JP6948339B2 - 糖類を全くまたはほとんど含有しない安定した乾燥組成物 - Google Patents
糖類を全くまたはほとんど含有しない安定した乾燥組成物 Download PDFInfo
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- JP6948339B2 JP6948339B2 JP2018548644A JP2018548644A JP6948339B2 JP 6948339 B2 JP6948339 B2 JP 6948339B2 JP 2018548644 A JP2018548644 A JP 2018548644A JP 2018548644 A JP2018548644 A JP 2018548644A JP 6948339 B2 JP6948339 B2 JP 6948339B2
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Description
ビフィドバクテリウム属の濃縮培養物を10%(w/w)のトレハロースと共に液体窒素に入れ、急速凍結した。得られた凍結粒子(ビーズ)を加熱することなく完全真空下で48時間凍結乾燥し、乾燥物にした。乾燥物の初期生存能は11.63 log CFU/gであった。この乾燥物の試料を、40℃、33%RHの加速安定性負荷条件に置いたところ、14日後には1.46 log unit/g、28日後には3.17 log unit/gまで、生存能が低下した。これらの結果は、生存微生物および唯一の凍結保護物質としてトレハロースを含有する乾燥試料が、元来不安定であることを示す。
本発明に係る乾燥プロバイオティクス組成物を製造した。加水分解エンドウタンパク質(75g、Friesland Capina Doma、Paramus、NJ)を75℃の温かい蒸留水100mLに溶解した。得られたエンドウ溶液の水素イオン濃度を20%の濃縮NaOH溶液を用いてpH8.5に調整した。ローカストビーンガム(3g、Tic gum、Belcamp、MD)、イヌリン(7%の糖を含有するインスタントイヌリン17g、Cargill Minneapolis、MN)およびアスコルビン酸ナトリウム(5g、Sigma)を乾燥物のまま混合し、羽根車式ミキサーにより700rpmでエンドウ溶液を攪拌しながら、そのエンドウ溶液に加えた。攪拌しながら、得られた混合液を冷却し、35℃〜40℃に維持した。
実施例1の乾燥プロバイオティクス製品および実施例2の乾燥プロバイオティクス組成物をそれぞれマルトデキストリンと等量(1:1の比)で混合し、加速化貯蔵条件下の防湿庫(デシケーター)に置いた。試料を定期的に採取し、標準微生物希釈液およびLMRS寒天のプレーティング手順を用いて細菌のCFU評価を行った。
二糖類のラクトースが本発明に係る乾燥プロバイオティクス組成物の安定性に及ぼす影響を評価した。実施例2に記載の方法により、乾燥物成分と凍結ビフィドバクテリウム属プロバイオティクス細菌(120g、細菌固形物10%(w/w)を含有)とを混合することによって5つの乾燥組成物を製造した。乾燥物成分には、ラクトースの量を増加させ、それに比例して加水分解エンドウタンパク質の量を減少させたものを含めた。その後、実施例3に記載の方法により安定性の試験を行った。
カルボン酸塩、アスコルビン酸ナトリウムおよびクエン酸ナトリウムが本発明に係る乾燥プロバイオティクス組成物の安定性に及ぼす影響を評価した。実施例2に記載の方法により、乾燥物成分と凍結ビフィドバクテリウム属プロバイオティクス細菌(120g、細菌固形物10%(w/w)を含有)とを混合することによって6つの乾燥組成物を製造した。乾燥物成分には、アスコルビン酸ナトリウム(組成物3〜5)、クエン酸ナトリウム(組成物6)およびビタミンE(組成物2〜4)を含めた。その後、実施例3に記載の方法により安定性の試験を行った。
