JP6951451B2 - エストロゲン受容体モジュレーター - Google Patents
エストロゲン受容体モジュレーター Download PDFInfo
- Publication number
- JP6951451B2 JP6951451B2 JP2019538615A JP2019538615A JP6951451B2 JP 6951451 B2 JP6951451 B2 JP 6951451B2 JP 2019538615 A JP2019538615 A JP 2019538615A JP 2019538615 A JP2019538615 A JP 2019538615A JP 6951451 B2 JP6951451 B2 JP 6951451B2
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- compound
- tetrahydro
- pyrido
- indole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 CCC(C)C1=CC(C2(CC)C(C)C2)=C(*)C2C1C2 Chemical compound CCC(C)C1=CC(C2(CC)C(C)C2)=C(*)C2C1C2 0.000 description 6
- ALHOKFPHBWNKDF-MPBGBICISA-N C[C@H](Cc1c2[nH]c3ccccc13)N(CC(F)(F)F)[C@@H]2c(cc(cc1)Br)c1OC Chemical compound C[C@H](Cc1c2[nH]c3ccccc13)N(CC(F)(F)F)[C@@H]2c(cc(cc1)Br)c1OC ALHOKFPHBWNKDF-MPBGBICISA-N 0.000 description 2
- SXOWHFQHUQKEAK-QIKQAKPGSA-N CC(CN([C@H](C)Cc(c1c2)c3[nH]c1ccc2F)[C@@H]3C(C(F)=CC1)=C(C)C1Br)C(OC)=O Chemical compound CC(CN([C@H](C)Cc(c1c2)c3[nH]c1ccc2F)[C@@H]3C(C(F)=CC1)=C(C)C1Br)C(OC)=O SXOWHFQHUQKEAK-QIKQAKPGSA-N 0.000 description 1
- BUVXXDQCPBBBSZ-UHFFFAOYSA-N CCC(C)(CC)CC(CO)(F)F Chemical compound CCC(C)(CC)CC(CO)(F)F BUVXXDQCPBBBSZ-UHFFFAOYSA-N 0.000 description 1
- OQTBSRIIHCNDGF-UHFFFAOYSA-N CCC(CC(C(F)F)F)C(C)C Chemical compound CCC(CC(C(F)F)F)C(C)C OQTBSRIIHCNDGF-UHFFFAOYSA-N 0.000 description 1
- VUZWAQHSVLWNSK-UHFFFAOYSA-N CCC(CC)C(C1OC)C=CC=C1C(C)(C)CC Chemical compound CCC(CC)C(C1OC)C=CC=C1C(C)(C)CC VUZWAQHSVLWNSK-UHFFFAOYSA-N 0.000 description 1
- WYEZTLYMQFJJRH-UHFFFAOYSA-N CCOCC1(COC1)N Chemical compound CCOCC1(COC1)N WYEZTLYMQFJJRH-UHFFFAOYSA-N 0.000 description 1
- XNAYPGSXPCMEGR-KVUUWBKYSA-N C[C@H](CN([C@H](C)Cc(c1c2)c3[nH]c1ccc2F)[C@@H]3c(c(C)c(cc1)OCCOS(C)(=O)=O)c1F)C(OC)=O Chemical compound C[C@H](CN([C@H](C)Cc(c1c2)c3[nH]c1ccc2F)[C@@H]3c(c(C)c(cc1)OCCOS(C)(=O)=O)c1F)C(OC)=O XNAYPGSXPCMEGR-KVUUWBKYSA-N 0.000 description 1
- IURRISDHEMQJRJ-OYLFLEFRSA-N C[C@H](Cc1c2[nH]c3c1cccc3)N(CC(F)(F)F)[C@@H]2c(c(F)c(cc1)OCCNCCCF)c1F Chemical compound C[C@H](Cc1c2[nH]c3c1cccc3)N(CC(F)(F)F)[C@@H]2c(c(F)c(cc1)OCCNCCCF)c1F IURRISDHEMQJRJ-OYLFLEFRSA-N 0.000 description 1
- OGXNITFFRCUOPE-XHCCPWGMSA-N C[C@H](Cc1c2[nH]c3c1cccc3)N(CC1(COC1)F)[C@@H]2c(cc(cc1)OCCNCCCF)c1OC Chemical compound C[C@H](Cc1c2[nH]c3c1cccc3)N(CC1(COC1)F)[C@@H]2c(cc(cc1)OCCNCCCF)c1OC OGXNITFFRCUOPE-XHCCPWGMSA-N 0.000 description 1
- GYILNKRTBRMCHH-DNOBIOAJSA-N C[C@H](Cc1c2[nH]c3ccccc13)N(CC(F)(F)F)[C@@H]2c(c(F)ccc1OCCN(CCCF)C(OC(C)(C)C)=O)c1F Chemical compound C[C@H](Cc1c2[nH]c3ccccc13)N(CC(F)(F)F)[C@@H]2c(c(F)ccc1OCCN(CCCF)C(OC(C)(C)C)=O)c1F GYILNKRTBRMCHH-DNOBIOAJSA-N 0.000 description 1
- SLTNEYDLIVCLGL-VOIUYBSRSA-N C[C@H](Cc1c2[nH]c3ccccc13)N(CC(F)(F)F)[C@@H]2c(cc(cc1)OCCNCCCF)c1F Chemical compound C[C@H](Cc1c2[nH]c3ccccc13)N(CC(F)(F)F)[C@@H]2c(cc(cc1)OCCNCCCF)c1F SLTNEYDLIVCLGL-VOIUYBSRSA-N 0.000 description 1
- CGWBNWSADUPPAJ-VOIUYBSRSA-N C[C@H](Cc1c2[nH]c3ccccc13)N(CC(F)(F)F)[C@@H]2c(cc(nc1)OCCNCCCF)c1OC Chemical compound C[C@H](Cc1c2[nH]c3ccccc13)N(CC(F)(F)F)[C@@H]2c(cc(nc1)OCCNCCCF)c1OC CGWBNWSADUPPAJ-VOIUYBSRSA-N 0.000 description 1
- WQRGBGPICCTFCJ-UHFFFAOYSA-N NCCN(CCCF)C(OCc1ccccc1)=O Chemical compound NCCN(CCCF)C(OCc1ccccc1)=O WQRGBGPICCTFCJ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762451971P | 2017-01-30 | 2017-01-30 | |
