SG10202012205XA - Triterpene saponin analogues - Google Patents
Triterpene saponin analoguesInfo
- Publication number
- SG10202012205XA SG10202012205XA SG10202012205XA SG10202012205XA SG10202012205XA SG 10202012205X A SG10202012205X A SG 10202012205XA SG 10202012205X A SG10202012205X A SG 10202012205XA SG 10202012205X A SG10202012205X A SG 10202012205XA SG 10202012205X A SG10202012205X A SG 10202012205XA
- Authority
- SG
- Singapore
- Prior art keywords
- triterpene saponin
- saponin analogues
- analogues
- triterpene
- saponin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/099—Bordetella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- C07H13/06—Fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K2039/10—Brucella; Bordetella, e.g. Bordetella pertussis; Not used, see subgroups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562252296P | 2015-11-06 | 2015-11-06 | |
| US201562268837P | 2015-12-17 | 2015-12-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10202012205XA true SG10202012205XA (en) | 2021-01-28 |
Family
ID=58662549
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10202012205XA SG10202012205XA (en) | 2015-11-06 | 2016-11-04 | Triterpene saponin analogues |
| SG11201803594TA SG11201803594TA (en) | 2015-11-06 | 2016-11-04 | Triterpene saponin analogues |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201803594TA SG11201803594TA (en) | 2015-11-06 | 2016-11-04 | Triterpene saponin analogues |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US20180327436A1 (en) |
| EP (2) | EP3370730A4 (en) |
| JP (3) | JP6900385B2 (en) |
| KR (1) | KR20180077180A (en) |
| CN (2) | CN108778289B (en) |
| AU (1) | AU2016349693B2 (en) |
| CA (1) | CA3003483C (en) |
| CL (1) | CL2018001192A1 (en) |
| IL (3) | IL293848A (en) |
| SG (2) | SG10202012205XA (en) |
| WO (1) | WO2017079582A1 (en) |
| ZA (1) | ZA201802891B (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3149015T3 (en) * | 2014-05-30 | 2021-09-27 | Memorial Sloan Kettering Cancer Center | MINIMUM SAPONIN ANALOGES, SYNTHESIS AND USE THEREOF |
| SG10202012205XA (en) | 2015-11-06 | 2021-01-28 | Adjuvance Technologies Inc | Triterpene saponin analogues |
| SG10202100536QA (en) * | 2017-04-13 | 2021-02-25 | Adjuvance Technologies Inc | Triterpene saponin synthesis, intermediates and adjuvant combinations |
| AU2018258070A1 (en) * | 2017-04-25 | 2019-10-24 | Adjuvance Technologies, Inc. | Triterpene saponin analogues |
| JP7177082B2 (en) * | 2017-04-25 | 2022-11-22 | アジュバンス・テクノロジーズ・インコーポレーテッド | Triterpene saponin analogues |
| JP2020536946A (en) * | 2017-10-16 | 2020-12-17 | アジュバンス・テクノロジーズ・インコーポレーテッド | Triterpene saponin analog |
| US20230128815A1 (en) * | 2020-03-23 | 2023-04-27 | Adjuvance Technologies, Inc. | Adjuvant compounds, salt forms, and formulations |
| EP4153210A2 (en) | 2020-05-19 | 2023-03-29 | Othair Prothena Limited | Multi-epitope vaccine for the treatment of alzheimer's disease |
| WO2023056089A1 (en) | 2021-10-03 | 2023-04-06 | Eisai R&D Management Co., Ltd. | Immunological adjuvant formulations comprising tlr4 agonist e6020 |
| WO2023081505A1 (en) * | 2021-11-08 | 2023-05-11 | Adjuvance Technologies, Inc. | Adjuvant compounds and formulations |
| EP4190359A1 (en) | 2021-12-03 | 2023-06-07 | Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE | Saponin-based adjuvants and vaccines |
