JP6921118B2 - アクアポリンを調節するための化合物 - Google Patents
アクアポリンを調節するための化合物 Download PDFInfo
- Publication number
- JP6921118B2 JP6921118B2 JP2018556376A JP2018556376A JP6921118B2 JP 6921118 B2 JP6921118 B2 JP 6921118B2 JP 2018556376 A JP2018556376 A JP 2018556376A JP 2018556376 A JP2018556376 A JP 2018556376A JP 6921118 B2 JP6921118 B2 JP 6921118B2
- Authority
- JP
- Japan
- Prior art keywords
- thiadiazole
- acetamide
- triazole
- sulfanyl
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- IDIAWHZRBFTHOG-UHFFFAOYSA-N CC(C)(C)[Si](C)(C)OCC(NCc1nnc(-c(cc2)ccc2OC)[s]1)=O Chemical compound CC(C)(C)[Si](C)(C)OCC(NCc1nnc(-c(cc2)ccc2OC)[s]1)=O IDIAWHZRBFTHOG-UHFFFAOYSA-N 0.000 description 1
- WTIHDAFXKHTFEG-UHFFFAOYSA-N CC(C)COc(cc1)ccc1C(O)=O Chemical compound CC(C)COc(cc1)ccc1C(O)=O WTIHDAFXKHTFEG-UHFFFAOYSA-N 0.000 description 1
- GGSMLASAMITWJL-UHFFFAOYSA-N CC(C)Oc(cc1)ccc1-c1nnc(NC(CCl)=O)[s]1 Chemical compound CC(C)Oc(cc1)ccc1-c1nnc(NC(CCl)=O)[s]1 GGSMLASAMITWJL-UHFFFAOYSA-N 0.000 description 1
- TZDXVPBZLGEBHL-UHFFFAOYSA-N CC(Cc(cc1)ccc1C1=NNC(NC(CCl)=O)S1)C1NC1 Chemical compound CC(Cc(cc1)ccc1C1=NNC(NC(CCl)=O)S1)C1NC1 TZDXVPBZLGEBHL-UHFFFAOYSA-N 0.000 description 1
- UDGLPEIWHGOCLO-UHFFFAOYSA-N CCN1C(CCOC)=NNC1(C)SCC(Nc1nnc(-c(cc2)ccc2OC)[s]1)=O Chemical compound CCN1C(CCOC)=NNC1(C)SCC(Nc1nnc(-c(cc2)ccc2OC)[s]1)=O UDGLPEIWHGOCLO-UHFFFAOYSA-N 0.000 description 1
- GMKFDKUHIRAVBS-UHFFFAOYSA-N CC[n]1c(S)nnc1Cc1ccccc1 Chemical compound CC[n]1c(S)nnc1Cc1ccccc1 GMKFDKUHIRAVBS-UHFFFAOYSA-N 0.000 description 1
- 0 CCc([n]1C*)nnc1SCC(Nc1nnc(-c2ccc(CC)cc2)[s]1)=O Chemical compound CCc([n]1C*)nnc1SCC(Nc1nnc(-c2ccc(CC)cc2)[s]1)=O 0.000 description 1
- JBYXJIIIXLRPKX-UHFFFAOYSA-N CCc([n]1CC)nnc1SCC(Nc1nnc(-c(cc2)ccc2S(C)(=NC)=O)[s]1)=O Chemical compound CCc([n]1CC)nnc1SCC(Nc1nnc(-c(cc2)ccc2S(C)(=NC)=O)[s]1)=O JBYXJIIIXLRPKX-UHFFFAOYSA-N 0.000 description 1
- WKLIMMLZGHORGN-UHFFFAOYSA-N CCc([n]1CC)nnc1SCC(Nc1nnc(-c2ccc(C(C)C)cc2)[s]1)=O Chemical compound CCc([n]1CC)nnc1SCC(Nc1nnc(-c2ccc(C(C)C)cc2)[s]1)=O WKLIMMLZGHORGN-UHFFFAOYSA-N 0.000 description 1
- HAOSKIWWMPHBND-UHFFFAOYSA-N CS(c(cc1)ccc1-c1nnc(N)[s]1)(=O)=O Chemical compound CS(c(cc1)ccc1-c1nnc(N)[s]1)(=O)=O HAOSKIWWMPHBND-UHFFFAOYSA-N 0.000 description 1
- BATIZPDGOUSHDS-UHFFFAOYSA-N CSc(cc1)ccc1-c1nnc(N)[s]1 Chemical compound CSc(cc1)ccc1-c1nnc(N)[s]1 BATIZPDGOUSHDS-UHFFFAOYSA-N 0.000 description 1
- KWHCPERWLHBLOT-UHFFFAOYSA-N CSc(cc1)ccc1C(O)=O Chemical compound CSc(cc1)ccc1C(O)=O KWHCPERWLHBLOT-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Emergency Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16167378 | 2016-04-28 | ||
| EP16167378.5 | 2016-04-28 | ||
| PCT/EP2017/060148 WO2017186893A1 (en) | 2016-04-28 | 2017-04-28 | Compounds for modulating aquaporins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019516677A JP2019516677A (ja) | 2019-06-20 |
| JP2019516677A5 JP2019516677A5 (enExample) | 2020-05-28 |
