AU2018211495B2 - Estrogen receptor modulators - Google Patents
Estrogen receptor modulators Download PDFInfo
- Publication number
- AU2018211495B2 AU2018211495B2 AU2018211495A AU2018211495A AU2018211495B2 AU 2018211495 B2 AU2018211495 B2 AU 2018211495B2 AU 2018211495 A AU2018211495 A AU 2018211495A AU 2018211495 A AU2018211495 A AU 2018211495A AU 2018211495 B2 AU2018211495 B2 AU 2018211495B2
- Authority
- AU
- Australia
- Prior art keywords
- compound
- formula
- indol
- pyrido
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CC*(*)CNC*(*)C*C(CCCCC1)CCCCC1[C@@]1(C)N(*)C(*)(*)Cc(c2c3)c1[n]c2ccc3F Chemical compound CC*(*)CNC*(*)C*C(CCCCC1)CCCCC1[C@@]1(C)N(*)C(*)(*)Cc(c2c3)c1[n]c2ccc3F 0.000 description 16
- RDUKJIDJNWKKSO-UHFFFAOYSA-N CCC(C)(CC)CC(F)(F)F Chemical compound CCC(C)(CC)CC(F)(F)F RDUKJIDJNWKKSO-UHFFFAOYSA-N 0.000 description 3
- NYUQPKXMLAWWRX-UHFFFAOYSA-N CCC(C)(CC)C(C)(C(O)=O)F Chemical compound CCC(C)(CC)C(C)(C(O)=O)F NYUQPKXMLAWWRX-UHFFFAOYSA-N 0.000 description 2
- QLBHDBFCAUAREV-DORSKGMSSA-N CC(C)[SH-]OCCOc(cc1)c(C)c([C@H]2N(C[C@H](C)C(OC)=O)[C@H](C)Cc3c2[nH]c2ccccc32)c1F Chemical compound CC(C)[SH-]OCCOc(cc1)c(C)c([C@H]2N(C[C@H](C)C(OC)=O)[C@H](C)Cc3c2[nH]c2ccccc32)c1F QLBHDBFCAUAREV-DORSKGMSSA-N 0.000 description 1
- JVRXCVYOVSBWAK-UHFFFAOYSA-N CCC(C)(CC)CC(C)(C(O)=O)F Chemical compound CCC(C)(CC)CC(C)(C(O)=O)F JVRXCVYOVSBWAK-UHFFFAOYSA-N 0.000 description 1
- AKDPHHHAPPNSJY-UHFFFAOYSA-N CCC(C)(CC)CC(C)(COC)F Chemical compound CCC(C)(CC)CC(C)(COC)F AKDPHHHAPPNSJY-UHFFFAOYSA-N 0.000 description 1
- UUAKUWRKQHYEHC-UHFFFAOYSA-N CCC(C)(CC)CC(CF)(F)F Chemical compound CCC(C)(CC)CC(CF)(F)F UUAKUWRKQHYEHC-UHFFFAOYSA-N 0.000 description 1
- QKELOGLRWAAFPI-UHFFFAOYSA-N CCC(C)(CC)CC(CO)C(F)=C Chemical compound CCC(C)(CC)CC(CO)C(F)=C QKELOGLRWAAFPI-UHFFFAOYSA-N 0.000 description 1
- OMERCSXDJFGWMN-UHFFFAOYSA-N CCC(C)(CC)CC(COC)(F)F Chemical compound CCC(C)(CC)CC(COC)(F)F OMERCSXDJFGWMN-UHFFFAOYSA-N 0.000 description 1
- WZSAEKNDTHWGEE-UHFFFAOYSA-N CCC(C)(CC)CC(COC)C(F)F Chemical compound CCC(C)(CC)CC(COC)C(F)F WZSAEKNDTHWGEE-UHFFFAOYSA-N 0.000 description 1
- MGJHVNHYIFTLOM-JTQLQIEISA-N CCC(C)(CC)C[C@@](C)(CO)F Chemical compound CCC(C)(CC)C[C@@](C)(CO)F MGJHVNHYIFTLOM-JTQLQIEISA-N 0.000 description 1
- DOHVYJNPEWBYMP-HGKLBZFMSA-N C[C@H](CC1c2ccccc2NC11)N(CC(F)F)[C@@H]1c(cc(cc1)Br)c1OC Chemical compound C[C@H](CC1c2ccccc2NC11)N(CC(F)F)[C@@H]1c(cc(cc1)Br)c1OC DOHVYJNPEWBYMP-HGKLBZFMSA-N 0.000 description 1