オリゴ糖、イヌリン、短鎖オリゴ糖およびガンマシクロデキストリンが本発明に係る乾燥プロバイオティクス組成物の安定性に及ぼす影響を評価した。カゼイン加水分解物(DMV internationalAmersfoort、the Netherlands)を75g、シクロデキストリン(Wacker、Munchen、Germany)、イヌリン(糖類7%を含有するインスタントイヌリン、Cargill Minneapolis、MN)または短鎖オリゴ糖(糖類5%を含有するOrafti P−95、Beneo、Tienen、Belgium)を17g、アラビアゴム(Tic gum、Belcamp、MD)を3g、およびクエン酸ナトリウムとアスコルビン酸ナトリウムとの混合物(1:1(w/w)、Sigma)を5g含有する組成物を、実施例2に記載の方法により製造した。続いて、実施例3に記載の方法により安定性の試験を行った。短鎖オリゴ糖を用いて製造した乾燥組成物は、単糖類および/または二糖類を1%(w/w)未満含んでいた。これらの組成物はすべて、初期生存能(log unit CFU/g)が11.2〜11.3 log CFU/gであり、40℃、33%RHで3か月後の生存能の低下量が0.43〜0.66 log CFU/gであった。
多糖類、ローカストビーンガム、アラビアゴム、カラギーナンおよびアルギン酸が本発明に係る乾燥プロバイオティクス組成物の安定性に及ぼす影響を評価した。カゼイン加水分解物(DMV internationalAmersfoort、the Netherlands)を75g、シクロデキストリン(Wacker、Munchen、Germany)を17g、アラビアゴム(Tic gum、Belcamp、MD)、ローカストビーンガム(Tic gum、Belcamp、MD)、アルギン酸(FMC BioPolymer、Philadelphia、PA)またはカラゲナン(Tic gum、Belcamp、MD)を3g、およびクエン酸ナトリウムとアスコルビン酸ナトリウムとの混合物(1:1(w/w)、Sigma)を5g含有する組成物を、実施例2に記載の方法により製造した。続いて、実施例3に記載の方法により安定性試験を行った。これらの組成物はすべて、初期生存能(log unit CFU/g)が11.2〜11.3 log CFU/gであり、40℃、33%RHで3か月後の生存能の低下量が0.46〜0.81 log CFU/gであった。
タンパク質源、エンドウタンパク質加水分解物、カゼイン加水分解物、およびコムギタンパク質加水分解物が本発明に係る乾燥プロバイオティクス組成物の安定性に及ぼす影響を評価した。カゼイン加水分解物(DMV international Amersfoort、the Netherlands)、コムギ加水分解物(Marcor Development Corp.、Carlstadt、NJ)またはエンドウタンパク質加水分解物(Friedsland Campina Domo、Paramus、NJ)を65g、シクロデキストリン(Wacker、Munchen Germany)を27g、アラビアゴム(Tic gum、Belcamp、MD)を3g、およびビタミンEとアスコルビン酸ナトリウムとの混合物(4:1(w/w)、Sigma)を5g含有する組成物を実施例2に記載の方法により製造した。また、ダイズ加水分解物(Sigma)を75g、イヌリン(糖類7%を含有するインスタントイヌリン、Cargill Minneapolis、MN)を17g、ローカストビーンガム(Tic gum、Belcamp、MD)、アルギン酸(FMC BioPolymer、Philadelphia、PA)またはカラギーナン(Tic gum、Belcamp、MD)を3g、およびクエン酸ナトリウムとアスコルビン酸ナトリウムとの混合物(1:1(w/w)、Sigma)を5g含有する組成物を実施例2に記載の方法により製造した。続いて、実施例3に記載の方法により安定性試験を行った。
様々なプロバイオティクス細菌、L.アシドフィルスおよびビフィドバクテリウム属細菌について、本発明に係る乾燥プロバイオティクス組成物における安定性を評価した。エンドウタンパク質加水分解物(Friedsland Campina Domo、Paramus、NJ)を75g、イヌリン(Cargill Minneapolis、MN)を17g、ローカストビーンガム(Tic gum、Belcamp、MD)を3g、クエン酸ナトリウムとアスコルビン酸ナトリウムとの混合物(1:1(w/w)、Sigma)を5g含有する組成物を実施例2に記載の方法により製造した。続いて、実施例3に記載の方法により安定性試験を行った。L.アシドフィルス組成物の初期生存能(log unit CFU/g)は、10.57 log CFU/gであり、40℃、33%RHで3か月後の生存能の低下量は0.64 log unit/gであった。ビフィドバクテリウム属細菌組成物の初期生存能(log unit CFU/g)は、11.11 log CFU/gであり、40℃、33%RHで3か月後の生存能の低下量は0.41 log unit/gであった。