| US62/451,971 | 2017-01-30 | ||
| US201762523695P | 2017-06-22 | 2017-06-22 | |
| US62/523,695 | 2017-06-22 | ||
| US201762560304P | 2017-09-19 | 2017-09-19 | |
| US62/560,304 | 2017-09-19 | ||
| US201762592485P | 2017-11-30 | 2017-11-30 | |
| US62/592,485 | 2017-11-30 | ||
| PCT/EP2018/052040 WO2018138303A1 (en) | 2017-01-30 | 2018-01-29 | Estrogen receptor modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020505354A JP2020505354A (ja) | 2020-02-20 |
| JP2020505354A5 JP2020505354A5 (enExample) | 2020-11-12 |
| JP6951451B2 true JP6951451B2 (ja) | 2021-10-20 |
Family
ID=61223883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019538615A Active JP6951451B2 (ja) | 2017-01-30 | 2018-01-29 | エストロゲン受容体モジュレーター |
Country Status (35)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102479822B1 (ko) | 2016-02-05 | 2022-12-21 | 인벤티스바이오 엘엘씨 | 선택적 에스트로겐 수용체 분해제 및 이들의 용도 |
| JP7291077B2 (ja) | 2016-12-16 | 2023-06-14 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｊａｋファミリーのキナーゼの低分子阻害物質 |
| JOP20190144A1 (ar) | 2016-12-16 | 2019-06-16 | Janssen Pharmaceutica Nv | إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز |
| TW202016110A (zh) | 2018-06-15 | 2020-05-01 | 比利時商健生藥品公司 | Ｊａｋ激酶家族之小分子抑制劑 |
| TWI915239B (zh) * | 2018-06-21 | 2026-02-11 | 瑞士商赫孚孟拉羅股份公司 | 3-((1r,3r)-1-(2,6-二氟-4-((1-(3-氟丙基)氮雜環丁-3-基)胺基)苯基)-3-甲基-1,3,4,9-四氫-2h-吡啶并[3,4-b]吲哚-2-基)-2,2-二氟丙-1-醇之固體形式及用於製備包含經取代苯基或吡啶基部分之稠合三環化合物之製程，包括其使用方法 |
| US20220370625A1 (en) * | 2019-09-19 | 2022-11-24 | Totus Medicines Inc. | Therapeutic conjugates |
| AU2022233254A1 (en) | 2021-03-11 | 2023-10-26 | Janssen Pharmaceutica Nv | Lorpucitinib for use in the treatment of jak mediated disorders |
| CN115557920B (zh) * | 2022-09-22 | 2024-02-20 | 吉林奥来德光电材料股份有限公司 | 一种发光辅助材料、其制备方法及有机电致发光器件 |
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| JP4555547B2 (ja) | 2000-08-10 | 2010-10-06 | ファイザー イタリア ソシエタ ア レスポンサビリタ リミタータ | キナーゼ阻害剤としての二環式ピラゾール、それらを製造するための方法およびそれらを含む医薬組成物 |
| EP1746157A4 (en) * | 2004-04-27 | 2009-02-18 | Chugai Pharmaceutical Co Ltd | PROCESS FOR PLASMA CELL PROGRAMMING |
| WO2006101434A1 (en) | 2005-03-22 | 2006-09-28 | Astrazeneca Ab | NOVEL TETRAHYDRO-1H-PYRIDO [4,3-b] INDOLE DERIVATIVES AS CB1’ RECEPTOR LIGANDS |
| FR2884252B1 (fr) | 2005-04-08 | 2007-05-18 | Aventis Pharma Sa | Nouveaux derives d'isoindoles, compositions les contenant, leur preparation et leurs utilisations pharmaceutiques notamment en tant qu'inhibiteurs d'activites de la proteine chaperone hsp90 |
| AR058223A1 (es) | 2005-11-25 | 2008-01-23 | Palau Pharma Sa | Un comuesto de derivados de pirazoloisoquinolina, un procedimiento para l a preparacion de dicho compuesto y una composicion farmaceutica que comprende dicho compuesto |
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| HUE052510T2 (hu) | 2009-05-27 | 2021-05-28 | Ptc Therapeutics Inc | Módszerek a rák és a nem daganatos állapotok kezelésére |
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| HUE033581T2 (hu) | 2010-06-10 | 2017-12-28 | Seragon Pharmaceuticals Inc | Ösztrogén receptor modulátorok és alkalmazásaik |
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| CN107406424B (zh) | 2014-12-18 | 2020-08-25 | 豪夫迈·罗氏有限公司 | 雌激素受体调节剂及其用途 |