- IJFJBADDIDNRKA-GBYZOUOMSA-N C[C@H](CN([C@H](C)Cc(c1c2)c3[nH]c1ccc2F)[C@@H]3c(c(C)c(cc1)OCCNCCC(C)F)c1F)C(OC)=O Chemical compound C[C@H](CN([C@H](C)Cc(c1c2)c3[nH]c1ccc2F)[C@@H]3c(c(C)c(cc1)OCCNCCC(C)F)c1F)C(OC)=O IJFJBADDIDNRKA-GBYZOUOMSA-N 0.000 description 1
- OTBYGSVELWVBBB-VOIUYBSRSA-N C[C@H](Cc1c2[nH]c3ccc(C)cc13)N(CC(CO)(F)F)[C@@H]2c(c(F)c(nc1)OCCNCCCF)c1F Chemical compound C[C@H](Cc1c2[nH]c3ccc(C)cc13)N(CC(CO)(F)F)[C@@H]2c(c(F)c(nc1)OCCNCCCF)c1F OTBYGSVELWVBBB-VOIUYBSRSA-N 0.000 description 1
- QDODXVUFTOFXMM-ONOMSOESSA-N C[C@H](Cc1c2[nH]c3ccccc13)N(CC(CO)(F)F)[C@@H]2c(cc(cc1)OCCN(CCCF)C(OC(C)(C)C)=O)c1OC Chemical compound C[C@H](Cc1c2[nH]c3ccccc13)N(CC(CO)(F)F)[C@@H]2c(cc(cc1)OCCN(CCCF)C(OC(C)(C)C)=O)c1OC QDODXVUFTOFXMM-ONOMSOESSA-N 0.000 description 1
- IBEAYWAIRITAHH-XUSGNXJCSA-N C[C@H](Cc1c2[nH]c3ccccc13)N(CC(F)(F)F)[C@@H]2c(c(F)c(cc1)[Br]=C)c1OC Chemical compound C[C@H](Cc1c2[nH]c3ccccc13)N(CC(F)(F)F)[C@@H]2c(c(F)c(cc1)[Br]=C)c1OC IBEAYWAIRITAHH-XUSGNXJCSA-N 0.000 description 1
- LCHNMPCOYQHBTK-WHLCRQNOSA-N C[C@H](Cc1c2[nH]c3ccccc13)N(CC(F)(F)F)[C@@H]2c(c(OC)ccc1OCCN(CCCF)C(OC(C)(C)C)=O)c1F Chemical compound C[C@H](Cc1c2[nH]c3ccccc13)N(CC(F)(F)F)[C@@H]2c(c(OC)ccc1OCCN(CCCF)C(OC(C)(C)C)=O)c1F LCHNMPCOYQHBTK-WHLCRQNOSA-N 0.000 description 1
- GVYANZIKBFFPNF-NSPYISDASA-N C[C@H](Cc1c2[nH]c3ccccc13)N(CC(F)(F)F)[C@@H]2c(cc(nc1)Cl)c1OC Chemical compound C[C@H](Cc1c2[nH]c3ccccc13)N(CC(F)(F)F)[C@@H]2c(cc(nc1)Cl)c1OC GVYANZIKBFFPNF-NSPYISDASA-N 0.000 description 1
- TVCMTFASVLFLHP-PIIWDFAUSA-N C[C@H](Cc1c2[nH]c3ccccc13)N(CC(F)(F)F)[C@@H]2c1cc(OCCN(CCCF)C(OC(C)(C)C)=O)ccc1OC Chemical compound C[C@H](Cc1c2[nH]c3ccccc13)N(CC(F)(F)F)[C@@H]2c1cc(OCCN(CCCF)C(OC(C)(C)C)=O)ccc1OC TVCMTFASVLFLHP-PIIWDFAUSA-N 0.000 description 1
- BCTHEWIGUGNARR-GFCCVEGCSA-N C[C@H](Cc1c[nH]c2ccc(C)cc12)NCCC(OC)=O Chemical compound C[C@H](Cc1c[nH]c2ccc(C)cc12)NCCC(OC)=O BCTHEWIGUGNARR-GFCCVEGCSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762451971P | 2017-01-30 | 2017-01-30 | |
| US62/451,971 | 2017-01-30 | ||
| US201762523695P | 2017-06-22 | 2017-06-22 | |
| US62/523,695 | 2017-06-22 | ||
| US201762560304P | 2017-09-19 | 2017-09-19 | |
| US62/560,304 | 2017-09-19 | ||
| US201762592485P | 2017-11-30 | 2017-11-30 | |
| US62/592,485 | 2017-11-30 | ||
| PCT/EP2018/052040 WO2018138303A1 (en) | 2017-01-30 | 2018-01-29 | Estrogen receptor modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2018211495A1 AU2018211495A1 (en) | 2019-09-12 |