実施例2に従って、生きたビフィドバクテリウム属細菌を含有する安定した乾燥組成物を製造し、粒径50〜250μmになるまでふるいにかけた。粒径50μm〜250μmの乾燥組成物粒子0.1gを、Gerber Good Start(Nestle Infant Nutrition、Florham Park、NJ)19.9gと混合して、プロバイオティクス細菌を含有する乳児用調製粉乳を製造した。最終製品は、8.03 log CFU/gのビフィドバクテリウム属細菌を含有していた。プロバイオティクス乳児用調製粉乳を未開封の180ccのHDPEボトルに詰め、25℃および40℃に制御された温度環境に曝した。ボトルの内部の水分活性は0.2Awであった。9か月間、または測定結果が1 log CFU/g未満に減少するまで、毎月、微生物の安定性を測定した。乳児用調製粉乳中のビフィドバクテリウム属細菌の生存能の低下量は、25℃で貯蔵したときは0.09 log CFU/gであり、40℃で貯蔵したときは0.82 log CFU/gであった。
実施例2に従って、ラクトバチルス アシドフィルスを含有する安定した乾燥組成物を製造し、錠剤、カプレットまたはカプセル等の経口剤形に製剤化する。圧縮剤(ブドウ糖)19.9gおよび粒径が50μm〜250μmの乾燥組成物粒子0.1gを含有するオレンジ味の錠剤を、1/2”round standard concave toolingを用いてロータリー打錠機で直接圧縮することによって調製する。最終製品は、約5E+8CFU/単位用量を含有する。錠剤の硬度は8〜10kpであり、分解時間は約20秒である。圧縮した錠剤は、100錠ずつ180ccのHDPEボトルに詰め、40℃、33%RHに制御された温湿度環境に曝す。12ヶ月間、または測定結果が1E+6CFU/単位用量未満に減少するまで、毎月、微生物の安定性を測定する。
実施例2に従って、ラクトバチルス アシドフィルスを含有する安定した乾燥組成物を製造する。そして、重量%で、ショ糖71%、マルトデキストリン14%、イヌリン10%、ブドウ糖2%、無水クエン酸1%、アラビアゴム0.3%、香料0.3%、リン酸三カルシウム0.3%、および粒径50μm〜250μmの乾燥プロバイオティクス組成物(L アシドフィルス)0.1重量%を含有する乾燥混合物をつくる。最終製品は、約1E+9CFU/単位用量(乾燥混合物30g)を含有する。製品はアルミ箔製の小袋に詰め(1単位用量/袋)、340mLの水に攪拌して飲用に供する。プロバイオティクスを含有する飲料用乾燥混合物について、12ヶ月間、または測定結果が1E+7CFU/単位用量未満に減少するまで、毎月、微生物の安定性を測定する。
実施例2の記載に従って、プロバイオティクスL.カゼイを含有する乾燥粉末10gを製造する。錠剤にするために、乾燥した安定プロバイオティクス組成物(100mg)をステアリン酸マグネシウム2%(w/w)および親水性ヒュームドシリカ2%(w/w)(AEROSIL(登録商標)200、Evonik Industries)を含有する市販のマルチビタミン粉末400mg(Centrum(登録商標)、Pfizer)と混合し、(1/2”錠剤直径容器を使用して)小型の錠剤プレス装置で圧縮する。各錠剤は、約1E+7CFU/錠剤を含有する。錠剤は、100錠ずつ180ccのHDPEボトルに詰め、40℃、33%RHに制御された温湿度環境に曝す。このボトルについて、12ヶ月間、または測定結果が1E+6CFU/単位用量未満に減少するまで、毎月、微生物の安定性を測定する。
実施例2に従って、根圏細菌(Rizobacteria)のような生物学的制御剤を乾燥組成物の形態で製造する。1E+6CFU/種子の用量で、乾燥組成物粉末により被覆したダイズで、乾燥根圏細菌組成物の有効性を評価する。被覆した種子を紙袋に詰め、室温(23〜25℃)で保管する。この紙袋について、12ヶ月間、または測定結果が1E+5CFU/単位用量未満に減少するまで、毎月、微生物の安定性を測定する。
市販のペレット状のイヌ用ペットフードを水分活性が0.1になるまでコンベクションオーブンで乾燥し、実施例2の記載に従って製造した安定したL.アシドフィルス乾燥組成物で被覆する。乾燥ペレットに、約5%の脂肪を基剤とする水分バリア(鶏脂40%、ココアバター40%および蜜蝋20%の混合物)を噴霧し、ドラムタンブラーで、乾燥粉末製剤(通常、ペットフード総量の0.1〜0.5%。当該量で1E+8CFU/g用量となる)と混合し、最後に、脂肪を基剤とする水分バリアを追加して噴霧し、被覆する。被覆物の総量は(ペットフードの)約15%である。被覆時間は約30分である。
