JP6906520B2 - チェックポイント阻害剤と組みわせて2−デオキシ−2−フルオロ−l−フコースを用いる癌治療 - Google Patents

チェックポイント阻害剤と組みわせて2−デオキシ−2−フルオロ−l−フコースを用いる癌治療 Download PDF

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JP6906520B2
JP6906520B2 JP2018528650A JP2018528650A JP6906520B2 JP 6906520 B2 JP6906520 B2 JP 6906520B2 JP 2018528650 A JP2018528650 A JP 2018528650A JP 2018528650 A JP2018528650 A JP 2018528650A JP 6906520 B2 JP6906520 B2 JP 6906520B2
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cancer
pharmaceutical composition
fucose
deoxy
fluoro
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JP2019501145A5 (enExample
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ガーダイ,シャイラ
ロウ,チェ−レウン
センター,ピーター
オケリー,ニコル
フィールド,ジェシカ
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シージェン インコーポレイテッド
シージェン インコーポレイテッド
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2018528650A 2015-12-04 2016-12-02 チェックポイント阻害剤と組みわせて2−デオキシ−2−フルオロ−l−フコースを用いる癌治療 Active JP6906520B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562263228P 2015-12-04 2015-12-04
US62/263,228 2015-12-04
US201662308583P 2016-03-15 2016-03-15
US62/308,583 2016-03-15
US201662321857P 2016-04-13 2016-04-13
US62/321,857 2016-04-13
PCT/US2016/064783 WO2017096274A1 (en) 2015-12-04 2016-12-02 Cancer treatment using 2-deoxy-2-fluoro-l-fucose in combination with a checkpoint inhibitor

Publications (3)

Publication Number Publication Date
JP2019501145A JP2019501145A (ja) 2019-01-17
JP2019501145A5 JP2019501145A5 (enExample) 2020-01-16
JP6906520B2 true JP6906520B2 (ja) 2021-07-21

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JP2018528650A Active JP6906520B2 (ja) 2015-12-04 2016-12-02 チェックポイント阻害剤と組みわせて2−デオキシ−2−フルオロ−l−フコースを用いる癌治療

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US (1) US20180353524A1 (enExample)
EP (1) EP3383404A4 (enExample)
JP (1) JP6906520B2 (enExample)
KR (1) KR20180086233A (enExample)
CN (1) CN108289903B (enExample)
AU (1) AU2016362993A1 (enExample)
BR (1) BR112018011261A2 (enExample)
CA (1) CA3005997A1 (enExample)
EA (1) EA201891340A1 (enExample)
IL (1) IL259479B (enExample)
MX (1) MX385283B (enExample)
SG (2) SG11201804263PA (enExample)
WO (1) WO2017096274A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2608796T3 (pl) 2010-08-05 2019-04-30 Seattle Genetics Inc Hamowanie fukozylacji białka w warunkach in vivo za pomocą analogów fukozy
CA3037380A1 (en) 2016-10-11 2018-04-19 Agenus Inc. Anti-lag-3 antibodies and methods of use thereof
KR102687149B1 (ko) 2017-06-07 2024-07-24 씨젠 인크. 감소된 표면 푸코실화를 갖는 t 세포 및 이를 생산하고 사용하는 방법
US11911404B2 (en) * 2017-10-13 2024-02-27 H. Lee Moffitt Cancer Center And Research Institute, Inc. Fucosylation and immune surveillance in melanoma
AU2019324170A1 (en) 2018-08-23 2021-02-18 Seagen, Inc. Anti-TIGIT antibodies
WO2020132096A1 (en) * 2018-12-19 2020-06-25 Seattle Genetics, Inc. Controlled fucosylation of antibodies
US20220305038A1 (en) * 2019-08-16 2022-09-29 H. Lee Moffitt Cancer Center And Research Institute, Inc. Fucosylation and immune modulation in cancer
CN111973749B (zh) * 2020-09-07 2023-03-21 威海人生药业集团股份有限公司 一种抗肿瘤免疫治疗的药物组合物
KR20230158005A (ko) 2021-03-18 2023-11-17 씨젠 인크. 생물학적 활성 화합물의 내재화된 접합체로부터의 선택적 약물 방출
US20240197761A1 (en) * 2021-04-16 2024-06-20 H. Lee Moffitt Cancer Center And Research Institute, Inc. Fucosylation and immune modulation in cancer
CN113274502B (zh) * 2021-05-05 2023-01-03 中山大学肿瘤防治中心(中山大学附属肿瘤医院、中山大学肿瘤研究所) 用于特定型三阴乳腺癌免疫治疗的组合物
US20240238318A1 (en) * 2021-05-06 2024-07-18 H. Lee Moffitt Cancer Center And Research Institute, Inc. L-fucose and anti-androgen receptor therapy for treatment of cancer
CN113413465B (zh) * 2021-06-15 2022-06-03 北京大学 岩藻糖基化抑制剂在抗癌导致炎症中的应用
CN115466297B (zh) * 2022-08-25 2023-07-07 青岛农业大学 L-岩藻糖的应用以及动物饲料
WO2024077106A2 (en) * 2022-10-04 2024-04-11 H. Lee Moffitt Cancer Center And Research Institute, Inc. Leveraging l-fucose-mediated signaling to induce monocyte-derived dendritic cell polarization
WO2024191807A1 (en) 2023-03-10 2024-09-19 Seagen Inc. Methods of treating cancer with anti-tigit antibodies

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2608796T3 (pl) * 2010-08-05 2019-04-30 Seattle Genetics Inc Hamowanie fukozylacji białka w warunkach in vivo za pomocą analogów fukozy
ES2991853T3 (es) * 2013-11-05 2024-12-05 Cognate Bioservices Inc Combinaciones de inhibidores del punto de control y terapéuticos para tratar el cáncer

Also Published As

Publication number Publication date
MX385283B (es) 2025-03-18
CN108289903A (zh) 2018-07-17
US20180353524A1 (en) 2018-12-13
MX2018006674A (es) 2018-11-09
EA201891340A1 (ru) 2018-11-30
SG11201804263PA (en) 2018-06-28
SG10202005298RA (en) 2020-07-29
EP3383404A4 (en) 2019-07-31
CN108289903B (zh) 2021-08-03
EP3383404A1 (en) 2018-10-10
CA3005997A1 (en) 2017-06-08
BR112018011261A2 (pt) 2018-11-21
JP2019501145A (ja) 2019-01-17
IL259479A (en) 2018-07-31
WO2017096274A1 (en) 2017-06-08
KR20180086233A (ko) 2018-07-30
AU2016362993A1 (en) 2018-07-12
IL259479B (en) 2022-03-01

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