum)、アブラツバキ(Camellia oleifera)、チャノキ(Camellia sinensis)、デスモディウム・アドセンデンス(Desmodium adscendens)、ジプソフィラ(Gypsophila)、パナックス・キンケフォウリアス(Panax quinqufolius)、トチバニンジン(Panax japonicas)、キラヤ・サポナリア(Quillaja saponaria)、サピンダス・デラワイー(Sapindus delavayi)、サピンダス・ムコロッシ(Sapindus mukorossi)、サピンダス・エマリジナタス(Sapindus emarginatus)、サピンダス・サポナリア(Sapindus saponaria)、サピンダス・トリホリアツス(Sapindus trifoliatus)、サポナリア・オフィシナリス(Saponaria officinalis)、ユッカ・シジゲラ(Yucca schidigera)、又はこれらの任意の混合物から選択されることを特徴とする組成物。
- 請求項10に記載の組成物において、前記サポニン抽出物が、アブラツバキ(Camellia oleifera)、カメリア・シネンシス(Camellia sinensis)、キラヤ・サポナリア(Quillaja saponaria)、サピンダス・ムコロッシ(Sapindus mukorossi)、及びサポナリア・オフィキナリス(Saponaria officinalis)又はそれらの任意の混合物からから選択される植物由来であることを特徴とする組成物。
- 請求項1に記載の組成物において、前記サポニン抽出物が、組成物の少なくとも0.001重量%の含有量であることを特徴とする組成物。
- 請求項1に記載の組成物において、前記組成物が0.01〜2重量%の含有量のサポニン抽出物を含むことを特徴とする組成物。
- 抗菌活性を有する添加組成物であって、前記組成物が、
少なくとも一のサポニン抽出物と、エゴノキ属の少なくとも一の植物種の樹脂及び/又は樹皮由来の少なくとも一のスタイラックス抽出物との組み合わせから成り、
前記サポニン抽出物が前記エゴノキ属の植物種とは異なるサポニン源由来であって、前記スタイラックス抽出物が、ケイ皮酸、ケイ皮酸誘導体及び/又は安息香酸誘導体の少なくとも一つを含むことを特徴とする組成物。 - 請求項14に記載の組成物において、前記スタイラックス抽出物が、スタイラックス・パラレオネウルス(Styrax paralleoneurus)(スマトラ安息香;Sumatra benzoin)、スタイラックス・トンキネンシス(Styrax tonkinensis)(シャム安息香;Siam Benzoin)、及びそれらの混合物の抽出物であることを特徴とする組成物。
- 請求項14に記載の組成物において、
前記サポニン抽出物が、アブラツバキ(Camellia oleifera)、チャノキ(Camellia sinensis)、キラヤ・サポナリア(Quillaja saponaria)、サピンダス・ムコロッシ(Sapindus mukorossi)、サピンダス・サポナリア(Sapindus saponaria)、及びサポナリア・オフィシナリス(Saponaria officinalis)、又はこれらの任意の混合物から選択される植物源から得られることを特徴とする組成物。 - 請求項14に記載の組成物において、前記サポニン抽出物と前記スタイラックス抽出物との重量比が、1:50乃至50:1の間であることを特徴とする組成物。
- 請求項14に記載の組成物において、前記サポニンが、前記組成物の少なくとも0.001重量%の含有量であることを特徴とする組成物。
- 請求項14に記載の組成物において、前記組成物が、0.01から2重量%の間の含有量のサポニンを含むことを特徴とする組成物。
- 請求項14に記載の組成物において、前記エゴノキ抽出物中のケイ皮酸、ケイ皮酸誘導体および安息香酸誘導体の総量が0.1乃至10重量%であることを特徴とする組成物。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL245378 | 2016-05-02 | ||
IL245378A IL245378A0 (en) | 2016-05-02 | 2016-05-02 | Preparations containing saponin and plant extracts |
IL248230A IL248230A0 (en) | 2016-10-06 | 2016-10-06 | Preparations containing saponin and plant extracts |
IL248230 | 2016-10-06 | ||
PCT/IL2017/050482 WO2017191629A1 (en) | 2016-05-02 | 2017-05-01 | Compositions of saponins and plant extracts |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2019514904A JP2019514904A (ja) | 2019-06-06 |
JP2019514904A5 JP2019514904A5 (ja) | 2020-06-18 |
JP6956307B2 true JP6956307B2 (ja) | 2021-11-02 |
Family
ID=58794131
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018555954A Active JP6956307B2 (ja) | 2016-05-02 | 2017-05-01 | サポニンと植物抽出物の組成物 |
Country Status (12)
Country | Link |
---|---|
US (2) | US20190150455A1 (ja) |
EP (1) | EP3451836B1 (ja) |
JP (1) | JP6956307B2 (ja) |
KR (1) | KR102518631B1 (ja) |
CN (2) | CN115088734A (ja) |
BR (1) | BR112018072352A2 (ja) |
CA (1) | CA3021595A1 (ja) |
DK (1) | DK3451836T3 (ja) |
IL (1) | IL262250B (ja) |
MX (1) | MX2018013184A (ja) |
PL (1) | PL3451836T3 (ja) |
WO (1) | WO2017191629A1 (ja) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3259991A1 (en) * | 2016-06-21 | 2017-12-27 | Universität Basel | Fungicidal compositions |
US11459445B2 (en) * | 2018-02-13 | 2022-10-04 | Sumitomo Chemical Company, Limited | Composition and molded body |