本発明に係るペレット状の魚用プロバイオティクス飼料をいくつかのプロバイオティクス混合物を用いて製造する。実施例2に記載の方法により、L.ラムノサス、L.アシドフィルスおよびビフィドバクテリウム ラクティスの混合物を含有する、安定した乾燥プロバイオティクス組成物を製造する。まずサケ用の市販のスターター飼料(Zeigler Bros.、Gardners、PA)を水分活性が0.1になるまでコンベクションオーブンで乾燥し、その後、ドラムタンブラーでプロバイオティクス組成物を被覆する。最初に、飼料ペレット(1000g)に、約5重量%の脂肪を基剤とする水分バリア(魚油40%、ココアバター40%および蜜蝋20%の混合物)を噴霧し、安定した乾燥プロバイオティクス組成物1g(1E+7CFU/g飼料の用量となる)と混合し、最後に脂肪を基剤とする水分バリアを追加して噴霧し、被覆する。被覆物の総量は(魚用飼料の)約10%である。
実施例2に記載の方法により製造した安定した乾燥L.アシドフィルス組成物を1部、および、コーン油等の植物油を2部含有する油混合物3%を、市販の肉食牛用またはニワトリ用飼料約500gに、ドラムタンブラーでトップコートする。プロバイオティクス細菌のCFU数は約lE+9/g飼料となる。被覆した飼料を、40℃、相対湿度43%のチャンバーに置く。係る極端な条件で14日間貯蔵した後のプロバイオティクス細菌の生存能の低下量は、最初のCFU数の1 log unit未満であると予想される。プロバイオティクスを被覆した別の飼料を30℃、相対湿度33%のチャンバーに置く。当該条件で6ヶ月間貯蔵した後のプロバイオティクス細菌の生存能の低下量は、最初のCFU数の1 log unit未満であると予想される。
実施例2に記載の方法により、生きたファージを含有する安定組成物10gを製造する。乾燥した生存ファージ組成物を魚油20gと混合し、得られた懸濁液をティラピア飼料ペレット1kgに被覆する。被覆した飼料を典型的な倉庫の貯蔵条件で保管する。魚餌中のファージの生存能は、本発明に係る組成物および方法を使用すると、高湿度の非冷蔵保管条件に14日間曝されても維持されると予想される。
Claims (24)
- 1または複数の生存微生物、少なくとも50重量%の1または複数の加水分解タンパク質、1または複数のカルボン酸塩、ならびに5重量%未満の1または複数の糖類を含む乾燥組成物であって、前記糖類は単糖類、二糖類およびその組合せからなる群から選択されるものであり、前記加水分解タンパク質は、加水分解乳タンパク質、加水分解エンドウタンパク質、加水分解ダイズタンパク質およびその組合せからなる群から選択されるものであり、各百分率は前記乾燥組成物の総重量を基準とする、前記乾燥組成物。
- 1または複数の生存微生物が、生きた細菌、真菌、酵母、単細胞藻類、ウイルスおよびファージからなる群から選択される、請求項1に記載の組成物。
- 細菌がプロバイオティクス細菌である、請求項2に記載の組成物。
- 1または複数の加水分解タンパク質が、加水分解カゼイン、加水分解エンドウタンパク質、加水分解ダイズタンパク質およびその組合せからなる群から選択される、請求項1に記載の組成物。
- 1または複数の加水分解タンパク質が、加水分解カゼイン、加水分解エンドウタンパク質およびその組合せからなる群から選択される、請求項1に記載の組成物。
- 1または複数のオリゴ糖をさらに含む、請求項1に記載の組成物。
- 乾燥組成物の総重量を基準として、5〜30重量%の1または複数のオリゴ糖を含む、請求項6に記載の組成物。
- 1または複数のオリゴ糖が、イヌリン、短鎖オリゴ糖、シクロデキストリン、マルトデキストリン、デキストラン、フラクトオリゴ糖(FOS)、ガラクトオリゴ糖(GOS)、マンナンオリゴ糖(MOS)およびその組合せからなる群から選択される、請求項6に記載の組成物。
- 1または複数のオリゴ糖が、イヌリン、短鎖オリゴ糖またはシクロデキストリンである、請求項6に記載の組成物。
- 1または複数の多糖類をさらに含む、請求項1に記載の組成物。
- 乾燥組成物の総重量を基準として、1〜10重量%の1または複数の多糖類を含む、請求項10に記載の組成物。
