JP6900385B2 - トリテルペンサポニン類似物 - Google Patents

トリテルペンサポニン類似物 Download PDF

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JP6900385B2
JP6900385B2 JP2018543061A JP2018543061A JP6900385B2 JP 6900385 B2 JP6900385 B2 JP 6900385B2 JP 2018543061 A JP2018543061 A JP 2018543061A JP 2018543061 A JP2018543061 A JP 2018543061A JP 6900385 B2 JP6900385 B2 JP 6900385B2
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oxygen
nitrogen
antigen
sulfur
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JP2018537527A (ja
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ジン・デービット・ワイ
チア・エリック
フェルナンデス−テハダ・アルベルト
ガードナー・ジェフリー
ルイス・ジェイソン
リヴィングストン・フィリップ
マーティン・ジェイ・タイラー
ノードストローム・ラース
ピラーセッティ・ナガ・バラ・キショレ
ラグパティ・ゴーヴィンド
タン・ディレック
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アジュバンス・テクノロジーズ・インコーポレーテッド
メモリアル スローン ケタリング キャンサー センター
メモリアル スローン ケタリング キャンサー センター
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Priority to JP2021099839A priority Critical patent/JP2021152043A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7024—Esters of saccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/099—Bordetella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K2039/10—Brucella; Bordetella, e.g. Bordetella pertussis; Not used, see subgroups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55583—Polysaccharides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
JP2018543061A 2015-11-06 2016-11-04 トリテルペンサポニン類似物 Active JP6900385B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021099839A JP2021152043A (ja) 2015-11-06 2021-06-16 トリテルペンサポニン類似物
JP2022176130A JP2023012519A (ja) 2015-11-06 2022-11-02 トリテルペンサポニン類似物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562252296P 2015-11-06 2015-11-06
US62/252,296 2015-11-06
US201562268837P 2015-12-17 2015-12-17
US62/268,837 2015-12-17
PCT/US2016/060564 WO2017079582A1 (en) 2015-11-06 2016-11-04 Triterpene saponin analogues

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021099839A Division JP2021152043A (ja) 2015-11-06 2021-06-16 トリテルペンサポニン類似物

Publications (2)

Publication Number Publication Date
JP2018537527A JP2018537527A (ja) 2018-12-20
JP6900385B2 true JP6900385B2 (ja) 2021-07-07

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JP2018543061A Active JP6900385B2 (ja) 2015-11-06 2016-11-04 トリテルペンサポニン類似物
JP2021099839A Pending JP2021152043A (ja) 2015-11-06 2021-06-16 トリテルペンサポニン類似物
JP2022176130A Pending JP2023012519A (ja) 2015-11-06 2022-11-02 トリテルペンサポニン類似物

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JP2021099839A Pending JP2021152043A (ja) 2015-11-06 2021-06-16 トリテルペンサポニン類似物
JP2022176130A Pending JP2023012519A (ja) 2015-11-06 2022-11-02 トリテルペンサポニン類似物

Country Status (12)

Country Link
US (5) US20180327436A1 (enExample)
EP (2) EP3370730A4 (enExample)
JP (3) JP6900385B2 (enExample)
KR (1) KR20180077180A (enExample)
CN (2) CN108778289B (enExample)
AU (1) AU2016349693B2 (enExample)
CA (1) CA3003483C (enExample)
CL (1) CL2018001192A1 (enExample)
IL (3) IL286493B (enExample)
SG (2) SG11201803594TA (enExample)
WO (1) WO2017079582A1 (enExample)
ZA (1) ZA201802891B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
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JP2020517686A (ja) * 2017-04-25 2020-06-18 アジュバンス・テクノロジーズ・インコーポレーテッド トリテルペンサポニン類似物
JP2022191284A (ja) * 2017-04-25 2022-12-27 アジュバンス・テクノロジーズ・インコーポレーテッド トリテルペンサポニン類似物
JP2023012519A (ja) * 2015-11-06 2023-01-25 アジュバンス・テクノロジーズ・インコーポレーテッド トリテルペンサポニン類似物

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CN117106004B (zh) * 2022-05-17 2026-06-19 北京科兴中维生物技术有限公司 三萜皂苷化合物及其制备方法及应用
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023012519A (ja) * 2015-11-06 2023-01-25 アジュバンス・テクノロジーズ・インコーポレーテッド トリテルペンサポニン類似物
JP2020517686A (ja) * 2017-04-25 2020-06-18 アジュバンス・テクノロジーズ・インコーポレーテッド トリテルペンサポニン類似物
JP7177082B2 (ja) 2017-04-25 2022-11-22 アジュバンス・テクノロジーズ・インコーポレーテッド トリテルペンサポニン類似物
JP2022191284A (ja) * 2017-04-25 2022-12-27 アジュバンス・テクノロジーズ・インコーポレーテッド トリテルペンサポニン類似物

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CN108778289A (zh) 2018-11-09
AU2016349693A1 (en) 2018-05-17
IL293848A (en) 2022-08-01
JP2023012519A (ja) 2023-01-25
AU2016349693B2 (en) 2022-08-11
SG11201803594TA (en) 2018-05-30
US20230219991A1 (en) 2023-07-13
CA3003483A1 (en) 2017-05-11
EP3370730A4 (en) 2019-07-31
KR20180077180A (ko) 2018-07-06
CN112812143A (zh) 2021-05-18
US20180327436A1 (en) 2018-11-15
IL259145A (en) 2018-06-28
JP2021152043A (ja) 2021-09-30
US20200239509A1 (en) 2020-07-30
CL2018001192A1 (es) 2018-11-23
US12037355B2 (en) 2024-07-16
US20210002316A1 (en) 2021-01-07
SG10202012205XA (en) 2021-01-28
CN108778289B (zh) 2020-11-17
US20240327443A1 (en) 2024-10-03
EP3370730A1 (en) 2018-09-12
IL259145B (en) 2021-09-30
IL286493B (en) 2022-07-01
US10906926B2 (en) 2021-02-02
JP2018537527A (ja) 2018-12-20
WO2017079582A1 (en) 2017-05-11
IL293848B1 (en) 2024-10-01
CA3003483C (en) 2022-09-13
IL293848B2 (en) 2025-02-01
EP4001290A1 (en) 2022-05-25
ZA201802891B (en) 2020-01-29
IL286493A (en) 2021-10-31

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