JP6921755B2 - 脳腫瘍幹細胞の成長、遊走および浸潤性を低下させ脳腫瘍患者の生存率を改善する方法および組成物 - Google Patents
脳腫瘍幹細胞の成長、遊走および浸潤性を低下させ脳腫瘍患者の生存率を改善する方法および組成物 Download PDFInfo
- Publication number
- JP6921755B2 JP6921755B2 JP2017549860A JP2017549860A JP6921755B2 JP 6921755 B2 JP6921755 B2 JP 6921755B2 JP 2017549860 A JP2017549860 A JP 2017549860A JP 2017549860 A JP2017549860 A JP 2017549860A JP 6921755 B2 JP6921755 B2 JP 6921755B2
- Authority
- JP
- Japan
- Prior art keywords
- wnt5a
- cells
- tumor
- cell
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Marine Sciences & Fisheries (AREA)
- Reproductive Health (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462090029P | 2014-12-10 | 2014-12-10 | |
| US62/090,029 | 2014-12-10 | ||
| PCT/IB2015/002577 WO2016092378A1 (en) | 2014-12-10 | 2015-12-09 | Methods and compositions for reducing growth, migration and invasiveness of brain cancer stem cells and improving survival of patients with brian tumors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018500390A JP2018500390A (ja) | 2018-01-11 |
| JP2018500390A5 JP2018500390A5 (cg-RX-API-DMAC7.html) | 2019-01-24 |
| JP6921755B2 true JP6921755B2 (ja) | 2021-08-18 |
Family
ID=55353245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017549860A Active JP6921755B2 (ja) | 2014-12-10 | 2015-12-09 | 脳腫瘍幹細胞の成長、遊走および浸潤性を低下させ脳腫瘍患者の生存率を改善する方法および組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10688167B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3229831B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6921755B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102674191B1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2015359043C1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2970140A1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK3229831T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2796973T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016092378A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10852069B2 (en) | 2010-05-04 | 2020-12-01 | Fractal Heatsink Technologies, LLC | System and method for maintaining efficiency of a fractal heat sink |
| KR102674191B1 (ko) * | 2014-12-10 | 2024-06-11 | 하이퍼스템 에스에이 | 뇌암 줄기 세포의 성장, 이동 및 침습성 감소 그리고 뇌종양을 가진 환자의 생존 개선 방법 및 조성물 |
| US20210008149A1 (en) * | 2017-10-25 | 2021-01-14 | Wntresearch Ab | Wnt5a peptides in reduction of cancer stem cells |
| KR101921836B1 (ko) | 2017-11-23 | 2018-11-26 | 서울대학교병원 | 피부성체 줄기세포의 분화 조절 방법, 및 피부성체 줄기세포의 분화 조절용 조성물 및 키트 |
| US20210041443A1 (en) * | 2018-04-24 | 2021-02-11 | Universidade Do Minho | Wnt6 as glioblastoma oncogenic biomarker, and uses of inhibitors thereof |
| EP3613757A1 (en) | 2018-08-20 | 2020-02-26 | Wntresearch AB | Solution phase routes for wnt hexapeptides |
| EP3666789A1 (en) * | 2018-12-14 | 2020-06-17 | Wntresearch AB | Linear solution phase routes for wnt hexapeptides |
| BR112021020635A2 (pt) * | 2019-04-16 | 2022-02-22 | Wntresearch Ab | Peptídeo wnt5a ou derivados do mesmo em combinação com um ou mais inibidores de ponto de controle para uso no tratamento do câncer de cólon, câncer colorretal ou câncer de mama |
| WO2021034784A1 (en) | 2019-08-16 | 2021-02-25 | Poltorak Technologies, LLC | Device and method for medical diagnostics |
| CN114081954B (zh) * | 2021-10-30 | 2023-02-28 | 中国人民解放军陆军军医大学第一附属医院 | 用于胶质母细胞瘤治疗的药物组合物以及预后的诊断试剂 |
| WO2025088835A1 (ja) * | 2023-10-25 | 2025-05-01 | 国立大学法人大阪大学 | ヒト化抗ckap4抗体又はその抗原結合性断片 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1521000A (en) | 1975-06-13 | 1978-08-09 | Syntex Puerto Rico Inc | Inhalation device |
| US4192309A (en) | 1978-09-05 | 1980-03-11 | Syntex Puerto Rico, Inc. | Inhalation device with capsule opener |
| US4227522A (en) | 1978-09-05 | 1980-10-14 | Syntex Puerto Rico, Inc. | Inhalation device |
| FR2550452B1 (fr) | 1982-10-08 | 1992-05-22 | Glaxo Group Ltd | Dispositif pour administrer des medicaments a des patients |
| US4778054A (en) | 1982-10-08 | 1988-10-18 | Glaxo Group Limited | Pack for administering medicaments to patients |
| FI88112C (fi) | 1985-07-30 | 1993-04-13 | Glaxo Group Ltd | Anordning foer administrering av laekemedel till patienter |
| JPH05963A (ja) | 1990-04-13 | 1993-01-08 | Toray Ind Inc | ポリペプチド類組成物 |
| US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| EP1226172A1 (en) * | 1999-11-05 | 2002-07-31 | Forskarpatent i Syd AB | Compounds, antibodies and methods for treating, preventing or diagnosing tumour metastasis |
| WO2006130082A1 (en) | 2005-05-30 | 2006-12-07 | Forskarpatent I Syd Ab | A peptide ligand to impair cancer cell migration |
| RU2517190C2 (ru) * | 2008-08-13 | 2014-05-27 | Внтрисерч Аб | Применение производных пептида wnt5-a для лечения меланомы и рака желудка |
| EP2523974A4 (en) | 2010-01-12 | 2013-11-06 | Oncomed Pharm Inc | WNT BINDING AGENTS AND USES THEREOF |
| EP2446895A1 (en) * | 2010-10-01 | 2012-05-02 | Stemgen S.P.A. | EPH receptor expression in tumor stem cells |
