JP6931357B2 - デングウイルス複製阻害剤としての置換インドリン誘導体 - Google Patents
デングウイルス複製阻害剤としての置換インドリン誘導体 Download PDFInfo
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- JP6931357B2 JP6931357B2 JP2018550333A JP2018550333A JP6931357B2 JP 6931357 B2 JP6931357 B2 JP 6931357B2 JP 2018550333 A JP2018550333 A JP 2018550333A JP 2018550333 A JP2018550333 A JP 2018550333A JP 6931357 B2 JP6931357 B2 JP 6931357B2
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- 0 CC(C(C(C(OC)=C1)=CCC1(C)Cl)Nc1cc(OCCO)cc(OC)c1)N(CC1)C(*2)C1=CC=C2OC(F)(F)F Chemical compound CC(C(C(C(OC)=C1)=CCC1(C)Cl)Nc1cc(OCCO)cc(OC)c1)N(CC1)C(*2)C1=CC=C2OC(F)(F)F 0.000 description 2
- ADGSBZFAGFBTES-UHFFFAOYSA-N CC(CC=C1C(C(N2c3cc(C(F)(F)F)ccc3CC2)=O)Nc2cc(OCCO)cc(OC)c2)(C=C1F)Cl Chemical compound CC(CC=C1C(C(N2c3cc(C(F)(F)F)ccc3CC2)=O)Nc2cc(OCCO)cc(OC)c2)(C=C1F)Cl ADGSBZFAGFBTES-UHFFFAOYSA-N 0.000 description 1
- ZMFUHLQOIFEOEQ-UHFFFAOYSA-N CC1(CCN2C(C(c(cc3)ccc3Cl)Nc3cc(OCCO)cc(OC)c3)=O)C2=CC(OC(F)(F)F)=CC1 Chemical compound CC1(CCN2C(C(c(cc3)ccc3Cl)Nc3cc(OCCO)cc(OC)c3)=O)C2=CC(OC(F)(F)F)=CC1 ZMFUHLQOIFEOEQ-UHFFFAOYSA-N 0.000 description 1
- GCPLTHWTLIZSJG-UHFFFAOYSA-N CCCOc1cc(OC)cc(CNC(C(N(CC2)c3c2c(C)cc(C(F)(F)F)c3)=O)c(cc2)ccc2Cl)c1 Chemical compound CCCOc1cc(OC)cc(CNC(C(N(CC2)c3c2c(C)cc(C(F)(F)F)c3)=O)c(cc2)ccc2Cl)c1 GCPLTHWTLIZSJG-UHFFFAOYSA-N 0.000 description 1
- JLQGSNHPBVTYGR-UHFFFAOYSA-N COc1cc(NC(C(N(CCc2c3)c2cc(C(F)(F)F)c3F)=O)c(cc2)ccc2Cl)cc(OCCO)c1 Chemical compound COc1cc(NC(C(N(CCc2c3)c2cc(C(F)(F)F)c3F)=O)c(cc2)ccc2Cl)cc(OCCO)c1 JLQGSNHPBVTYGR-UHFFFAOYSA-N 0.000 description 1
- CKTANWPZOFZHDD-UHFFFAOYSA-N COc1cc(NC(C(N(CCc2c3)c2cc(C(F)(F)F)c3OC)=O)c(cc2)ccc2Cl)cc(OCCO)c1 Chemical compound COc1cc(NC(C(N(CCc2c3)c2cc(C(F)(F)F)c3OC)=O)c(cc2)ccc2Cl)cc(OCCO)c1 CKTANWPZOFZHDD-UHFFFAOYSA-N 0.000 description 1
- BFQDAUKOPCJOEL-UHFFFAOYSA-N COc1cc(NC(C(N(CCc2c3)c2cc(C(F)(F)F)c3OC)=O)c(ccc(Cl)c2)c2OC)cc(OCCO)c1 Chemical compound COc1cc(NC(C(N(CCc2c3)c2cc(C(F)(F)F)c3OC)=O)c(ccc(Cl)c2)c2OC)cc(OCCO)c1 BFQDAUKOPCJOEL-UHFFFAOYSA-N 0.000 description 1
- RYVZHFQJBSWIRA-UHFFFAOYSA-N COc1cc(NC(C(N(CCc2c3)c2cc(OC(F)(F)F)c3OC)=O)c(cc2)ccc2Cl)cc(OCCO)c1 Chemical compound COc1cc(NC(C(N(CCc2c3)c2cc(OC(F)(F)F)c3OC)=O)c(cc2)ccc2Cl)cc(OCCO)c1 RYVZHFQJBSWIRA-UHFFFAOYSA-N 0.000 description 1
- MQVWLIMHQAZAPP-UHFFFAOYSA-N COc1cc(NC(C(N2c3cc(C(F)(F)F)ccc3CC2)=O)c(cc2)ccc2Cl)cc(OCCO)c1 Chemical compound COc1cc(NC(C(N2c3cc(C(F)(F)F)ccc3CC2)=O)c(cc2)ccc2Cl)cc(OCCO)c1 MQVWLIMHQAZAPP-UHFFFAOYSA-N 0.000 description 1
- FPTSWDDGRMWUQD-UHFFFAOYSA-N COc1cc(NC(C(N2c3cc(C(F)(F)F)ccc3CC2)=O)c(ccc(Cl)c2)c2OC)cc(OCCO)c1 Chemical compound COc1cc(NC(C(N2c3cc(C(F)(F)F)ccc3CC2)=O)c(ccc(Cl)c2)c2OC)cc(OCCO)c1 FPTSWDDGRMWUQD-UHFFFAOYSA-N 0.000 description 1
- RFVIXCXNRKGQLU-UHFFFAOYSA-N COc1cc(OCCO)cc(NC(C(N(CCc2c3)c2cc(C(F)(F)F)c3OC)=O)c(ccc(Cl)c2)c2F)c1 Chemical compound COc1cc(OCCO)cc(NC(C(N(CCc2c3)c2cc(C(F)(F)F)c3OC)=O)c(ccc(Cl)c2)c2F)c1 RFVIXCXNRKGQLU-UHFFFAOYSA-N 0.000 description 1
- ZKKVUVQDTPPFBZ-UHFFFAOYSA-N Cc1cc(OC(F)(F)F)cc2c1CCN2C(C(C(CC1)=CC=C1Cl)Nc1cc(OCCO)cc(OC)c1)=O Chemical compound Cc1cc(OC(F)(F)F)cc2c1CCN2C(C(C(CC1)=CC=C1Cl)Nc1cc(OCCO)cc(OC)c1)=O ZKKVUVQDTPPFBZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16163281 | 2016-03-31 | ||
| EP16163281.5 | 2016-03-31 | ||
| PCT/EP2017/057663 WO2017167953A1 (en) | 2016-03-31 | 2017-03-31 | Substituted indoline derivatives as dengue viral replication inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019510027A JP2019510027A (ja) | 2019-04-11 |
| JP2019510027A5 JP2019510027A5 (US20080131398A1-20080605-C00009.png) | 2019-05-23 |
| JP6931357B2 true JP6931357B2 (ja) | 2021-09-01 |
Family
ID=55646444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018550333A Active JP6931357B2 (ja) | 2016-03-31 | 2017-03-31 | デングウイルス複製阻害剤としての置換インドリン誘導体 |
Country Status (20)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| WO2017167953A1 (en) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| EA201892214A1 (ru) | 2016-03-31 | 2019-03-29 | Янссен Фармасьютикалз, Инк. | Замещенные производные индола в качестве ингибиторов репликации вирусов денге |
| EA201892200A1 (ru) | 2016-04-01 | 2019-03-29 | Янссен Фармасьютикалз, Инк. | Замещенные производные соединений индола в качестве ингибиторов репликации вирусов денге |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| UA125970C2 (uk) | 2017-05-22 | 2022-07-20 | Янссен Фармасьютікалз, Інк. | Заміщені похідні індоліну як інгібітори реплікації вірусів денге |
| MX2019013893A (es) | 2017-05-22 | 2020-01-20 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue. |
| CN109485596A (zh) * | 2018-12-19 | 2019-03-19 | 山东理工职业学院 | 一种含吲哚啉的登革病毒抑制剂的制备方法 |
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| AU1200899A (en) | 1997-10-27 | 1999-05-17 | Eli Lilly And Company | Morpholino-n-ethyl ester prodrugs of indole spla2 inhibitors |
| GB0110832D0 (en) | 2001-05-03 | 2001-06-27 | Virogen Ltd | Antiviral compounds |
| WO2003050295A2 (en) | 2001-12-12 | 2003-06-19 | Conforma Therapeutics Corporation | Assays and implements for determining and modulating hsp90 binding activity |
| GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
| EP1844042A1 (en) | 2005-01-14 | 2007-10-17 | Genelabs Technologies, Inc. | Indole derivatives for treating viral infections |
| EP1853317A2 (en) | 2005-02-09 | 2007-11-14 | Migenix Inc. | Compositions and methods for treating or preventing flaviviridae infections |
| CN102056483A (zh) | 2008-06-03 | 2011-05-11 | 西佳技术公司 | 用于治疗或预防登革病毒感染的小分子抑制剂 |
| TWI614024B (zh) * | 2008-08-11 | 2018-02-11 | 曼凱公司 | 超快起作用胰島素之用途 |
| ES2612731T3 (es) | 2008-08-19 | 2017-05-18 | Janssen Pharmaceutica Nv | Antagonistas de receptores al frío de mentol |
| TWI453207B (zh) | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶，其組合物及使用其之治療方法 |
| EP2393359A4 (en) | 2009-02-09 | 2012-10-03 | Enanta Pharm Inc | COMPOUND DIBENZIMIDAZOLE DERIVATIVES |
| GB0910003D0 (en) | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| US8993604B2 (en) | 2009-06-30 | 2015-03-31 | Siga Technologies, Inc. | Treatment and prevention of dengue virus infections |
| AU2011205797B2 (en) | 2010-01-15 | 2015-07-16 | Gilead Sciences, Inc. | Inhibitors of Flaviviridae viruses |
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| JP5716205B2 (ja) | 2011-03-29 | 2015-05-13 | 学校法人日本大学 | グルコシダーゼ活性阻害用組成物及びそのスクリーニング方法 |
