JP6922092B2 - 片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法 - Google Patents

片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法 Download PDF

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JP6922092B2
JP6922092B2 JP2020530455A JP2020530455A JP6922092B2 JP 6922092 B2 JP6922092 B2 JP 6922092B2 JP 2020530455 A JP2020530455 A JP 2020530455A JP 2020530455 A JP2020530455 A JP 2020530455A JP 6922092 B2 JP6922092 B2 JP 6922092B2
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dose
headaches
migraine
pharmaceutical composition
rasumijitan
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JP2020530861A (ja
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シーナ・オーロラ
カーク・ウィリス・ジョンソン
ジョン・ヘンリー・クリージ
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イーライ リリー アンド カンパニー
イーライ リリー アンド カンパニー
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Priority to JP2025115518A priority patent/JP2025165940A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2020530455A 2017-09-06 2018-08-30 片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法 Active JP6922092B2 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2021122905A JP7183355B2 (ja) 2017-09-06 2021-07-28 片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法
JP2022186221A JP7480261B2 (ja) 2017-09-06 2022-11-22 片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法
JP2024070372A JP7711255B2 (ja) 2017-09-06 2024-04-24 片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法
JP2025115518A JP2025165940A (ja) 2017-09-06 2025-07-09 片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法

Applications Claiming Priority (3)

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US201762554726P 2017-09-06 2017-09-06
US62/554,726 2017-09-06
PCT/US2018/048730 WO2019050759A1 (en) 2017-09-06 2018-08-30 POLYTHERAPY OF LASMIDITAN AND CGRP ANTAGONIST FOR USE IN THE TREATMENT OF MIGRAINE

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JP2021122905A Division JP7183355B2 (ja) 2017-09-06 2021-07-28 片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法

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JP2020530861A JP2020530861A (ja) 2020-10-29
JP6922092B2 true JP6922092B2 (ja) 2021-08-18

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JP2020530455A Active JP6922092B2 (ja) 2017-09-06 2018-08-30 片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法
JP2021122905A Active JP7183355B2 (ja) 2017-09-06 2021-07-28 片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法
JP2022186221A Active JP7480261B2 (ja) 2017-09-06 2022-11-22 片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法
JP2024070372A Active JP7711255B2 (ja) 2017-09-06 2024-04-24 片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法
JP2025115518A Withdrawn JP2025165940A (ja) 2017-09-06 2025-07-09 片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法

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JP2021122905A Active JP7183355B2 (ja) 2017-09-06 2021-07-28 片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法
JP2022186221A Active JP7480261B2 (ja) 2017-09-06 2022-11-22 片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法
JP2024070372A Active JP7711255B2 (ja) 2017-09-06 2024-04-24 片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法
JP2025115518A Withdrawn JP2025165940A (ja) 2017-09-06 2025-07-09 片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法

Country Status (17)

Country Link
US (1) US20200268735A1 (https=)
EP (2) EP3678665A1 (https=)
JP (5) JP6922092B2 (https=)
KR (3) KR20230025945A (https=)
CN (3) CN116059204A (https=)
AU (1) AU2018329568B2 (https=)
BR (1) BR112020002077A2 (https=)
CA (1) CA3073996C (https=)
EA (1) EA202090457A1 (https=)
IL (2) IL314347A (https=)
MA (2) MA50073A (https=)
MX (2) MX2020002554A (https=)
MY (1) MY205182A (https=)
SG (1) SG11202001387WA (https=)
TW (1) TWI754772B (https=)
WO (1) WO2019050759A1 (https=)
ZA (1) ZA202000443B (https=)