| JP6921118B2 true JP6921118B2 (ja) | 2021-08-18 |
Family
ID=55854711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018556376A Active JP6921118B2 (ja) | 2016-04-28 | 2017-04-28 | アクアポリンを調節するための化合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10730865B2 (enExample) |
| EP (1) | EP3448853B1 (enExample) |
| JP (1) | JP6921118B2 (enExample) |
| CA (1) | CA3022195C (enExample) |
| DK (1) | DK3448853T3 (enExample) |
| ES (1) | ES2902409T3 (enExample) |
| HR (1) | HRP20212031T1 (enExample) |
| HU (1) | HUE057193T2 (enExample) |
| LT (1) | LT3448853T (enExample) |
| PL (1) | PL3448853T3 (enExample) |
| PT (1) | PT3448853T (enExample) |
| WO (1) | WO2017186893A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111393444B (zh) * | 2019-01-02 | 2022-10-28 | 上海迪赛诺化学制药有限公司 | 一种阿巴卡韦羟基醋酸酯的制备方法 |
| WO2025137265A1 (en) | 2023-12-20 | 2025-06-26 | Saint Michael's College, Inc. | Methods and compositions for reducing gliaptosis: macroglia-induced neuronal cell death |
| CN118001408B (zh) * | 2024-04-08 | 2024-06-25 | 北京大学 | 一种水通道蛋白9磷酸化抑制剂的用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US333792A (en) * | 1886-01-05 | Stop watch | ||
| WO2004089367A1 (en) | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | Pharmaceutical use of substituted 1,2,4-triazoles |
| GB0704394D0 (en) * | 2007-03-07 | 2007-04-11 | Senexis Ltd | Compounds |
| JP6671382B2 (ja) | 2014-10-29 | 2020-03-25 | アポグリクス アクツィエブーラーグＡｐｏＧｌｙｘ ＡＢ | 特に糖尿病の治療に有用である２−（１，２，４−トリアゾール−３−イルスルファニル）−ｎ−１，３，４−チアジアゾール−２−イルアセトアミドの誘導体 |
-
2017
- 2017-04-28 ES ES17720125T patent/ES2902409T3/es active Active
- 2017-04-28 EP EP17720125.8A patent/EP3448853B1/en active Active
- 2017-04-28 PT PT177201258T patent/PT3448853T/pt unknown
- 2017-04-28 US US16/096,521 patent/US10730865B2/en active Active
- 2017-04-28 HU HUE17720125A patent/HUE057193T2/hu unknown
- 2017-04-28 JP JP2018556376A patent/JP6921118B2/ja active Active
- 2017-04-28 HR HRP20212031TT patent/HRP20212031T1/hr unknown
- 2017-04-28 PL PL17720125T patent/PL3448853T3/pl unknown
- 2017-04-28 WO PCT/EP2017/060148 patent/WO2017186893A1/en not_active Ceased
- 2017-04-28 CA CA3022195A patent/CA3022195C/en active Active
- 2017-04-28 LT LTEPPCT/EP2017/060148T patent/LT3448853T/lt unknown
- 2017-04-28 DK DK17720125.8T patent/DK3448853T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| LT3448853T (lt) | 2022-01-10 |
| HRP20212031T1 (hr) | 2022-04-01 |
| JP2019516677A (ja) | 2019-06-20 |
| ES2902409T3 (es) | 2022-03-28 |
| PL3448853T3 (pl) | 2022-02-28 |
| HUE057193T2 (hu) | 2022-04-28 |
| EP3448853B1 (en) | 2021-11-17 |
| PT3448853T (pt) | 2021-12-30 |
| US10730865B2 (en) | 2020-08-04 |
| WO2017186893A1 (en) | 2017-11-02 |
| US20190127360A1 (en) | 2019-05-02 |
| DK3448853T3 (da) | 2021-12-06 |
| EP3448853A1 (en) | 2019-03-06 |
| CA3022195A1 (en) | 2017-11-02 |
| CA3022195C (en) | 2024-02-13 |
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