- 1または複数の多糖類が、アルギン酸、アラビアゴム、ローカストビーンガム、カラギーナン、デンプン、加工デンプンおよびその組合せからなる群から選択される、請求項10に記載の組成物。
- 乾燥組成物の総重量を基準として、1〜10重量%の1または複数のカルボン酸塩を含む、請求項1に記載の組成物。
- 1または複数のカルボン酸塩が、乳酸、アスコルビン酸、マレイン酸、シュウ酸、マロン酸、リンゴ酸、コハク酸、クエン酸、グルコン酸、グルタミン酸およびその組合せからなる群から選択されるカルボン酸の塩である、請求項1に記載の組成物。
- 1または複数のカルボン酸塩がアスコルビン酸塩、クエン酸塩およびその組合せからなる群から選択される、請求項1に記載の組成物。
- 少なくとも1×1010CFU/gの初期生存能を有し、生存能の低下量が、温度40℃、相対湿度33%で3ヶ月後に、1 log CFU/g未満である、請求項1に記載の組成物。
- 1または複数の加水分解タンパク質が、加水分解エンドウタンパク質または加水分解カゼインである、請求項16に記載の組成物。
- 乾燥組成物の総重量を基準として、1〜5重量%のビタミンEをさらに含む、請求項1に記載の組成物。
- 1または複数のオリゴ糖および1または複数の多糖類をさらに含む、請求項1に記載の組成物。
- 1または複数の生存微生物、少なくとも50重量%の1または複数の加水分解タンパク質、1または複数のカルボン酸塩、ならびに5重量%未満の1または複数の糖類を含む乾燥組成物であって、前記糖類は単糖類、二糖類およびその組合せからなる群から選択されるものであり、前記加水分解タンパク質は、加水分解乳タンパク質、加水分解エンドウタンパク質、加水分解ダイズタンパク質およびその組合せからなる群から選択されるものであり、各百分率は前記乾燥組成物の総重量を基準とする、前記乾燥組成物を製造する方法であって、下記(a)〜(d)を含む前記方法;
(a)1または複数の生存微生物、1または複数の加水分解タンパク質、1または複数の糖類および1または複数のカルボン酸塩をアルカリ水性溶媒中で合わせてスラリーを形成する工程、
(b)前記スラリーを液体窒素中で急速凍結して、ビーズ、液滴または紐の形態の凍結固体粒子を形成する工程、
(c)前記凍結固体粒子の温度をその凍結温度より高く維持しながら、真空下で蒸発によって前記凍結固体粒子を一次乾燥し、それにより一次乾燥物を形成する工程、
(d)全強度の真空、熱源温度20℃以上で、水分活性が0.3Aw以下に低下するのに十分な時間、前記一次乾燥物を二次乾燥し、それにより乾燥組成物を調製する工程。 - 1または複数のオリゴ糖および1または複数の多糖類をアルカリ水性溶媒に加えて工程(a)のスラリーを形成する工程をさらに含む、請求項20に記載の方法。
- 工程(a)の前に、1または複数の加水分解タンパク質、1または複数のオリゴ糖、1または複数の多糖類、1または複数のカルボン酸塩および1または複数の糖類を滅菌する工程をさらに含む、請求項21に記載の方法。
- 組成物で製品を作製する工程をさらに含み、前記製品が医薬品、栄養補助食品、食品、飼料および特別な食事製品からなる群から選択される、請求項20に記載の方法。
- 1または複数の加水分解タンパク質が、加水分解カゼイン、加水分解エンドウタンパク質、加水分解ダイズタンパク質およびその組合せからなる群から選択される、請求項20に記載の方法。
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PCT/US2016/064176 WO2017095897A1 (en) | 2015-12-04 | 2016-11-30 | Stable dry compositions having no or little sugars |
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CN107744017A (zh) * | 2017-06-27 | 2018-03-02 | 中食月太(北京)健康科技有限公司 | 一种含水解酪蛋白的益生菌固体饮料及其制备方法 |
WO2019090093A1 (en) * | 2017-11-03 | 2019-05-09 | Advanced Bionutrition Corp. | Composition containing viable microorganisms and methods of making |