| WO2023139145A1 (en) | 2022-01-19 | 2023-07-27 | Asociación Centro De Investigación Cooperativa En Biociencias-Cic Biogune | Saponin-based adjuvants and vaccines |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5231112A (en) | 1984-04-12 | 1993-07-27 | The Liposome Company, Inc. | Compositions containing tris salt of cholesterol hemisuccinate and antifungal |
| US5916588A (en) | 1984-04-12 | 1999-06-29 | The Liposome Company, Inc. | Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use |
| US4684479A (en) | 1985-08-14 | 1987-08-04 | Arrigo Joseph S D | Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures |
| US6759057B1 (en) | 1986-06-12 | 2004-07-06 | The Liposome Company, Inc. | Methods and compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs |
| IE60901B1 (en) | 1986-08-21 | 1994-08-24 | Vestar Inc | Improved treatment of systemic fungal infections with phospholipid particles encapsulating polyene antifungal antibiotics |
| US6406713B1 (en) | 1987-03-05 | 2002-06-18 | The Liposome Company, Inc. | Methods of preparing low-toxicity drug-lipid complexes |
| AU598958B2 (en) | 1987-11-12 | 1990-07-05 | Vestar, Inc. | Improved amphotericin b liposome preparation |
| US5215680A (en) | 1990-07-10 | 1993-06-01 | Cavitation-Control Technology, Inc. | Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles |
| ES2208946T3 (en) | 1996-08-23 | 2004-06-16 | Sequus Pharmaceuticals, Inc. | LIPOSOMES CONTAINING A CISPLATIN COMPOUND. |
| EP0932390A1 (en) | 1996-10-11 | 1999-08-04 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method |
| US6056973A (en) | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
| AU725257B2 (en) | 1996-10-15 | 2000-10-12 | Transave, Inc. | N-acyl phosphatidylethanolamine-mediated liposomal drug delivery |
| US6080725A (en) * | 1997-05-20 | 2000-06-27 | Galenica Pharmaceuticals, Inc. | Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof |
| US6262029B1 (en) * | 1998-08-14 | 2001-07-17 | Galenica Pharmaceuticals, Inc. | Chemically modified saponins and the use thereof as adjuvants |
| WO2001015727A2 (en) | 1999-09-02 | 2001-03-08 | Antigenics Inc. | Compositions of immunostimulatory polymers and saponin adjuvants and uses thereof |
| GB0401239D0 (en) | 2004-01-21 | 2004-02-25 | Molecularnature Ltd | Adjuvant compositions |
| GB0504436D0 (en) | 2005-03-03 | 2005-04-06 | Glaxosmithkline Biolog Sa | Vaccine |
| TWI457133B (en) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | Novel composition |
| GB0700562D0 (en) * | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
| CA2687632C (en) | 2007-05-24 | 2013-01-15 | Glaxosmithkline Biologicals S.A. | Lyophilised antigen composition |
| CL2008003808A1 (en) | 2007-12-21 | 2011-03-11 | Glaxosmithkline Biologicals Sa | Malaria vaccine component comprising an rts, s and / or an immunogenic particle that is derived from the cs protein of one or more strains of p. vivax and hepatitis b antigen s or an immunogenic particle comprising rts, csv-s and optionally the unbound antigen s and a stabilizing agent; and vaccine. |
| KR102256410B1 (en) * | 2008-04-08 | 2021-05-26 | 슬로안-케테링인스티튜트퍼캔서리서치 | Triterpene saponins, methods of synthesis, and uses thereof |
| AU2009237647A1 (en) | 2008-04-16 | 2009-10-22 | Glaxosmithkline Biologicals S.A. | Vaccine |
| US20130309273A1 (en) | 2012-05-17 | 2013-11-21 | Kimberly Hassett | Thermostable Vaccine Compositions and Methods of Preparing Same |