| US9278119B2 (en) * | 2011-07-01 | 2016-03-08 | Wntresearch Ab | Treatment of prostate cancer and a method for determining the prognosis for prostate cancer patients |
| US20140171356A1 (en) | 2012-12-12 | 2014-06-19 | The Board Of Trustees Of The Leland Stanford Junior University | Chemically immobilized wnt protein and methods of use |
| KR102674191B1 (ko) * | 2014-12-10 | 2024-06-11 | 하이퍼스템 에스에이 | 뇌암 줄기 세포의 성장, 이동 및 침습성 감소 그리고 뇌종양을 가진 환자의 생존 개선 방법 및 조성물 |
-
2015
- 2015-12-09 KR KR1020177018938A patent/KR102674191B1/ko active Active
- 2015-12-09 US US15/533,842 patent/US10688167B2/en active Active
- 2015-12-09 AU AU2015359043A patent/AU2015359043C1/en active Active
- 2015-12-09 CA CA2970140A patent/CA2970140A1/en active Pending
- 2015-12-09 EP EP15834638.7A patent/EP3229831B1/en active Active
- 2015-12-09 WO PCT/IB2015/002577 patent/WO2016092378A1/en not_active Ceased
- 2015-12-09 JP JP2017549860A patent/JP6921755B2/ja active Active
- 2015-12-09 DK DK15834638.7T patent/DK3229831T3/da active
- 2015-12-09 ES ES15834638T patent/ES2796973T3/es active Active
-
2020
- 2020-05-13 US US15/931,081 patent/US11357840B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR102674191B1 (ko) | 2024-06-11 |
| EP3229831B1 (en) | 2020-03-11 |
| US10688167B2 (en) | 2020-06-23 |
| ES2796973T3 (es) | 2020-11-30 |
| EP3229831A1 (en) | 2017-10-18 |
| KR20170098861A (ko) | 2017-08-30 |
| AU2015359043B2 (en) | 2021-09-02 |
| AU2015359043C1 (en) | 2022-01-06 |
| NZ732532A (en) | 2024-10-25 |
| CA2970140A1 (en) | 2016-06-16 |
| AU2015359043A1 (en) | 2017-06-29 |
| WO2016092378A1 (en) | 2016-06-16 |
| US11357840B2 (en) | 2022-06-14 |
| US20200345821A1 (en) | 2020-11-05 |
| US20170368158A1 (en) | 2017-12-28 |
| DK3229831T3 (da) | 2020-06-15 |
| JP2018500390A (ja) | 2018-01-11 |
| HK1245152A1 (en) | 2018-08-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6921755B2 (ja) | 脳腫瘍幹細胞の成長、遊走および浸潤性を低下させ脳腫瘍患者の生存率を改善する方法および組成物 | |
| JP7379428B2 (ja) | Nk細胞におけるサイトカイン誘導性sh2タンパク質の阻害 | |
| Lonardo et al. | Pancreatic stellate cells form a niche for cancer stem cells and promote their self-renewal and invasiveness | |
| ES2363765T3 (es) | Agonistas de fgfr. | |
| CN107709359A (zh) | Ror1‑ror2结合的调节剂 | |
| Nair | Epidermal growth factor receptor family and its role in cancer progression | |
| US10010581B2 (en) | Syndecan peptides and polypeptides and uses thereof | |
| Mizejewski | Breast Cancer, chemokines, and metastasis: a search for decoy ligands of the CXCR4 receptor | |
| ES2330918T3 (es) | Inhibidor del activador del factor de crecimiento de hepatocitos para usar en la modulacion de la angiogenesis y la cardiovascularizacion. | |
| CN105764513A (zh) | 干细胞调控ii | |
| US10189881B2 (en) | MPS peptides and use thereof | |
| KR20140142733A (ko) | Egfl7 표적화 및/또는 결합 폴리펩타이드, 그리고 신생혈관생성을 저해하는 방법 | |
| KR102384795B1 (ko) | 전이성 암의 치료 및 예방을 위한 제약 조성물 및 방법 | |
| TWI609692B (zh) | 新穎stip1多肽及其用途 | |
| US10080777B2 (en) | Syndecan peptides and polypeptides and uses thereof | |
| CN111139299B (zh) | Josd2蛋白在制备治疗恶性肿瘤药物中的应用 | |
| HK1245152B (en) | Methods and compositions for reducing growth, migration and invasiveness of brain cancer stem cells and improving survival of patients with brian tumors | |
| Benvenuti et al. | Discovery and Function of the HGF/MET and the MSP/RON Kinase Signaling Pathways in Cancer | |
| TWI808063B (zh) | 治療或預防癌症的方法 | |
| Jiang et al. | cGAS-STING signaling in melanoma: regulation and therapeutic targeting | |
| AU2008200559A1 (en) | VEGFR-3 Binding peptides and their use for inhibiting angiogenesis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20181210 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20181210 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20190830 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20190830 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20191129 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20200210 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20200507 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200710 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20201105 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210305 |
|
| C60 | Trial request (containing other claim documents, opposition documents) |
Free format text: JAPANESE INTERMEDIATE CODE: C60 Effective date: 20210305 |
|
| C11 | Written invitation by the commissioner to file amendments |
Free format text: JAPANESE INTERMEDIATE CODE: C11 Effective date: 20210325 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20210604 |
|
| C21 | Notice of transfer of a case for reconsideration by examiners before appeal proceedings |
Free format text: JAPANESE INTERMEDIATE CODE: C21 Effective date: 20210607 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20210701 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20210728 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6921755 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |