ZA201802891B - Triterpene saponin analogues - Google Patents
Triterpene saponin analoguesInfo
- Publication number
- ZA201802891B ZA201802891B ZA2018/02891A ZA201802891A ZA201802891B ZA 201802891 B ZA201802891 B ZA 201802891B ZA 2018/02891 A ZA2018/02891 A ZA 2018/02891A ZA 201802891 A ZA201802891 A ZA 201802891A ZA 201802891 B ZA201802891 B ZA 201802891B
- Authority
- ZA
- South Africa
- Prior art keywords
- triterpene saponin
- saponin analogues
- analogues
- triterpene
- saponin
- Prior art date
Links
- 229930182493 triterpene saponin Natural products 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/099—Bordetella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- C07H13/06—Fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K2039/10—Brucella; Bordetella, e.g. Bordetella pertussis; Not used, see subgroups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562252296P | 2015-11-06 | 2015-11-06 | |
| US201562268837P | 2015-12-17 | 2015-12-17 | |
| PCT/US2016/060564 WO2017079582A1 (en) | 2015-11-06 | 2016-11-04 | Triterpene saponin analogues |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201802891B true ZA201802891B (en) | 2020-01-29 |
Family
ID=58662549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2018/02891A ZA201802891B (en) | 2015-11-06 | 2018-05-03 | Triterpene saponin analogues |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US20180327436A1 (enExample) |
| EP (2) | EP3370730A4 (enExample) |
| JP (3) | JP6900385B2 (enExample) |
| KR (1) | KR20180077180A (enExample) |
| CN (2) | CN108778289B (enExample) |
| AU (1) | AU2016349693B2 (enExample) |
| CA (1) | CA3003483C (enExample) |
| CL (1) | CL2018001192A1 (enExample) |
| IL (3) | IL286493B (enExample) |
| SG (2) | SG11201803594TA (enExample) |
| WO (1) | WO2017079582A1 (enExample) |
| ZA (1) | ZA201802891B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6774943B2 (ja) * | 2014-05-30 | 2020-10-28 | メモリアル スローン ケタリング キャンサー センター | 極小サポニンアナログ、その合成および使用 |
| US20180327436A1 (en) * | 2015-11-06 | 2018-11-15 | Adjuvance Technologies, Inc. | Triterpene saponin analogues |
| JP2020516657A (ja) * | 2017-04-13 | 2020-06-11 | アジュバンス・テクノロジーズ・インコーポレーテッド | トリテルペンサポニン合成、中間体及びアジュバントの組み合わせ |
| JP7177082B2 (ja) * | 2017-04-25 | 2022-11-22 | アジュバンス・テクノロジーズ・インコーポレーテッド | トリテルペンサポニン類似物 |
| SG10202108075YA (en) * | 2017-04-25 | 2021-09-29 | Adjuvance Technologies Inc | Triterpene saponin analogues |
| CA3075822A1 (en) * | 2017-10-16 | 2019-04-25 | Adjuvance Technologies, Inc. | Triterpene saponin analogues |
| US20230128815A1 (en) * | 2020-03-23 | 2023-04-27 | Adjuvance Technologies, Inc. | Adjuvant compounds, salt forms, and formulations |
| AU2021276401A1 (en) | 2020-05-19 | 2022-12-15 | Othair Prothena Limited | Multi-epitope vaccine for the treatment of Alzheimer's disease |
| EP4192497A4 (en) | 2020-08-07 | 2024-08-21 | Othair Prothena Limited | MULTI-EPITOPIC VACCINE FOR THE TREATMENT OF ALZHEIMER'S DISEASE |
| WO2023056089A1 (en) | 2021-10-03 | 2023-04-06 | Eisai R&D Management Co., Ltd. | Immunological adjuvant formulations comprising tlr4 agonist e6020 |
| WO2023081505A1 (en) * | 2021-11-08 | 2023-05-11 | Adjuvance Technologies, Inc. | Adjuvant compounds and formulations |
| EP4190359A1 (en) | 2021-12-03 | 2023-06-07 | Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE | Saponin-based adjuvants and vaccines |
| WO2023139145A1 (en) | 2022-01-19 | 2023-07-27 | Asociación Centro De Investigación Cooperativa En Biociencias-Cic Biogune | Saponin-based adjuvants and vaccines |
| CN117106004A (zh) * | 2022-05-17 | 2023-11-24 | 北京科兴中维生物技术有限公司 | 三萜皂苷化合物及其制备方法及应用 |
| WO2024218268A1 (en) | 2023-04-20 | 2024-10-24 | Asociación Centro De Investigación Cooperativa En Biociencias-Cic Biogune | Saponin derivatives as adjuvants and photoaffinity probes |
| WO2024261351A2 (en) | 2024-05-08 | 2024-12-26 | Vaccine Formulation Institute Ch Ltd. | Immunologically active saponin fractions and adjuvant formulations |
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| JPS5341202B2 (enExample) | 1974-03-12 | 1978-11-01 | ||