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PL2413933T5 (pl) 2009-04-02 2021-10-18 Colucid Pharmaceuticals, Inc. 2,4,6-trifluoro-N-[6-(1-metylopiperydyno-4-karbonylo)pirydyn-2-ylo]benzamid do leczenia migreny drogą doustną lub dożylną
TWI685505B (zh) * 2011-05-20 2020-02-21 美商艾爾德生物控股有限責任公司 抗降血鈣素基因相關胜肽（ａｎｔｉ-ｃｇｒｐ）組成物及其用途
US12168004B2 (en) 2014-02-05 2024-12-17 Merck Sharp & Dohme Llc Treatment of migraine
JP6491669B2 (ja) 2014-02-05 2019-03-27 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Ｃｇｒｐ活性化合物の錠剤製剤
KR20190075130A (ko) 2016-12-06 2019-06-28 코루시드 파마슈티컬즈 인코포레이티드 피리디노일피페리딘 5-ht1f 작용제에 관한 조성물 및 방법
TWI754772B (zh) * 2017-09-06 2022-02-11 美商美國禮來大藥廠 用於治療偏頭痛之拉米迪坦(lasmiditan)與cgrp拮抗劑之組合療法
US20190374518A1 (en) * 2018-06-08 2019-12-12 Allergan Pharmaceuticals International Limited Treatment of migraine
US12383545B1 (en) 2018-06-08 2025-08-12 Allergan Pharmaceuticals International Limited Treatment of migraine
TWI826514B (zh) 2018-09-04 2023-12-21 美商美國禮來大藥廠 用於預防偏頭痛之拉米迪坦(lasmiditan)長期夜間投藥
JP2022517433A (ja) * 2019-01-20 2022-03-08 バイオヘイブン・ファーマシューティカル・ホールディング・カンパニー・リミテッド 突出性の片頭痛を処置するためのｃｇｒｐアンタゴニスト
TWI776175B (zh) 2019-07-09 2022-09-01 美商美國禮來大藥廠 大規模製備2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺半琥珀酸鹽的方法及中間體，以及2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺醋酸鹽之製備
CN116390712A (zh) 2020-07-29 2023-07-04 阿勒根制药国际有限公司 治疗偏头痛
CA3206184A1 (en) 2020-12-22 2022-06-30 Allergan Pharmaceuticals International Limited Treatment of migraine
WO2023049920A1 (en) 2021-09-27 2023-03-30 Allergan Pharmaceuticals International Limited Combination comprising atogepant for treating migraine
CN116270505A (zh) * 2021-12-20 2023-06-23 南京科默生物医药有限公司 含半琥珀酸拉司米地坦的口服固体制剂及其3d打印制备技术
JP7499538B1 (ja) 2023-03-29 2024-06-14 ロゴスサイエンス株式会社 慢性疼痛の治療、改善およびセルフケアシステム

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TWI754772B (zh) * 2017-09-06 2022-02-11 美商美國禮來大藥廠 用於治療偏頭痛之拉米迪坦(lasmiditan)與cgrp拮抗劑之組合療法

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Publication number Publication date
JP7480261B2 (ja) 2024-05-09
KR20200036919A (ko) 2020-04-07
EP4397317A2 (en) 2024-07-10
EP3678665A1 (en) 2020-07-15
MY205182A (en) 2024-10-04
CN111032044A (zh) 2020-04-17
EP4397317A3 (en) 2024-10-16
EA202090457A1 (ru) 2020-06-10
KR20260027357A (ko) 2026-02-27
JP2023029872A (ja) 2023-03-07
JP7183355B2 (ja) 2022-12-05
US20200268735A1 (en) 2020-08-27
IL314347A (en) 2024-09-01
AU2018329568A1 (en) 2020-02-06
MA50073A (fr) 2020-07-15
JP7711255B2 (ja) 2025-07-22
TWI754772B (zh) 2022-02-11
JP2021176884A (ja) 2021-11-11
MA71474A (fr) 2025-04-30
MX2020002554A (es) 2020-07-13
CA3073996C (en) 2022-05-31
AU2018329568B2 (en) 2021-09-23
JP2020530861A (ja) 2020-10-29
WO2019050759A1 (en) 2019-03-14
SG11202001387WA (en) 2020-03-30
JP2024109585A (ja) 2024-08-14
ZA202000443B (en) 2022-07-27
TW201919624A (zh) 2019-06-01
JP2025165940A (ja) 2025-11-05
MX2023008760A (es) 2023-08-02
KR20230025945A (ko) 2023-02-23
IL273031A (en) 2020-04-30
CA3073996A1 (en) 2019-03-14
CN116509861A (zh) 2023-08-01
BR112020002077A2 (pt) 2020-07-28
NZ761634A (en) 2024-05-31
CN116059204A (zh) 2023-05-05

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