| AU2018211495B2 true AU2018211495B2 (en) | 2020-05-21 |
Family
ID=61223883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2018211495A Active AU2018211495B2 (en) | 2017-01-30 | 2018-01-29 | Estrogen receptor modulators |
Country Status (35)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2842579T3 (es) | 2016-02-05 | 2021-07-14 | Inventisbio Llc | Degradadores de los receptores de estrógenos selectivos y sus usos |
| JOP20190144A1 (ar) | 2016-12-16 | 2019-06-16 | Janssen Pharmaceutica Nv | إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز |
| RS63500B1 (sr) | 2016-12-16 | 2022-09-30 | Janssen Pharmaceutica Nv | Jedinjenja imidazo[4,5-d]pirolo[2,3-b]piridina kao inhibitori janus kinaza |
| TW202016110A (zh) | 2018-06-15 | 2020-05-01 | 比利時商健生藥品公司 | Ｊａｋ激酶家族之小分子抑制劑 |
| US20220370625A1 (en) * | 2019-09-19 | 2022-11-24 | Totus Medicines Inc. | Therapeutic conjugates |
| KR20230156752A (ko) | 2021-03-11 | 2023-11-14 | 얀센 파마슈티카 엔브이 | Jak 매개 장애의 치료에 사용하기 위한 로르푸시티닙 |
| CN115557920B (zh) * | 2022-09-22 | 2024-02-20 | 吉林奥来德光电材料股份有限公司 | 一种发光辅助材料、其制备方法及有机电致发光器件 |
Citations (4)
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| US20120157402A1 (en) * | 2009-05-27 | 2012-06-21 | Liangxian Cao | Methods for treating brain tumors |
| US20140357661A1 (en) * | 2013-05-28 | 2014-12-04 | Astrazeneca Ab | Chemical compounds |
| US20160175289A1 (en) * | 2014-12-18 | 2016-06-23 | Genentech, Inc. | TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF |
| WO2018019793A1 (en) * | 2016-07-25 | 2018-02-01 | Astrazeneca Ab | N-(2-(4-((1r,3r)-3-methyl-2,3,4,9-tetrahydro-1h-pyrido[3,4-b]indol-1-yl)phenoxy)ethyl)propan-1-amine derivatives and related compounds as selective down-regulators of the estrogen receptor for treating cancer |
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| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| ATE480539T1 (de) | 2000-08-10 | 2010-09-15 | Pfizer Italia Srl | Bizyklische pyrazole wirksam als kinase inhibitoren, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen |
| WO2005111208A1 (ja) * | 2004-04-27 | 2005-11-24 | Chugai Seiyaku Kabushiki Kaisha | プラズマ細胞の増殖方法 |
| WO2006101434A1 (en) | 2005-03-22 | 2006-09-28 | Astrazeneca Ab | NOVEL TETRAHYDRO-1H-PYRIDO [4,3-b] INDOLE DERIVATIVES AS CB1’ RECEPTOR LIGANDS |
| FR2884252B1 (fr) | 2005-04-08 | 2007-05-18 | Aventis Pharma Sa | Nouveaux derives d'isoindoles, compositions les contenant, leur preparation et leurs utilisations pharmaceutiques notamment en tant qu'inhibiteurs d'activites de la proteine chaperone hsp90 |