CN111658683A (zh) * | 2020-05-15 | 2020-09-15 | 广东药科大学 | 诃子提取物在制备马拉色菌抑制剂中的应用 |
CN117561008A (zh) * | 2021-04-09 | 2024-02-13 | 马登制造业有限公司 | 弹性体制品 |
CN115501260A (zh) * | 2021-06-07 | 2022-12-23 | 中国科学院过程工程研究所 | 一种藜麦麸皮皂苷的提取方法及其应用 |
AU2022399994A1 (en) * | 2021-12-01 | 2024-05-23 | Sava Healthcare Ltd | A pharmaceutical formulation and a process for its preparation |
KR102677718B1 (ko) * | 2022-01-11 | 2024-06-24 | 국민대학교산학협력단 | 호로파 추출물을 포함하는 바이오필름 형성 억제용 조성물 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1048617C (zh) * | 1993-06-30 | 2000-01-26 | 湖北农学院 | 一种用于杀菌、杀虫的组合增效剂 |
US5639794A (en) * | 1995-06-07 | 1997-06-17 | Proguard, Inc. | Use of saponin in methods and compositions for pathogen control |
IT1276374B1 (it) * | 1995-06-09 | 1997-10-31 | Luciano Pecchiai | Uso di essenze aromatiche estrattive e di trasudati-essudati delle piante, particolarmente in campo medico, zootecnico ed agronomico. |
AU7174998A (en) | 1997-05-01 | 1998-11-24 | Medlogic Global Corporation | Compositions for cosmetic applications |
JP2003500452A (ja) | 1999-05-27 | 2003-01-07 | アーマディーロ・ファーマシューティカルス・インコーポレーテッド | 天然資源から抽出した生物活性物質の医薬製剤 |
JP4171149B2 (ja) * | 1999-12-16 | 2008-10-22 | 日本エンバイロケミカルズ株式会社 | 木材保存剤 |
IL133760A (en) | 1999-12-28 | 2007-10-31 | Pharmaskin Ltd | Composition for the treatment of dandruff |
CN1470255A (zh) * | 2002-07-22 | 2004-01-28 | 王智民 | 自丹参三七中提取的制备物及其复方制备方法和医疗用途 |
JP4623946B2 (ja) * | 2003-08-01 | 2011-02-02 | 丸善製薬株式会社 | 新規サポニン及びその製造方法、並びに抗真菌剤 |
US20060018867A1 (en) | 2004-05-12 | 2006-01-26 | Ichimaru Pharcos Co., Ltd | Cosmetic composition and production thereof |
DE102004027856A1 (de) * | 2004-06-08 | 2006-07-06 | Ullrich, Oliver, Prof. Dr. Dr. | Neue Pflanzenextrakte mit neuropotektiven, neuroregenerativen und entzündungshemmenden Eigenschaften |
US7416742B2 (en) * | 2004-06-16 | 2008-08-26 | Sartec Corporation | Methods and compositions for controlling microorganism populations in the digestive system of animals |
CN101085222B (zh) | 2007-07-20 | 2010-06-02 | 李桂荣 | 一种止痛膏 |
GB2449135B (en) * | 2007-09-14 | 2009-11-11 | Anushya Sundaresan | Styrax benzoin rejuvenating cosmetic preparation |
WO2009153800A1 (en) | 2008-06-17 | 2009-12-23 | Pawan Kumar Goel | A novel process for extraction of furostanolic saponins from fenugreek seeds |
GB201011816D0 (en) | 2010-07-14 | 2010-09-01 | Imp Innovations | Feature characterization for breathing monitor |
US8992995B2 (en) * | 2010-08-02 | 2015-03-31 | Bay Song Art, Inc. | Skin care ointment |
EP2648809B1 (en) | 2010-12-09 | 2019-04-03 | Y&B Mother's Choice Ltd. | Natural formulations |
WO2012077119A2 (en) * | 2010-12-09 | 2012-06-14 | Y&B Mother's Choice Ltd. | Formulations comprising saponins and uses thereof |
CN103598225B (zh) * | 2013-11-29 | 2015-07-15 | 浙江师范大学 | 防治水稻病害的生物杀菌剂 |
-
2017
- 2017-05-01 DK DK17726381.1T patent/DK3451836T3/da active
- 2017-05-01 CN CN202210152799.0A patent/CN115088734A/zh active Pending
- 2017-05-01 MX MX2018013184A patent/MX2018013184A/es unknown
- 2017-05-01 PL PL17726381T patent/PL3451836T3/pl unknown
- 2017-05-01 WO PCT/IL2017/050482 patent/WO2017191629A1/en unknown
