JP6888827B2 - 末梢におけるセロトニン受容体をモジュレートするための化合物または方法 - Google Patents
末梢におけるセロトニン受容体をモジュレートするための化合物または方法 Download PDFInfo
- Publication number
- JP6888827B2 JP6888827B2 JP2017560505A JP2017560505A JP6888827B2 JP 6888827 B2 JP6888827 B2 JP 6888827B2 JP 2017560505 A JP2017560505 A JP 2017560505A JP 2017560505 A JP2017560505 A JP 2017560505A JP 6888827 B2 JP6888827 B2 JP 6888827B2
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- JP
- Japan
- Prior art keywords
- compound
- fold
- receptor
- compounds
- serotonin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
- C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
- C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562163652P | 2015-05-19 | 2015-05-19 | |
| US62/163,652 | 2015-05-19 | ||
| PCT/US2016/033185 WO2016187377A1 (en) | 2015-05-19 | 2016-05-19 | Compounds and methods for modulating serotonin receptors in the periphery |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018521971A JP2018521971A (ja) | 2018-08-09 |
| JP2018521971A5 JP2018521971A5 (https=) | 2019-06-27 |
| JP6888827B2 true JP6888827B2 (ja) | 2021-06-16 |
Family
ID=57320754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017560505A Active JP6888827B2 (ja) | 2015-05-19 | 2016-05-19 | 末梢におけるセロトニン受容体をモジュレートするための化合物または方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10548856B2 (https=) |
| EP (1) | EP3297979B1 (https=) |
| JP (1) | JP6888827B2 (https=) |
| CN (1) | CN107614467A (https=) |
| BR (1) | BR112017024745A2 (https=) |
| CA (1) | CA3015750A1 (https=) |
| DK (1) | DK3297979T3 (https=) |
| WO (1) | WO2016187377A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102483492B1 (ko) * | 2019-09-02 | 2023-01-02 | 한양대학교 에리카산학협력단 | 2,5-이치환된 피리미딘 유도체 및 이를 포함하는 약학적 조성물 |
| EP4200287A4 (en) * | 2020-08-19 | 2024-12-18 | Northeastern University | SEROTONIN RECEPTOR MODULATORS |
| AU2022310353A1 (en) * | 2021-07-14 | 2024-02-01 | Northeastern University | Serotonin 5-ht2a, 5-ht2b, and 5-ht2c receptor inverse agonists |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9601110D0 (sv) * | 1996-03-22 | 1996-03-22 | Astra Ab | Substituted 1,2,3,4-tetrahydronaphthalene derivatives |
| WO2006105117A2 (en) * | 2005-03-28 | 2006-10-05 | Dynogen Pharmaceuticals, Inc. | Method of treating disorders and conditions using peripherally-restricted antagonists and inhibitors |
| EP2029566B1 (en) * | 2006-06-22 | 2011-04-27 | Ramot, at Tel Aviv University Ltd. | Novel serotonin reuptake inhibitors as drugs having peripheral-system-restricted activity |
| EP1956006A1 (en) * | 2007-02-06 | 2008-08-13 | Laboratorios del Dr. Esteve S.A. | Heterocyclyl-substituted-tetrahydro-naphthalen derivatives as 5-HT7 receptor ligands |
| EP1975161A1 (en) * | 2007-03-28 | 2008-10-01 | Laboratorios del Dr. Esteve S.A. | Heterocyclyl-substituted- tetrahydro-napthalen-amine derivatives, their preparation and use as medicaments |
| EP2164324B1 (en) * | 2007-06-15 | 2014-08-13 | University Of Florida Research Foundation | Therapeutic compounds |
| WO2008154044A1 (en) * | 2007-06-15 | 2008-12-18 | University Of Florida Research Foundation | Therapeutic compounds and methods of use |
| WO2009061436A1 (en) * | 2007-11-06 | 2009-05-14 | University Of Florida Research Foundation | Compound for activating 5-ht2c receptors in combination with an amphetamine compound |
| JP5932636B2 (ja) | 2009-05-05 | 2016-06-08 | ユニバーシティ オブ フロリダ リサーチ ファウンデーション，インコーポレイテッド | 治療化合物 |
| BR112016027096B1 (pt) * | 2014-05-19 | 2023-04-11 | Northeastern University | Composições farmacêuticas e compostos de receptores-alvo de serotonina e seus usos |
-
2016
- 2016-05-19 CN CN201680028629.4A patent/CN107614467A/zh active Pending
- 2016-05-19 JP JP2017560505A patent/JP6888827B2/ja active Active
- 2016-05-19 BR BR112017024745A patent/BR112017024745A2/pt not_active Application Discontinuation
- 2016-05-19 CA CA3015750A patent/CA3015750A1/en active Pending
- 2016-05-19 DK DK16797266.0T patent/DK3297979T3/da active
- 2016-05-19 EP EP16797266.0A patent/EP3297979B1/en active Active
- 2016-05-19 WO PCT/US2016/033185 patent/WO2016187377A1/en not_active Ceased
- 2016-05-19 US US15/574,971 patent/US10548856B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20180125798A1 (en) | 2018-05-10 |
| US10548856B2 (en) | 2020-02-04 |
| BR112017024745A2 (pt) | 2018-11-13 |
| EP3297979B1 (en) | 2024-11-20 |
| CA3015750A1 (en) | 2016-11-24 |
| EP3297979A4 (en) | 2019-01-09 |
| CN107614467A (zh) | 2018-01-19 |
| WO2016187377A1 (en) | 2016-11-24 |
| DK3297979T3 (da) | 2025-01-02 |
| JP2018521971A (ja) | 2018-08-09 |
| EP3297979A1 (en) | 2018-03-28 |
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