| AR058223A1 (es) | 2005-11-25 | 2008-01-23 | Palau Pharma Sa | Un comuesto de derivados de pirazoloisoquinolina, un procedimiento para l a preparacion de dicho compuesto y una composicion farmaceutica que comprende dicho compuesto |
| JP2010505961A (ja) | 2006-10-09 | 2010-02-25 | タケダ サン ディエゴ インコーポレイテッド | キナーゼ阻害剤 |
| WO2010138695A1 (en) | 2009-05-27 | 2010-12-02 | Ptc Therapeutics, Inc. | Methods for treating neurofibromatosis |
| PL2434891T3 (pl) | 2009-05-27 | 2020-12-28 | Ptc Therapeutics, Inc. | Sposoby leczenia nowotworu złośliwego i stanów nienowotworowych |
| HRP20170786T1 (hr) | 2010-06-10 | 2017-08-11 | Seragon Pharmaceuticals, Inc. | Modulatori estrogenskog receptora i njihove uporabe |
| US8853423B2 (en) | 2010-06-17 | 2014-10-07 | Seragon Pharmaceuticals, Inc. | Indane estrogen receptor modulators and uses thereof |
| MX357496B (es) | 2011-12-14 | 2018-07-11 | Seragon Pharmaceuticals Inc | Moduladores del receptor de estrógenos fluorados y sus usos. |
| UA117249C2 (uk) | 2013-06-19 | 2018-07-10 | Серагон Фармасьютікалз, Інк. | Модулятор рецептора естрогену та його застосування |
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| EP3233828B1 (en) | 2014-12-18 | 2020-03-04 | F. Hoffmann-La Roche AG | Estrogen receptor modulators and uses thereof |
| JP2017538727A (ja) | 2014-12-18 | 2017-12-28 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 癌の治療に有用な２，３−ジフェニルクロメンの誘導体 |
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| WO2016189011A1 (en) | 2015-05-26 | 2016-12-01 | F. Hoffmann-La Roche Ag | Heterocyclic estrogen receptor modulators and uses thereof |
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| HUE055321T2 (hu) | 2015-10-01 | 2021-11-29 | Olema Pharmaceuticals Inc | Tetrahidro-1H-pirido[3,4-b]indol anti-ösztrogén hatóanyagok |
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| JP7241542B2 (ja) | 2016-04-08 | 2023-03-17 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | テトラヒドロイソキノリン エストロゲン受容体モジュレーター及びその使用 |
| US10125135B2 (en) | 2016-04-20 | 2018-11-13 | Astrazeneca Ab | Chemical compounds |
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| CN109415361B (zh) | 2016-06-29 | 2022-03-08 | 浙江海正药业股份有限公司 | 丙烯酸类衍生物及其制备方法和其在医药上的用途 |
| CN107814798B (zh) | 2016-09-14 | 2020-11-03 | 四川科伦博泰生物医药股份有限公司 | 3-取代丙烯酸类化合物及其制备方法和用途 |
| CA3087528C (en) | 2016-09-15 | 2024-01-30 | Arvinas, Inc. | Indole derivatives as estrogen receptor degraders |