- 2017-05-01 BR BR112018072352A patent/BR112018072352A2/pt not_active Application Discontinuation
- 2017-05-01 CN CN201780041495.4A patent/CN109414025A/zh active Pending
- 2017-05-01 JP JP2018555954A patent/JP6956307B2/ja active Active
- 2017-05-01 CA CA3021595A patent/CA3021595A1/en not_active Abandoned
- 2017-05-01 EP EP17726381.1A patent/EP3451836B1/en active Active
- 2017-05-01 KR KR1020187034912A patent/KR102518631B1/ko active IP Right Grant
- 2017-05-01 US US16/092,899 patent/US20190150455A1/en not_active Abandoned
-
2018
- 2018-10-10 IL IL262250A patent/IL262250B/en active IP Right Grant
-
2023
- 2023-04-03 US US18/194,873 patent/US20230232839A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
KR102518631B1 (ko) | 2023-04-07 |
IL262250A (en) | 2018-11-29 |
CA3021595A1 (en) | 2017-11-09 |
PL3451836T3 (pl) | 2021-12-27 |
CN109414025A (zh) | 2019-03-01 |
US20230232839A1 (en) | 2023-07-27 |
JP2019514904A (ja) | 2019-06-06 |
EP3451836B1 (en) | 2021-08-25 |
KR20190006985A (ko) | 2019-01-21 |
DK3451836T3 (da) | 2021-11-22 |
IL262250B (en) | 2021-04-29 |
BR112018072352A2 (pt) | 2019-10-01 |
WO2017191629A1 (en) | 2017-11-09 |
US20190150455A1 (en) | 2019-05-23 |
EP3451836A1 (en) | 2019-03-13 |
MX2018013184A (es) | 2019-07-04 |
CN115088734A (zh) | 2022-09-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6956307B2 (ja) | サポニンと植物抽出物の組成物 | |
US9474283B2 (en) | Formulations comprising saponins and uses thereof | |
ES2846675T3 (es) | Actividad antimicrobiana, antibacteriana y que inhibe la germinación de esporas de compuestos extraídos de aguacate | |
KR20190133561A (ko) | 유제놀 및 갈릭산을 유효성분으로 함유하는 항균 및 항진균 조성물 | |
KR20170040002A (ko) | 홍삼 에탄올 추출물의 부탄올 분획물을 포함하는 여드름 개선용 화장료 조성물 | |
KR102065185B1 (ko) | 항균, 항염, 피부주름 개선, 및 피부 미백 활성을 갖는 피부상태 개선용 조성물 | |
KR102327236B1 (ko) | 식물 복합 추출물을 유효성분으로 포함하는 항균 및 소취용 조성물 | |
AU2022436163A1 (en) | Antimicrobial natural compositions | |
KR101986629B1 (ko) | 포도 전정가지 추출물을 유효성분으로 함유하는 항가려움용 조성물 | |
KR101952715B1 (ko) | 천연 화합물을 포함하는 칸디다증 개선용 항진균 조성물 | |
KR102158134B1 (ko) | 오미자 추출물을 유효성분으로 함유하는 항균용 조성물 | |
KR102315700B1 (ko) | 보리수나무 잎 추출물을 포함하는 여드름 치료 또는 예방용 조성물 | |
JP4472428B2 (ja) | 抗菌剤 | |
KR101598194B1 (ko) | 헤어 및 바디용 다기능 소취 화장료 조성물 | |
KR101921050B1 (ko) | 천연 화합물을 포함하는 여드름 개선용 항균 조성물 | |
WO2023144808A1 (en) | Antimicrobial compositions | |
IL279361A (en) | Antimicrobial preparations | |
KR20150144129A (ko) | 꽃송이버섯 발효물을 이용한 피부 주름개선용 화장료 조성물 | |
KR102290554B1 (ko) | 천연 약초 추출물을 함유하는 항말라리아 조성물 | |
KR102206568B1 (ko) | 발효 옻 추출물을 포함하는 항균 조성물 | |
KR20240050845A (ko) | 여드름 완화 효과가 있는 토복령 추출물을 포함하는 조성물 | |
KR20150084412A (ko) | 파래로부터 분리된 신규한 항생 펩타이드 및 이의 용도 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200501 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20200501 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20201215 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20201216 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210315 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20210803 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20210823 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6956307 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |