SG11201702464WA - Mono- or di-substituted indoles as dengue viral replication inhibitors - Google Patents

Mono- or di-substituted indoles as dengue viral replication inhibitors

Info

Publication number
SG11201702464WA
SG11201702464WA SG11201702464WA SG11201702464WA SG11201702464WA SG 11201702464W A SG11201702464W A SG 11201702464WA SG 11201702464W A SG11201702464W A SG 11201702464WA SG 11201702464W A SG11201702464W A SG 11201702464WA SG 11201702464W A SG11201702464W A SG 11201702464WA
Authority
SG
Singapore
Prior art keywords
mono
viral replication
replication inhibitors
substituted indoles
dengue viral
Prior art date
Application number
SG11201702464WA
Inventor
Bart Rudolf Romanie Kesteleyn
Jean-François Bonfanti
Tim Hugo Maria Jonckers
Pierre Jean-Marie Bernard Raboisson
Dorothée Alice Marie-Eve Bardiot
Arnaud Didier M Marchand
Original Assignee
Janssen Pharmaceuticals Inc
Univ Leuven Kath
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54207512&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201702464W(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceuticals Inc, Univ Leuven Kath filed Critical Janssen Pharmaceuticals Inc
Publication of SG11201702464WA publication Critical patent/SG11201702464WA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/62Detectors specially adapted therefor
    • G01N30/72Mass spectrometers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N2030/022Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027Liquid chromatography
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG11201702464WA 2014-10-01 2015-09-30 Mono- or di-substituted indoles as dengue viral replication inhibitors SG11201702464WA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14187373 2014-10-01
EP15156073 2015-02-23
PCT/EP2015/072534 WO2016050831A1 (en) 2014-10-01 2015-09-30 Mono- or di-substituted indoles as dengue viral replication inhibitors

Publications (1)

Publication Number Publication Date
SG11201702464WA true SG11201702464WA (en) 2017-04-27

Family

ID=54207512

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201702464WA SG11201702464WA (en) 2014-10-01 2015-09-30 Mono- or di-substituted indoles as dengue viral replication inhibitors

Country Status (30)

Country Link
US (1) US10206902B2 (en)
EP (1) EP3201177B1 (en)
JP (1) JP6701185B2 (en)
KR (1) KR102478309B1 (en)
CN (1) CN107001265B (en)
AU (1) AU2015326920A1 (en)
BR (1) BR112017006708A2 (en)
CA (1) CA2958022A1 (en)
CL (1) CL2017000742A1 (en)
CY (1) CY1121972T1 (en)
DK (1) DK3201177T3 (en)
EA (1) EA033845B1 (en)
ES (1) ES2711117T3 (en)
HR (1) HRP20190139T1 (en)
HU (1) HUE042628T2 (en)
IL (1) IL251401A0 (en)
LT (1) LT3201177T (en)
MA (1) MA40769B1 (en)
ME (1) ME03344B (en)
MX (1) MX2017004298A (en)
PH (1) PH12017500503A1 (en)
PL (1) PL3201177T3 (en)
PT (1) PT3201177T (en)
RS (1) RS58394B1 (en)
SG (1) SG11201702464WA (en)
SI (1) SI3201177T1 (en)
TW (1) TW201619130A (en)
UY (1) UY36339A (en)
WO (1) WO2016050831A1 (en)
ZA (1) ZA201702299B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201116559D0 (en) 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
ES2761774T3 (en) 2014-10-01 2020-05-21 Merck Patent Gmbh Boronic acid derivatives
US9453018B2 (en) 2014-10-01 2016-09-27 Bristol-Myers Squibb Company Pyrimidinones as factor XIa inhibitors
JOP20160086B1 (en) * 2015-05-08 2021-08-17 2 Katholieke Univ Leuven Ku Leuven Research And Development Mono- or di-substituted indole derivatives as dengue viral replication inhibitors
JO3633B1 (en) 2015-09-16 2020-08-27 Katholieke Univ Leuven Ku Leuven Research & Development Mono- or di-substituted indole derivatives as dengue viral replication inhibitors
JOP20160198B1 (en) * 2015-09-16 2022-03-14 Janssen Pharmaceuticals Inc Mono- or di-substituted indole derivatives as dengue viral replication inhibitors
SG11201808270PA (en) 2016-03-31 2018-10-30 Janssen Pharmaceuticals Inc Substituted indoline derivatives as dengue viral replication inhibitors
SI3436435T1 (en) 2016-03-31 2021-08-31 Janssen Pharmaceuticals, Inc. Substituted indole derivatives as dengue viral replication inhibitors
JP7007290B2 (en) * 2016-04-01 2022-01-24 ヤンセン ファーマシューティカルズ,インコーポレーテッド Substituted indole compound derivative as a dengue virus replication inhibitor
JOP20170069B1 (en) 2016-04-01 2021-08-17 1 Janssen Pharmaceuticals Inc Substituted indoline derivatives as dengue viral replication inhibitors
JOP20180026A1 (en) 2017-03-31 2019-01-30 Univ Leuven Kath Substituted indoline derivatives as dengue viral replication inhibitors
JOP20180025B1 (en) 2017-03-31 2021-08-17 Janssen Pharmaceuticals Inc Substituted indoline derivatives as dengue viral replication inhibitors
AU2018274100B2 (en) 2017-05-22 2022-06-23 Janssen Pharmaceuticals, Inc. Substituted indoline derivatives as dengue viral replication inhibitors
IL270727B2 (en) 2017-05-22 2023-03-01 Janssen Pharmaceuticals Inc Substituted indoline derivatives as dengue viral replication inhibitors
CN114989131B (en) * 2022-05-30 2023-10-24 云南大学 N' - (2- (benzo [1,3] dioxolan-5-yl) acyl) aryl hydrazide compound as well as synthesis and application thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2928645A1 (en) * 2008-03-14 2009-09-18 Sanofi Aventis Sa NOVEL CARBAZOLE DERIVATIVES INHIBITORS OF HSP90, COMPOSITIONS CONTAINING SAME AND USE THEREOF
CN102186833A (en) * 2008-08-18 2011-09-14 耶鲁大学 MIF modulators
GB201116559D0 (en) * 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
RS58461B1 (en) * 2014-10-01 2019-04-30 Janssen Pharmaceuticals Inc Mono- or di-substituted indole derivatives as dengue viral replication inhibitors

