KR20230025945A - 편두통의 치료에 사용하기 위한 라스미디탄 및 cgrp 길항제의 조합 요법 - Google Patents

편두통의 치료에 사용하기 위한 라스미디탄 및 cgrp 길항제의 조합 요법 Download PDF

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Publication number
KR20230025945A
KR20230025945A KR1020237004878A KR20237004878A KR20230025945A KR 20230025945 A KR20230025945 A KR 20230025945A KR 1020237004878 A KR1020237004878 A KR 1020237004878A KR 20237004878 A KR20237004878 A KR 20237004878A KR 20230025945 A KR20230025945 A KR 20230025945A
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KR
South Korea
Prior art keywords
headache
lasmiditan
dose
administered
galcanezumab
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Ceased
Application number
KR1020237004878A
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English (en)
Korean (ko)
Inventor
쉬나 오로라
커크 윌리스 존슨
존 헨리 크레게
Original Assignee
일라이 릴리 앤드 캄파니
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Priority to KR1020267004013A priority Critical patent/KR20260027357A/ko
Publication of KR20230025945A publication Critical patent/KR20230025945A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020237004878A 2017-09-06 2018-08-30 편두통의 치료에 사용하기 위한 라스미디탄 및 cgrp 길항제의 조합 요법 Ceased KR20230025945A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020267004013A KR20260027357A (ko) 2017-09-06 2018-08-30 편두통의 치료에 사용하기 위한 라스미디탄 및 cgrp 길항제의 조합 요법

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762554726P 2017-09-06 2017-09-06
US62/554,726 2017-09-06
PCT/US2018/048730 WO2019050759A1 (en) 2017-09-06 2018-08-30 POLYTHERAPY OF LASMIDITAN AND CGRP ANTAGONIST FOR USE IN THE TREATMENT OF MIGRAINE
KR1020207006231A KR20200036919A (ko) 2017-09-06 2018-08-30 편두통의 치료에 사용하기 위한 라스미디탄 및 cgrp 길항제의 조합 요법

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020207006231A Division KR20200036919A (ko) 2017-09-06 2018-08-30 편두통의 치료에 사용하기 위한 라스미디탄 및 cgrp 길항제의 조합 요법

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020267004013A Division KR20260027357A (ko) 2017-09-06 2018-08-30 편두통의 치료에 사용하기 위한 라스미디탄 및 cgrp 길항제의 조합 요법

Publications (1)

Publication Number Publication Date
KR20230025945A true KR20230025945A (ko) 2023-02-23

Family

ID=63529021

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020237004878A Ceased KR20230025945A (ko) 2017-09-06 2018-08-30 편두통의 치료에 사용하기 위한 라스미디탄 및 cgrp 길항제의 조합 요법
KR1020267004013A Pending KR20260027357A (ko) 2017-09-06 2018-08-30 편두통의 치료에 사용하기 위한 라스미디탄 및 cgrp 길항제의 조합 요법
KR1020207006231A Ceased KR20200036919A (ko) 2017-09-06 2018-08-30 편두통의 치료에 사용하기 위한 라스미디탄 및 cgrp 길항제의 조합 요법

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020267004013A Pending KR20260027357A (ko) 2017-09-06 2018-08-30 편두통의 치료에 사용하기 위한 라스미디탄 및 cgrp 길항제의 조합 요법
KR1020207006231A Ceased KR20200036919A (ko) 2017-09-06 2018-08-30 편두통의 치료에 사용하기 위한 라스미디탄 및 cgrp 길항제의 조합 요법

Country Status (17)

Country Link
US (1) US20200268735A1 (https=)
EP (2) EP3678665A1 (https=)
JP (5) JP6922092B2 (https=)
KR (3) KR20230025945A (https=)
CN (3) CN116059204A (https=)
AU (1) AU2018329568B2 (https=)
BR (1) BR112020002077A2 (https=)
CA (1) CA3073996C (https=)
EA (1) EA202090457A1 (https=)
IL (2) IL314347A (https=)
MA (2) MA50073A (https=)
MX (2) MX2020002554A (https=)
MY (1) MY205182A (https=)
SG (1) SG11202001387WA (https=)
TW (1) TWI754772B (https=)
WO (1) WO2019050759A1 (https=)
ZA (1) ZA202000443B (https=)