| US5231112A (en) | 1984-04-12 | 1993-07-27 | The Liposome Company, Inc. | Compositions containing tris salt of cholesterol hemisuccinate and antifungal |
| US5916588A (en) | 1984-04-12 | 1999-06-29 | The Liposome Company, Inc. | Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use |
| US4769239A (en) | 1984-08-21 | 1988-09-06 | Merck & Co., Inc. | Vaccine against varicella-zoster virus |
| US4684479A (en) | 1985-08-14 | 1987-08-04 | Arrigo Joseph S D | Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures |
| US6759057B1 (en) | 1986-06-12 | 2004-07-06 | The Liposome Company, Inc. | Methods and compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs |
| IE60901B1 (en) | 1986-08-21 | 1994-08-24 | Vestar Inc | Improved treatment of systemic fungal infections with phospholipid particles encapsulating polyene antifungal antibiotics |
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| US5583112A (en) | 1987-05-29 | 1996-12-10 | Cambridge Biotech Corporation | Saponin-antigen conjugates and the use thereof |
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| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
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| JP6774943B2 (ja) * | 2014-05-30 | 2020-10-28 | メモリアル スローン ケタリング キャンサー センター | 極小サポニンアナログ、その合成および使用 |
| MX2017008055A (es) | 2014-12-18 | 2017-09-28 | Glaxosmithkline Biologicals Sa | Vacunacion. |
| US20180327436A1 (en) * | 2015-11-06 | 2018-11-15 | Adjuvance Technologies, Inc. | Triterpene saponin analogues |
| EP3389669B1 (en) | 2015-12-17 | 2023-03-15 | Memorial Sloan-Kettering Cancer Center | Triterpene saponin variants, methods of synthesis and use thereof |
| GB201621686D0 (en) | 2016-12-20 | 2017-02-01 | Glaxosmithkline Biologicals Sa | Novel methods for inducing an immune response |
| JP2020516657A (ja) | 2017-04-13 | 2020-06-11 | アジュバンス・テクノロジーズ・インコーポレーテッド | トリテルペンサポニン合成、中間体及びアジュバントの組み合わせ |
| JP7177082B2 (ja) | 2017-04-25 | 2022-11-22 | アジュバンス・テクノロジーズ・インコーポレーテッド | トリテルペンサポニン類似物 |
| SG10202108075YA (en) | 2017-04-25 | 2021-09-29 | Adjuvance Technologies Inc | Triterpene saponin analogues |
| KR102755593B1 (ko) | 2017-09-08 | 2025-01-20 | 액세스 투 어드밴스드 헬스 인스티튜트 | 사포닌을 포함하는 리포솜 제형 및 사용 방법 |
| CA3075822A1 (en) | 2017-10-16 | 2019-04-25 | Adjuvance Technologies, Inc. | Triterpene saponin analogues |
| WO2019175145A1 (en) | 2018-03-12 | 2019-09-19 | Janssen Vaccines & Prevention B.V. | Vaccines against urinary tract infections |
| US20220409721A1 (en) | 2019-11-05 | 2022-12-29 | Adjuvance Technologies, Inc. | Varicella zoster |
-
2016
- 2016-11-04 US US15/774,081 patent/US20180327436A1/en not_active Abandoned
- 2016-11-04 IL IL286493A patent/IL286493B/en unknown
- 2016-11-04 SG SG11201803594TA patent/SG11201803594TA/en unknown
- 2016-11-04 WO PCT/US2016/060564 patent/WO2017079582A1/en not_active Ceased
- 2016-11-04 KR KR1020187012783A patent/KR20180077180A/ko not_active Ceased
- 2016-11-04 JP JP2018543061A patent/JP6900385B2/ja active Active
- 2016-11-04 IL IL293848A patent/IL293848B2/en unknown
- 2016-11-04 EP EP16863057.2A patent/EP3370730A4/en not_active Withdrawn
- 2016-11-04 CN CN201680078068.9A patent/CN108778289B/zh active Active
- 2016-11-04 SG SG10202012205XA patent/SG10202012205XA/en unknown
- 2016-11-04 CN CN202011417416.5A patent/CN112812143A/zh active Pending
- 2016-11-04 CA CA3003483A patent/CA3003483C/en active Active
- 2016-11-04 AU AU2016349693A patent/AU2016349693B2/en active Active
- 2016-11-04 EP EP21210191.9A patent/EP4001290A1/en active Pending
-
2018
- 2018-05-03 CL CL2018001192A patent/CL2018001192A1/es unknown
- 2018-05-03 ZA ZA2018/02891A patent/ZA201802891B/en unknown
- 2018-05-03 IL IL259145A patent/IL259145B/en unknown
-
2020
- 2020-03-23 US US16/827,220 patent/US10906926B2/en active Active
- 2020-08-27 US US17/005,110 patent/US20210002316A1/en not_active Abandoned
-
2021
- 2021-06-16 JP JP2021099839A patent/JP2021152043A/ja active Pending
-
2022
- 2022-11-02 JP JP2022176130A patent/JP2023012519A/ja active Pending
-
2023
- 2023-03-08 US US18/180,421 patent/US12037355B2/en active Active
-
2024
- 2024-06-04 US US18/733,207 patent/US20240327443A1/en active Pending
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