Also Published As

Publication number Publication date
WO2016050831A1 (en) 2016-04-07
HRP20190139T1 (en) 2019-03-22
BR112017006708A2 (en) 2017-12-26
KR102478309B1 (en) 2022-12-15
EP3201177B1 (en) 2018-11-21
SI3201177T1 (en) 2019-05-31
CL2017000742A1 (en) 2017-11-03
LT3201177T (en) 2019-03-12
PT3201177T (en) 2019-02-12
PL3201177T3 (en) 2019-05-31
ES2711117T3 (en) 2019-04-30
TW201619130A (en) 2016-06-01
KR20170063675A (en) 2017-06-08
AU2015326920A1 (en) 2017-03-02
HUE042628T2 (en) 2019-07-29
DK3201177T3 (en) 2019-03-04
UY36339A (en) 2016-04-01
MA40769B1 (en) 2019-03-29
EA201790700A1 (en) 2017-08-31
CN107001265A (en) 2017-08-01
JP2017531638A (en) 2017-10-26
ME03344B (en) 2019-10-20
MX2017004298A (en) 2017-07-19
CA2958022A1 (en) 2016-04-07
EP3201177A1 (en) 2017-08-09
CN107001265B (en) 2021-06-15
MA40769A (en) 2017-09-09
IL251401A0 (en) 2017-05-29
RS58394B1 (en) 2019-04-30
EA033845B1 (en) 2019-12-02
JP6701185B2 (en) 2020-05-27
ZA201702299B (en) 2018-12-19
CY1121972T1 (en) 2020-10-14
US20170224658A1 (en) 2017-08-10
PH12017500503A1 (en) 2017-08-30
US10206902B2 (en) 2019-02-19

Similar Documents

Publication Publication Date Title
ZA202002435B (en) Mono- or di-substituted indole derivatives as dengue viral replication inhibitors
HRP20190139T1 (en) Mono- or di-substituted indoles as dengue viral replication inhibitors
HRP20190199T1 (en) Mono- or di-substituted indole derivatives as dengue viral replication inhibitors
HK1258320A1 (en) Mono- or di-substituted indole derivatives as dengue viral replication inhibitors
HK1257842A1 (en) Mono- or di-substituted indole derivatives as dengue viral replication inhibitors
HK1246688A1 (en) Indole derivatives as dengue viral replication inhibitors
PT3294738T (en) Mono- or di-substituted indole derivatives as dengue viral replication inhibitors