| US20140072622A1 (en) | 2011-05-17 | 2014-03-13 | Glaxosmithkline Biologicals S.A. | Vaccine against streptococcus pneumoniae |
| US20150037374A1 (en) | 2013-07-31 | 2015-02-05 | Csl Limited | Anti-tumor compositions and uses thereof |
| DK3149015T3 (en) * | 2014-05-30 | 2021-09-27 | Memorial Sloan Kettering Cancer Center | MINIMUM SAPONIN ANALOGES, SYNTHESIS AND USE THEREOF |
| SG10202012205XA (en) | 2015-11-06 | 2021-01-28 | Adjuvance Technologies Inc | Triterpene saponin analogues |
| WO2017106836A1 (en) | 2015-12-17 | 2017-06-22 | Memorial Sloan-Kettering Cancer Center | Triterpene saponin variants, methods of synthesis and use thereof |
-
2016
- 2016-11-04 SG SG10202012205XA patent/SG10202012205XA/en unknown
- 2016-11-04 SG SG11201803594TA patent/SG11201803594TA/en unknown
- 2016-11-04 JP JP2018543061A patent/JP6900385B2/en active Active
- 2016-11-04 IL IL293848A patent/IL293848A/en unknown
- 2016-11-04 CA CA3003483A patent/CA3003483C/en active Active
- 2016-11-04 EP EP16863057.2A patent/EP3370730A4/en not_active Withdrawn
- 2016-11-04 KR KR1020187012783A patent/KR20180077180A/en not_active Application Discontinuation
- 2016-11-04 WO PCT/US2016/060564 patent/WO2017079582A1/en active Application Filing
- 2016-11-04 AU AU2016349693A patent/AU2016349693B2/en active Active
- 2016-11-04 EP EP21210191.9A patent/EP4001290A1/en active Pending
- 2016-11-04 CN CN201680078068.9A patent/CN108778289B/en active Active
- 2016-11-04 CN CN202011417416.5A patent/CN112812143A/en active Pending
- 2016-11-04 US US15/774,081 patent/US20180327436A1/en not_active Abandoned
- 2016-11-04 IL IL286493A patent/IL286493B/en unknown
-
2018
- 2018-05-03 ZA ZA2018/02891A patent/ZA201802891B/en unknown
- 2018-05-03 CL CL2018001192A patent/CL2018001192A1/en unknown
- 2018-05-03 IL IL259145A patent/IL259145B/en unknown
-
2020
- 2020-03-23 US US16/827,220 patent/US10906926B2/en active Active
- 2020-08-27 US US17/005,110 patent/US20210002316A1/en not_active Abandoned
-
2021
- 2021-06-16 JP JP2021099839A patent/JP2021152043A/en active Pending
-
2022
- 2022-11-02 JP JP2022176130A patent/JP2023012519A/en active Pending
-
2023
- 2023-03-08 US US18/180,421 patent/US20230219991A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL286493A (en) | 2021-10-31 |
| JP2018537527A (en) | 2018-12-20 |
| CN112812143A (en) | 2021-05-18 |
| SG11201803594TA (en) | 2018-05-30 |
| EP3370730A4 (en) | 2019-07-31 |
| WO2017079582A1 (en) | 2017-05-11 |
| AU2016349693A1 (en) | 2018-05-17 |
| IL293848A (en) | 2022-08-01 |
| CA3003483A1 (en) | 2017-05-11 |
| ZA201802891B (en) | 2020-01-29 |
| CN108778289A (en) | 2018-11-09 |
| KR20180077180A (en) | 2018-07-06 |
| IL259145A (en) | 2018-06-28 |
| CL2018001192A1 (en) | 2018-11-23 |
| JP2023012519A (en) | 2023-01-25 |
| US20180327436A1 (en) | 2018-11-15 |
| US20200239509A1 (en) | 2020-07-30 |
| EP3370730A1 (en) | 2018-09-12 |
| AU2016349693B2 (en) | 2022-08-11 |
| IL259145B (en) | 2021-09-30 |
| US10906926B2 (en) | 2021-02-02 |
| EP4001290A1 (en) | 2022-05-25 |
| US20230219991A1 (en) | 2023-07-13 |
| CN108778289B (en) | 2020-11-17 |
| JP2021152043A (en) | 2021-09-30 |
| IL286493B (en) | 2022-07-01 |
| CA3003483C (en) | 2022-09-13 |
| US20210002316A1 (en) | 2021-01-07 |
| JP6900385B2 (en) | 2021-07-07 |
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