| JP2017538727A (ja) | 2014-12-18 | 2017-12-28 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 癌の治療に有用な２，３−ジフェニルクロメンの誘導体 |
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| CN106518768B (zh) | 2015-09-15 | 2021-07-02 | 江苏恒瑞医药股份有限公司 | 丙烯酸类衍生物、其制备方法及其在医药上的应用 |
| DK3355884T3 (da) | 2015-10-01 | 2021-08-02 | Olema Pharmaceuticals Inc | Tetrahydro-1h-pyrido[3,4-b]indol-antiøstrogenlægemidler |
| CN108349952A (zh) | 2015-11-09 | 2018-07-31 | 豪夫迈·罗氏有限公司 | 四氢萘雌激素受体调节剂及其用途 |
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| JP7291077B2 (ja) | 2016-12-16 | 2023-06-14 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｊａｋファミリーのキナーゼの低分子阻害物質 |
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| GEP20207202B (en) | 2017-01-30 | 2020-12-25 | Chiesi Farm Spa | Tyrosine amide derivatives as rho-kinase inhibitors |
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2018
- 2018-01-29 EP EP19203383.5A patent/EP3689873B1/en active Active
- 2018-01-29 MA MA052555A patent/MA52555A/fr unknown
- 2018-01-29 DK DK18705097.6T patent/DK3494116T3/da active
- 2018-01-29 MX MX2019008438A patent/MX2019008438A/es unknown
- 2018-01-29 AU AU2018211495A patent/AU2018211495B2/en active Active
- 2018-01-29 PL PL18705097T patent/PL3494116T3/pl unknown
- 2018-01-29 WO PCT/EP2018/052040 patent/WO2018138303A1/en not_active Ceased
- 2018-01-29 LT LTEP18705097.6T patent/LT3494116T/lt unknown
- 2018-01-29 PT PT187050976T patent/PT3494116T/pt unknown
- 2018-01-29 JP JP2019538615A patent/JP6951451B2/ja active Active
- 2018-01-29 MY MYPI2019004298A patent/MY196317A/en unknown
- 2018-01-29 JO JOP/2019/0183A patent/JOP20190183B1/ar active
- 2018-01-29 TW TW107103088A patent/TWI794205B/zh active
- 2018-01-29 SI SI201830022T patent/SI3494116T1/sl unknown
- 2018-01-29 CR CR20190379A patent/CR20190379A/es unknown
- 2018-01-29 UA UAA201909412A patent/UA125043C2/uk unknown
- 2018-01-29 US US15/881,962 patent/US10221173B2/en active Active
- 2018-01-29 RS RS20200018A patent/RS59770B1/sr unknown
- 2018-01-29 PE PE2019001434A patent/PE20191500A1/es unknown
- 2018-01-29 CN CN201880008715.8A patent/CN110214140B/zh active Active
- 2018-01-29 TN TNP/2020/000009A patent/TN2020000009A1/en unknown
- 2018-01-29 ES ES19203383T patent/ES2931320T3/es active Active
- 2018-01-29 HU HUE18705097A patent/HUE047761T2/hu unknown
- 2018-01-29 EP EP18705097.6A patent/EP3494116B1/en active Active
- 2018-01-29 KR KR1020197025253A patent/KR102246668B1/ko active Active
- 2018-01-29 ES ES18705097T patent/ES2766249T3/es active Active
- 2018-01-29 SG SG11201906767XA patent/SG11201906767XA/en unknown
- 2018-01-29 SM SM20200010T patent/SMT202000010T1/it unknown
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2019
- 2019-01-31 US US16/263,683 patent/US10590132B2/en active Active
- 2019-07-15 CL CL2019001991A patent/CL2019001991A1/es unknown
- 2019-07-16 DO DO2019000183A patent/DOP2019000183A/es unknown
- 2019-07-17 ZA ZA2019/04696A patent/ZA201904696B/en unknown
- 2019-07-25 IL IL268263A patent/IL268263B/en unknown
- 2019-07-26 PH PH12019501724A patent/PH12019501724A1/en unknown
- 2019-07-26 NI NI201900080A patent/NI201900080A/es unknown
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