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| UA117261C2 (uk) | 2013-10-23 | 2018-07-10 | ЯНССЕН САЙЄНСЕЗ АЙРЛЕНД ЮСі | Похідні карбоксаміду та їх застосування як медикаментів для лікування гепатиту b |
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| NO2721243T3 (US20080131398A1-20080605-C00009.png) | 2014-10-01 | 2018-10-20 | ||
| HUE041888T2 (hu) | 2014-10-01 | 2019-06-28 | Janssen Pharmaceuticals Inc | Mono- vagy diszubsztituált indol-származékok mind dengue vírus replikáció inhibitorok |
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| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
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| JP6788683B2 (ja) | 2016-03-31 | 2020-11-25 | 武田薬品工業株式会社 | 複素環化合物 |
| WO2017167953A1 (en) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Substituted indoline derivatives as dengue viral replication inhibitors |
| EA201892214A1 (ru) * | 2016-03-31 | 2019-03-29 | Янссен Фармасьютикалз, Инк. | Замещенные производные индола в качестве ингибиторов репликации вирусов денге |
| IL296966A (en) | 2016-04-01 | 2022-12-01 | Amgen Inc | Chimeric flt-3 receptors and methods of using them |
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| US11570992B2 (en) | 2016-04-01 | 2023-02-07 | Basf Se | Bicyclic compounds |
| KR102356433B1 (ko) | 2016-04-01 | 2022-01-27 | 시그날 파마소티칼 엘엘씨 | 치환된 아미노퓨린 화합물, 이의 조성물, 및 그것에 의한 치료 방법 |
| JOP20170069B1 (ar) * | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| MX2019013893A (es) | 2017-05-22 | 2020-01-20 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue. |
| UA125970C2 (uk) | 2017-05-22 | 2022-07-20 | Янссен Фармасьютікалз, Інк. | Заміщені похідні індоліну як інгібітори реплікації вірусів денге |
| CN109485596A (zh) * | 2018-12-19 | 2019-03-19 | 山东理工职业学院 | 一种含吲哚啉的登革病毒抑制剂的制备方法 |
-
2017
- 2017-03-31 WO PCT/EP2017/057663 patent/WO2017167953A1/en active Application Filing
- 2017-03-31 ES ES17714475T patent/ES2923771T3/es active Active
- 2017-03-31 US US16/088,459 patent/US10913716B2/en active Active
- 2017-03-31 EP EP17714475.5A patent/EP3436436B1/en active Active
- 2017-03-31 CA CA3013407A patent/CA3013407A1/en not_active Abandoned
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2018
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Also Published As
| Publication number | Publication date |
|---|---|
| US20200339511A1 (en) | 2020-10-29 |
| CR20180496A (es) | 2018-12-06 |
| MX2018011788A (es) | 2019-05-20 |
| KR20180132056A (ko) | 2018-12-11 |
| IL261943A (en) | 2018-10-31 |
| ECSP18073366A (es) | 2018-10-31 |
| CL2018002718A1 (es) | 2018-12-14 |
| JP2019510027A (ja) | 2019-04-11 |
| SG11201808270PA (en) | 2018-10-30 |
| AU2017240077A1 (en) | 2018-08-09 |
| EA201892216A1 (ru) | 2019-03-29 |
| MA44498A (fr) | 2019-02-06 |
| US10913716B2 (en) | 2021-02-09 |
| ES2923771T3 (es) | 2022-09-30 |
| KR102359735B1 (ko) | 2022-02-08 |
| PH12018502016A1 (en) | 2019-07-15 |
| CA3013407A1 (en) | 2017-10-05 |
| WO2017167953A1 (en) | 2017-10-05 |
| CN109195949A (zh) | 2019-01-11 |
| CN109195949B (zh) | 2021-09-17 |
| CO2018008421A2 (es) | 2018-10-22 |
| BR112018069601A2 (pt) | 2019-01-29 |
| EP3436436A1 (en) | 2019-02-06 |
| EP3436436B1 (en) | 2022-05-11 |
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