JP2019165690A (ja) * | 2018-03-23 | 2019-10-03 | 株式会社ダイセル | 魚類飼育用飼料、魚類の養殖方法及び魚類飼育用飼料の添加剤 |
US10806169B2 (en) * | 2018-05-15 | 2020-10-20 | Kate Farms, Inc. | Hydrolyzed pea protein-based nutrient composition |
KR102174589B1 (ko) * | 2018-08-03 | 2020-11-05 | 부경대학교 산학협력단 | 뱀장어 사료내 항생제 대체를 위한 신바이오틱스 개발 |
JP7178203B2 (ja) * | 2018-08-07 | 2022-11-25 | 株式会社ヤクルト本社 | 乳酸菌凍結乾燥菌体の製造方法 |
KR102189273B1 (ko) * | 2019-02-13 | 2020-12-09 | 의령왕메추리 영농조합법인 | 메추리 급이사료 조성물 |
JP7377478B2 (ja) * | 2019-09-27 | 2023-11-10 | 学校法人東海大学 | 魚介類養殖方法、プロバイオティクス細菌液、およびプロバイオティクス細菌含有飼料 |
KR102453960B1 (ko) * | 2020-01-20 | 2022-10-11 | 조선대학교산학협력단 | 프로바이오틱스 및 돈혈장 가수분해물을 유효성분으로 포함하는 뱀장어용 사료첨가제 조성물 |
KR102599037B1 (ko) * | 2023-05-08 | 2023-11-03 | 김나경 | 약알칼리수를 이용한 이유식의 제조방법 |
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US6653062B1 (en) | 2000-07-26 | 2003-11-25 | Wisconsin Alumni Research Foundation | Preservation and storage medium for biological materials |
US20030194423A1 (en) * | 2002-04-15 | 2003-10-16 | Mars, Inc. | Composition for enhancing nutritional content of food |
US8871266B2 (en) | 2003-10-01 | 2014-10-28 | Commonwealth Scientific & Industrial Research Organisation | Probiotic storage and delivery |
ES2439698T3 (es) | 2004-08-20 | 2014-01-24 | Actogenix N.V. | Procedimiento para mejorar la conservación de lactococos |
US20100189767A1 (en) | 2006-09-19 | 2010-07-29 | Eyal Shimoni | Probiotic compositions and methods of making same |
CA2673120C (en) | 2006-12-18 | 2012-08-07 | Advanced Bionutrition Corporation | A dry food product containing live probiotic |
NZ597053A (en) | 2009-05-26 | 2014-02-28 | Advanced Bionutrition Corp | Stable dry powder composition comprising biologically active microorganisms and/or bioactive materials and methods of making |
US20110070334A1 (en) | 2009-09-20 | 2011-03-24 | Nagendra Rangavajla | Probiotic Stabilization |
EP2529004B1 (en) * | 2010-01-28 | 2017-06-07 | Advanced Bionutrition Corporation | Dry glassy composition comprising a bioactive material |