| JP6744489B2 (ja) | 2016-10-24 | 2020-08-19 | アストラゼネカ・アクチエボラーグＡｓｔｒａｚｅｎｅｃａ Ａｋｔｉｅｂｏｌａｇ | 癌の治療において有用な６，７，８，９−テトラヒドロ−３Ｈ−ピラゾロ［４，３−ｆ］イソキノリン誘導体 |
| BR102016024814A2 (pt) | 2016-10-24 | 2018-05-08 | Aché Laboratórios Farmacêuticos S.A. | composto, processo de obtenção do composto, composição farmacêutica, uso do composto e método de tratamento de desordens psiquiátricas e/ou distúrbios do sono |
| JOP20190144A1 (ar) | 2016-12-16 | 2019-06-16 | Janssen Pharmaceutica Nv | إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز |
| TWI831738B (zh) | 2016-12-16 | 2024-02-11 | 美商瑞塔醫藥有限責任公司 | 用於抑制ＲＯＲγ及其他用途的嘧啶三環烯酮衍生物 |
| RS63500B1 (sr) | 2016-12-16 | 2022-09-30 | Janssen Pharmaceutica Nv | Jedinjenja imidazo[4,5-d]pirolo[2,3-b]piridina kao inhibitori janus kinaza |
| HUE052067T2 (hu) | 2016-12-16 | 2021-04-28 | Lilly Co Eli | Mutáns IDH1 és mutáns IDH2 inhibitor 7-feniletilamino-4H-pirimido[4,5-d][1,3]oxazin-2-on vegyületek |
| CN110291072A (zh) | 2016-12-16 | 2019-09-27 | 巴斯夫欧洲公司 | 农药化合物 |
| UA122035C2 (uk) | 2016-12-16 | 2020-08-25 | Пфайзер Інк. | Агоністи рецептора glp-1 та їх застосування |
| BR112019015707A2 (pt) | 2017-01-30 | 2020-03-24 | Chiesi Farmaceutici S.P.A. | Composto, composição farmacêutica. uso de um composto, combinação de um composto e dispositivo |
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2018
- 2018-01-29 JO JOP/2019/0183A patent/JOP20190183B1/ar active
- 2018-01-29 MA MA052555A patent/MA52555A/fr unknown
- 2018-01-29 CN CN201880008715.8A patent/CN110214140B/zh active Active
- 2018-01-29 US US15/881,962 patent/US10221173B2/en active Active
- 2018-01-29 LT LTEP18705097.6T patent/LT3494116T/lt unknown
- 2018-01-29 EP EP18705097.6A patent/EP3494116B1/en active Active
- 2018-01-29 HU HUE18705097A patent/HUE047761T2/hu unknown
- 2018-01-29 EP EP19203383.5A patent/EP3689873B1/en active Active
- 2018-01-29 ES ES18705097T patent/ES2766249T3/es active Active
- 2018-01-29 AU AU2018211495A patent/AU2018211495B2/en active Active
- 2018-01-29 RS RS20200018A patent/RS59770B1/sr unknown
- 2018-01-29 JP JP2019538615A patent/JP6951451B2/ja active Active
- 2018-01-29 MX MX2019008438A patent/MX2019008438A/es unknown
- 2018-01-29 ES ES19203383T patent/ES2931320T3/es active Active
- 2018-01-29 KR KR1020197025253A patent/KR102246668B1/ko active Active
- 2018-01-29 MY MYPI2019004298A patent/MY196317A/en unknown
- 2018-01-29 SG SG11201906767XA patent/SG11201906767XA/en unknown
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