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PL2413933T5 (pl) 2009-04-02 2021-10-18 Colucid Pharmaceuticals, Inc. 2,4,6-trifluoro-N-[6-(1-metylopiperydyno-4-karbonylo)pirydyn-2-ylo]benzamid do leczenia migreny drogą doustną lub dożylną
TWI685505B (zh) * 2011-05-20 2020-02-21 美商艾爾德生物控股有限責任公司 抗降血鈣素基因相關胜肽（ａｎｔｉ-ｃｇｒｐ）組成物及其用途
US12168004B2 (en) 2014-02-05 2024-12-17 Merck Sharp & Dohme Llc Treatment of migraine
JP6491669B2 (ja) 2014-02-05 2019-03-27 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Ｃｇｒｐ活性化合物の錠剤製剤
KR20190075130A (ko) 2016-12-06 2019-06-28 코루시드 파마슈티컬즈 인코포레이티드 피리디노일피페리딘 5-ht1f 작용제에 관한 조성물 및 방법
TWI754772B (zh) * 2017-09-06 2022-02-11 美商美國禮來大藥廠 用於治療偏頭痛之拉米迪坦(lasmiditan)與cgrp拮抗劑之組合療法
US20190374518A1 (en) * 2018-06-08 2019-12-12 Allergan Pharmaceuticals International Limited Treatment of migraine
US12383545B1 (en) 2018-06-08 2025-08-12 Allergan Pharmaceuticals International Limited Treatment of migraine
TWI826514B (zh) 2018-09-04 2023-12-21 美商美國禮來大藥廠 用於預防偏頭痛之拉米迪坦(lasmiditan)長期夜間投藥
JP2022517433A (ja) * 2019-01-20 2022-03-08 バイオヘイブン・ファーマシューティカル・ホールディング・カンパニー・リミテッド 突出性の片頭痛を処置するためのｃｇｒｐアンタゴニスト
TWI776175B (zh) 2019-07-09 2022-09-01 美商美國禮來大藥廠 大規模製備2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺半琥珀酸鹽的方法及中間體，以及2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺醋酸鹽之製備
CN116390712A (zh) 2020-07-29 2023-07-04 阿勒根制药国际有限公司 治疗偏头痛
CA3206184A1 (en) 2020-12-22 2022-06-30 Allergan Pharmaceuticals International Limited Treatment of migraine
WO2023049920A1 (en) 2021-09-27 2023-03-30 Allergan Pharmaceuticals International Limited Combination comprising atogepant for treating migraine
CN116270505A (zh) * 2021-12-20 2023-06-23 南京科默生物医药有限公司 含半琥珀酸拉司米地坦的口服固体制剂及其3d打印制备技术
JP7499538B1 (ja) 2023-03-29 2024-06-14 ロゴスサイエンス株式会社 慢性疼痛の治療、改善およびセルフケアシステム

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TWI263497B (en) 2002-03-29 2006-10-11 Lilly Co Eli Pyridinoylpiperidines as 5-HT1F agonists
US20050065094A1 (en) * 2003-09-05 2005-03-24 Boehringer Ingelheim International Gmbh Use of telmisartan for the prevention and treatment of vascular headache
WO2005046659A2 (en) * 2003-11-12 2005-05-26 Nps Pharmaceuticals, Inc. Migraine treatments including isovaleramide compounds and serotonin agonists
DE102004063753A1 (de) * 2004-12-29 2006-07-13 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung ausgewählter CGRP-Antagonisten in Kombination mit anderen Arzneistoffen gegen Migräne für die Behandlung von Migräne
US8697876B2 (en) * 2010-04-02 2014-04-15 Colucid Pharmaceuticals, Inc. Compositions and methods of synthesis of pyridinolypiperidine 5-HT1F agonists
AR081434A1 (es) * 2010-06-10 2012-08-29 Lilly Co Eli Anticuerpo del peptido relacionado con el gen calcitonina (cgrp), composicion farmaceutica que lo comprende, uso de dicho anticuerpo para preparar un medicamento util para tratar dolor de osteoartritis o migranas y fragmento de union a antigeno de dicho anticuerpo
AR104847A1 (es) * 2015-06-17 2017-08-16 Lilly Co Eli Formulación de anticuerpo anti-cgrp
WO2018055574A1 (en) * 2016-09-23 2018-03-29 Teva Pharmaceuticals International Gmbh Treating refractory migraine
RU2770066C2 (ru) * 2017-03-02 2022-04-14 Бет Изрейэл Диконисс Медикал Сентер, Инк. Отбор пациентов с головной болью, восприимчивых к антителам, направленным против кальцитонин ген-родственного пептида
TWI754772B (zh) * 2017-09-06 2022-02-11 美商美國禮來大藥廠 用於治療偏頭痛之拉米迪坦(lasmiditan)與cgrp拮抗劑之組合療法

Also Published As

Publication number Publication date
JP7480261B2 (ja) 2024-05-09
KR20200036919A (ko) 2020-04-07
EP4397317A2 (en) 2024-07-10
EP3678665A1 (en) 2020-07-15
MY205182A (en) 2024-10-04
CN111032044A (zh) 2020-04-17
EP4397317A3 (en) 2024-10-16
EA202090457A1 (ru) 2020-06-10
KR20260027357A (ko) 2026-02-27
JP6922092B2 (ja) 2021-08-18
JP2023029872A (ja) 2023-03-07
JP7183355B2 (ja) 2022-12-05
US20200268735A1 (en) 2020-08-27
IL314347A (en) 2024-09-01
AU2018329568A1 (en) 2020-02-06
MA50073A (fr) 2020-07-15
JP7711255B2 (ja) 2025-07-22
TWI754772B (zh) 2022-02-11
JP2021176884A (ja) 2021-11-11
MA71474A (fr) 2025-04-30
MX2020002554A (es) 2020-07-13
CA3073996C (en) 2022-05-31
AU2018329568B2 (en) 2021-09-23
JP2020530861A (ja) 2020-10-29
WO2019050759A1 (en) 2019-03-14
SG11202001387WA (en) 2020-03-30
JP2024109585A (ja) 2024-08-14
ZA202000443B (en) 2022-07-27
TW201919624A (zh) 2019-06-01
JP2025165940A (ja) 2025-11-05
MX2023008760A (es) 2023-08-02
IL273031A (en) 2020-04-30
CA3073996A1 (en) 2019-03-14
CN116509861A (zh) 2023-08-01
BR112020002077A2 (pt) 2020-07-28
NZ761634A (en) 2024-05-31
CN116059204A (zh) 2023-05-05

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