US9504750B2 (en) * | 2010-01-28 | 2016-11-29 | Advanced Bionutrition Corporation | Stabilizing composition for biological materials |
BR112012023025B1 (pt) * | 2010-03-12 | 2021-06-01 | Société des Produits Nestlé S.A. | Composição nutricional, e método para mascarar sabores estranhos de leucina na mesma |
CN103140145B (zh) * | 2010-08-13 | 2014-08-20 | 高级生物营养公司 | 用于生物材料的干的贮存稳定用组合物 |
BR112013014044A2 (pt) * | 2010-12-06 | 2017-10-31 | Degama Barrier Ltd | composição, produto alimentício e processo para prepará-lo |
MX2013007736A (es) | 2010-12-29 | 2013-07-24 | Nestec Sa | Una composicion nutricional que comprende fibra y probioticos para reducir sintomas intestinales relacionados con estres. |
BR112014023234B1 (pt) * | 2012-03-23 | 2020-12-08 | Advanced Bionutrition Corporation | composição de estabilização seca em um estado vítreo amorfo para um material bioativo, método para produzir a referida composição e produtos preparados com a mesma |
CA2994112C (en) | 2015-07-29 | 2023-08-08 | Advanced Bionutrition Corp. | Stable dry probiotic compositions for special dietary uses |
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AU2016365214B2 (en) | 2021-02-25 |
AU2016365214A1 (en) | 2018-05-31 |
WO2017095897A1 (en) | 2017-06-08 |
JP2019503707A (ja) | 2019-02-14 |
US20180325967A1 (en) | 2018-11-15 |
US10792313B2 (en) | 2020-10-06 |
KR20180081170A (ko) | 2018-07-13 |
CL2018001492A1 (es) | 2018-07-13 |
CN108368474A (zh) | 2018-08-03 |
EP3383999A1 (en) | 2018-10-10 |
BR112018010789A2 (pt) | 2018-11-21 |
EP3383999A4 (en) | 2019-07-03 |
CN108368474B (zh) | 2021-11-16 |
RU2731158C2 (ru) | 2020-08-31 |
RU2018117943A3 (ja) | 2020-03-26 |
MX2018006567A (es) | 2018-08-01 |
NZ742496A (en) | 2021-10-29 |
CA3005048C (en) | 2023-03-28 |
RU2018117943A (ru) | 2020-01-09 |
CA3005048A1 (en) | 2017-06-08 |
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